WO2016062269A1 - 阿那格雷在用于制备治疗癌症的医药组合物中的用途 - Google Patents
阿那格雷在用于制备治疗癌症的医药组合物中的用途 Download PDFInfo
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- WO2016062269A1 WO2016062269A1 PCT/CN2015/092666 CN2015092666W WO2016062269A1 WO 2016062269 A1 WO2016062269 A1 WO 2016062269A1 CN 2015092666 W CN2015092666 W CN 2015092666W WO 2016062269 A1 WO2016062269 A1 WO 2016062269A1
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- cancer
- anagrelide
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- cells
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Definitions
- the present invention is an application of a new indication for anagrelide drugs, in particular, the use of the anagrelide drug for inhibiting various cancers.
- Anagrelide HCl is a platelet drug. The specific mechanism of action is not clear. It may reduce platelet production by reducing megakaryocyte over-maturation. It is mainly used to treat essential thrombocytosis. Anagrelide is a drug that has long been approved by the FDA and has a large number of drug transfer and human research results.
- cancer has long been the leading cause of death worldwide, and the number of cancer patients has increased year by year. Therefore, treating cancer has become an important issue.
- cancer drug treatment whether it is chemotherapy or target treatment, is intended to prevent cancer cells from replicating and dividing to block the spread and spread of tumors. According to statistics, only about five out of every 10,000 new drugs can enter the first phase of clinical trials. Further, many cancer cells successively develop drug resistance, which greatly reduces the effectiveness of drug use, and ultimately leads to failure of cancer treatment. This shows that drug development has a certain degree of difficulty.
- the present invention aims at the development of new indications for anagrelide drugs, and achieves the goal of new use of old drugs.
- the present invention provides the use of an Anagrelide HCl for the preparation of a pharmaceutical composition for the treatment of cancer, wherein the pharmaceutical composition comprises an effective amount of anagrelide and a pharmaceutically acceptable salt.
- the cancer is one or more selected from the group consisting of a chest-related cancer, an abdominal cavity-related cancer, an endocrine-related cancer, and a digestive tract-related cancer.
- the cancer is selected from the group consisting of an osteosarcoma-related cancer, a skin One or more of cancer-related cancers and blood cancer-related cancers.
- chest cavity related cancer refers to lung cancer
- the abdominal cavity-related cancer is selected from the group consisting of bladder cancer or/and cervical cancer.
- the endocrine-related cancer is one or more selected from the group consisting of prostate cancer, breast cancer, and ovarian cancer.
- the endocrine-related cancer is one or more selected from the group consisting of gastric cancer, liver cancer, colon cancer, pancreatic cancer, and tongue cancer.
- the effective concentration of the anagrelide drug is 20 to 500 mg/kg/day.
- Figure 1 shows the use of the anagrelide of the present invention for inhibiting cancer cell analysis results.
- FIG. 2 shows the effect of anagrelide on tumor volume
- Figure 3 shows the inhibitory effect of high-dose and low-dose anagrelide growth
- Subculture of cell lines of different cancer types including cancerous lung cancer, gastric cancer, liver cancer, rectal cancer, skin cancer, cervical cancer, prostate cancer, bladder cancer, breast cancer, blood cancer, pancreatic cancer, ovarian cancer, tongue cancer Osteosarcoma, kidney cancer, and the control group also used normal cells of the kidney (HEK293 (Kidney)) and lung epithelial cells BEAS-2B (Lung Epithelial) for testing.
- HEK293 Kidney
- BEAS-2B Lung Epithelial
- the cells corresponding to different species should also be counted with the corresponding culture solution (Table 1), and the number of cells should be 2 ⁇ 10 6 cells.
- the dish was then added to the culture medium in which the cell strain was cultured to a volume of 10 ml, and the cultivation was continued for 2-3 days. The cells were then counted and dispensed into 96-well plates where the number of cells per well was fixed at 3000 cells and the volume was 100 ul.
- the original culture solution in the 96-well plate was aspirated, and a commercially available drug having a concentration of 10 ⁇ m and a volume of 100 ul was added to each well. After 72 hours, 100 ul of diluted WST-1 reagent was added to each well, and the dilution ratio was the culture solution and The volume ratio of the WST-1 stock solution is 9:1. Finally, the total volume of each well plate is 200 ul. Then, the 96-well plate is placed at 37 ° C for 30-90 minutes, using an elisa reader (ELISA) on the OD450. The absorbance values were detected and the survival rate of each cancer cell line was calculated.
- ELISA elisa reader
- the analysis of the inhibitory effect of anagrelide on the cells of the abdominal cavity-related cancer was mainly tested on two kinds of cells related to the abdominal cavity-related cancer.
- the bladder cancer cell lines were TSGH and T24, respectively (Table 3), cervical cancer cell lines. They were HeLa cell line (Table 4), kidney cancer was 786-O cell line (Table 5), and the results of cancer cell inhibition experiments were performed 4 times each, and the average value was calculated. The results are shown below.
- the gastric cancer cell lines were AGS and MKN-45, respectively (Table 9), liver cancer cell lines. They were HepG2 and Hep3B, respectively (Table 10), the colorectal cancer cell lines were HCT116-wt and LoVo cell lines (Table 11), and the pancreatic cancer cell lines were AsPC and BxPC cell lines, respectively (Table 12).
- the tongue cancer cell line was a SAS cell line (Table 13), and the results of the cancer cell inhibition experiments were performed 4 times each, and the average value was calculated, and the results are shown below.
- the osteosarctic cancer cell line is U2OS cell line (Table 14)
- the skin cancer cell line is A375 and BCC, respectively. Fifteen), the results of the cancer suppression experiments performed 3 to 4 times each, and the average value was calculated, and the results are listed as follows.
- Analyzed anagrelide was tested on a variety of normal cells.
- the normal kidney cell line was HEK293 cell line (Table 16), and the normal lung epithelial cell line was BEAS-2B cell line (Table 17).
- the cancer cells inhibited the experimental results and calculated their average values, and the results are listed below.
