MX2021003549A - Anticuerpos dobles especificos. - Google Patents
Anticuerpos dobles especificos.Info
- Publication number
- MX2021003549A MX2021003549A MX2021003549A MX2021003549A MX2021003549A MX 2021003549 A MX2021003549 A MX 2021003549A MX 2021003549 A MX2021003549 A MX 2021003549A MX 2021003549 A MX2021003549 A MX 2021003549A MX 2021003549 A MX2021003549 A MX 2021003549A
- Authority
- MX
- Mexico
- Prior art keywords
- specific antibodies
- dual specific
- antibodies
- antibody
- nucleic acid
- Prior art date
Links
- 230000009977 dual effect Effects 0.000 title abstract 5
- 108091028043 Nucleic acid sequence Proteins 0.000 abstract 2
- 150000007523 nucleic acids Chemical group 0.000 abstract 2
- 230000004075 alteration Effects 0.000 abstract 1
- 239000000427 antigen Substances 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
- 230000002209 hydrophobic effect Effects 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/244—Interleukins [IL]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/244—Interleukins [IL]
- C07K16/247—IL-4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
- C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/567—Framework region [FR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Endocrinology (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
La invención brinda anticuerpos específicos dobles y métodos de fabricación y uso de estos anticuerpos. En general, los anticuerpos específicos dobles se generan mediante identificación de un anticuerpo monoespecífico con residuos VL de región variable de cadena ligera que son electrostáticos o hidrofóbicos y alteración la secuencia de ácido nucleico que codifica uno o más residuos accesibles para el solvente en el VH del anticuerpo solo o en combinación con alteración de la secuencia de ácido nucleico que codifica el VL del anticuerpo. Se expresan el VH y el VL alterado y se seleccionan anticuerpos específicos dobles o fragmentos de unión a antígeno de estos. También se brindan ejemplos de anticuerpos específicos dobles, así como métodos de uso de los anticuerpos.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361919552P | 2013-12-20 | 2013-12-20 | |
US201461946547P | 2014-02-28 | 2014-02-28 |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2021003549A true MX2021003549A (es) | 2021-05-27 |
Family
ID=52293284
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2016006529A MX2016006529A (es) | 2013-12-20 | 2014-12-18 | Anticuerpos dobles especificos. |
MX2021003549A MX2021003549A (es) | 2013-12-20 | 2016-05-19 | Anticuerpos dobles especificos. |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2016006529A MX2016006529A (es) | 2013-12-20 | 2014-12-18 | Anticuerpos dobles especificos. |
Country Status (10)
Country | Link |
---|---|
US (2) | US10683348B2 (es) |
EP (1) | EP3083682B1 (es) |
JP (2) | JP7325166B2 (es) |
KR (2) | KR20230155605A (es) |
CN (2) | CN114702594A (es) |
BR (1) | BR112016011027A2 (es) |
CA (2) | CA2931113C (es) |
MX (2) | MX2016006529A (es) |
RU (2) | RU2020129339A (es) |
WO (1) | WO2015095539A1 (es) |
Families Citing this family (67)
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LT3606954T (lt) | 2017-04-05 | 2022-09-26 | F. Hoffmann-La Roche Ag | Anti-lag3 antikūnai |
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AR115052A1 (es) | 2018-04-18 | 2020-11-25 | Hoffmann La Roche | Anticuerpos multiespecíficos y utilización de los mismos |
AR117727A1 (es) | 2018-12-21 | 2021-08-25 | Hoffmann La Roche | Anticuerpos que se unen a cd3 |
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CR20220277A (es) | 2019-12-18 | 2022-08-31 | Hoffmann La Roche | Anticuerpos anti-ccl2 biespecifico |
