KR20220154244A - SERPINA1 iRNA 조성물 및 이의 사용 방법 - Google Patents
SERPINA1 iRNA 조성물 및 이의 사용 방법 Download PDFInfo
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- KR20220154244A KR20220154244A KR1020227038298A KR20227038298A KR20220154244A KR 20220154244 A KR20220154244 A KR 20220154244A KR 1020227038298 A KR1020227038298 A KR 1020227038298A KR 20227038298 A KR20227038298 A KR 20227038298A KR 20220154244 A KR20220154244 A KR 20220154244A
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- rnai agent
- nucleotides
- seq
- double
- stranded rnai
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- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- A61K31/712—Nucleic acids or oligonucleotides having modified sugars, i.e. other than ribose or 2'-deoxyribose
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- C12N2330/00—Production
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
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Applications Claiming Priority (10)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361826125P | 2013-05-22 | 2013-05-22 | |
| US61/826,125 | 2013-05-22 | ||
| US201361898695P | 2013-11-01 | 2013-11-01 | |
| US61/898,695 | 2013-11-01 | ||
| US201461979727P | 2014-04-15 | 2014-04-15 | |
| US61/979,727 | 2014-04-15 | ||
| US201461989028P | 2014-05-06 | 2014-05-06 | |
| US61/989,028 | 2014-05-06 | ||
| KR1020217026982A KR102463973B1 (ko) | 2013-05-22 | 2014-05-22 | SERPINA1 iRNA 조성물 및 이의 사용 방법 |
| PCT/US2014/039109 WO2014190137A1 (en) | 2013-05-22 | 2014-05-22 | SERPINA1 iRNA COMPOSITIONS AND METHODS OF USE THEREOF |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020217026982A Division KR102463973B1 (ko) | 2013-05-22 | 2014-05-22 | SERPINA1 iRNA 조성물 및 이의 사용 방법 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20220154244A true KR20220154244A (ko) | 2022-11-21 |
Family
ID=51934144
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020217026982A Active KR102463973B1 (ko) | 2013-05-22 | 2014-05-22 | SERPINA1 iRNA 조성물 및 이의 사용 방법 |
| KR1020157036053A Expired - Fee Related KR102295648B1 (ko) | 2013-05-22 | 2014-05-22 | SERPINA1 iRNA 조성물 및 이의 사용 방법 |
| KR1020227038298A Withdrawn KR20220154244A (ko) | 2013-05-22 | 2014-05-22 | SERPINA1 iRNA 조성물 및 이의 사용 방법 |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020217026982A Active KR102463973B1 (ko) | 2013-05-22 | 2014-05-22 | SERPINA1 iRNA 조성물 및 이의 사용 방법 |
| KR1020157036053A Expired - Fee Related KR102295648B1 (ko) | 2013-05-22 | 2014-05-22 | SERPINA1 iRNA 조성물 및 이의 사용 방법 |
Country Status (33)
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105861503A (zh) | 2011-11-18 | 2016-08-17 | 阿尔尼拉姆医药品有限公司 | 修饰的RNAi试剂 |
| TWI664187B (zh) | 2013-05-22 | 2019-07-01 | 阿尼拉製藥公司 | 絲胺酸蛋白酶抑制因子A1 iRNA組成物及其使用方法 |
| AU2014284298B2 (en) * | 2013-07-03 | 2020-12-10 | Novo Nordisk A/S | Methods and compositions for the specific inhibition of alpha-1 antitrypsin by double-stranded RNA |
| CA3215908A1 (en) | 2014-05-22 | 2015-11-26 | Alnylam Pharmaceuticals, Inc. | Angiotensinogen (agt) irna compositions and methods of use thereof |
| TW201620526A (zh) * | 2014-06-17 | 2016-06-16 | 愛羅海德研究公司 | 用於抑制α-1抗胰蛋白酶基因表現之組合物及方法 |
| IL316808A (en) | 2014-08-20 | 2025-01-01 | Alnylam Pharmaceuticals Inc | Modified double-stranded RNA materials and their uses |
| WO2016037165A1 (en) | 2014-09-07 | 2016-03-10 | Selecta Biosciences, Inc. | Methods and compositions for attenuating exon skipping anti-viral transfer vector immune responses |
| PL3234134T3 (pl) * | 2014-12-17 | 2020-12-28 | Proqr Therapeutics Ii B.V. | Ukierunkowana edycja rna |