- mice Female BALB/cAnN.Cg-Foxn1nu/CrlNarl mice were used as samples (purchased from National Laboratory Animal Center), weighing 21 ⁇ 1g, subcutaneously injected into cervical cancer cells (HeLa), and the test drugs were divided into three.
- the drug was administered by intraperitoneal injection every day; the tumor size was measured twice a week, and the tumor volume measurement formula was as follows: (L ⁇ W2); L represents the longest diameter of the tumor; W represents the shortest diameter of the tumor.
- high and low doses of anagrelide can effectively slow down the tumor volume and simultaneously reduce the tumor volume, and the high dose of anagrelide has a better effect.
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Abstract
本发明提供了阿那格雷在制备治疗癌症的医药组合物中的用途,所述癌症包括肺癌、膀胱癌、肾脏癌、子宫颈癌、前列腺癌、乳癌、卵巢癌、胃癌、肝癌、大肠癌、胰脏癌、舌癌等。
Description
本发明为阿那格雷药物的新适应症的应用,尤其该阿那格雷药物具有抑制多种癌症的用途。
阿那格雷(Anagrelide HCl)是血小板药,其具体作用机制尚不明确,可能是通过减少巨核细胞过度成熟而减少血小板生成,临床上主要是用于治疗原发性血小板增多症。阿那格雷是早已被FDA所认可的用药,具有大量药物机转及人体研究成果资料。
由于临床应用上的明显差异,因此从来没有人认为阿那格雷具有抑制癌症细胞的可能性。
癌症长期高居全球死因之首,且罹患癌症人数更是逐年攀升,因此治疗癌症俨然成为重要的课题。一般来说,癌症药物治疗无论是化学治疗或标靶治疗,目的多是让癌细胞无法复制、分裂,来阻断肿瘤的蔓延扩张。根据统计,平均每一万个新药约只有五个能够进入第一期临床试验。进一步,许多癌细胞相继产生抗药性,使药物的使用成效大幅降低,最终导致癌症治疗失败。由此可见药物开发具有一定的困难程度。
因此,如何能让癌症药物的快速的可以被开发出来,并且尽可能的减少临床失败的机率,在癌症病学上是一个非常急迫又重要的课题。
发明内容
为解决上述的问题,本发明针对阿那格雷药物进行新适应症的研发,而达到老药新用的目标。
经过实验设计结果显示阿那格雷药物对正常细胞没有或仅有微小的毒性,但阿那格雷在肿瘤细胞之间具有选择性的影响。
本发明提供一种阿那格雷药物(Anagrelide HCl)在用于制备治疗癌症的医药组合物中用途,其中所述医药组合物包含有效剂量的阿那格雷及药学上可接受的盐类所组成。
本发明一实施例中,其中所述癌症是选自由胸腔相关癌症、腹腔相关癌症、内分泌相关癌症及消化道相关癌症中的一种或多种。
本发明一实施例中,其中所述癌症是选自由骨肉瘤相关癌症、皮
肤癌相关癌症、血癌相关癌症中的一种或多种。
本发明一实施例中,其中所述胸腔相关癌症是指肺癌。
本发明一实施例中,其中所述腹腔相关癌症是选自由膀胱癌或/和子宫颈癌。
本发明一实施例中,其中所述内分泌相关癌症是选自由前列腺癌、乳癌及卵巢癌中的一种或多种。
本发明一实施例中,其中所述内分泌相关癌症是选自由胃癌、肝癌、大肠癌、胰脏癌及舌癌中的一种或多种。
本发明一实施例中,其中所述阿那格雷药物的有效剂量浓度为20~500mg/kg/天。
图1显示本发明阿那格雷用药应用于抑制癌细胞分析结果。
图2显示阿那格雷用药可对肿瘤体积的效果
图3显示高剂量及低剂量阿那格雷肿瘤生长的抑制效果
各种癌症细胞株建立
将不同癌症类型的细胞株进行继代培养,癌症细胞种类包含肺癌、胃癌、肝癌、直肠癌、皮肤癌、子宫颈癌、前列腺癌、膀胱癌、乳癌、血癌、胰腺癌、卵巢癌、舌癌、骨肉瘤、肾脏癌,并且对照组亦使用肾脏(HEK293(Kidney))、肺部上皮细胞BEAS-2B(Lung Epithelial)的正常细胞做测试。(表一)
先将各细胞于培养液培养后,由于各细胞的属性不同,因此针对不同种的细胞也要用相对应的培养液(表一),计算细胞数目,将2×106细胞数置入培养皿,然后加入培养该细胞株的培养液补至体积为10ml,继续培养2-3天。之后将细胞计数,并分装至96孔盘,其中每孔的细胞数目固定为3000个细胞,且体积为100ul。
表一、癌症测试细胞株及其培养所用的培养液
细胞存活分析方法
将96孔盘中原有的培养液吸掉,每孔加入浓度10um、体积100ul的市售药物,放置72小时后,每孔再加入100ul已稀释的WST-1试剂,该稀释比例为培养液与WST-1原液的体积比为9:1,最后每个孔盘的总体积为200ul,然后将96孔盘放置于37℃,30~90分钟,利用elisa reader(酶联免疫检测仪)于OD450侦测吸光值,并计算各癌症细胞株的存活率。
阿那格雷药对于各种癌细胞分析结果
阿那格雷对胸腔相关癌症细胞抑制效果的测试
本分析阿那格雷对胸腔相关癌症细胞抑制效果的测试,主要针对两种肺癌细胞进行测试,癌细胞株分别为A549和H1650两个细胞株,各做4次的癌细胞抑制实验结果,并且计算其平均值,结果表列如后。(表二)
表二、阿那格雷对肺癌相关癌症细胞抑制测试
0524-10min | 0526-10min | 0529-10min | 0531-10min | 平均 | |
A549 | 76.0 | 82.9 | 129.9 | 101.1 | 97.5 |
1-10min | 2-20min | 3-20min | 4-20min | 平均 | |
H1650 | 93.3 | 96.9 | 117.0 | 183.0 | 122.6 |
阿那格雷对腹腔相关癌症细胞抑制效果的测试
本分析阿那格雷对腹腔相关癌症细胞抑制效果的测试,主要针对两种腹腔相关癌症种类细胞进行测试,膀胱癌细胞株分别为TSGH和T24两个细胞株(表三),子宫颈癌细胞株分别为HeLa细胞株(表四),肾脏癌为786-O细胞株(表五),各做4次的癌细胞抑制实验结果,并且计算其平均值,结果表列如后。
表三、阿那格雷对膀胱癌相关癌症细胞抑制测试
表四、阿那格雷对子宫颈癌相关癌症细胞抑制测试
0524-10min | 0526-10min | 0529-10min | 0531-10min | 平均 | |
HeLa | 24.8 | 28.1 | 17.7 | 28.6 | 24.8 |
1 | 2 | 3 | 4 | 平均 | |
C-334 | 95.2 | 93.3 | 100.3 | 97.7 | 96.6 |
表五、阿那格雷对肾脏癌相关癌症细胞抑制测试
1 | 2 | 3 | 4 | 平均 | |
786-O | 96.0 | 72.3 | 84.9 | 96.5 | 87.4 |
阿那格雷对内分泌相关癌症细胞抑制效果的测试
