JP2016052331A5 - - Google Patents
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- Publication number
- JP2016052331A5 JP2016052331A5 JP2016000233A JP2016000233A JP2016052331A5 JP 2016052331 A5 JP2016052331 A5 JP 2016052331A5 JP 2016000233 A JP2016000233 A JP 2016000233A JP 2016000233 A JP2016000233 A JP 2016000233A JP 2016052331 A5 JP2016052331 A5 JP 2016052331A5
- Authority
- JP
- Japan
- Prior art keywords
- nucleic acid
- signal peptide
- seq
- plant
- influenza
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 101710154606 Hemagglutinin Proteins 0.000 claims 12
- 101710093908 Outer capsid protein VP4 Proteins 0.000 claims 12
- 101710135467 Outer capsid protein sigma-1 Proteins 0.000 claims 12
- 101710176177 Protein A56 Proteins 0.000 claims 12
- 239000000185 hemagglutinin Substances 0.000 claims 12
- 108020004707 nucleic acids Proteins 0.000 claims 7
- 102000039446 nucleic acids Human genes 0.000 claims 7
- 150000007523 nucleic acids Chemical class 0.000 claims 6
- 239000002773 nucleotide Substances 0.000 claims 6
- 125000003729 nucleotide group Chemical group 0.000 claims 6
- 108010076504 Protein Sorting Signals Proteins 0.000 claims 5
- 241000196324 Embryophyta Species 0.000 claims 4
- 206010022000 influenza Diseases 0.000 claims 4
- 230000001105 regulatory effect Effects 0.000 claims 3
- 241000723655 Cowpea mosaic virus Species 0.000 claims 2
- 102000006010 Protein Disulfide-Isomerase Human genes 0.000 claims 2
- 239000002245 particle Substances 0.000 claims 2
- 108020003519 protein disulfide isomerase Proteins 0.000 claims 2
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US99060307P | 2007-11-27 | 2007-11-27 | |
| US1327207P | 2007-12-12 | 2007-12-12 | |
| US2277508P | 2008-01-22 | 2008-01-22 | |
| CAPCT/CA2008/001281 | 2008-07-11 | ||
| PCT/CA2008/001281 WO2009009876A1 (en) | 2007-07-13 | 2008-07-11 | Influenza virus-like particles (vlps) comprising hemagglutinin produced within a plant |
| CAPCT/CA2009/000032 | 2009-01-12 | ||
| PCT/CA2009/000032 WO2009076778A1 (en) | 2007-11-27 | 2009-01-12 | Recombinant influenza virus-like particles (vlps) produced in transgenic plants expressing hemagglutinin |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011516934A Division JP5921884B2 (ja) | 2008-07-11 | 2009-07-02 | 赤血球凝集素を含むインフルエンザウイルス様粒子(vlps) |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016052331A JP2016052331A (ja) | 2016-04-14 |
| JP2016052331A5 true JP2016052331A5 (enExample) | 2016-06-30 |
| JP6215363B2 JP6215363B2 (ja) | 2017-10-18 |
Family
ID=40795157
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010542486A Pending JP2011509661A (ja) | 2007-11-27 | 2009-01-12 | ヘマグルチニンを発現するトランスジェニック植物において産生された組換え型インフルエンザウイルス様粒子(vlp) |
| JP2014039035A Active JP5990207B2 (ja) | 2007-11-27 | 2014-02-28 | ヘマグルチニンを発現するトランスジェニック植物において産生された組換え型インフルエンザウイルス様粒子(vlp) |
| JP2015231583A Withdrawn JP2016032477A (ja) | 2007-11-27 | 2015-11-27 | ヘマグルチニンを発現するトランスジェニック植物において産生された組換え型インフルエンザウイルス様粒子(vlp) |
| JP2016000233A Active JP6215363B2 (ja) | 2007-11-27 | 2016-01-04 | 赤血球凝集素を含むインフルエンザウイルス様粒子(VLPs) |
Family Applications Before (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010542486A Pending JP2011509661A (ja) | 2007-11-27 | 2009-01-12 | ヘマグルチニンを発現するトランスジェニック植物において産生された組換え型インフルエンザウイルス様粒子(vlp) |
| JP2014039035A Active JP5990207B2 (ja) | 2007-11-27 | 2014-02-28 | ヘマグルチニンを発現するトランスジェニック植物において産生された組換え型インフルエンザウイルス様粒子(vlp) |
| JP2015231583A Withdrawn JP2016032477A (ja) | 2007-11-27 | 2015-11-27 | ヘマグルチニンを発現するトランスジェニック植物において産生された組換え型インフルエンザウイルス様粒子(vlp) |