| AU2016257996A1 (en) * | 2015-05-06 | 2017-10-26 | Alnylam Pharmaceuticals, Inc. | Factor XII (Hageman Factor) (F12), Kallikrein B, Plasma (Fletcher Factor) 1 (KLKB1), and Kininogen 1 (KNG1) iRNA compositions and methods of use thereof |
| US11091759B2 (en) | 2015-12-07 | 2021-08-17 | Genzyme Corporation | Methods and compositions for treating a Serpinc1-associated disorder |
| WO2018013912A1 (en) * | 2016-07-15 | 2018-01-18 | The Board Of Regents Of The University Of Oklahoma | Anti-arid3a treatments for inflammatory disorders |
| EP3544617A4 (en) * | 2016-11-23 | 2020-08-05 | Alnylam Pharmaceuticals, Inc. | REDUCED OFF-TARGET MODIFIED RNA AGENTS |
| TWI788312B (zh) * | 2016-11-23 | 2023-01-01 | 美商阿尼拉製藥公司 | 絲胺酸蛋白酶抑制因子A1 iRNA組成物及其使用方法 |
| EP3548005A4 (en) | 2016-11-29 | 2020-06-17 | Puretech Health LLC | Exosomes for delivery of therapeutic agents |
| TWI826365B (zh) * | 2017-01-10 | 2023-12-21 | 美商愛羅海德製藥公司 | α-1抗胰蛋白酶 (AAT) RNAi 藥劑、包含AAT RNAi 藥劑之組合物及使用方法 |
| WO2018183705A1 (en) * | 2017-03-29 | 2018-10-04 | Cornell University | Oxidation-resistant aat gene therapy |
| AU2018347583A1 (en) | 2017-10-13 | 2020-05-21 | Selecta Biosciences, Inc. | Methods and compositions for attenuating anti-viral transfer vector IgM responses |
| WO2019100039A1 (en) * | 2017-11-20 | 2019-05-23 | Alnylam Pharmaceuticals, Inc. | Serum amyloid p component (apcs) irna compositions and methods of use thereof |
| TWI851574B (zh) * | 2018-05-14 | 2024-08-11 | 美商阿尼拉製藥公司 | 血管收縮素原(AGT)iRNA組成物及其使用方法 |
| US12428684B2 (en) * | 2018-07-05 | 2025-09-30 | Active Genomes Expressed Diagnostics Corp | Methods for detecting and treating a tumorigenic phenotype of the liver |
| EP3969052A1 (en) * | 2019-05-17 | 2022-03-23 | Alnylam Pharmaceuticals Inc. | Oral delivery of oligonucleotides |
| EP3976802A1 (en) | 2019-05-28 | 2022-04-06 | Selecta Biosciences, Inc. | Methods and compositions for attenuated anti-viral transfer vector immune response |
| CN117677697A (zh) * | 2021-07-08 | 2024-03-08 | 奥利克斯医药有限公司 | 靶向MARC1基因的RNAi制剂及其用途 |
| AR124636A1 (es) * | 2021-08-25 | 2023-04-19 | Dicerna Pharmaceuticals Inc | COMPOSICIONES Y MÉTODOS PARA INHIBIR LA EXPRESIÓN DE a-1 ANTITRIPSINA |
| WO2023064367A1 (en) | 2021-10-12 | 2023-04-20 | Selecta Biosciences, Inc. | Methods and compositions for attenuating anti-viral transfer vector igm responses |
| WO2023172624A1 (en) | 2022-03-09 | 2023-09-14 | Selecta Biosciences, Inc. | Immunosuppressants in combination with anti-igm agents and related dosing |
| WO2025219443A1 (en) * | 2024-04-19 | 2025-10-23 | Uniqure Biopharma B.V. | Nucleic acid for a1at regulation |
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| US513030A (en) | 1894-01-16 | Machine for waxing or coating paper | ||
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| US1861608A (en) | 1929-12-21 | 1932-06-07 | Emerson Electric Mfg Co | Fan and means for directing the air current therethrough |
| US1861108A (en) | 1930-01-24 | 1932-05-31 | Eugene O Brace | Integral clutch and transmission control |
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| US3974808A (en) | 1975-07-02 | 1976-08-17 | Ford Motor Company | Air intake duct assembly |
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| FR2567892B1 (fr) | 1984-07-19 | 1989-02-17 | Centre Nat Rech Scient | Nouveaux oligonucleotides, leur procede de preparation et leurs applications comme mediateurs dans le developpement des effets des interferons |
| US5430136A (en) | 1984-10-16 | 1995-07-04 | Chiron Corporation | Oligonucleotides having selectably cleavable and/or abasic sites |
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