JP2016523863A5 - - Google Patents
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- JP2016523863A5 JP2016523863A5 JP2016521853A JP2016521853A JP2016523863A5 JP 2016523863 A5 JP2016523863 A5 JP 2016523863A5 JP 2016521853 A JP2016521853 A JP 2016521853A JP 2016521853 A JP2016521853 A JP 2016521853A JP 2016523863 A5 JP2016523863 A5 JP 2016523863A5
- Authority
- JP
- Japan
- Prior art keywords
- antigen
- pharmaceutical composition
- antibody
- binding fragment
- administered
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361837912P | 2013-06-21 | 2013-06-21 | |
| US61/837,912 | 2013-06-21 | ||
| EP14305670.3 | 2014-05-07 | ||
| EP14305670 | 2014-05-07 | ||
| PCT/US2014/043440 WO2014205365A1 (en) | 2013-06-21 | 2014-06-20 | Methods for treating nasal polyposis by administering an il-4r antagonist |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018243929A Division JP6640977B2 (ja) | 2013-06-21 | 2018-12-27 | Ｉｌ−４ｒアンタゴニストの投与により鼻茸を処置する方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016523863A JP2016523863A (ja) | 2016-08-12 |
| JP2016523863A5 true JP2016523863A5 (enExample) | 2017-06-29 |
| JP6463351B2 JP6463351B2 (ja) | 2019-01-30 |
Family
ID=50736018
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016521853A Active JP6463351B2 (ja) | 2013-06-21 | 2014-06-20 | Ｉｌ−４ｒアンタゴニストの投与により鼻茸を処置する方法 |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US10059771B2 (enExample) |
| EP (3) | EP4663250A3 (enExample) |
| JP (1) | JP6463351B2 (enExample) |
| KR (4) | KR20210132232A (enExample) |
| CN (2) | CN111437387B (enExample) |
| AU (4) | AU2014284235C1 (enExample) |
| CA (1) | CA2915839A1 (enExample) |
| CY (1) | CY1122754T1 (enExample) |
| ES (1) | ES3050809T3 (enExample) |
| HU (1) | HUE073368T2 (enExample) |
| IL (1) | IL243246B (enExample) |
| MX (1) | MX368068B (enExample) |
| PL (2) | PL3613432T3 (enExample) |
| PT (1) | PT3613432T (enExample) |
| RS (1) | RS59354B1 (enExample) |
| RU (1) | RU2674680C2 (enExample) |
| SG (2) | SG11201509625PA (enExample) |
| SI (1) | SI3010539T1 (enExample) |
| TW (2) | TWI709411B (enExample) |
| WO (1) | WO2014205365A1 (enExample) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7608693B2 (en) * | 2006-10-02 | 2009-10-27 | Regeneron Pharmaceuticals, Inc. | High affinity human antibodies to human IL-4 receptor |
| IL312711A (en) | 2012-08-21 | 2024-07-01 | Regeneron Pharma | Methods for the treatment or prevention of asthma through the administration of an antagonist to 4R-IL |
| KR102576903B1 (ko) | 2012-09-07 | 2023-09-13 | 리제너론 파아마슈티컬스, 인크. | Ｉｌ-4ｒ 길항제 투여로 아토피성 피부염을 치료하는 방법 |
| TWI755763B (zh) | 2013-06-04 | 2022-02-21 | 美商再生元醫藥公司 | 藉由投與il-4r抑制劑以治療過敏及增強過敏原-特異之免疫療法的方法 |
| HRP20191709T1 (hr) * | 2013-06-21 | 2019-12-13 | Sanofi Biotechnology | Postupci liječenja nosne polipoze davanjem antagonista il-4r |
| KR20210132232A (ko) | 2013-06-21 | 2021-11-03 | 사노피 바이오테크놀로지 | Il-4r 길항제를 투여함에 의한 비용종증의 치료 방법 |
