CA3204788C - ANTIBODIES COMPRISING AN ANTIGEN BINDING SITE THAT BINDS PRECISELY TO TWO DIFFERENT ANTIGENIC DETERMINANTS, AND METHODS OF PRODUCTION - Google Patents

ANTIBODIES COMPRISING AN ANTIGEN BINDING SITE THAT BINDS PRECISELY TO TWO DIFFERENT ANTIGENIC DETERMINANTS, AND METHODS OF PRODUCTION

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Publication number
CA3204788C
CA3204788C CA3204788A CA3204788A CA3204788C CA 3204788 C CA3204788 C CA 3204788C CA 3204788 A CA3204788 A CA 3204788A CA 3204788 A CA3204788 A CA 3204788A CA 3204788 C CA3204788 C CA 3204788C
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Prior art keywords
amino acid
acid sequence
seq
antibody
antigen
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CA3204788A
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English (en)
French (fr)
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CA3204788A1 (en
Inventor
Germaine Fuh
Chingwei V. Lee
Patrick Koenig
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Genentech Inc
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Priority to CA3204788A priority Critical patent/CA3204788C/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • C07K16/247—IL-4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Endocrinology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CA3204788A 2013-12-20 2014-12-18 ANTIBODIES COMPRISING AN ANTIGEN BINDING SITE THAT BINDS PRECISELY TO TWO DIFFERENT ANTIGENIC DETERMINANTS, AND METHODS OF PRODUCTION Active CA3204788C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA3204788A CA3204788C (en) 2013-12-20 2014-12-18 ANTIBODIES COMPRISING AN ANTIGEN BINDING SITE THAT BINDS PRECISELY TO TWO DIFFERENT ANTIGENIC DETERMINANTS, AND METHODS OF PRODUCTION

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201361919552P 2013-12-20 2013-12-20
US61/919,552 2013-12-20
US201461946547P 2014-02-28 2014-02-28
US61/946,547 2014-02-28
CA3204788A CA3204788C (en) 2013-12-20 2014-12-18 ANTIBODIES COMPRISING AN ANTIGEN BINDING SITE THAT BINDS PRECISELY TO TWO DIFFERENT ANTIGENIC DETERMINANTS, AND METHODS OF PRODUCTION
CA2931113A CA2931113C (en) 2013-12-20 2014-12-18 Antibodies comprising an antigen-binding site that specifically binds to two different epitopes and methods of making them

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CA2931113A Division CA2931113C (en) 2013-12-20 2014-12-18 Antibodies comprising an antigen-binding site that specifically binds to two different epitopes and methods of making them

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CA3276932 Division 2014-12-18

Publications (2)

Publication Number Publication Date
CA3204788A1 CA3204788A1 (en) 2015-06-25
CA3204788C true CA3204788C (en) 2025-11-18

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CA3204788A Active CA3204788C (en) 2013-12-20 2014-12-18 ANTIBODIES COMPRISING AN ANTIGEN BINDING SITE THAT BINDS PRECISELY TO TWO DIFFERENT ANTIGENIC DETERMINANTS, AND METHODS OF PRODUCTION
CA2931113A Active CA2931113C (en) 2013-12-20 2014-12-18 Antibodies comprising an antigen-binding site that specifically binds to two different epitopes and methods of making them

Family Applications After (1)

Application Number Title Priority Date Filing Date
CA2931113A Active CA2931113C (en) 2013-12-20 2014-12-18 Antibodies comprising an antigen-binding site that specifically binds to two different epitopes and methods of making them

Country Status (10)

Country Link
US (5) US10683348B2 (cg-RX-API-DMAC7.html)
EP (1) EP3083682B1 (cg-RX-API-DMAC7.html)
JP (4) JP7325166B2 (cg-RX-API-DMAC7.html)
KR (3) KR20250154523A (cg-RX-API-DMAC7.html)
CN (2) CN105849124B (cg-RX-API-DMAC7.html)
BR (1) BR112016011027A2 (cg-RX-API-DMAC7.html)
CA (2) CA3204788C (cg-RX-API-DMAC7.html)
MX (2) MX380937B (cg-RX-API-DMAC7.html)
RU (1) RU2732032C2 (cg-RX-API-DMAC7.html)
WO (1) WO2015095539A1 (cg-RX-API-DMAC7.html)

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