DK1450855T3 - Undertrykkelse af allergiske reaktioner ved hjælp af transdermal indgivelse af allergener i forbindelse med eller konjugeret til toxin-underenheder eller fragmenter deraf - Google Patents
Undertrykkelse af allergiske reaktioner ved hjælp af transdermal indgivelse af allergener i forbindelse med eller konjugeret til toxin-underenheder eller fragmenter derafInfo
- Publication number
- DK1450855T3 DK1450855T3 DK02751507T DK02751507T DK1450855T3 DK 1450855 T3 DK1450855 T3 DK 1450855T3 DK 02751507 T DK02751507 T DK 02751507T DK 02751507 T DK02751507 T DK 02751507T DK 1450855 T3 DK1450855 T3 DK 1450855T3
- Authority
- DK
- Denmark
- Prior art keywords
- ctb
- responses
- allergen
- administration
- found
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/164—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/35—Allergens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/35—Allergens
- A61K39/36—Allergens from pollen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/6415—Toxins or lectins, e.g. clostridial toxins or Pseudomonas exotoxins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/646—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the entire peptide or protein drug conjugate elicits an immune response, e.g. conjugate vaccines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55544—Bacterial toxins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
- A61K2039/6037—Bacterial toxins, e.g. diphteria toxoid [DT], tetanus toxoid [TT]
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Virology (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Pulmonology (AREA)
- Transplantation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US29314201P | 2001-05-23 | 2001-05-23 | |
| PCT/IB2002/003053 WO2002093998A2 (en) | 2001-05-23 | 2002-05-23 | Suppression of allergic reactions by transdermal administration of allergens in conjunction with or conjugated to toxin subunits or fragments thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1450855T3 true DK1450855T3 (da) | 2010-01-11 |
Family
ID=23127818
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK02751507T DK1450855T3 (da) | 2001-05-23 | 2002-05-23 | Undertrykkelse af allergiske reaktioner ved hjælp af transdermal indgivelse af allergener i forbindelse med eller konjugeret til toxin-underenheder eller fragmenter deraf |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20050074462A1 (da) |
| EP (1) | EP1450855B1 (da) |
| JP (1) | JP4339598B2 (da) |
| AT (1) | ATE440617T1 (da) |
| AU (1) | AU2002339121B2 (da) |
| CA (1) | CA2447795A1 (da) |
| DE (1) | DE60233519D1 (da) |
| DK (1) | DK1450855T3 (da) |
| WO (1) | WO2002093998A2 (da) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE60227157D1 (de) * | 2001-02-13 | 2008-07-31 | Us Gov Sec Army | Impstoffe zur transkutanen immunisierung gegen reisediarrhö |
| FR2822049B1 (fr) | 2001-03-13 | 2003-08-01 | Dbv Medica 1 | Patch destine notamment a depister l'etat de sensibilisation d'un sujet a un allergene, procede de fabrication et utilisation |
| US7635488B2 (en) | 2001-03-13 | 2009-12-22 | Dbv Technologies | Patches and uses thereof |
| US20040137004A1 (en) * | 2002-03-19 | 2004-07-15 | Glenn Gregory M | Patch for transcutaneous immunization |
| WO2004084837A2 (en) * | 2003-03-24 | 2004-10-07 | Mercia Pharma Llc | Methods and compositions for treating and preventing inflammatory conditions |
| WO2005027774A2 (en) * | 2003-09-17 | 2005-03-31 | Baby Boost, Inc. | Method and apparatus for preventing allergies |
| EP1956985A2 (en) * | 2005-11-23 | 2008-08-20 | Universität Zürich | Allergy treatment by epicutaneous allergen administration |
| US8449894B2 (en) * | 2006-05-26 | 2013-05-28 | City Of Hope | Aspergillus vaccine preparation and methods of making and using thereof |
| JP5127208B2 (ja) * | 2006-08-24 | 2013-01-23 | 独立行政法人理化学研究所 | 組換えスギ花粉抗原融合遺伝子と可溶性産物の製造方法 |
| WO2009004900A1 (ja) * | 2007-06-29 | 2009-01-08 | Josai University Corporation | ユビキノン含有免疫アジュバント |
| FR2924350B1 (fr) | 2007-12-03 | 2010-08-13 | Dbv Tech | Procede et compositions pour la vaccination par voie cutanee |
| FR2924349B1 (fr) | 2007-12-03 | 2010-01-01 | Dbv Tech | Methode de desensibilitation aux allergenes |
| DE102008006394A1 (de) * | 2008-01-28 | 2009-07-30 | Beiersdorf Ag | Verwendung von Wirkstoffkomplexen aus Panthenol, Glycerin, Citrat und/oder Bisabolol gegen Pollenallergien |
| EP2305292A4 (en) | 2008-08-01 | 2013-02-20 | So Pharmaceutical Corp | TRANSDERMAL IMMUNIZER OF S / O TYPE |
