JP2017501711A5 - - Google Patents
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- JP2017501711A5 JP2017501711A5 JP2016541346A JP2016541346A JP2017501711A5 JP 2017501711 A5 JP2017501711 A5 JP 2017501711A5 JP 2016541346 A JP2016541346 A JP 2016541346A JP 2016541346 A JP2016541346 A JP 2016541346A JP 2017501711 A5 JP2017501711 A5 JP 2017501711A5
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- Prior art keywords
- amino acid
- acid sequence
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- antibody
- antigen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 125000003275 alpha amino acid group Chemical group 0.000 claims 58
- 239000000427 antigen Substances 0.000 claims 39
- 102000036639 antigens Human genes 0.000 claims 39
- 108091007433 antigens Proteins 0.000 claims 39
- 238000000034 method Methods 0.000 claims 34
- 239000012634 fragment Substances 0.000 claims 31
- 239000003814 drug Substances 0.000 claims 10
- 208000006673 asthma Diseases 0.000 claims 5
- 102000003816 Interleukin-13 Human genes 0.000 claims 4
- 108090000176 Interleukin-13 Proteins 0.000 claims 4
- 125000000539 amino acid group Chemical group 0.000 claims 4
- 150000001413 amino acids Chemical class 0.000 claims 4
- 239000002904 solvent Substances 0.000 claims 4
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 230000002209 hydrophobic effect Effects 0.000 claims 3
- 150000007523 nucleic acids Chemical group 0.000 claims 3
- 230000002062 proliferating effect Effects 0.000 claims 3
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims 2
- 102000009109 Fc receptors Human genes 0.000 claims 2
- 108010087819 Fc receptors Proteins 0.000 claims 2
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 2
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 2
- 108010052285 Membrane Proteins Proteins 0.000 claims 2
- 102000018697 Membrane Proteins Human genes 0.000 claims 2
- 210000004027 cell Anatomy 0.000 claims 2
- 229940127089 cytotoxic agent Drugs 0.000 claims 2
- 238000001727 in vivo Methods 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 108091033319 polynucleotide Proteins 0.000 claims 2
- 102000040430 polynucleotide Human genes 0.000 claims 2
- 239000002157 polynucleotide Substances 0.000 claims 2
- ZFXYFBGIUFBOJW-UHFFFAOYSA-N theophylline Chemical compound O=C1N(C)C(=O)N(C)C2=C1NC=N2 ZFXYFBGIUFBOJW-UHFFFAOYSA-N 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- KUVIULQEHSCUHY-XYWKZLDCSA-N Beclometasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(Cl)[C@@H]1[C@@H]1C[C@H](C)[C@@](C(=O)COC(=O)CC)(OC(=O)CC)[C@@]1(C)C[C@@H]2O KUVIULQEHSCUHY-XYWKZLDCSA-N 0.000 claims 1
- 102000004127 Cytokines Human genes 0.000 claims 1
- 108090000695 Cytokines Proteins 0.000 claims 1
- 102100026120 IgG receptor FcRn large subunit p51 Human genes 0.000 claims 1
- 101710177940 IgG receptor FcRn large subunit p51 Proteins 0.000 claims 1
- 108010054477 Immunoglobulin Fab Fragments Proteins 0.000 claims 1
- 102000001706 Immunoglobulin Fab Fragments Human genes 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 102000007562 Serum Albumin Human genes 0.000 claims 1
- 108010071390 Serum Albumin Proteins 0.000 claims 1
- QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 claims 1
- NDAUXUAQIAJITI-UHFFFAOYSA-N albuterol Chemical compound CC(C)(C)NCC(O)C1=CC=C(O)C(CO)=C1 NDAUXUAQIAJITI-UHFFFAOYSA-N 0.000 claims 1
- 201000009961 allergic asthma Diseases 0.000 claims 1
- 239000004037 angiogenesis inhibitor Substances 0.000 claims 1
- 239000005557 antagonist Substances 0.000 claims 1
- 229940121363 anti-inflammatory agent Drugs 0.000 claims 1
- 239000002260 anti-inflammatory agent Substances 0.000 claims 1
- 230000001028 anti-proliverative effect Effects 0.000 claims 1
- 229940125715 antihistaminic agent Drugs 0.000 claims 1
- 239000000739 antihistaminic agent Substances 0.000 claims 1
- 239000002246 antineoplastic agent Substances 0.000 claims 1
- 229950000210 beclometasone dipropionate Drugs 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 229960000265 cromoglicic acid Drugs 0.000 claims 1
- IMZMKUWMOSJXDT-UHFFFAOYSA-N cromoglycic acid Chemical compound O1C(C(O)=O)=CC(=O)C2=C1C=CC=C2OCC(O)COC1=CC=CC2=C1C(=O)C=C(C(O)=O)O2 IMZMKUWMOSJXDT-UHFFFAOYSA-N 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 239000002254 cytotoxic agent Substances 0.000 claims 1
- 231100000599 cytotoxic agent Toxicity 0.000 claims 1
- 238000012350 deep sequencing Methods 0.000 claims 1
- 239000012636 effector Substances 0.000 claims 1
- 230000001605 fetal effect Effects 0.000 claims 1
- 125000001165 hydrophobic group Chemical group 0.000 claims 1
- 210000002540 macrophage Anatomy 0.000 claims 1
