JP2016523225A5 - - Google Patents

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JP2016523225A5
JP2016523225A5 JP2016516763A JP2016516763A JP2016523225A5 JP 2016523225 A5 JP2016523225 A5 JP 2016523225A5 JP 2016516763 A JP2016516763 A JP 2016516763A JP 2016516763 A JP2016516763 A JP 2016516763A JP 2016523225 A5 JP2016523225 A5 JP 2016523225A5
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JP6401250B2 (ja
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JP2016516763A 2013-05-29 2014-05-28 7−(6−(2−ヒドロキシプロパン−2−イル)ピリジン−3−イル)−1−((trans)−4−メトキシシクロヘキシル)−3,4−ジヒドロピラジノ[2,3−b]ピラジン−2(1H)−オン、その固体形態の医薬組成物、及びその使用方法 Active JP6401250B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361828506P 2013-05-29 2013-05-29
US61/828,506 2013-05-29
PCT/US2014/039712 WO2014193912A1 (en) 2013-05-29 2014-05-28 Pharmaceutical compositions of 7-(6-(2-hydroxypropan-2-yl)pyridin-3-yl)-1-((trans)-4-methoxycyclohexyl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1h)-one, a solid form thereof and methods of their use

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JP2016523225A JP2016523225A (ja) 2016-08-08
JP2016523225A5 true JP2016523225A5 (enExample) 2017-06-29
JP6401250B2 JP6401250B2 (ja) 2018-10-10

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JP2016516763A Active JP6401250B2 (ja) 2013-05-29 2014-05-28 7−(6−(2−ヒドロキシプロパン−2−イル)ピリジン−3−イル)−1−((trans)−4−メトキシシクロヘキシル)−3,4−ジヒドロピラジノ[2,3−b]ピラジン−2(1H)−オン、その固体形態の医薬組成物、及びその使用方法

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US (4) US9604939B2 (enExample)
EP (1) EP3003313A1 (enExample)
JP (1) JP6401250B2 (enExample)
CN (4) CN107474051B (enExample)
CA (2) CA3143529A1 (enExample)
HK (1) HK1223286A1 (enExample)
MX (1) MX2015015880A (enExample)
NZ (1) NZ629486A (enExample)
WO (1) WO2014193912A1 (enExample)

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CN110062624B (zh) * 2016-10-14 2023-07-28 中国医学科学院药物研究所 二氢小檗碱型化合物在制备治疗stat3信号通路相关肿瘤疾病药品中的用途
EP3641772B1 (en) 2017-06-22 2023-08-02 Celgene Corporation Treatment of hepatocellular carcinoma characterized by hepatitis b virus infection
BR112021021405A2 (pt) 2019-04-26 2022-02-15 Bobby Gallagher Capacidade de manutenção de estação e desconexão de emergência melhoradas para uma embarcação conectada a um poço submarino em águas rasas

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BR112015026257B1 (pt) * 2013-04-17 2022-12-20 Signal Pharmaceuticals, Llc Uso de um composto dihidropirazino-pirazina e enzalutamida, composição farmacêutica que os compreende, e kit
AU2014254057A1 (en) 2013-04-17 2015-11-05 Signal Pharmaceuticals, Llc Combination therapy comprising a TOR kinase inhibitor and N-(3-(5-fluoro-2-(4-(2-methoxyethoxy)phenylamino)pyrimidin-4-ylamino)phenyl)acrylamide for treating cancer
JP2016522177A (ja) 2013-04-17 2016-07-28 シグナル ファーマシューティカルズ,エルエルシー ジヒドロピラジノ−ピラジンによる癌治療
NZ629411A (en) 2013-04-17 2017-06-30 Signal Pharm Llc Treatment of cancer with dihydropyrazino-pyrazines
MX368286B (es) 2013-04-17 2019-09-27 Signal Pharm Llc Terapia de combinacion que comprende un inhibidor de tor cinasa y un compuesto de quinazolinona 5-sustituida para tratar cancer.
TW201526897A (zh) 2013-04-17 2015-07-16 Signal Pharm Llc 使用tor激酶抑制劑組合療法以治療癌症之方法
SG11201508527VA (en) 2013-04-17 2015-11-27 Signal Pharm Llc Pharmaceutical formulations, processes, solid forms and methods of use relating to 1-ethyl-7-(2-methyl-6-(1h-1,2,4-triazol-3-yl) pyridin-3-yl) -3,4-dihydropyrazino[2,3-b]pyrazin-2(1h)-one

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