本分析阿那格雷对腹腔相关癌症细胞抑制效果的测试,主要针对三种内分泌相关癌症种类细胞进行测试,前列腺癌细胞株分别为PC-3和LNCap两个细胞株(表六),乳癌细胞株分别为MCF7和MDA-MB-231两个细胞株(表七),卵巢癌细胞株分别为NIH-OVCAR-3细胞株和TOV-21G(表八),各做4次的癌细胞抑制实验结果,并且计算其平均值,结果表列如后。
表六、阿那格雷对前列腺癌相关癌症细胞抑制测试
表七、阿那格雷对乳癌相关癌症细胞抑制测试
表八、阿那格雷对卵巢癌相关癌症细胞抑制测试
阿那格雷对消化道相关癌症细胞抑制效果的测试
分析阿那格雷对消化道相关癌症细胞抑制效果的测试,主要针对五种消化道相关癌症种类细胞进行测试,胃癌细胞株分别为AGS和MKN-45两个细胞株(表九),肝癌细胞株分别为HepG2和Hep3B两个细胞株(表十),大肠癌细胞株分别为HCT116-wt和LoVo细胞株(表十一),胰脏癌细胞株分别为AsPC和BxPC细胞株(表十二),舌癌细胞株为SAS细胞株(表十三),各做4次的癌细胞抑制实验结果,并且计算其平均值,结果表列如后。
表九、阿那格雷对胃癌相关癌症细胞抑制测试
表十、阿那格雷对肝癌相关癌症细胞抑制测试
0524-20min | 0526-20min | 0529-20min | 0531-20min | 平均 | |
HepG2 | 107.6 | 123.1 | 113.0 | 111.7 | 113.8 |
0612-20min | 0614-20min | 0616-20min | 0619-20min | 平均 | |
Hep3B | 98.5 | 117.1 | 120.6 | 103.0 | 109.8 |
表十一、阿那格雷对大肠癌相关癌症细胞抑制测试
0602-30min | 0605-10min | 0607-10min | 0609-10min | 平均 | |
HCT116-wt | 96.8 | 116.8 | 124.3 | 87.4 | 106.3 |
0616-10min | 0619-10min | 0621-10min | 0623-10min | 平均 | |
LoVo | 95.9 | 148.1 | 88.0 | 113.1 | 111.3 |
表十二、阿那格雷对胰脏癌相关癌症细胞抑制测试
1-7-3-30min | 1-7-4-30min | 1-7-7-30min | 1-4-30min | 平均 | |
AsPC | 99.0 | 93.1 | 83.2 | 71.2 | 86.6 |
3-7-3-30min | 3-7-4-30min | 3-7-7-30min | 3-4-30min | 平均 | |
BxPC | 72.3 | 59.2 | 94.4 | 75.4 | 75.3 |
表十三、阿那格雷对舌癌相关癌症细胞抑制测试
6-26-10min | 6-28-10min | 6-30-10min | 7-3-10min | 平均 | |
SAS | 90.3 | 107.4 | 94.9 | 118.4 | 102.7 |
阿那格雷对其他癌症细胞抑制效果的测试
分析阿那格雷对其他类型癌正进行测试,骨肉癌细胞株为U2OS细胞株(表十四),皮肤癌细胞株分别为A375和BCC两个细胞株(表
十五),各做3~4次的癌细胞抑制实验结果,并且计算其平均值,结果表列如后。
表十四、阿那格雷对骨肉瘤相关癌症细胞抑制测试
6-26-10min | 6-28-10min | 6-30-10min | 7-3-10min | 平均 | |
U2OS | 88.6 | 89.6 | 96.9 | 94.4 | 92.4 |
表十五、阿那格雷对皮肤癌相关癌症细胞抑制测试
0602-30min | 0605-10min | 0607-10min | 0609-10min | 平均 | |
A375 | 96.6 | 117.7 | 87.4 | 103.6 | 101.3 |
0602-30min | 0605-10min | 0607-10min | 0609-10min | 平均 | |
BCC | 79.1 | 112.9 | 89.0 | 93.7 |
对照组实验设计
阿那格雷对正常细胞抑制效果的测试
分析阿那格雷对多种正常细胞进行测试,正常肾脏细胞株为HEK293细胞株(表十六),正常肺部上皮细胞细胞株为BEAS-2B细胞株(表十七),各做4次的癌细胞抑制实验结果,并且计算其平均值,结果表列如后。
表十六、阿那格雷对正常肾脏细胞抑制测试
平均 | |
HEK293 | 93.0 |
表十七、阿那格雷对正常肺部上皮细胞抑制测试
0510-10min | 0512-10min | 0515-10min | 0517-10min | 平均 | |
BEAS-2B | 68.3 | 76.7 | 105.9 | 104.5 | 88.9 |
针对阿那格雷对各种癌症细胞抑制效果汇整于表十八中,清楚看出阿那格雷对于多项癌症有明显的抑制效果。经过发明人实验结果,阿那格雷药物对于不同的癌症细胞有明显的抑制效果。(图一)
表十八、阿那格雷对各种癌症细胞抑制效果的汇整
癌症细胞 | 抑制效果 |
肺癌 | 110.01 |
膀胱癌 | 118.65 |
子宫颈癌 | 24.82 |
肾脏癌 | 87.44 |
前列腺癌 | 127.85 |
乳癌 | 105.79 |
卵巢癌 | 105.26 |
胃癌 | 119.65 |
肝癌 | 118.65 |
大肠癌 | 108.79 |
胰脏癌 | 110.05 |
舌癌 | 102.75 |
骨肉癌 | 92.37 |
皮肤癌 | 97.51 |
正常细胞 | 抑制效果 |
肾脏 | 93.00 |
肺部上皮细胞 | 88.86 |
动物实验分析
本实验使用雌性BALB/cAnN.Cg-Foxn1nu/CrlNarl小鼠为样本(购自国家实验动物中心),体重为21±1g,皮下注射子宫颈癌细胞(HeLa)后随机分笼,测试药物分成三组:正常对照组、低剂量(100mg/kg/day)、高剂量(200mg/kg/day)。肿瘤形成超过100mm3后,每天采取腹腔注射方式给予药物;每周测量肿瘤大小两次,肿瘤体积测量公式如下:(L×W2);L代表肿瘤最长直径;W代表肿瘤最短直径。
依据第2图的结果,低剂量与高剂量的阿那格雷均对肿瘤具有良好的抑制效果,且于实验过程中各组小鼠的重量均未出现明显降低的现象,因此表示阿那格雷不论高低剂量在治疗过程均能使受测小鼠具有良好的健康状态而不死亡。
依据第3图的结果,高低剂量的阿那格雷可有效减缓肿瘤体积增长,并可同时减少肿瘤体积,其中以高剂量的阿那格雷具有较佳的效果。
上列详细说明是针对本发明之一可行实施例的具体说明,惟该实施例并非用以限制本发明的专利范围,凡未脱离本发明技艺精神所为的等效实施或变更,均应包含于本发明的专利范围中。
Claims (8)
- 一种阿那格雷药物在用于制备治疗癌症的医药组合物中的用途,其特征是,所述医药组合物是选自由有效剂量的阿那格雷(Anagrelide HCl)及药学上可接受的盐类所组成。
- 如权利要求1所述的用途,其特征是,所述癌症为胸腔相关癌症、腹腔相关癌症、内分泌相关癌症、消化道相关癌症中的一种或多种。
- 如权利要求1所述的用途,其特征是,所述癌症是选自骨肉瘤相关癌症、皮肤癌相关癌症中的一种或多种。
- 如权利要求2所述的用途,其特征是,所述胸腔相关癌症是指肺癌。
- 如权利要求2所述的用途,其特征是,所述腹腔相关癌症是选自膀胱癌、子宫颈癌、肾脏癌中的一种或多种。
- 如权利要求2所述的用途,其特征是,所述内分泌相关癌症系选自由前列腺癌、乳癌、卵巢癌中的一种或多种。
- 如权利要求2所述的用途,其特征是,所述消化道相关癌症系选自由胃癌、肝癌、大肠癌、胰脏癌、舌癌中的一种或多种。
- 如权利要求1所述的用途,其特征是,所述有效剂量浓度为每日20mg/kg~500mg/kg。
