MX2019003235A - Metodos para tratar dermatitis atopica severa administrando un inhibidor de receptor de isoleucina-4. - Google Patents
Metodos para tratar dermatitis atopica severa administrando un inhibidor de receptor de isoleucina-4.Info
- Publication number
- MX2019003235A MX2019003235A MX2019003235A MX2019003235A MX2019003235A MX 2019003235 A MX2019003235 A MX 2019003235A MX 2019003235 A MX2019003235 A MX 2019003235A MX 2019003235 A MX2019003235 A MX 2019003235A MX 2019003235 A MX2019003235 A MX 2019003235A
- Authority
- MX
- Mexico
- Prior art keywords
- methods
- inhibitor
- atopic dermatitis
- administering
- severe atopic
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 4
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 208000037851 severe atopic dermatitis Diseases 0.000 title abstract 2
- 206010012438 Dermatitis atopic Diseases 0.000 abstract 2
- 102000010787 Interleukin-4 Receptors Human genes 0.000 abstract 2
- 108010038486 Interleukin-4 Receptors Proteins 0.000 abstract 2
- 201000008937 atopic dermatitis Diseases 0.000 abstract 2
- 229930105110 Cyclosporin A Natural products 0.000 abstract 1
- PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 abstract 1
- 108010036949 Cyclosporine Proteins 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 238000009121 systemic therapy Methods 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/02—Peptides of undefined number of amino acids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/244—Interleukins [IL]
- C07K16/247—IL-4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Dermatology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Endocrinology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
- Steroid Compounds (AREA)
Abstract
La presente invención provee métodos para tratar dermatitis atópica (AD) moderada a severa o severa. Los métodos de la presente invención comprenden administrar a un sujeto que lo necesite una o más dosis de un inhibidor del receptor de interleucina-4 (IL-4R) tal como un anticuerpo anti-IL-4R. En ciertas modalidades, los métodos de la presente invención se usan para tratar la AD severa en un paciente cuya enfermedad no es controlada con terapia sistémica (por ejemplo, ciclosporina A) o cuando dicha terapia no es recomendable.
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662397988P | 2016-09-22 | 2016-09-22 | |
| US201762442083P | 2017-01-04 | 2017-01-04 | |
| US201762443819P | 2017-01-09 | 2017-01-09 | |
| US201762445774P | 2017-01-13 | 2017-01-13 | |
| US201762519896P | 2017-06-15 | 2017-06-15 | |
| EP17306081 | 2017-08-18 | ||
| PCT/US2017/052772 WO2018057776A1 (en) | 2016-09-22 | 2017-09-21 | Methods for treating severe atopic dermatitis by administering an il-4r inhibitor |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2019003235A true MX2019003235A (es) | 2019-07-08 |
Family
ID=59974890
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2019003235A MX2019003235A (es) | 2016-09-22 | 2017-09-21 | Metodos para tratar dermatitis atopica severa administrando un inhibidor de receptor de isoleucina-4. |
| MX2023014187A MX2023014187A (es) | 2016-09-22 | 2019-03-21 | Un inhibidor de receptor de interleucina-4 para usarse en el tratamiento de la dermatitis atopica severa. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2023014187A MX2023014187A (es) | 2016-09-22 | 2019-03-21 | Un inhibidor de receptor de interleucina-4 para usarse en el tratamiento de la dermatitis atopica severa. |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20220110999A1 (es) |
| EP (2) | EP4345110A3 (es) |
| JP (2) | JP7164530B2 (es) |
| KR (3) | KR20240146104A (es) |
| CN (2) | CN118203659A (es) |
| AU (2) | AU2017332732B2 (es) |
| CA (1) | CA3037499A1 (es) |
| ES (1) | ES2974376T3 (es) |
| HU (1) | HUE066662T2 (es) |
| IL (2) | IL310371A (es) |
| MX (2) | MX2019003235A (es) |
| PL (1) | PL3515465T3 (es) |
| RU (1) | RU2759630C2 (es) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI697334B (zh) | 2013-06-04 | 2020-07-01 | 美商再生元醫藥公司 | 藉由投與ｉｌ-４ｒ抑制劑以治療過敏及增強過敏原-特異之免疫療法的方法 |
| EP4353254A3 (en) | 2014-02-28 | 2024-07-03 | Regeneron Pharmaceuticals, Inc. | Methods for treating skin infection by administering an il-4r antagonist |
| WO2018045130A1 (en) | 2016-09-01 | 2018-03-08 | Regeneron Pharmaceuticals, Inc. | Methods for preventing or treating allergy by administering an il-4r antagonist |
