JP2016520312A5 - - Google Patents

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JP2016520312A5
JP2016520312A5 JP2016515076A JP2016515076A JP2016520312A5 JP 2016520312 A5 JP2016520312 A5 JP 2016520312A5 JP 2016515076 A JP2016515076 A JP 2016515076A JP 2016515076 A JP2016515076 A JP 2016515076A JP 2016520312 A5 JP2016520312 A5 JP 2016520312A5
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JP
Japan
Prior art keywords
double
stranded rnai
nucleotide
nucleotides
pharmaceutical composition
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JP2016515076A
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English (en)
Japanese (ja)
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JP2016520312A (ja
JP6495250B2 (ja
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Priority claimed from PCT/US2014/039109 external-priority patent/WO2014190137A1/en
Publication of JP2016520312A publication Critical patent/JP2016520312A/ja
Publication of JP2016520312A5 publication Critical patent/JP2016520312A5/ja
Priority to JP2019040571A priority Critical patent/JP6931015B2/ja
Application granted granted Critical
Publication of JP6495250B2 publication Critical patent/JP6495250B2/ja
Expired - Fee Related legal-status Critical Current
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JP2016515076A 2013-05-22 2014-05-22 SERPINA1 iRNA組成物およびその使用方法 Expired - Fee Related JP6495250B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2019040571A JP6931015B2 (ja) 2013-05-22 2019-03-06 SERPINA1 iRNA組成物およびその使用方法

Applications Claiming Priority (9)

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US201361826125P 2013-05-22 2013-05-22
US61/826,125 2013-05-22
US201361898695P 2013-11-01 2013-11-01
US61/898,695 2013-11-01
US201461979727P 2014-04-15 2014-04-15
US61/979,727 2014-04-15
US201461989028P 2014-05-06 2014-05-06
US61/989,028 2014-05-06
PCT/US2014/039109 WO2014190137A1 (en) 2013-05-22 2014-05-22 SERPINA1 iRNA COMPOSITIONS AND METHODS OF USE THEREOF

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JP2019040571A Division JP6931015B2 (ja) 2013-05-22 2019-03-06 SERPINA1 iRNA組成物およびその使用方法

Publications (3)

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JP2016520312A JP2016520312A (ja) 2016-07-14
JP2016520312A5 true JP2016520312A5 (enExample) 2019-02-14
JP6495250B2 JP6495250B2 (ja) 2019-04-03

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JP2016515076A Expired - Fee Related JP6495250B2 (ja) 2013-05-22 2014-05-22 SERPINA1 iRNA組成物およびその使用方法
JP2019040571A Expired - Fee Related JP6931015B2 (ja) 2013-05-22 2019-03-06 SERPINA1 iRNA組成物およびその使用方法
JP2021131617A Pending JP2021191278A (ja) 2013-05-22 2021-08-12 SERPINA1 iRNA組成物およびその使用方法

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JP2019040571A Expired - Fee Related JP6931015B2 (ja) 2013-05-22 2019-03-06 SERPINA1 iRNA組成物およびその使用方法
JP2021131617A Pending JP2021191278A (ja) 2013-05-22 2021-08-12 SERPINA1 iRNA組成物およびその使用方法

Country Status (33)

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US (5) US9574192B2 (enExample)
EP (2) EP3412774A1 (enExample)
JP (3) JP6495250B2 (enExample)
KR (3) KR102463973B1 (enExample)
CN (2) CN113018307A (enExample)
AU (2) AU2014268509B2 (enExample)
BR (1) BR112015029139B1 (enExample)
CA (1) CA2912826A1 (enExample)
CL (1) CL2015003441A1 (enExample)
CY (1) CY1122159T1 (enExample)
DK (1) DK2999785T3 (enExample)
DO (1) DOP2015000288A (enExample)
EA (1) EA038792B1 (enExample)
ES (1) ES2676146T3 (enExample)
GT (1) GT201500330A (enExample)
HR (1) HRP20181030T1 (enExample)
HU (1) HUE038146T2 (enExample)
IL (3) IL242637B (enExample)
LT (1) LT2999785T (enExample)
MX (2) MX379208B (enExample)
MY (1) MY176712A (enExample)
PE (2) PE20160030A1 (enExample)
PL (1) PL2999785T3 (enExample)
PT (1) PT2999785T (enExample)
RS (1) RS57418B1 (enExample)
RU (1) RU2015154721A (enExample)
SG (3) SG10201913872XA (enExample)
SI (1) SI2999785T1 (enExample)
SM (1) SMT201800403T1 (enExample)
TW (2) TW201936624A (enExample)
UY (2) UY40064A (enExample)
WO (1) WO2014190137A1 (enExample)
ZA (1) ZA201509252B (enExample)

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WO2018013912A1 (en) * 2016-07-15 2018-01-18 The Board Of Regents Of The University Of Oklahoma Anti-arid3a treatments for inflammatory disorders
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WO2019100039A1 (en) * 2017-11-20 2019-05-23 Alnylam Pharmaceuticals, Inc. Serum amyloid p component (apcs) irna compositions and methods of use thereof
TWI851574B (zh) * 2018-05-14 2024-08-11 美商阿尼拉製藥公司 血管收縮素原(AGT)iRNA組成物及其使用方法
US12428684B2 (en) * 2018-07-05 2025-09-30 Active Genomes Expressed Diagnostics Corp Methods for detecting and treating a tumorigenic phenotype of the liver
AU2020279101B2 (en) * 2019-05-17 2025-07-24 Alnylam Pharmaceuticals, Inc. Oral delivery of oligonucleotides
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WO2021150969A1 (en) * 2020-01-24 2021-07-29 Alnylam Pharmaceuticals, Inc. LEUCINE-RICH REPEAT KINASE 2 (LRRK2) iRNA AGENT COMPOSITIONS AND METHODS OF USE THEREOF
US20230257745A1 (en) * 2020-07-10 2023-08-17 Alnylam Pharmaceuticals, Inc. Circular siRNAs
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CN117897483A (zh) * 2021-08-25 2024-04-16 戴瑟纳制药公司 用于抑制α-1抗胰蛋白酶表达的组合物和方法
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