| US11246915B2 (en) | 2010-09-15 | 2022-02-15 | Applied Molecular Transport Inc. | Cholix toxin-derived fusion molecules for oral delivery of biologically active cargo |
| AU2011302645B2 (en) | 2010-09-15 | 2015-02-26 | Applied Molecular Transport, Llc | Systems and methods of delivery of bioactive agents using bacterial toxin-derived transport sequences |
| AU2013305945B2 (en) | 2012-08-21 | 2018-07-26 | Regeneron Pharmaceuticals Inc. | Methods for treating or preventing asthma by administering an IL-4R antagonist |
| TWI755763B (zh) | 2013-06-04 | 2022-02-21 | 美商再生元醫藥公司 | 藉由投與il-4r抑制劑以治療過敏及增強過敏原-特異之免疫療法的方法 |
| TWI634900B (zh) | 2013-07-11 | 2018-09-11 | 再生元醫藥公司 | 藉由投與ｉｌ－４ｒ抑制劑治療嗜酸性食道炎的方法 |
| KR20220070544A (ko) | 2014-02-28 | 2022-05-31 | 리제너론 파아마슈티컬스, 인크. | Ｉｌ-4ｒ 길항제의 투여에 의한 피부 감염의 치료 방법 |
| RU2723178C2 (ru) | 2014-05-07 | 2020-06-09 | ЭППЛАЙД МОЛЕКЬЮЛАР ТРАНСПОРТ ЭлЭлСи | Слитые молекулы, происходящие от Cholix-токсина, для пероральной доставки биологически активных нагрузок |
| EP3218412A1 (en) | 2014-11-14 | 2017-09-20 | Sanofi Biotechnology | Methods for treating chronic sinusitis with nasal polyps by administering an il-4r antagonist |
| AU2017321682A1 (en) | 2016-09-01 | 2019-04-11 | Regeneron Pharmaceuticals, Inc. | Methods for preventing or treating allergy by administering an IL-4R antagonist |
| US20180092983A1 (en) * | 2016-10-05 | 2018-04-05 | Tian Xin Wang | Methods and reagents to treat autoimmune diseases and allergy |
| TW202332696A (zh) | 2016-12-01 | 2023-08-16 | 美商再生元醫藥公司 | 治療發炎症狀的方法 |
| WO2019028367A1 (en) | 2017-08-04 | 2019-02-07 | Regeneron Pharmaceuticals, Inc. | METHODS OF TREATING ESOPHAGITIS WITH ACTIVE EOSINOPHILES |
| PT3515465T (pt) | 2017-08-18 | 2024-03-04 | Regeneron Pharma | Métodos para o tratamento de uma dermatite atópica grave mediante a administração de um inibidor de il-4r |
| US11034768B2 (en) | 2017-10-30 | 2021-06-15 | Sanofi Biotechnology | Methods for treating or preventing asthma by administering an IL-4R antagonist |
| CA3099066A1 (en) | 2018-05-13 | 2019-11-21 | Regeneron Pharmaceuticals, Inc. | Methods for treating atopic dermatitis by administering an il-4r inhibitor |
| JP2022506990A (ja) | 2018-11-07 | 2022-01-17 | アプライド モレキュラー トランスポート インコーポレイテッド | トランスサイトーシスのための送達構築物および関連する方法 |
| SG11202109002XA (en) | 2019-03-21 | 2021-09-29 | Regeneron Pharma | Combination of il-4/il-13 pathway inhibitors and plasma cell ablation for treating allergy |
| AU2020325021A1 (en) | 2019-08-05 | 2022-01-06 | Regeneron Pharmaceuticals, Inc. | Methods for treating allergy and enhancing allergen-specific immunotherapy by administering an IL-4R antagonist |
| EP3844169A4 (en) | 2019-08-16 | 2021-12-15 | Applied Molecular Transport Inc. | COMPOSITIONS, FORMULATIONS AND PRODUCTION AND PURIFICATION OF INTERLEUKINS |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2227861B1 (da) * | 1973-05-04 | 1976-07-02 | Anvar | |
| US5980898A (en) * | 1996-11-14 | 1999-11-09 | The United States Of America As Represented By The U.S. Army Medical Research & Material Command | Adjuvant for transcutaneous immunization |
| US7097845B2 (en) * | 1997-04-23 | 2006-08-29 | Jacob Sten Petersen | Combinations of antigen and mucosal binding component for inducing specific immunological tolerance |
| JP4875799B2 (ja) * | 1998-02-25 | 2012-02-15 | アメリカ合衆国 | Ａｄｐ−リボシル化外毒素により誘引される経皮免疫応答を促進するための皮膚浸透性エンハンサーおよびバリア崩壊剤の使用 |
| CA2333750A1 (en) * | 1998-06-23 | 1999-12-29 | Dale T. Umetsu | Adjuvant therapy |
-
2002
- 2002-05-23 WO PCT/IB2002/003053 patent/WO2002093998A2/en active IP Right Grant
- 2002-05-23 CA CA002447795A patent/CA2447795A1/en not_active Abandoned
- 2002-05-23 AU AU2002339121A patent/AU2002339121B2/en not_active Ceased
- 2002-05-23 US US10/477,909 patent/US20050074462A1/en not_active Abandoned
- 2002-05-23 DK DK02751507T patent/DK1450855T3/da active
- 2002-05-23 DE DE60233519T patent/DE60233519D1/de not_active Expired - Lifetime
- 2002-05-23 AT AT02751507T patent/ATE440617T1/de not_active IP Right Cessation
- 2002-05-23 JP JP2002590728A patent/JP4339598B2/ja not_active Expired - Fee Related
- 2002-05-23 EP EP02751507A patent/EP1450855B1/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP1450855A2 (en) | 2004-09-01 |
| AU2002339121B2 (en) | 2007-03-22 |
| ATE440617T1 (de) | 2009-09-15 |
| JP2004536804A (ja) | 2004-12-09 |
| US20050074462A1 (en) | 2005-04-07 |
| EP1450855B1 (en) | 2009-08-26 |
| JP4339598B2 (ja) | 2009-10-07 |
| WO2002093998A9 (en) | 2005-05-26 |
| CA2447795A1 (en) | 2002-11-28 |
| DE60233519D1 (de) | 2009-10-08 |
| WO2002093998A3 (en) | 2004-06-03 |
| WO2002093998A2 (en) | 2002-11-28 |
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