| TWI634900B (zh) | 2013-07-11 | 2018-09-11 | 再生元醫藥公司 | 藉由投與ｉｌ－４ｒ抑制劑治療嗜酸性食道炎的方法 |
| IL315136A (en) | 2014-02-21 | 2024-10-01 | Sanofi Biotechnology | Methods for treating or preventing asthma by administering an il-4rantagonist |
| KR102927870B1 (ko) | 2014-02-28 | 2026-02-19 | 리제너론 파아마슈티컬스, 인크. | Ｉｌ-4ｒ 길항제의 투여에 의한 피부 감염의 치료 방법 |
| WO2016077675A1 (en) | 2014-11-14 | 2016-05-19 | Sanofi Biotechnology | Methods for treating chronic sinusitis with nasal polyps by administering an il-4r antagonist |
| AU2017220184B2 (en) | 2016-02-19 | 2024-04-18 | Regeneron Pharmaceuticals, Inc. | Methods for enhancing efficacy of a vaccine by administering an IL-4R antagonist |
| US11771743B2 (en) * | 2016-09-01 | 2023-10-03 | Regeneron Pharmaceuticals, Inc. | Methods for preventing or treating allergy by administering an IL-4R antagonist |
| US10485844B2 (en) | 2016-09-22 | 2019-11-26 | Regeneron Pharmaceuticals, Inc. | Methods for treating severe atopic dermatitis by administering an IL-4R inhibitor |
| TWI857389B (zh) * | 2016-12-01 | 2024-10-01 | 美商再生元醫藥公司 | 治療發炎症狀的方法 |
| CN108339118A (zh) * | 2017-01-23 | 2018-07-31 | 瑞阳(苏州)生物科技有限公司 | 治疗或预防阻塞性睡眠呼吸暂停的药物组合物 |
| WO2019028367A1 (en) | 2017-08-04 | 2019-02-07 | Regeneron Pharmaceuticals, Inc. | METHODS OF TREATING ESOPHAGITIS WITH ACTIVE EOSINOPHILES |
| EP3703818B1 (en) | 2017-10-30 | 2023-11-01 | Sanofi Biotechnology | Il-4r antagonist for use in a method for treating or preventing asthma |
| GB201802487D0 (en) * | 2018-02-15 | 2018-04-04 | Argenx Bvba | Cytokine combination therapy |
| CN108373505B (zh) * | 2018-04-20 | 2019-08-20 | 北京智仁美博生物科技有限公司 | 抗il-4r抗体及其用途 |
| MA52624A (fr) | 2018-05-13 | 2021-03-24 | Regeneron Pharma | Méthodes de traitement de la dermatite atopique par administration d'un inhibiteur de l'il-4r |
| CN113166259A (zh) * | 2018-11-09 | 2021-07-23 | 亚洲大学校产学协力团 | 对人IL-4受体α具有高亲和力的人抗体及其用途 |
| CN111494625B (zh) | 2018-12-25 | 2022-06-21 | 江苏荃信生物医药股份有限公司 | 用于治疗il-4和/或il-13介导的信号转导相关的疾病的药物组合物 |
| US12472241B2 (en) | 2018-12-28 | 2025-11-18 | Regeneron Pharmaceuticals, Inc. | Treatment of respiratory disorders with arachidonate 15-lipoxygenase (ALOX15) inhibitors |
| AU2020231343B2 (en) * | 2019-03-06 | 2026-03-26 | Regeneron Pharmaceuticals, Inc. | IL-4/IL-13 pathway inhibitors for enhanced efficacy in treating cancer |
| SG11202109002XA (en) | 2019-03-21 | 2021-09-29 | Regeneron Pharma | Combination of il-4/il-13 pathway inhibitors and plasma cell ablation for treating allergy |
| CA3147436A1 (en) | 2019-07-16 | 2021-01-21 | Sanofi Biotechnology | Methods for treating or preventing asthma by administering an il-4r antagonist |
| AU2020325021B2 (en) | 2019-08-05 | 2024-05-30 | Regeneron Pharmaceuticals, Inc. | Methods for treating allergy and enhancing allergen-specific immunotherapy by administering an IL-4R antagonist |
| EP4010373A1 (en) | 2019-08-05 | 2022-06-15 | Regeneron Pharmaceuticals, Inc. | Methods for treating atopic dermatitis by administering an il-4r antagonist |