CA3161390A1 (en) | 2019-12-18 | 2021-06-24 | Tina WEINZIERL | Antibodies binding to hla-a2/mage-a4 |
KR20220118527A (ko) | 2019-12-23 | 2022-08-25 | 제넨테크, 인크. | 아포지질단백질 l1-특이적 항체 및 이용 방법 |
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SK1152003A3 (en) * | 2000-06-29 | 2003-07-01 | Abbott Lab | Dual specificity antibodies and methods of making and using |
EP1399484B1 (en) * | 2001-06-28 | 2010-08-11 | Domantis Limited | Dual-specific ligand and its use |
CN1678634A (zh) * | 2002-06-28 | 2005-10-05 | 多曼蒂斯有限公司 | 免疫球蛋白单个变体抗原结合区及其特异性构建体 |
DK2059533T3 (da) | 2006-08-30 | 2013-02-25 | Genentech Inc | Multispecifikke antistoffer |
EP2050764A1 (en) * | 2007-10-15 | 2009-04-22 | sanofi-aventis | Novel polyvalent bispecific antibody format and uses thereof |
CA2755640C (en) * | 2009-03-20 | 2018-05-22 | Genentech, Inc. | Bispecific antibody with a single antigen-binding domain specific for both her3 and egfr |
JP5901517B2 (ja) * | 2009-05-28 | 2016-04-13 | グラクソ グループ リミテッドGlaxo Group Limited | 抗原結合性タンパク質 |
JP2014516542A (ja) * | 2011-05-27 | 2014-07-17 | デュタリス ゲゼルシャフト ミット ベシュレンクテル ハフツング | 二重標的化 |
MX2015013901A (es) | 2013-04-05 | 2015-12-11 | Genentech Inc | Anticuerpos anti-il-4 y anticuerpos biespecificos y sus usos. |
-
2014
- 2014-12-18 CA CA2931113A patent/CA2931113C/en active Active
- 2014-12-18 CA CA3204788A patent/CA3204788A1/en active Pending
- 2014-12-18 BR BR112016011027A patent/BR112016011027A2/pt not_active Application Discontinuation
- 2014-12-18 JP JP2016541346A patent/JP7325166B2/ja active Active
- 2014-12-18 KR KR1020237037490A patent/KR20230155605A/ko active Application Filing
- 2014-12-18 KR KR1020167014866A patent/KR102597804B1/ko active IP Right Grant
- 2014-12-18 WO PCT/US2014/071193 patent/WO2015095539A1/en active Application Filing
- 2014-12-18 RU RU2020129339A patent/RU2020129339A/ru unknown
- 2014-12-18 CN CN202210315371.3A patent/CN114702594A/zh active Pending
- 2014-12-18 EP EP14824722.4A patent/EP3083682B1/en active Active
- 2014-12-18 CN CN201480067934.5A patent/CN105849124B/zh active Active
- 2014-12-18 MX MX2016006529A patent/MX2016006529A/es unknown
- 2014-12-18 RU RU2016129247A patent/RU2732032C2/ru active
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2016
- 2016-05-19 MX MX2021003549A patent/MX2021003549A/es unknown
- 2016-05-27 US US15/167,030 patent/US10683348B2/en active Active
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2020
- 2020-04-28 US US16/860,891 patent/US12006360B2/en active Active
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2023
- 2023-08-21 JP JP2023134016A patent/JP2023179409A/ja active Pending
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WO2015095539A1 (en) | 2015-06-25 |
KR20160099086A (ko) | 2016-08-19 |
US20200255512A1 (en) | 2020-08-13 |
KR20230155605A (ko) | 2023-11-10 |
CA3204788A1 (en) | 2015-06-25 |
CN105849124B (zh) | 2022-04-12 |
EP3083682B1 (en) | 2024-04-17 |
KR102597804B1 (ko) | 2023-11-07 |
EP3083682C0 (en) | 2024-04-17 |
CA2931113C (en) | 2023-07-11 |
EP3083682A1 (en) | 2016-10-26 |
JP2020162609A (ja) | 2020-10-08 |
JP2023179409A (ja) | 2023-12-19 |
JP2017501711A (ja) | 2017-01-19 |
CN105849124A (zh) | 2016-08-10 |
CN114702594A (zh) | 2022-07-05 |
US10683348B2 (en) | 2020-06-16 |
BR112016011027A2 (pt) | 2017-12-05 |
CA2931113A1 (en) | 2015-06-25 |
US12006360B2 (en) | 2024-06-11 |
RU2732032C2 (ru) | 2020-09-10 |
JP7325166B2 (ja) | 2023-08-14 |
US20160257744A1 (en) | 2016-09-08 |
MX2016006529A (es) | 2016-08-03 |
RU2020129339A (ru) | 2020-10-02 |
RU2016129247A (ru) | 2018-01-25 |
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