- 210000000822 natural killer cell Anatomy 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 102000005962 receptors Human genes 0.000 claims 1
- 108020003175 receptors Proteins 0.000 claims 1
- 229960002052 salbutamol Drugs 0.000 claims 1
- 150000003431 steroids Chemical class 0.000 claims 1
- 229960000278 theophylline Drugs 0.000 claims 1
- 125000000430 tryptophan group Chemical group [H]N([H])C(C(=O)O*)C([H])([H])C1=C([H])N([H])C2=C([H])C([H])=C([H])C([H])=C12 0.000 claims 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 claims 1
- 125000001493 tyrosinyl group Chemical group [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2020092097A JP7504664B2 (ja) | 2013-12-20 | 2020-05-27 | 二重特異性抗体 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361919552P | 2013-12-20 | 2013-12-20 | |
| US61/919,552 | 2013-12-20 | ||
| US201461946547P | 2014-02-28 | 2014-02-28 | |
| US61/946,547 | 2014-02-28 | ||
| PCT/US2014/071193 WO2015095539A1 (en) | 2013-12-20 | 2014-12-18 | Dual specific antibodies |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020092097A Division JP7504664B2 (ja) | 2013-12-20 | 2020-05-27 | 二重特異性抗体 |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2017501711A JP2017501711A (ja) | 2017-01-19 |
| JP2017501711A5 true JP2017501711A5 (cg-RX-API-DMAC7.html) | 2018-02-08 |
| JPWO2015095539A5 JPWO2015095539A5 (cg-RX-API-DMAC7.html) | 2022-03-09 |
| JP7325166B2 JP7325166B2 (ja) | 2023-08-14 |
Family
ID=52293284
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016541346A Active JP7325166B2 (ja) | 2013-12-20 | 2014-12-18 | 二重特異性抗体 |
| JP2020092097A Active JP7504664B2 (ja) | 2013-12-20 | 2020-05-27 | 二重特異性抗体 |
| JP2023134016A Withdrawn JP2023179409A (ja) | 2013-12-20 | 2023-08-21 | 二重特異性抗体 |
| JP2025133768A Pending JP2025179073A (ja) | 2013-12-20 | 2025-08-08 | 二重特異性抗体 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020092097A Active JP7504664B2 (ja) | 2013-12-20 | 2020-05-27 | 二重特異性抗体 |
| JP2023134016A Withdrawn JP2023179409A (ja) | 2013-12-20 | 2023-08-21 | 二重特異性抗体 |
| JP2025133768A Pending JP2025179073A (ja) | 2013-12-20 | 2025-08-08 | 二重特異性抗体 |
Country Status (10)
| Country | Link |
|---|---|
| US (5) | US10683348B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP3083682B1 (cg-RX-API-DMAC7.html) |
| JP (4) | JP7325166B2 (cg-RX-API-DMAC7.html) |
| KR (3) | KR20250154523A (cg-RX-API-DMAC7.html) |
| CN (2) | CN105849124B (cg-RX-API-DMAC7.html) |
| BR (1) | BR112016011027A2 (cg-RX-API-DMAC7.html) |
| CA (2) | CA3204788C (cg-RX-API-DMAC7.html) |
| MX (2) | MX380937B (cg-RX-API-DMAC7.html) |
| RU (1) | RU2732032C2 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2015095539A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (101)
| Publication number | Priority date | Publication date | Assignee | Title |
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| HUE067896T2 (hu) | 2016-04-27 | 2024-11-28 | Abbvie Mfg Management Unlimited Company | Olyan betegségek kezelési módszerei az anti-IL-13 antitestek alkalmazásával, amelyekben az IL-13 aktivitás káros |
| TW201829463A (zh) | 2016-11-18 | 2018-08-16 | 瑞士商赫孚孟拉羅股份公司 | 抗hla-g抗體及其用途 |
| CA3221995C (en) | 2017-02-08 | 2024-05-28 | Dragonfly Therapeutics, Inc. | Multi-specific binding proteins for activation of natural killer cells and therapeutic uses thereof to treat cancer |
| SG11201907646YA (en) | 2017-02-20 | 2019-09-27 | Dragonfly Therapeutics Inc | Proteins binding her2, nkg2d and cd16 |
| WO2018162376A1 (en) * | 2017-03-07 | 2018-09-13 | F. Hoffmann-La Roche Ag | Method for discovery of alternative antigen specific antibody variants |
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| IL268620B2 (en) | 2017-04-05 | 2024-04-01 | Hoffmann La Roche | Antibodies against LAG3 pharmaceutical formulations containing them, and their uses for cancer treatment |
| KR102709785B1 (ko) | 2017-09-29 | 2024-09-24 | 지앙수 헨그루이 파마슈티컬스 컴퍼니 리미티드 | Ｉｌ－５ 항체, 이의 항원 결합 단편 및 이의 의학적 적용 |
| TWI805665B (zh) | 2017-12-21 | 2023-06-21 | 瑞士商赫孚孟拉羅股份公司 | 結合hla-a2/wt1之抗體 |
| JP2021511793A (ja) | 2018-01-31 | 2021-05-13 | エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト | Ｌａｇ３に結合する抗原結合部位を含む二重特異性抗体 |
| WO2019149715A1 (en) | 2018-01-31 | 2019-08-08 | F. Hoffmann-La Roche Ag | Stabilized immunoglobulin domains |
| PT3749346T (pt) | 2018-02-08 | 2024-09-05 | Dragonfly Therapeutics Inc | Combinações de domínios variáveis de anticorpos dirigidas ao receptor nkg2d |
| KR20200118824A (ko) | 2018-02-08 | 2020-10-16 | 드래곤플라이 쎄라퓨틱스, 인크. | 자연 살해 세포를 활성화시키는 다중-특이성 결합 단백질을 수반하는 암의 병용 요법 |
| TWI829667B (zh) | 2018-02-09 | 2024-01-21 | 瑞士商赫孚孟拉羅股份公司 | 結合gprc5d之抗體 |
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