HK1223286A1 - 7-(6-(2-羟基丙-2-基)吡啶-3-基)-1-((反式)-4-甲氧基环己基)-3，4-二氢吡嗪并[2，3-b]吡嗪-2(1h)-酮的药物组合物、其固体形式及它们的使用方法 - Google Patents

7-(6-(2-羟基丙-2-基)吡啶-3-基)-1-((反式)-4-甲氧基环己基)-3，4-二氢吡嗪并[2，3-b]吡嗪-2(1h)-酮的药物组合物、其固体形式及它们的使用方法 Download PDF

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Publication number
HK1223286A1
HK1223286A1 HK16111579.8A HK16111579A HK1223286A1 HK 1223286 A1 HK1223286 A1 HK 1223286A1 HK 16111579 A HK16111579 A HK 16111579A HK 1223286 A1 HK1223286 A1 HK 1223286A1
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Hong Kong
Prior art keywords
dihydropyrazino
methoxycyclohexyl
hydroxypropan
pyrazin
pyridin
Prior art date
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HK16111579.8A
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English (en)
Chinese (zh)
Inventor
瑪麗．喬治．彼徹姆斯
玛丽．乔治．彼彻姆斯
安東尼奧．克裏斯蒂安．費雷蒂
安东尼奥．克里斯蒂安．费雷蒂
胡安．安東尼奧．甘博亞
胡安．安东尼奥．甘博亚
凱文．克洛普弗
凯文．克洛普弗
威廉．愛德華．柯內可
威廉．爱德华．柯内可
馬修．邁克爾．克雷萊茵
马修．迈克尔．克雷莱茵
阿尼爾．門諾
阿尼尔．门诺
阿曼達．尼科爾．米克洛斯
阿曼达．尼科尔．米克洛斯
約翰．菲茨杰拉德．特拉弗斯
约翰．菲茨杰拉德．特拉弗斯
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西格诺药品有限公司
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Publication of HK1223286A1 publication Critical patent/HK1223286A1/zh

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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
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    • A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
HK16111579.8A 2013-05-29 2014-05-28 7-(6-(2-羟基丙-2-基)吡啶-3-基)-1-((反式)-4-甲氧基环己基)-3，4-二氢吡嗪并[2，3-b]吡嗪-2(1h)-酮的药物组合物、其固体形式及它们的使用方法 HK1223286A1 (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361828506P 2013-05-29 2013-05-29
US61/828,506 2013-05-29
PCT/US2014/039712 WO2014193912A1 (en) 2013-05-29 2014-05-28 Pharmaceutical compositions of 7-(6-(2-hydroxypropan-2-yl)pyridin-3-yl)-1-((trans)-4-methoxycyclohexyl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1h)-one, a solid form thereof and methods of their use

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HK1223286A1 true HK1223286A1 (zh) 2017-07-28

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US (4) US9604939B2 (enExample)
EP (1) EP3003313A1 (enExample)
JP (1) JP6401250B2 (enExample)
CN (4) CN107474051B (enExample)
CA (2) CA3143529A1 (enExample)
HK (1) HK1223286A1 (enExample)
MX (1) MX2015015880A (enExample)
NZ (1) NZ629486A (enExample)
WO (1) WO2014193912A1 (enExample)

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CN110062624B (zh) * 2016-10-14 2023-07-28 中国医学科学院药物研究所 二氢小檗碱型化合物在制备治疗stat3信号通路相关肿瘤疾病药品中的用途
EP3641772B1 (en) 2017-06-22 2023-08-02 Celgene Corporation Treatment of hepatocellular carcinoma characterized by hepatitis b virus infection
BR112021021405A2 (pt) 2019-04-26 2022-02-15 Bobby Gallagher Capacidade de manutenção de estação e desconexão de emergência melhoradas para uma embarcação conectada a um poço submarino em águas rasas

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