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PCT/CN2015/092702 WO2016062274A1 (zh) | 2014-10-24 | 2015-10-23 | 消化系统疾病用药物在制备抑制癌症的医药组合物中的应用 |
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PCT/CN2015/092761 WO2016062279A1 (zh) | 2014-10-24 | 2015-10-23 | 苹果酸丙氯陪拉辛锭用于制备治疗癌症药物的用途 |
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PCT/CN2015/092632 WO2016062266A1 (zh) | 2014-10-24 | 2015-10-23 | 氨氯地平在制备抑制癌症的医药组合物中的用途 |
PCT/CN2015/092779 WO2016062288A1 (zh) | 2014-10-24 | 2015-10-23 | 代谢性疾病药物用于制备抑制癌症的医药组合物的用途 |
PCT/CN2015/092771 WO2016062283A1 (zh) | 2014-10-24 | 2015-10-23 | 抗发炎用药物在制备抑制癌症的医药组合物中的应用 |
PCT/CN2015/092714 WO2016062275A1 (zh) | 2014-10-24 | 2015-10-23 | 阿折地平在制备治疗癌症的医药组合物中的用途 |
PCT/CN2015/092768 WO2016062281A1 (zh) | 2014-10-24 | 2015-10-23 | 心血管疾病用药物在制备抑制癌症的医药组合物中的应用 |
PCT/CN2015/092781 WO2016062290A1 (zh) | 2014-10-24 | 2015-10-23 | 氨苯蝶啶药物在用于制备治疗癌症的医药组合物中的用途 |
PCT/CN2015/092753 WO2016062278A1 (zh) | 2014-10-24 | 2015-10-23 | 内分泌疾病用药在制备抑制癌症的医药组合物中的应用 |
PCT/CN2015/092746 WO2016062277A1 (zh) | 2014-10-24 | 2015-10-23 | 驱虫药用于制备抗癌医药组合物中的应用 |
PCT/CN2015/092777 WO2016062287A1 (zh) | 2014-10-24 | 2015-10-23 | 山喜多药物在用于制备抑制癌症的医药组合物中的用途 |
PCT/CN2015/092775 WO2016062285A1 (zh) | 2014-10-24 | 2015-10-23 | 神经系统疾病用药在制备抗癌医药组合物中的应用 |
PCT/CN2015/092677 WO2016062270A1 (zh) | 2014-10-24 | 2015-10-23 | 呼吸系统疾病用药用于制备抗癌医药组合物的用途 |
PCT/CN2015/092697 WO2016062272A1 (zh) | 2014-10-24 | 2015-10-23 | 免疫疾病用药物在制备抑制癌症的医药组合物中的应用 |
PCT/CN2015/092776 WO2016062286A1 (zh) | 2014-10-24 | 2015-10-23 | 脱克钙药物在用于制备治疗癌症的医药组合物中的用途 |
PCT/CN2015/092666 WO2016062269A1 (zh) | 2014-10-24 | 2015-10-23 | 阿那格雷在用于制备治疗癌症的医药组合物中的用途 |
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PCT/CN2015/092686 WO2016062271A1 (zh) | 2014-10-24 | 2015-10-23 | 抗生素药物用于制备治疗癌症的医药组合物的用途 |
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PCT/CN2015/092702 WO2016062274A1 (zh) | 2014-10-24 | 2015-10-23 | 消化系统疾病用药物在制备抑制癌症的医药组合物中的应用 |
PCT/CN2015/092780 WO2016062289A1 (zh) | 2014-10-24 | 2015-10-23 | 帕罗西汀药物用于制备治疗癌症的医药组合物中的用途 |
PCT/CN2015/092761 WO2016062279A1 (zh) | 2014-10-24 | 2015-10-23 | 苹果酸丙氯陪拉辛锭用于制备治疗癌症药物的用途 |
PCT/CN2015/092617 WO2016062265A1 (zh) | 2014-10-24 | 2015-10-23 | 莫诺苯宗药物在用于制备治疗癌症的医药组合物中的用途 |
PCT/CN2015/092632 WO2016062266A1 (zh) | 2014-10-24 | 2015-10-23 | 氨氯地平在制备抑制癌症的医药组合物中的用途 |
PCT/CN2015/092779 WO2016062288A1 (zh) | 2014-10-24 | 2015-10-23 | 代谢性疾病药物用于制备抑制癌症的医药组合物的用途 |
PCT/CN2015/092771 WO2016062283A1 (zh) | 2014-10-24 | 2015-10-23 | 抗发炎用药物在制备抑制癌症的医药组合物中的应用 |
PCT/CN2015/092714 WO2016062275A1 (zh) | 2014-10-24 | 2015-10-23 | 阿折地平在制备治疗癌症的医药组合物中的用途 |
PCT/CN2015/092768 WO2016062281A1 (zh) | 2014-10-24 | 2015-10-23 | 心血管疾病用药物在制备抑制癌症的医药组合物中的应用 |
PCT/CN2015/092781 WO2016062290A1 (zh) | 2014-10-24 | 2015-10-23 | 氨苯蝶啶药物在用于制备治疗癌症的医药组合物中的用途 |
PCT/CN2015/092753 WO2016062278A1 (zh) | 2014-10-24 | 2015-10-23 | 内分泌疾病用药在制备抑制癌症的医药组合物中的应用 |
PCT/CN2015/092746 WO2016062277A1 (zh) | 2014-10-24 | 2015-10-23 | 驱虫药用于制备抗癌医药组合物中的应用 |
PCT/CN2015/092777 WO2016062287A1 (zh) | 2014-10-24 | 2015-10-23 | 山喜多药物在用于制备抑制癌症的医药组合物中的用途 |
PCT/CN2015/092775 WO2016062285A1 (zh) | 2014-10-24 | 2015-10-23 | 神经系统疾病用药在制备抗癌医药组合物中的应用 |
PCT/CN2015/092677 WO2016062270A1 (zh) | 2014-10-24 | 2015-10-23 | 呼吸系统疾病用药用于制备抗癌医药组合物的用途 |
PCT/CN2015/092697 WO2016062272A1 (zh) | 2014-10-24 | 2015-10-23 | 免疫疾病用药物在制备抑制癌症的医药组合物中的应用 |