| AU2020349263B2 (en) | 2019-09-20 | 2023-08-17 | Maruho Co., Ltd. | Pharmaceutical composition |
| IL293487A (en) | 2019-12-09 | 2022-08-01 | Sanofi Biotechnology | Methods for the treatment of digitally identified il-4/il-13-related disorders |
| EP3992974A1 (en) | 2020-11-02 | 2022-05-04 | Sanofi Biotechnology | Methods for treating digitally-identified il-4/il-13 related disorders |
| CN117693362A (zh) * | 2021-08-02 | 2024-03-12 | 甘李药业股份有限公司 | 含有抗il-4r抗体的稳定制剂 |
| CN117368487A (zh) * | 2023-09-28 | 2024-01-09 | 首都医科大学附属北京同仁医院 | 一种利用局部IgE预测或评估奥马珠单抗在治疗复发性鼻息肉中疗效的方法和应用 |
| US20250230251A1 (en) | 2023-12-20 | 2025-07-17 | Bristol-Myers Squibb Company | Antibodies targeting il-18 receptor beta (il-18rb) and related methods |
Family Cites Families (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8808015D0 (en) | 1988-04-06 | 1988-05-05 | Ritter M A | Chemical compounds |
| WO1990005183A1 (en) | 1988-10-31 | 1990-05-17 | Immunex Corporation | Interleukin-4 receptors |
| JP3315427B2 (ja) | 1992-03-05 | 2002-08-19 | 大日本除蟲菊株式会社 | 皮膚炎治療剤 |
| US5714146A (en) | 1992-08-26 | 1998-02-03 | Board Of Regents Of The University Of Washington | IL-4 bone therapy |
| EP0604693A1 (en) | 1992-12-29 | 1994-07-06 | Schering-Plough | Monoclonal antibodies against the human interleukin-4 receptor and hybridomas producing the same |
| US6927044B2 (en) | 1998-09-25 | 2005-08-09 | Regeneron Pharmaceuticals, Inc. | IL-1 receptor based cytokine traps |
| WO2001092340A2 (en) | 2000-05-26 | 2001-12-06 | Immunex Corporation | Use of interleukin-4 antagonists and compositions thereof |
| US7879328B2 (en) | 2000-06-16 | 2011-02-01 | Human Genome Sciences, Inc. | Antibodies that immunospecifically bind to B lymphocyte stimulator |
| AU2001267917A1 (en) | 2000-07-26 | 2002-02-05 | Kenjirou Tsuchida | Antipruritic compositions and compositions promoting wound healing |
| US6596541B2 (en) | 2000-10-31 | 2003-07-22 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| US8178098B2 (en) | 2001-04-03 | 2012-05-15 | National Jewish Health | Method to inhibit airway hyperresponsiveness using aerosolized T cell receptor antibodies |
| WO2005032399A2 (en) * | 2003-05-30 | 2005-04-14 | The Regents Of The University Of California | Il4 receptor antagonists for horse, dog and cat |
| NZ547588A (en) | 2003-11-07 | 2009-05-31 | Immunex Corp | Antibodies that bind interleukin-4 receptor |
| CA2550933A1 (en) | 2003-12-22 | 2005-07-14 | Amgen Inc. | Methods for identifying functional antibodies |
| EP1723173B1 (en) | 2004-02-27 | 2008-05-14 | Regeneron Pharmaceuticals, Inc. | Il-4/il-13 specific polypeptides and therapeutic uses thereof |
| US20090098142A1 (en) | 2004-06-09 | 2009-04-16 | Kasaian Marion T | Methods and compositions for treating and monitoring treatment of IL-13-associated disorders |
| JP5234445B2 (ja) | 2004-10-05 | 2013-07-10 | 源一郎 杣 | 薬剤 |
