JP2017530962A5 - - Google Patents
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- JP2017530962A5 JP2017530962A5 JP2017514825A JP2017514825A JP2017530962A5 JP 2017530962 A5 JP2017530962 A5 JP 2017530962A5 JP 2017514825 A JP2017514825 A JP 2017514825A JP 2017514825 A JP2017514825 A JP 2017514825A JP 2017530962 A5 JP2017530962 A5 JP 2017530962A5
- Authority
- JP
- Japan
- Prior art keywords
- methyl
- amino
- indazol
- difluoro
- phenoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 150000001875 compounds Chemical class 0.000 claims description 39
- 150000003839 salts Chemical class 0.000 claims description 36
- -1 C 1 -C 4 - alkoxy Chemical group 0.000 claims description 35
- DTQVDTLACAAQTR-UHFFFAOYSA-N Trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-N 0.000 claims description 32
- 150000001204 N-oxides Chemical class 0.000 claims description 19
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 8
- 238000000034 method Methods 0.000 claims description 5
- MCAHKQZJTSJTMD-QGZVFWFLSA-N (2R)-3-[3,5-difluoro-4-[[3-[5-methoxy-4-[(3-methoxypyridin-4-yl)amino]pyrimidin-2-yl]indazol-1-yl]methyl]phenoxy]-2-methylpropan-1-ol Chemical compound FC=1C=C(OC[C@@H](CO)C)C=C(C=1CN1N=C(C2=CC=CC=C12)C1=NC=C(C(=N1)NC1=C(C=NC=C1)OC)OC)F MCAHKQZJTSJTMD-QGZVFWFLSA-N 0.000 claims description 4
- TWGTVRYYTDSEDP-UHFFFAOYSA-N 2-[3,5-difluoro-4-[[3-[5-methoxy-4-[(2-methylpyrimidin-4-yl)amino]pyrimidin-2-yl]indazol-1-yl]methyl]phenoxy]ethanol Chemical compound COC1=CN=C(N=C1NC1=CC=NC(C)=N1)C1=NN(CC2=C(F)C=C(OCCO)C=C2F)C2=C1C=CC=C2 TWGTVRYYTDSEDP-UHFFFAOYSA-N 0.000 claims description 4
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2017
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