PCT/CN2015/092776 WO2016062286A1 (zh) | 2014-10-24 | 2015-10-23 | 脱克钙药物在用于制备治疗癌症的医药组合物中的用途 |
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PCT/CN2015/092686 WO2016062271A1 (zh) | 2014-10-24 | 2015-10-23 | 抗生素药物用于制备治疗癌症的医药组合物的用途 |
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Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US11324746B2 (en) | 2014-12-22 | 2022-05-10 | Arovella Therapeutics Limited | Use of anagrelide for treating cancer |
Families Citing this family (43)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3708564A1 (en) | 2005-12-28 | 2020-09-16 | Vertex Pharmaceuticals Incorporated | A solid form of n-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide |
AU2015335391B2 (en) * | 2014-10-24 | 2018-06-21 | Launx Biomedical Co., Ltd. | Uses of duloxetine HCL medicament in preparing pharmaceutical composition for treatment of cancer |
WO2017116049A1 (ko) * | 2015-12-31 | 2017-07-06 | 경북대학교 산학협력단 | 설폰아마이드계 화합물을 유효성분으로 포함하는 암의 치료 및 전이 억제용 약학적 조성물 |
EP3241562A1 (en) * | 2016-05-02 | 2017-11-08 | Fundació Institut Mar d'Investigacio Medica | Zonisamide for use in the treatment of breast cancer |
CN106074474A (zh) * | 2016-06-15 | 2016-11-09 | 中南大学湘雅医院 | 羟苄丝肼及其在药学上可接受的盐在制备抗肿瘤药物方面的应用 |
WO2018072135A1 (zh) | 2016-10-19 | 2018-04-26 | 微菌方舟生物科技股份有限公司 | 二氢吡啶类钙拮抗剂用于治疗癌症的用途 |
CN108066345A (zh) * | 2016-11-14 | 2018-05-25 | 武汉华杰世纪生物医药有限公司 | 一种具有抗肿瘤作用的化合物 |
MX2019007391A (es) | 2016-12-20 | 2019-08-16 | Lts Lohmann Therapie Systeme Ag | Sistema terapeutico transdermico que contiene asenapina. |
EP3558276A1 (en) | 2016-12-20 | 2019-10-30 | LTS Lohmann Therapie-Systeme AG | Transdermal therapeutic system containing asenapine and polysiloxane or polyisobutylene |
US20200179404A1 (en) * | 2017-06-09 | 2020-06-11 | Regents Of The University Of Minnesota | Skin care formulations and skin cancer treatment |
WO2019002204A1 (en) | 2017-06-26 | 2019-01-03 | Lts Lohmann Therapie-Systeme Ag | TRANSDERMAL THERAPEUTIC SYSTEM CONTAINING ASENAPINE AND SILICONE-TYPE ACRYLIC HYBRID POLYMER |
WO2019008516A2 (en) * | 2017-07-03 | 2019-01-10 | Menri Group Ltd. | TREATMENT OF CANCER WITH DIHYDROPYRIDINES |
JP2019064976A (ja) * | 2017-10-03 | 2019-04-25 | 国立大学法人 熊本大学 | 抗がん剤 |
KR101933805B1 (ko) | 2017-10-17 | 2018-12-28 | 성균관대학교산학협력단 | 옥셀라딘시트레이트를 유효성분으로 포함하는 뇌암 예방 또는 치료용 약학적 조성물 |
CN108186652A (zh) * | 2017-12-28 | 2018-06-22 | 深圳大学 | 缝隙连接细胞间通迅抑制剂甘珀酸在制备预防和治疗肝细胞癌药物中的应用 |
WO2019152475A1 (en) | 2018-01-30 | 2019-08-08 | Apnimed, Inc. (Delaware) | Methods and compositions for treating sleep apnea |
WO2019204764A1 (en) * | 2018-04-19 | 2019-10-24 | Washington University | Compositions and methods of use thereof for treatment of proteinopathies |
WO2019243452A1 (en) | 2018-06-20 | 2019-12-26 | Lts Lohmann Therapie-Systeme Ag | Transdermal therapeutic system containing asenapine |
FR3090084B1 (fr) | 2018-12-18 | 2023-10-13 | Securengy | Projectile pour armes à feu ou air comprimé pour emport liquide ou pulvérulent. |
US20220072089A1 (en) * | 2018-12-19 | 2022-03-10 | University Of Vermont And State Agricultural College | Cancer therapeutic compositions and methods |
CN113924090A (zh) * | 2019-04-04 | 2022-01-11 | 大邱庆北尖端医疗产业振兴财团 | 用于预防或治疗癌症的包含曲美布汀或其药学上可接受的盐作为活性成分的药物组合物 |
