JP2019529560A5 - - Google Patents

Info

Publication number

JP2019529560A5

JP2019529560A5 JP2019537047A JP2019537047A JP2019529560A5 JP 2019529560 A5 JP2019529560 A5 JP 2019529560A5 JP 2019537047 A JP2019537047 A JP 2019537047A JP 2019537047 A JP2019537047 A JP 2019537047A JP 2019529560 A5 JP2019529560 A5 JP 2019529560A5

Authority

JP

Japan

Prior art keywords

pharmaceutical composition

composition according

inhibitor

patient

csa

Prior art date

2017-09-21

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• 239000008194 pharmaceutical composition Substances 0.000 claims 32
• 102000010787 Interleukin-4 Receptors Human genes 0.000 claims 23
• 108010038486 Interleukin-4 Receptors Proteins 0.000 claims 23
• 239000003112 inhibitor Substances 0.000 claims 23
• 229930105110 Cyclosporin A Natural products 0.000 claims 16
• 108010036949 Cyclosporine Proteins 0.000 claims 16
• 229960001265 ciclosporin Drugs 0.000 claims 16
• PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 claims 15
• 125000003275 alpha amino acid group Chemical group 0.000 claims 12
• 238000002560 therapeutic procedure Methods 0.000 claims 9
• 206010012438 Dermatitis atopic Diseases 0.000 claims 7
• 201000008937 atopic dermatitis Diseases 0.000 claims 7
• 229940125379 topical corticosteroid Drugs 0.000 claims 7
• 230000009885 systemic effect Effects 0.000 claims 6
• 239000000427 antigen Substances 0.000 claims 5
• 102000036639 antigens Human genes 0.000 claims 5
• 108091007433 antigens Proteins 0.000 claims 5
• 239000003814 drug Substances 0.000 claims 5
• 239000012634 fragment Substances 0.000 claims 5
• 229960003444 immunosuppressant agent Drugs 0.000 claims 5
• 239000003018 immunosuppressive agent Substances 0.000 claims 5
• 230000001861 immunosuppressant effect Effects 0.000 claims 4
• 230000000699 topical effect Effects 0.000 claims 4
• 239000003246 corticosteroid Substances 0.000 claims 3
• 229960001334 corticosteroids Drugs 0.000 claims 3
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
• 238000011156 evaluation Methods 0.000 claims 3
• 230000004044 response Effects 0.000 claims 3
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
• 201000004624 Dermatitis Diseases 0.000 claims 2
• 208000003251 Pruritus Diseases 0.000 claims 2
• 208000010668 atopic eczema Diseases 0.000 claims 2
• LMEKQMALGUDUQG-UHFFFAOYSA-N azathioprine Chemical compound CN1C=NC([N+]([O-])=O)=C1SC1=NC=NC2=C1NC=N2 LMEKQMALGUDUQG-UHFFFAOYSA-N 0.000 claims 2
• 201000010099 disease Diseases 0.000 claims 2
• 229940079593 drug Drugs 0.000 claims 2
• 239000003974 emollient agent Substances 0.000 claims 2
• 238000002483 medication Methods 0.000 claims 2
• 238000000034 method Methods 0.000 claims 2
• 238000001126 phototherapy Methods 0.000 claims 2
• 229940124597 therapeutic agent Drugs 0.000 claims 2
• 208000019901 Anxiety disease Diseases 0.000 claims 1
• 206010010744 Conjunctivitis allergic Diseases 0.000 claims 1
• 208000004262 Food Hypersensitivity Diseases 0.000 claims 1
• 208000035533 House dust allergy Diseases 0.000 claims 1
• 206010020751 Hypersensitivity Diseases 0.000 claims 1
• 102000008070 Interferon-gamma Human genes 0.000 claims 1
• 108010074328 Interferon-gamma Proteins 0.000 claims 1
• FBOZXECLQNJBKD-ZDUSSCGKSA-N L-methotrexate Chemical compound C=1N=C2N=C(N)N=C(N)C2=NC=1CN(C)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 FBOZXECLQNJBKD-ZDUSSCGKSA-N 0.000 claims 1
• 206010067125 Liver injury Diseases 0.000 claims 1
• 206010061481 Renal injury Diseases 0.000 claims 1
• 206010039085 Rhinitis allergic Diseases 0.000 claims 1
• 206010048908 Seasonal allergy Diseases 0.000 claims 1
• 230000002411 adverse Effects 0.000 claims 1
• 208000002205 allergic conjunctivitis Diseases 0.000 claims 1
• 208000026935 allergic disease Diseases 0.000 claims 1
• 201000010105 allergic rhinitis Diseases 0.000 claims 1
• 229940125715 antihistaminic agent Drugs 0.000 claims 1
• 239000000739 antihistaminic agent Substances 0.000 claims 1
• 230000036506 anxiety Effects 0.000 claims 1
• 208000006673 asthma Diseases 0.000 claims 1
• 208000024998 atopic conjunctivitis Diseases 0.000 claims 1
• 229960002170 azathioprine Drugs 0.000 claims 1
• 230000037396 body weight Effects 0.000 claims 1
• 229940046731 calcineurin inhibitors Drugs 0.000 claims 1
• 208000035475 disorder Diseases 0.000 claims 1
• 229950003468 dupilumab Drugs 0.000 claims 1
• 230000000694 effects Effects 0.000 claims 1
• 230000005713 exacerbation Effects 0.000 claims 1
• 235000020932 food allergy Nutrition 0.000 claims 1
• 231100000753 hepatic injury Toxicity 0.000 claims 1
• 230000009610 hypersensitivity Effects 0.000 claims 1
• 208000015181 infectious disease Diseases 0.000 claims 1
• 229960003130 interferon gamma Drugs 0.000 claims 1
• 208000037806 kidney injury Diseases 0.000 claims 1
• 229960000485 methotrexate Drugs 0.000 claims 1
• 239000000203 mixture Substances 0.000 claims 1
• RTGDFNSFWBGLEC-SYZQJQIISA-N mycophenolate mofetil Chemical compound COC1=C(C)C=2COC(=O)C=2C(O)=C1C\C=C(/C)CCC(=O)OCCN1CCOCC1 RTGDFNSFWBGLEC-SYZQJQIISA-N 0.000 claims 1
• 229960004866 mycophenolate mofetil Drugs 0.000 claims 1
• 239000000546 pharmaceutical excipient Substances 0.000 claims 1
• 208000037851 severe atopic dermatitis Diseases 0.000 claims 1
• 208000017520 skin disease Diseases 0.000 claims 1
• 230000003637 steroidlike Effects 0.000 claims 1
• 229940037128 systemic glucocorticoids Drugs 0.000 claims 1
• 238000009121 systemic therapy Methods 0.000 claims 1
• 231100000402 unacceptable toxicity Toxicity 0.000 claims 1