| TW200902555A (en) | 2005-01-03 | 2009-01-16 | Hoffmann La Roche | Antibodies against IL-13 receptor alpha 1 and uses thereof |
| NZ587107A (en) | 2006-06-02 | 2012-05-25 | Regeneron Pharma | High affinity antibodies to human il-6 receptor |
| LT2769992T (lt) * | 2006-10-02 | 2021-04-12 | Regeneron Pharmaceuticals, Inc. | Didelio afiniškumo žmogaus antikūnai, atpažįstantys žmogaus il-4 receptorių |
| US7608693B2 (en) | 2006-10-02 | 2009-10-27 | Regeneron Pharmaceuticals, Inc. | High affinity human antibodies to human IL-4 receptor |
| EP2022507A1 (en) | 2007-08-07 | 2009-02-11 | Universität Hamburg | Antibody compositions specific for lgE, lgG4 and lgA epitopes as tools for the design of hypoallergenic molecules for specific immunotherapy |
| DK2245064T3 (da) * | 2007-12-21 | 2014-10-27 | Medimmune Ltd | BINDINGSELEMENTER TIL INTERLEUKIN-4-RECEPTOR-ALFA (IL-4Ralfa) |
| US8092804B2 (en) | 2007-12-21 | 2012-01-10 | Medimmune Limited | Binding members for interleukin-4 receptor alpha (IL-4Rα)-173 |
| WO2009121847A2 (en) * | 2008-04-02 | 2009-10-08 | Apogenix Gmbh | Binding agents directed against il-4 receptor for the treatment of tumors, inflammatory and immunological disorders |
| US20110301046A1 (en) | 2008-12-01 | 2011-12-08 | Children's Hospital Medical Center | Methods of Determining Efficacy of Glucocorticoid Treatment of Eosinophilic Esophagitis |
| US20120088814A1 (en) * | 2009-03-31 | 2012-04-12 | Isis Pharmaceuticals, Inc. | Methods of modulating an immune response to a viral infection |
| RU2403071C1 (ru) * | 2009-09-03 | 2010-11-10 | Логина Наталия Алексеевна | Способ лечения хронических рецидивирующих воспалительных заболеваний слизистой носа и околоносовых пазух методом эндоназальной аутолимфоцитотерапии |
| EP2547964B1 (en) * | 2010-03-16 | 2016-04-13 | Airsonett AB | Treatment of asthma, allergic rhinitis and improvement of quality of sleep by temperature controlled laminar airflow treatment |
| CN106267189B (zh) | 2010-10-06 | 2021-02-26 | 瑞泽恩制药公司 | 含有抗白介素-4受体(il-4r)的抗体的稳定制剂 |
| UA111731C2 (uk) * | 2010-10-06 | 2016-06-10 | Рідженерон Фармасьютікалз, Інк. | Стабілізована композиція, яка містить антитіло до рецептора інтерлейкіну-4 (іl-4r), варіанти |
| US20130052190A1 (en) * | 2011-02-22 | 2013-02-28 | Oxagen Limited | CRTH2 Antagonists for Treatment of Eosinophilic Diseases and Conditions |
| RU2469737C1 (ru) * | 2011-06-28 | 2012-12-20 | Федеральное государственное учреждение "Санкт-Петербургский научно-исследовательский институт уха, горла, носа и речи" Министерства здравоохранения и социального развития России (СПб НИИ ЛОР МИНЗДРАВСОЦРАЗВИТИЯ РОССИИ) | Способ лечения хронического риносинусита |
| KR20140113667A (ko) | 2011-12-16 | 2014-09-24 | 아토픽스 테라퓨릭스 리미티드 | 호산구성 식도염의 치료를 위한 ｃｒｔｈ2 길항제 및 양성자 펌프 저해제의 조합 |
| IL312711A (en) | 2012-08-21 | 2024-07-01 | Regeneron Pharma | Methods for the treatment or prevention of asthma through the administration of an antagonist to 4R-IL |
