JP2021523933A5 - - Google Patents

Info

Publication number
JP2021523933A5
JP2021523933A5 JP2021506390A JP2021506390A JP2021523933A5 JP 2021523933 A5 JP2021523933 A5 JP 2021523933A5 JP 2021506390 A JP2021506390 A JP 2021506390A JP 2021506390 A JP2021506390 A JP 2021506390A JP 2021523933 A5 JP2021523933 A5 JP 2021523933A5
Authority
JP
Japan
Prior art keywords
trifluoromethyl
pyrazine
imidazo
phenyl
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2021506390A
Other languages
English (en)
Japanese (ja)
Other versions
JP2021523933A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2019/028555 external-priority patent/WO2019204816A1/en
Publication of JP2021523933A publication Critical patent/JP2021523933A/ja
Publication of JP2021523933A5 publication Critical patent/JP2021523933A5/ja
Pending legal-status Critical Current

Links

JP2021506390A 2018-04-20 2019-04-22 ミトコンドリア脱共役剤として有用なイミダゾピリジン Pending JP2021523933A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862660880P 2018-04-20 2018-04-20
US62/660,880 2018-04-20
PCT/US2019/028555 WO2019204816A1 (en) 2018-04-20 2019-04-22 Imidazopyridines useful as mitochondrial uncouplers

Publications (2)

Publication Number Publication Date
JP2021523933A JP2021523933A (ja) 2021-09-09
JP2021523933A5 true JP2021523933A5 (enExample) 2022-04-26

Family

ID=67139787

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2021506390A Pending JP2021523933A (ja) 2018-04-20 2019-04-22 ミトコンドリア脱共役剤として有用なイミダゾピリジン
JP2021506388A Pending JP2021522327A (ja) 2018-04-20 2019-04-22 ミトコンドリア脱共役剤として有用なオキサジアゾロピラジンおよびオキサジアゾロピリジン
JP2021506391A Pending JP2021523934A (ja) 2018-04-20 2019-04-22 ミトコンドリア脱共役剤として有用なアミノピラジンおよび関連化合物

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2021506388A Pending JP2021522327A (ja) 2018-04-20 2019-04-22 ミトコンドリア脱共役剤として有用なオキサジアゾロピラジンおよびオキサジアゾロピリジン
JP2021506391A Pending JP2021523934A (ja) 2018-04-20 2019-04-22 ミトコンドリア脱共役剤として有用なアミノピラジンおよび関連化合物

Country Status (12)

Country Link
US (3) US20210253538A1 (enExample)
EP (4) EP3781567B1 (enExample)
JP (3) JP2021523933A (enExample)
KR (3) KR20210003831A (enExample)
CN (3) CN112262146A (enExample)
AU (2) AU2019256722A1 (enExample)
BR (2) BR112020021466A2 (enExample)
CA (2) CA3097752A1 (enExample)
IL (2) IL278069A (enExample)
MX (2) MX2020011049A (enExample)
WO (3) WO2019204813A1 (enExample)
ZA (2) ZA202006296B (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3781567B1 (en) 2018-04-20 2022-08-24 Virginia Tech Intellectual Properties, Inc. Imidazopyridines useful as mitochondrial uncouplers
WO2020191503A1 (en) * 2019-03-27 2020-10-01 Algernon Pharmaceuticals Inc. Methods and uses of bromantane and derivatives thereof for treating lung disease, fatty liver disease, and kidney disorders
EP4178955A1 (en) 2020-07-11 2023-05-17 Pfizer Inc. Antiviral heteroaryl ketone derivatives
US11351149B2 (en) 2020-09-03 2022-06-07 Pfizer Inc. Nitrile-containing antiviral compounds
EP4482494A4 (en) * 2022-02-21 2026-02-25 Univ Colorado Regents RE-SENSITIZATION OF MULTI-DRUG-RESISTANT GRAM-NEGATIVE (MDR) BACTERIA TO COLISTIN USING IONOPHORES

