KR20170049604A - Bub1 억제제로서의 벤질 치환된 인다졸 - Google Patents

Bub1 억제제로서의 벤질 치환된 인다졸 Download PDF

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KR20170049604A
KR20170049604A KR1020177010425A KR20177010425A KR20170049604A KR 20170049604 A KR20170049604 A KR 20170049604A KR 1020177010425 A KR1020177010425 A KR 1020177010425A KR 20177010425 A KR20177010425 A KR 20177010425A KR 20170049604 A KR20170049604 A KR 20170049604A
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methyl
amino
indazol
alkyl
compound
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Korean (ko)
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안네 맨겔
한스-게오르크 레르첸
만프레트 뫼베스
토마스 뮐러
라르스 배르팍커
마리온 히치콕
아르베트 클레베
요하임 쿠흔케
한스 브림
게르하르트 지마이스터
빌헬름 보네
아모리 에르네스토 페르난데스-몬탈반
옌스 슈로더
우르슐라 묀닝
지몬 홀톤
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바이엘 파마 악티엔게젤샤프트
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Publication of KR20170049604A publication Critical patent/KR20170049604A/ko
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/04Antineoplastic agents specific for metastasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
KR1020177010425A 2014-09-19 2015-09-17 Bub1 억제제로서의 벤질 치환된 인다졸 Withdrawn KR20170049604A (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP14185604.7 2014-09-19
EP14185604 2014-09-19
EP15176903 2015-07-15
EP15176903.1 2015-07-15
PCT/EP2015/071340 WO2016042084A1 (en) 2014-09-19 2015-09-17 Benzyl substituted indazoles as bub1 inhibitors

Publications (1)

Publication Number Publication Date
KR20170049604A true KR20170049604A (ko) 2017-05-10

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KR1020177010425A Withdrawn KR20170049604A (ko) 2014-09-19 2015-09-17 Bub1 억제제로서의 벤질 치환된 인다졸

Country Status (27)

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US (1) US10350206B2 (enExample)
EP (1) EP3194379A1 (enExample)
JP (1) JP6664385B2 (enExample)
KR (1) KR20170049604A (enExample)
CN (1) CN107001331A (enExample)
AP (1) AP2017009803A0 (enExample)
AU (1) AU2015316796A1 (enExample)
BR (1) BR112017005444A2 (enExample)
CA (1) CA2961589A1 (enExample)
CL (1) CL2017000654A1 (enExample)
CO (1) CO2017002532A2 (enExample)
CR (1) CR20170100A (enExample)
CU (1) CU20170029A7 (enExample)
DO (1) DOP2017000078A (enExample)
EA (1) EA032401B1 (enExample)
EC (1) ECSP17016797A (enExample)
IL (1) IL251071A0 (enExample)
MA (1) MA39484A (enExample)
MX (1) MX2017003664A (enExample)
NI (1) NI201700034A (enExample)
PE (1) PE20170697A1 (enExample)
PH (1) PH12017500509A1 (enExample)
SG (1) SG11201702082VA (enExample)
TN (1) TN2017000092A1 (enExample)
TW (1) TW201615636A (enExample)
UY (1) UY36311A (enExample)
WO (1) WO2016042084A1 (enExample)

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AR111960A1 (es) 2017-05-26 2019-09-04 Incyte Corp Formas cristalinas de un inhibidor de fgfr y procesos para su preparación
PL3788047T3 (pl) 2018-05-04 2025-04-14 Incyte Corporation Stałe postacie inhibitora fgfr i sposoby ich otrzymywania
KR20210018264A (ko) 2018-05-04 2021-02-17 인사이트 코포레이션 Fgfr 억제제의 염
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US11591329B2 (en) 2019-07-09 2023-02-28 Incyte Corporation Bicyclic heterocycles as FGFR inhibitors
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CR20220169A (es) 2019-10-14 2022-10-27 Incyte Corp Heterociclos bicíclicos como inhibidores de fgfr
US11566028B2 (en) 2019-10-16 2023-01-31 Incyte Corporation Bicyclic heterocycles as FGFR inhibitors
JP7720840B2 (ja) 2019-12-04 2025-08-08 インサイト・コーポレイション Fgfr阻害剤としての三環式複素環
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WO2021146424A1 (en) 2020-01-15 2021-07-22 Incyte Corporation Bicyclic heterocycles as fgfr inhibitors
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CN107001331A (zh) 2017-08-01
CL2017000654A1 (es) 2017-12-11
AU2015316796A1 (en) 2017-03-30
SG11201702082VA (en) 2017-04-27
PE20170697A1 (es) 2017-06-24
DOP2017000078A (es) 2017-06-30
US20170273980A1 (en) 2017-09-28
CO2017002532A2 (es) 2017-07-11
NI201700034A (es) 2017-06-16
EA032401B1 (ru) 2019-05-31
MX2017003664A (es) 2017-07-13
EA201790649A1 (ru) 2017-09-29
EP3194379A1 (en) 2017-07-26
JP2017530962A (ja) 2017-10-19
TN2017000092A1 (en) 2018-07-04
ECSP17016797A (es) 2017-05-31
PH12017500509A1 (en) 2017-08-30
JP6664385B2 (ja) 2020-03-13
CR20170100A (es) 2017-04-24
BR112017005444A2 (pt) 2018-04-24
TW201615636A (zh) 2016-05-01
WO2016042084A1 (en) 2016-03-24
CU20170029A7 (es) 2017-08-08
IL251071A0 (en) 2017-04-30
MA39484A (fr) 2016-03-24
AP2017009803A0 (en) 2017-03-31
UY36311A (es) 2016-04-29
US10350206B2 (en) 2019-07-16
CA2961589A1 (en) 2016-03-24

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Patent event date: 20170417

Patent event code: PA01051R01D

Comment text: International Patent Application

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