| KR102576903B1 (ko) | 2012-09-07 | 2023-09-13 | 리제너론 파아마슈티컬스, 인크. | Ｉｌ-4ｒ 길항제 투여로 아토피성 피부염을 치료하는 방법 |
| TWI755763B (zh) | 2013-06-04 | 2022-02-21 | 美商再生元醫藥公司 | 藉由投與il-4r抑制劑以治療過敏及增強過敏原-特異之免疫療法的方法 |
| KR20210132232A (ko) | 2013-06-21 | 2021-11-03 | 사노피 바이오테크놀로지 | Il-4r 길항제를 투여함에 의한 비용종증의 치료 방법 |
| IL315136A (en) * | 2014-02-21 | 2024-10-01 | Sanofi Biotechnology | Methods for treating or preventing asthma by administering an il-4rantagonist |
| WO2016077675A1 (en) | 2014-11-14 | 2016-05-19 | Sanofi Biotechnology | Methods for treating chronic sinusitis with nasal polyps by administering an il-4r antagonist |
-
2014
- 2014-06-20 KR KR1020217034479A patent/KR20210132232A/ko not_active Ceased
- 2014-06-20 KR KR1020267009138A patent/KR20260048354A/ko active Pending
- 2014-06-20 AU AU2014284235A patent/AU2014284235C1/en active Active
- 2014-06-20 EP EP25192276.1A patent/EP4663250A3/en active Pending
- 2014-06-20 WO PCT/US2014/043440 patent/WO2014205365A1/en not_active Ceased
- 2014-06-20 CN CN202010182762.3A patent/CN111437387B/zh active Active
- 2014-06-20 JP JP2016521853A patent/JP6463351B2/ja active Active
- 2014-06-20 MX MX2015017970A patent/MX368068B/es active IP Right Grant
- 2014-06-20 CA CA2915839A patent/CA2915839A1/en active Pending
- 2014-06-20 EP EP19187112.8A patent/EP3613432B1/en not_active Revoked
- 2014-06-20 KR KR1020167000981A patent/KR20160024916A/ko not_active Ceased
- 2014-06-20 SI SI201431352T patent/SI3010539T1/sl unknown
- 2014-06-20 KR KR1020237014744A patent/KR20230066127A/ko not_active Ceased
- 2014-06-20 PL PL19187112.8T patent/PL3613432T3/pl unknown
- 2014-06-20 RS RSP20191274 patent/RS59354B1/sr unknown
- 2014-06-20 RU RU2016101632A patent/RU2674680C2/ru active
- 2014-06-20 ES ES19187112T patent/ES3050809T3/es active Active
- 2014-06-20 PL PL14742021T patent/PL3010539T3/pl unknown
- 2014-06-20 SG SG11201509625PA patent/SG11201509625PA/en unknown
- 2014-06-20 EP EP14742021.0A patent/EP3010539B1/en active Active
- 2014-06-20 US US14/310,419 patent/US10059771B2/en active Active
- 2014-06-20 CN CN201480035350.XA patent/CN105517570B/zh active Active
- 2014-06-20 SG SG10201710557QA patent/SG10201710557QA/en unknown
- 2014-06-20 TW TW103121405A patent/TWI709411B/zh active
- 2014-06-20 TW TW109133577A patent/TWI757893B/zh active
- 2014-06-20 HU HUE19187112A patent/HUE073368T2/hu unknown
- 2014-06-20 PT PT191871128T patent/PT3613432T/pt unknown
-
2015
- 2015-12-20 IL IL243246A patent/IL243246B/en active IP Right Grant
-
2018
- 2018-07-18 US US16/038,816 patent/US20190040146A1/en active Pending
-
2019
- 2019-10-24 CY CY20191101111T patent/CY1122754T1/el unknown
- 2019-11-07 AU AU2019261751A patent/AU2019261751B2/en active Active
-
2022
- 2022-02-25 AU AU2022201336A patent/AU2022201336B2/en active Active
-
2025
- 2025-07-14 AU AU2025205430A patent/AU2025205430A1/en active Pending
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