Family Cites Families (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2501680A1 (fr) 1981-03-12 1982-09-17 Elf Aquitaine Synthese de tetra mercaptides stanniques
US4472840A (en) 1981-09-21 1984-09-25 Jefferies Steven R Method of inducing osseous formation by implanting bone graft material
US4559157A (en) 1983-04-21 1985-12-17 Creative Products Resource Associates, Ltd. Cosmetic applicator useful for skin moisturizing
LU84979A1 (fr) 1983-08-30 1985-04-24 Oreal Composition cosmetique ou pharmaceutique sous forme aqueuse ou anhydre dont la phase grasse contient un polyether oligomere et polyethers oligomeres nouveaux
US4820508A (en) 1987-06-23 1989-04-11 Neutrogena Corporation Skin protective composition
US5606019A (en) 1987-10-29 1997-02-25 Protien Polymer Technologies, Inc. Synthetic protein as implantables
JP2668259B2 (ja) * 1988-02-18 1997-10-27 塩野義製薬株式会社 複素環化合物および抗潰瘍剤
GB2215209B (en) 1988-03-14 1992-08-26 Osmed Inc Method and apparatus for biodegradable, osteogenic, bone graft substitute device
US4992478A (en) 1988-04-04 1991-02-12 Warner-Lambert Company Antiinflammatory skin moisturizing composition and method of preparing same
US4938949A (en) 1988-09-12 1990-07-03 University Of New York Treatment of damaged bone marrow and dosage units therefor
JPH0327172A (ja) 1989-06-19 1991-02-05 Nissan Chem Ind Ltd 布の漂白方法
US5645591A (en) 1990-05-29 1997-07-08 Stryker Corporation Synthetic bone matrix
JPH0741461A (ja) * 1993-05-27 1995-02-10 Eisai Co Ltd スルホン酸エステル誘導体
WO2000052001A1 (en) * 1999-03-03 2000-09-08 Samjin Pharmaceutical Co., Ltd. Piperazine derivatives and process for the preparation thereof
ATE307121T1 (de) * 2000-02-16 2005-11-15 Neurogen Corp Substituierte arylpyrazine
US6777446B2 (en) * 2000-09-05 2004-08-17 Tularik, Inc. FXR modulators
WO2004007472A1 (ja) * 2002-07-10 2004-01-22 Ono Pharmaceutical Co., Ltd. Ｃｃｒ４アンタゴニストおよびその医薬用途
EP1529531A1 (en) 2003-11-04 2005-05-11 4Sc Ag Oxadiazolopyrazine derivatives as pharmaceutically active compounds
WO2005044270A1 (en) 2003-11-04 2005-05-19 4Sc Ag Oxadiazolopyrazine derivatives as pharmaceutically active compounds
JP2008515979A (ja) * 2004-10-14 2008-05-15 コンパス ファーマシューティカルズ リミティド ライアビリティ カンパニー フラザノ‘３，４−ビピラジン（ｂｉｐｙｒａｚｉｎｅ）及び抗腫瘍剤としてのその使用
WO2006124874A2 (en) 2005-05-12 2006-11-23 Kalypsys, Inc. Inhibitors of b-raf kinase
ES2270715B1 (es) 2005-07-29 2008-04-01 Laboratorios Almirall S.A. Nuevos derivados de pirazina.
ES2412007T3 (es) * 2005-12-21 2013-07-09 Janssen Pharmaceutica, N.V. Derivados de pirazinona sustituida novedosos para uso en enfermedades mediadas por MCH-1
EP2017277A1 (en) 2007-06-29 2009-01-21 4Sc Ag Thiophene-imidazopyridines
AU2008345225A1 (en) 2007-12-21 2009-07-09 University Of Rochester Method for altering the lifespan of eukaryotic organisms
PL2424530T3 (pl) * 2009-04-30 2016-07-29 Univ Midwestern Sposób i kompozycja do leczenia cukrzycowej kwasicy ketonowej
WO2012020742A1 (ja) * 2010-08-10 2012-02-16 塩野義製薬株式会社 新規複素環誘導体およびそれらを含有する医薬組成物
KR20140077963A (ko) * 2011-10-20 2014-06-24 글락소스미스클라인 엘엘씨 시르투인 조절제로서의 치환된 비시클릭 아자-헤테로사이클 및 유사체
KR101481952B1 (ko) * 2012-04-13 2015-01-22 한국과학기술연구원 신경보호제로서의 유레아 유도체
US9492448B2 (en) 2012-06-20 2016-11-15 University Of Virginia Patent Foundation Compositions and methods for regulating glucose homeostasis and insulin action
TW201441203A (zh) 2012-11-05 2014-11-01 Medeia Therapeutics Ltd Ｎ－取代４－胺苯酚及對應醌亞胺
WO2015000715A1 (en) * 2013-07-02 2015-01-08 Syngenta Participations Ag Pesticidally active bi- or tricyclic heterocycles with sulfur containing substituents
KR101428622B1 (ko) 2014-01-07 2014-08-13 국방과학연구소 옥사디아졸로 피라진기를 포함하는 화합물 또는 염을 포함하는 리튬 이차 전지용 전극 및 이를 포함하는 리튬 이차 전지
CN107108521A (zh) * 2014-10-28 2017-08-29 盐野义制药株式会社 具有ampk活化作用的杂环衍生物
HK1243636A1 (zh) 2014-11-18 2018-07-20 Rutgers, The State University Of New Jersey 用於治疗代谢疾病和癌症的新的线粒体解偶联剂
WO2017151063A1 (en) 2016-03-03 2017-09-08 Agency For Science, Technology And Research Use of furazano[3,4-b]pyrazine derivatives for chemotherapy
TWI754702B (zh) * 2016-12-28 2022-02-11 德商Ｕｃｂ製藥有限公司 （氮雜）吲哚－和苯並呋喃－３－磺醯胺類
EP3630115B1 (en) 2017-05-22 2025-12-10 University Of Virginia Patent Foundation Compositions and methods for preparing and using mitochondrial uncouplers
EP3781567B1 (en) * 2018-04-20 2022-08-24 Virginia Tech Intellectual Properties, Inc. Imidazopyridines useful as mitochondrial uncouplers