US20220202771A1 (en) * | 2019-04-05 | 2022-06-30 | University Of North Texas Health Science Center At Fort Worth | Antidepressants for the Treatment or Prevention of Memory Loss and/or Cognitive Decline or Dysfunction in Aging |
US20220146492A1 (en) * | 2019-04-11 | 2022-05-12 | Ian Basil Shine | Cell membrane permeability restoring therapy |
CN110179803A (zh) * | 2019-05-31 | 2019-08-30 | 天津科技大学 | 一种噻吨溴类化合物的应用 |
CN110742890A (zh) * | 2019-10-24 | 2020-02-04 | 暨南大学 | 洛美利嗪在制备抗结肠癌药物中的应用 |
CN110840887A (zh) * | 2019-11-18 | 2020-02-28 | 杭州彗搏科技有限公司 | 三氯苯达唑在制备治疗乳腺癌的药物中的应用 |
CN110876800B (zh) * | 2019-11-18 | 2023-06-27 | 中南大学 | 米卡芬净在制备抗肿瘤药物中的应用及抗肿瘤药物 |
CN111067899B (zh) * | 2020-01-08 | 2021-03-05 | 温州医科大学 | 一种抗疟药物磷酸伯氨喹在制备治疗白血病药物上的应用 |
US11304969B2 (en) * | 2020-01-24 | 2022-04-19 | The Florida International Univeristy Board Of Trustees | Treatments of prostate cancer |
CN111973593A (zh) * | 2020-05-09 | 2020-11-24 | 深圳市罗湖区人民医院 | 硝唑尼特及其药学上可接受的盐在制备治疗膀胱癌药物中的用途 |
CN111557941A (zh) * | 2020-06-15 | 2020-08-21 | 浙江大学 | Plod2的小分子抑制剂米诺地尔在肿瘤治疗中的应用 |
CN111848717A (zh) * | 2020-08-07 | 2020-10-30 | 四川大学 | 靶向调控线粒体能量代谢的化合物及其应用和药物 |
TW202214245A (zh) * | 2020-08-10 | 2022-04-16 | 國立彰化師範大學 | 雙非癌藥物用於製備治療癌症之醫藥組合物的用途 |
CN112274525B (zh) * | 2020-12-04 | 2022-04-08 | 遵义医科大学 | 一种化疗药物组合物及其应用 |
CN112336725A (zh) * | 2020-12-11 | 2021-02-09 | 吴照球 | 甲氧苄啶的医药新用途 |
CN112569342A (zh) * | 2020-12-21 | 2021-03-30 | 中南大学 | 卡泊芬净和/或其可药用盐在制备抗肿瘤药物中的应用及抗肿瘤药物 |
CN112569215A (zh) * | 2020-12-30 | 2021-03-30 | 东莞市人民医院 | 度米芬在制备防治结直肠癌的药物中的应用 |
EP4108244A1 (en) * | 2021-06-25 | 2022-12-28 | Universität Regensburg | Ss-lactam antibiotic with significant activity against cancer e.g. colon malignancies |
CN113663071B (zh) * | 2021-06-28 | 2022-12-30 | 四川大学 | Fbxl2激活剂在制备治疗egfr驱动的肺癌的药物中的用途 |
WO2023006954A1 (en) | 2021-07-30 | 2023-02-02 | Fundació Institut D'investigació Biomèdica De Bellvitge (Idibell) | Asenapine for use in cancer |
WO2023035200A1 (zh) * | 2021-09-09 | 2023-03-16 | 中国福利会国际和平妇幼保健院 | 五氟利多在制备治疗子宫内膜癌的药物中的应用 |
CN115887455B (zh) * | 2022-08-04 | 2024-04-05 | 北京大学人民医院 | 钙离子通道阻滞剂阿折地平在制备治疗子宫内膜癌的药物中的应用 |
CN116570579A (zh) * | 2023-06-13 | 2023-08-11 | 深圳市泛谷药业股份有限公司 | 一种含有阿戈美拉汀和氟伏沙明的药物组合物及其应用 |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2014164704A2 (en) * | 2013-03-11 | 2014-10-09 | The Broad Institute, Inc. | Compounds and compositions for the treatment of cancer |
CN104161759A (zh) * | 2013-05-16 | 2014-11-26 | 中国科学院上海药物研究所 | 阿那格雷及其衍生物的抗肿瘤用途 |
Family Cites Families (60)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0721335B1 (en) * | 1993-10-01 | 2005-08-31 | Roche Palo Alto LLC | Mycophenolate mofetil high dose oral suspensions |
KR100264348B1 (ko) * | 1994-12-28 | 2000-08-16 | 디르크 반테 | 항-죽종형성제로서 네비볼롤을 함유하는 조성물 |
AU746887B2 (en) * | 1998-09-15 | 2002-05-02 | Eli Lilly And Company | Treatment of persistent pain |
US6927223B1 (en) * | 2000-05-26 | 2005-08-09 | Washington State University Research Foundation | Use of serotonin agents for adjunct therapy in the treatment of cancer |
WO2002004406A2 (en) * | 2000-07-07 | 2002-01-17 | Trustees Of Tufts College | 9-substituted minocycline compounds |
IL139975A0 (en) * | 2000-11-29 | 2002-02-10 | Univ Ramot | Anti proliferative drugs |
US20040072824A1 (en) * | 2001-06-01 | 2004-04-15 | Adam Telerman | Methods and compositions for the treatment of cancer |
GB0202337D0 (en) * | 2002-02-01 | 2002-03-20 | Univ Birmingham | Cancer treatment |