| CN111514292B (zh) * | 2018-12-25 | 2023-06-20 | 江苏荃信生物医药股份有限公司 | 抗人白介素4受体α单克隆抗体的制药用途 |
| BR112021018627A2 (pt) | 2019-03-21 | 2021-11-23 | Regeneron Pharma | Combinação de inibidores da via de il-4/il-13 e ablação de células plasmáticas para o tratamento de alergia |
| MX2022001030A (es) | 2019-08-05 | 2022-04-26 | Regeneron Pharma | Metodos para tratar alergia y mejorar la inmunoterapia especifica de alergenos mediante la administracion de un antagonista de il-4r. |
| CA3147113A1 (en) | 2019-08-05 | 2021-02-11 | Regeneron Pharmaceuticals, Inc. | Methods for treating atopic dermatitis by administering an il-4r antagonist |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK2990420T3 (en) | 2000-05-26 | 2017-04-03 | Immunex Corp | USE OF INTERLEUKIN-4 RECEPTOR ANTIBODIES AND COMPOSITIONS THEREOF |
| EP1692184B1 (en) | 2003-11-07 | 2012-03-07 | Immunex Corporation | Antibodies that bind interleukin-4 receptor |
| US7608693B2 (en) | 2006-10-02 | 2009-10-27 | Regeneron Pharmaceuticals, Inc. | High affinity human antibodies to human IL-4 receptor |
| CA2664343C (en) | 2006-10-02 | 2016-04-26 | Regeneron Pharmaceuticals, Inc. | High affinity human antibodies to human il-4 receptor |
| US8092804B2 (en) | 2007-12-21 | 2012-01-10 | Medimmune Limited | Binding members for interleukin-4 receptor alpha (IL-4Rα)-173 |
| SG189220A1 (en) | 2010-10-06 | 2013-05-31 | Regeneron Pharma | Stabilized formulations containing anti-interleukin-4 receptor (il-4r) antibodies |
| PT3889181T (pt) | 2012-09-07 | 2024-05-29 | Regeneron Pharma | Um anticorpo antagonista de il-4r para utilização no tratamento da dermatite atópica por administração |
| TWI634900B (zh) * | 2013-07-11 | 2018-09-11 | 再生元醫藥公司 | 藉由投與ｉｌ－４ｒ抑制劑治療嗜酸性食道炎的方法 |
-
2017
- 2017-09-21 CN CN202410243081.1A patent/CN118203659A/zh active Pending
- 2017-09-21 HU HUE17777145A patent/HUE066662T2/hu unknown
- 2017-09-21 CN CN201780071612.1A patent/CN109963577B/zh active Active
- 2017-09-21 CA CA3037499A patent/CA3037499A1/en active Pending
- 2017-09-21 JP JP2019537047A patent/JP7164530B2/ja active Active
- 2017-09-21 EP EP23216251.1A patent/EP4345110A3/en active Pending
- 2017-09-21 PL PL17777145.8T patent/PL3515465T3/pl unknown
- 2017-09-21 AU AU2017332732A patent/AU2017332732B2/en active Active
- 2017-09-21 KR KR1020247032347A patent/KR20240146104A/ko unknown
- 2017-09-21 RU RU2019111921A patent/RU2759630C2/ru active
- 2017-09-21 IL IL310371A patent/IL310371A/en unknown
- 2017-09-21 IL IL265516A patent/IL265516B2/en unknown
- 2017-09-21 EP EP17777145.8A patent/EP3515465B1/en active Active
- 2017-09-21 MX MX2019003235A patent/MX2019003235A/es unknown
- 2017-09-21 KR KR1020227045686A patent/KR20230006049A/ko active Application Filing
- 2017-09-21 KR KR1020197011455A patent/KR20190053250A/ko active Application Filing
- 2017-09-21 ES ES17777145T patent/ES2974376T3/es active Active
-
2019
- 2019-03-21 MX MX2023014187A patent/MX2023014187A/es unknown
-
2021
- 2021-09-22 US US17/482,273 patent/US20220110999A1/en active Pending
-
2022
- 2022-08-12 JP JP2022128592A patent/JP2022160685A/ja active Pending
-
2024
- 2024-06-11 AU AU2024203951A patent/AU2024203951A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP4345110A2 (en) | 2024-04-03 |
| KR20230006049A (ko) | 2023-01-10 |
| EP3515465A1 (en) | 2019-07-31 |
| EP4345110A3 (en) | 2024-06-12 |
| IL265516B1 (en) | 2024-02-01 |
| US20220110999A1 (en) | 2022-04-14 |
| IL310371A (en) | 2024-03-01 |
| KR20240146104A (ko) | 2024-10-07 |
| CN109963577A (zh) | 2019-07-02 |
| CN118203659A (zh) | 2024-06-18 |
| PL3515465T3 (pl) | 2024-08-12 |
| IL265516A (en) | 2019-05-30 |
| CA3037499A1 (en) | 2018-03-29 |
| JP2022160685A (ja) | 2022-10-19 |
| KR20190053250A (ko) | 2019-05-17 |
| JP7164530B2 (ja) | 2022-11-01 |
| RU2759630C2 (ru) | 2021-11-16 |
| CN109963577B (zh) | 2024-03-12 |
| AU2017332732B2 (en) | 2024-03-14 |
| HUE066662T2 (hu) | 2024-09-28 |
| AU2024203951A1 (en) | 2024-07-04 |
| EP3515465B1 (en) | 2024-02-07 |
| RU2019111921A3 (es) | 2020-12-29 |
| ES2974376T3 (es) | 2024-06-27 |
| JP2019529560A (ja) | 2019-10-17 |
| MX2023014187A (es) | 2024-01-16 |
| AU2017332732A1 (en) | 2019-04-11 |
| RU2019111921A (ru) | 2020-10-22 |
| IL265516B2 (en) | 2024-06-01 |
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