Similar Documents

Publication Publication Date Title
AU2019301628C1 (en) Pyridine carboxamide compounds for inhibiting NaV1.8
JP7623275B2 (ja) ＮａＶ１．８を阻害するピリダジン化合物
JP6643545B2 (ja) Ｔｒｐｍ８拮抗剤としてのアザスピロ誘導体
JP2021530478A5 (enExample)
TWI694076B (zh) 三唑并嘧啶化合物及其用途
CA2651363A1 (en) Triazolopyrazine derivatives useful as anti-cancer agents
WO2014147586A1 (en) 1-(2-(ethylamino)pyrimidin-4-yl)pyrrolidin-2-ones as inhibitors of mutant idh
JP2013544893A5 (enExample)
JP2016525075A5 (enExample)
JP2013518864A5 (enExample)
HUE030773T2 (en) Nitrogen-containing heterocyclic compounds with inhibitory effect on the production of quinurenine
NZ594606A (en) Fused ring compound and use thereof
JP2012522763A5 (enExample)
TW200916458A (en) Heterocyclic compounds and methods of use thereof
JP2018526419A5 (enExample)
JP2018534355A5 (enExample)
JP2010516699A5 (enExample)
JP2021522327A5 (enExample)
RU2017145964A (ru) Аминобензизоксазольные соединения в качестве агонистов α7-никотиновых ацетилхолиновых рецепторов
JP2015524483A5 (enExample)
JP2021523934A5 (enExample)
JP2013525490A5 (enExample)
CA3257285A1 (en) HETEROARYL COMPOUNDS FOR PAIN RELIEF
JP2022509848A (ja) てんかん治療用複素環化合物
FI4225753T3 (fi) Voimakkaita ja selektiivisiä yhdisteitä serotoniini 1b -reseptorin modulaattoreina