US7135575B2 (en) * | 2003-03-03 | 2006-11-14 | Array Biopharma, Inc. | P38 inhibitors and methods of use thereof |
CN1878556A (zh) * | 2003-09-18 | 2006-12-13 | 康宾纳特克斯公司 | 治疗肿瘤的联合药物 |
KR20060124607A (ko) * | 2003-11-06 | 2006-12-05 | 셀진 코포레이션 | 암 및 그 밖의 질환의 치료 및 관리를 위하여탈리도마이드를 사용하는 방법 및 조성물 |
EP1753425A4 (en) * | 2004-05-12 | 2009-08-05 | Biorunx Co Ltd | THERAPEUTIC AGENT COMPRISING A NICOTINIC ACID OR DERIVATIVES AS AN EFFECTIVE INGREDIENT FOR THE PREVENTION OR TREATMENT OF CANCER |
DK1753713T3 (en) * | 2004-05-21 | 2016-11-28 | Harvard College | SYNTHESIS OF TETRACYCLINES AND ANALOGS THEREOF |
CN1279980C (zh) * | 2004-10-14 | 2006-10-18 | 孔庆忠 | 一种抗实体肿瘤药物组合物 |
JP2006298781A (ja) * | 2005-04-15 | 2006-11-02 | Geno Membrane:Kk | エストロン3硫酸トランスポーター活性阻害剤 |
TW200716141A (en) * | 2005-05-05 | 2007-05-01 | Combinatorx Inc | Compositions and methods for treatment for neoplasms |
CN101223149A (zh) * | 2005-07-05 | 2008-07-16 | 特瓦制药工业有限公司 | 制备缬沙坦的方法 |
ES2661169T3 (es) * | 2005-07-28 | 2018-03-27 | Academisch Ziekenhuis Bij De Universiteit Van Amsterdam | Compuestos de monofenol, bencenodiol, o sulfhidrilo para uso en el tratamiento de melanomas |
US8148356B2 (en) * | 2005-08-24 | 2012-04-03 | Cumberland Pharmaceuticals, Inc. | Acetylcysteine composition and uses therefor |
AU2007230724B2 (en) * | 2006-03-23 | 2014-01-30 | Amgen Inc. | Methods and compositions for making and using polymorphs of cinacalcet |
CN101099724A (zh) * | 2006-07-07 | 2008-01-09 | 上海复旦复华药业有限公司 | 一种微粉化来曲唑及其组合物 |
CN101103976A (zh) * | 2006-07-14 | 2008-01-16 | 海南盛科生命科学研究院 | 一种含阿那曲唑的口服药物组合物及其制备工艺 |
US20100273868A1 (en) * | 2007-01-05 | 2010-10-28 | Cornerstone Therapeutics Inc. | R-Zileuton for Use in Conditions Associated with Increased 5-Lipoxygenase and/or Leukotriene Activity (EG Asthma) |
CN101730526A (zh) * | 2007-03-07 | 2010-06-09 | 阿布拉科斯生物科学有限公司 | 作为抗癌剂的包含雷帕霉素和白蛋白的纳米颗粒 |
CA2691196C (en) * | 2007-06-21 | 2016-05-24 | Amgen Inc. | Methods of synthesizing cinacalcet and salts thereof |
WO2009025854A1 (en) * | 2007-08-22 | 2009-02-26 | Burnham Institute For Medical Research | Smips: small molecule inhibitors of p27 depletion in cancers and other proliferative diseases |
US20120082659A1 (en) * | 2007-10-02 | 2012-04-05 | Hartmut Land | Methods And Compositions Related To Synergistic Responses To Oncogenic Mutations |
CN100563645C (zh) * | 2007-12-06 | 2009-12-02 | 济南帅华医药科技有限公司 | 一种治疗实体肿瘤的蓓萨罗丁缓释植入剂 |
WO2009126274A2 (en) * | 2008-04-08 | 2009-10-15 | New York University School Of Medicine | Methods and compositions for the treatment of cancers, such as melanomas and gliomas |
CN101569624A (zh) * | 2008-04-29 | 2009-11-04 | 石药集团中奇制药技术(石家庄)有限公司 | 氨氯地平在制备治疗细胞增生性疾病药物中的用途 |
EP2123626A1 (en) * | 2008-05-21 | 2009-11-25 | Laboratorios del Dr. Esteve S.A. | Co-crystals of duloxetine and co-crystal formers for the treatment of pain |
EP2303255A1 (en) * | 2008-06-03 | 2011-04-06 | Université Paris Diderot - Paris 7 | Pharmaceutical compositions useful for the treatment of cancers, in particular acute myeloid leukemia and acute promyelocytic leukemia |
CN101612400A (zh) * | 2009-07-22 | 2009-12-30 | 陈志龙 | 血管紧张素ⅱ的1型受体拮抗剂在抗肿瘤中的应用 |
CN101690816A (zh) * | 2009-08-16 | 2010-04-07 | 王丽燕 | 含钙拮抗剂、aⅱ受体拮抗剂和他汀类药的药物组合物 |
CN101991553B (zh) * | 2009-08-21 | 2015-02-25 | 北京以岭生物工程技术有限公司 | 一种依西美坦片及其制备方法 |
