WO2009004900A1 - ユビキノン含有免疫アジュバント - Google Patents

ユビキノン含有免疫アジュバント Download PDF

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Publication number
WO2009004900A1
WO2009004900A1 PCT/JP2008/060642 JP2008060642W WO2009004900A1 WO 2009004900 A1 WO2009004900 A1 WO 2009004900A1 JP 2008060642 W JP2008060642 W JP 2008060642W WO 2009004900 A1 WO2009004900 A1 WO 2009004900A1
Authority
WO
WIPO (PCT)
Prior art keywords
immunoadjuvant
ubiquinone
vaccine composition
disclosed
antibody
Prior art date
Application number
PCT/JP2008/060642
Other languages
English (en)
French (fr)
Inventor
Shuji Sato
Takeshi Goto
Naoya Ohmori
Kueichen Chiang
Yayoi Shimada
Original Assignee
Josai University Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Josai University Corporation filed Critical Josai University Corporation
Priority to JP2009521566A priority Critical patent/JPWO2009004900A1/ja
Publication of WO2009004900A1 publication Critical patent/WO2009004900A1/ja

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C50/00—Quinones
    • C07C50/26—Quinones containing groups having oxygen atoms singly bound to carbon atoms
    • C07C50/28—Quinones containing groups having oxygen atoms singly bound to carbon atoms with monocyclic quinoid structure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

　本発明は、優れた抗体産生増強機能を有しかつ安全性の高い、免疫アジュバントおよびこれを含むワクチン組成物に関する。より詳しくは、本発明は、式（Ｉ）で表されるユビキノンを含んでなる免疫アジュバントおよびそのワクチン組成物に関する。 【化１】
PCT/JP2008/060642 2007-06-29 2008-06-11 ユビキノン含有免疫アジュバント WO2009004900A1 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2009521566A JPWO2009004900A1 (ja) 2007-06-29 2008-06-11 ユビキノン含有免疫アジュバント

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US92950907P 2007-06-29 2007-06-29
US60/929,509 2007-06-29

Publications (1)

Publication Number Publication Date
WO2009004900A1 true WO2009004900A1 (ja) 2009-01-08

Family

ID=40225954

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/060642 WO2009004900A1 (ja) 2007-06-29 2008-06-11 ユビキノン含有免疫アジュバント

Country Status (3)

Country Link
US (1) US20090252751A1 (ja)
JP (1) JPWO2009004900A1 (ja)
WO (1) WO2009004900A1 (ja)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012023614A1 (ja) * 2010-08-20 2012-02-23 学校法人 城西大学 免疫抑制活性を有するモノクローナル抗体またはその抗原結合断片

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2000502087A (ja) * 1995-12-15 2000-02-22 ナショナル リサーチ カウンシル オブ カナダ アジュバンドおよび送達賦形剤としての、アーケオソーム類、補酵素ｑ▲下１０▼を含有するアーケオソーム類、および補酵素ｑ▲下１０▼を含有する他の種類のリポソーム類
WO2006025580A1 (ja) * 2004-09-03 2006-03-09 Amateraspharma Inc. 抗ヒストンｈ１モノクローナル抗体およびこれを産生するハイブリドーマ

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050074462A1 (en) * 2001-05-23 2005-04-07 Duotol Ab Supression of allergic reactions by transdermal administration of allergens conjugated to cholera toxin or fragments thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2000502087A (ja) * 1995-12-15 2000-02-22 ナショナル リサーチ カウンシル オブ カナダ アジュバンドおよび送達賦形剤としての、アーケオソーム類、補酵素ｑ▲下１０▼を含有するアーケオソーム類、および補酵素ｑ▲下１０▼を含有する他の種類のリポソーム類
WO2006025580A1 (ja) * 2004-09-03 2006-03-09 Amateraspharma Inc. 抗ヒストンｈ１モノクローナル抗体およびこれを産生するハイブリドーマ

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
"Men'ekigaku Yogo Jiten, Kabushiki Kaisha Saishin Igakusha", 30 November 1984 (1984-11-30) *
AZUMA I. ET AL.: "The effect of ubiquinone-7 and its metabolites on the immune response. IV. Chemical structure-adjuvant activity relationship fo quinonyl derivatives on humoral immune response", INT. J. VITAM. NUTR. RES., vol. 48, no. 3, 1978, pages 255 - 261 *
MAKABI-PANZU B. ET AL.: "Coenzyme Q10 in vesicles composed of archaeal ether lipids or conventional lipids enahces the immuno-adjuvanticity to encapsulated protein", VACCINE, vol. 16, no. 16, 1998, pages 1504 - 1510, XP004129201 *
NAITO S.: "Keihi Men'eki Vaccine", CLINICAL IMMUNOLOGY & ALLERGOLOGY, vol. 47, no. 2, 25 February 2007 (2007-02-25), pages 226 - 231 *

Also Published As

Publication number Publication date
US20090252751A1 (en) 2009-10-08
JPWO2009004900A1 (ja) 2010-08-26

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