JP2019535716A5 - - Google Patents

Info

Publication number

JP2019535716A5

JP2019535716A5 JP2019525911A JP2019525911A JP2019535716A5 JP 2019535716 A5 JP2019535716 A5 JP 2019535716A5 JP 2019525911 A JP2019525911 A JP 2019525911A JP 2019525911 A JP2019525911 A JP 2019525911A JP 2019535716 A5 JP2019535716 A5 JP 2019535716A5

Authority

JP

Japan

Prior art keywords

pharmaceutical composition

composition according

antibody

dose

antigen

Prior art date

2017-11-28

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
• Discuss

• 239000008194 pharmaceutical composition Substances 0.000 claims 31
• 208000008035 Back Pain Diseases 0.000 claims 14
• 102000015336 Nerve Growth Factor Human genes 0.000 claims 13
• 108010025020 Nerve Growth Factor Proteins 0.000 claims 13
• 229940053128 nerve growth factor Drugs 0.000 claims 13
• 208000008930 Low Back Pain Diseases 0.000 claims 11
• 239000000427 antigen Substances 0.000 claims 11
• 102000036639 antigens Human genes 0.000 claims 11
• 108091007433 antigens Proteins 0.000 claims 11
• 239000012634 fragment Substances 0.000 claims 11
• 208000002193 Pain Diseases 0.000 claims 6
• 230000036407 pain Effects 0.000 claims 6
• 108010047041 Complementarity Determining Regions Proteins 0.000 claims 4
• 206010020751 Hypersensitivity Diseases 0.000 claims 4
• 125000003275 alpha amino acid group Chemical group 0.000 claims 4
• 230000036592 analgesia Effects 0.000 claims 4
• 230000000202 analgesic effect Effects 0.000 claims 4
• 229940035676 analgesics Drugs 0.000 claims 4
• 239000000730 antalgic agent Substances 0.000 claims 4
• BQJCRHHNABKAKU-KBQPJGBKSA-N morphine Chemical compound O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O BQJCRHHNABKAKU-KBQPJGBKSA-N 0.000 claims 4
• 238000002560 therapeutic procedure Methods 0.000 claims 4
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 3
• RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 claims 3
• 208000026251 Opioid-Related disease Diseases 0.000 claims 3
• 229940079593 drug Drugs 0.000 claims 3
• 239000003814 drug Substances 0.000 claims 3
• USSIQXCVUWKGNF-UHFFFAOYSA-N 6-(dimethylamino)-4,4-diphenylheptan-3-one Chemical compound C=1C=CC=CC=1C(CC(C)N(C)C)(C(=O)CC)C1=CC=CC=C1 USSIQXCVUWKGNF-UHFFFAOYSA-N 0.000 claims 2
• 208000012671 Gastrointestinal haemorrhages Diseases 0.000 claims 2
• 206010067125 Liver injury Diseases 0.000 claims 2
• XADCESSVHJOZHK-UHFFFAOYSA-N Meperidine Chemical compound C=1C=CC=CC=1C1(C(=O)OCC)CCN(C)CC1 XADCESSVHJOZHK-UHFFFAOYSA-N 0.000 claims 2
• BRUQQQPBMZOVGD-XFKAJCMBSA-N Oxycodone Chemical compound O=C([C@@H]1O2)CC[C@@]3(O)[C@H]4CC5=CC=C(OC)C2=C5[C@@]13CCN4C BRUQQQPBMZOVGD-XFKAJCMBSA-N 0.000 claims 2
• 208000026935 allergic disease Diseases 0.000 claims 2
• 230000006378 damage Effects 0.000 claims 2
• XYYVYLMBEZUESM-UHFFFAOYSA-N dihydrocodeine Natural products C1C(N(CCC234)C)C2C=CC(=O)C3OC2=C4C1=CC=C2OC XYYVYLMBEZUESM-UHFFFAOYSA-N 0.000 claims 2
• 206010013663 drug dependence Diseases 0.000 claims 2
• 229960002428 fentanyl Drugs 0.000 claims 2
• PJMPHNIQZUBGLI-UHFFFAOYSA-N fentanyl Chemical compound C=1C=CC=CC=1N(C(=O)CC)C(CC1)CCN1CCC1=CC=CC=C1 PJMPHNIQZUBGLI-UHFFFAOYSA-N 0.000 claims 2
• 208000030304 gastrointestinal bleeding Diseases 0.000 claims 2
• 231100000234 hepatic damage Toxicity 0.000 claims 2
• LLPOLZWFYMWNKH-CMKMFDCUSA-N hydrocodone Chemical compound C([C@H]1[C@H](N(CC[C@@]112)C)C3)CC(=O)[C@@H]1OC1=C2C3=CC=C1OC LLPOLZWFYMWNKH-CMKMFDCUSA-N 0.000 claims 2
• 229960000240 hydrocodone Drugs 0.000 claims 2
• OROGSEYTTFOCAN-UHFFFAOYSA-N hydrocodone Natural products C1C(N(CCC234)C)C2C=CC(O)C3OC2=C4C1=CC=C2OC OROGSEYTTFOCAN-UHFFFAOYSA-N 0.000 claims 2
• WVLOADHCBXTIJK-YNHQPCIGSA-N hydromorphone Chemical compound O([C@H]1C(CC[C@H]23)=O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O WVLOADHCBXTIJK-YNHQPCIGSA-N 0.000 claims 2
• 229960001410 hydromorphone Drugs 0.000 claims 2
• 230000009610 hypersensitivity Effects 0.000 claims 2
• 238000001990 intravenous administration Methods 0.000 claims 2
• 210000003734 kidney Anatomy 0.000 claims 2
• 230000008818 liver damage Effects 0.000 claims 2
• 238000002483 medication Methods 0.000 claims 2
• 229960001797 methadone Drugs 0.000 claims 2
• 229960005181 morphine Drugs 0.000 claims 2
• 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 claims 2
• 229940005483 opioid analgesics Drugs 0.000 claims 2
• 229960002085 oxycodone Drugs 0.000 claims 2
• 229960005489 paracetamol Drugs 0.000 claims 2
• -1 percodone Chemical compound 0.000 claims 2
• 229960000482 pethidine Drugs 0.000 claims 2
• 239000000546 pharmaceutical excipient Substances 0.000 claims 2
• 238000007920 subcutaneous administration Methods 0.000 claims 2
• 208000011117 substance-related disease Diseases 0.000 claims 2
• LLPOLZWFYMWNKH-UHFFFAOYSA-N trans-dihydrocodeinone Natural products C1C(N(CCC234)C)C2CCC(=O)C3OC2=C4C1=CC=C2OC LLPOLZWFYMWNKH-UHFFFAOYSA-N 0.000 claims 2
• 208000030961 allergic reaction Diseases 0.000 claims 1