CN101863806B (zh) * | 2010-03-18 | 2013-02-13 | 湖北省医药工业研究院有限公司 | 抗前列腺癌药物(r)-比卡鲁胺的制备方法 |
WO2011146583A2 (en) * | 2010-05-19 | 2011-11-24 | Elan Pharma International Limited | Nanoparticulate cinacalcet formulations |
JP5978424B2 (ja) * | 2010-07-29 | 2016-08-24 | 国立大学法人京都大学 | 抗がん剤のスクリーニング方法 |
US20130261142A1 (en) * | 2010-12-15 | 2013-10-03 | Hung-Cheng Lai | Compounds used for treating cancer and the use thereof |
CN102631354B (zh) * | 2011-02-11 | 2015-01-21 | 广东泰禾医药科技有限公司 | 含维生素d3和二甲双胍的药物组合物 |
CN102688493B (zh) * | 2011-03-25 | 2014-09-10 | 鼎泓国际投资(香港)有限公司 | 含有白藜芦醇及白藜芦醇类衍生物和Bc1-2抑制剂的药物组合物及其应用 |
CN102813643B (zh) * | 2011-06-10 | 2014-09-24 | 北京蛋白质组研究中心 | bumetanide在抑制肝癌细胞转移中的应用 |
EP2760473A1 (en) * | 2011-09-27 | 2014-08-06 | Biomed Valley Discoveries, Inc. | Compositions and methods of treating gliomas |
CN109985228A (zh) * | 2011-11-10 | 2019-07-09 | 凯伊药品公司 | 拟钙剂及其使用方法 |
CN102600077B (zh) * | 2012-03-29 | 2013-06-05 | 江苏豪森药业股份有限公司 | 吉西他滨或其盐纳米乳剂注射液及其制备方法 |
ES2384069B1 (es) * | 2012-03-29 | 2013-07-04 | Hospital Sant Joan De Déu | Cinacalcet y tumores neuroblásticos |
CN103536607A (zh) * | 2012-07-10 | 2014-01-29 | 邵金辉 | 土霉素,普罗帕酮和安乃近的抗肿瘤作用 |
WO2014018563A2 (en) * | 2012-07-23 | 2014-01-30 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for the treatment of cancer |
WO2014036654A1 (en) * | 2012-09-06 | 2014-03-13 | Mcmaster University | Compounds and methods for selectively targeting cancer stem cells |
BR112015006176B1 (pt) * | 2012-09-21 | 2023-04-18 | Intensity Therapeutics, Inc | Uso de um agente terapêutico e de um agente de intensificação de permeação intracelular |
AR092899A1 (es) * | 2012-10-04 | 2015-05-06 | Ab Science | Uso de masitinib para el tratamiento del cancer en subpoblaciones de pacientes identificados que utilizan factores de prediccion |
CN103356687B (zh) * | 2012-10-19 | 2016-06-01 | 厦门大学 | 一种伊维菌素及其衍生物的用途 |
CN105142631A (zh) * | 2013-01-14 | 2015-12-09 | 健康诊所有限公司 | 抗癌药物和用途 |
CN103933569B (zh) * | 2013-01-22 | 2017-01-11 | 复旦大学 | 一种抗肺癌药物组合物及其应用、药盒和包装件 |
US20140271727A1 (en) * | 2013-03-18 | 2014-09-18 | National Yang-Ming University | Method of using an antidepressant for increasing immunity of a subject and treating cancer |
CN103396419A (zh) * | 2013-08-13 | 2013-11-20 | 海宁市绿升医药科技有限公司 | 肿瘤光动力治疗药二氢卟吩e6-15-乙酯及其制备方法 |
CN103536925B (zh) * | 2013-10-28 | 2015-07-01 | 中国医学科学院基础医学研究所 | 强心苷化合物在非小细胞肺癌治疗中的应用 |
CN103622975B (zh) * | 2013-11-07 | 2016-06-15 | 广东药学院 | 格列吡嗪在制备治疗肿瘤药物中的应用 |
KR20160143775A (ko) * | 2014-04-08 | 2016-12-14 | 더 메서디스트 하스피틀 | iNOS-억제 조성물들 및 이들의 유방암 치료제로서의 용도 |
AU2015335391B2 (en) * | 2014-10-24 | 2018-06-21 | Launx Biomedical Co., Ltd. | Uses of duloxetine HCL medicament in preparing pharmaceutical composition for treatment of cancer |
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Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2014164704A2 (en) * | 2013-03-11 | 2014-10-09 | The Broad Institute, Inc. | Compounds and compositions for the treatment of cancer |
CN104161759A (zh) * | 2013-05-16 | 2014-11-26 | 中国科学院上海药物研究所 | 阿那格雷及其衍生物的抗肿瘤用途 |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US11324746B2 (en) | 2014-12-22 | 2022-05-10 | Arovella Therapeutics Limited | Use of anagrelide for treating cancer |
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