Country Status (18)
| Country | Link |
|---|---|
| US (4) | US20100310604A1 (enExample) |
| EP (2) | EP2610345B1 (enExample) |
| JP (4) | JP2011509661A (enExample) |
| KR (1) | KR20100120157A (enExample) |
| CN (2) | CN103122354B (enExample) |
| AU (1) | AU2009202819B2 (enExample) |
| CA (1) | CA2707235C (enExample) |
| CR (1) | CR11612A (enExample) |
| DK (1) | DK2610345T3 (enExample) |
| ES (1) | ES2554703T3 (enExample) |
| IL (1) | IL206967A (enExample) |
| IS (1) | IS2982B (enExample) |
| MA (1) | MA32439B1 (enExample) |
| MX (1) | MX2010007962A (enExample) |
| NZ (1) | NZ587108A (enExample) |
| PT (1) | PT2610345E (enExample) |
| WO (1) | WO2009076778A1 (enExample) |
| ZA (1) | ZA201005917B (enExample) |
Families Citing this family (56)
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| CA2615372A1 (en) | 2007-07-13 | 2009-01-13 | Marc-Andre D'aoust | Influenza virus-like particles (vlps) comprising hemagglutinin |
| PT2610345E (pt) | 2007-11-27 | 2016-01-11 | Medicago Inc | Partículas semelhantes ao vírus (vlps) da gripe recombinantes produzidas em plantas transgénicas que expressam hemaglutinina |
| EP2294202B1 (en) * | 2008-07-08 | 2015-05-20 | Medicago Inc. | Soluble recombinant influenza antigens |
| CN102165062B (zh) | 2008-07-18 | 2017-09-08 | 麦迪卡格公司 | 新的流感病毒免疫表位 |
| CN102271704A (zh) | 2008-11-28 | 2011-12-07 | 梅里亚有限公司 | 重组禽流感疫苗及其用途 |
| CA2787099A1 (en) | 2009-03-30 | 2010-10-14 | Anice C. Lowen | Influenza virus hemagglutinin polypeptides containing stem domains, vaccines and uses thereof |
| JP5871796B2 (ja) * | 2009-06-24 | 2016-03-01 | メディカゴ インコーポレイテッド | ヘマグルチニンを含むキメラインフルエンザウイルス様粒子 |
| ES2662778T3 (es) * | 2009-09-22 | 2018-04-09 | Medicago Inc. | Método de preparación de proteínas derivadas de plantas |
| KR20120101572A (ko) | 2009-12-28 | 2012-09-13 | 메리얼 리미티드 | 재조합 ndv 항원 및 이의 용도 |
| EP3505632B1 (en) * | 2009-12-28 | 2022-08-03 | Sanofi Vaccine Technologies, S.A.S. | Production of heterologous polypeptides in microalgae, microalgal extracellular bodies, compositions, and methods of making and uses thereof |
| US9701723B2 (en) | 2010-02-18 | 2017-07-11 | Icahn School Of Medicine At Mount Sinai | Vaccines for use in the prophylaxis and treatment of influenza virus disease |
| EP2944322B1 (en) | 2010-03-12 | 2018-01-17 | Merial, Inc | Bluetongue virus recombinant vaccines and uses thereof |
| CN102939103A (zh) | 2010-03-30 | 2013-02-20 | 西奈山医学院 | 流感病毒疫苗及其应用 |
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| JP6025214B2 (ja) | 2010-11-04 | 2016-11-16 | メディカゴ インコーポレイテッド | 植物発現系 |
| TWI526539B (zh) * | 2010-12-22 | 2016-03-21 | 苜蓿股份有限公司 | 植物中生產類病毒顆粒(vlp)的方法及以該方法生產之vlp |
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| JP5846624B2 (ja) * | 2011-05-30 | 2016-01-20 | 公益財団法人ヒューマンサイエンス振興財団 | H5n1型インフルエンザワクチン及び感染防御キット |
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| KR20140068205A (ko) | 2011-09-20 | 2014-06-05 | 마운트 시나이 스쿨 오브 메디슨 | 인플루엔자 바이러스 백신 및 이의 용도 |
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| US11390878B2 (en) * | 2011-09-30 | 2022-07-19 | Medicago Inc. | Increasing protein yield in plants |
| CN116218900A (zh) | 2011-09-30 | 2023-06-06 | 麦迪卡格公司 | 增加植物中病毒样颗粒的产率 |
| CN104284978B (zh) * | 2012-05-11 | 2018-02-02 | 麦迪卡格公司 | 植物中类轮状病毒颗粒的产生 |
| KR20150104117A (ko) | 2012-12-18 | 2015-09-14 | 이칸 스쿨 오브 메디슨 엣 마운트 시나이 | 인플루엔자 바이러스 백신 및 그의 용도 |
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| US12467058B2 (en) | 2013-03-28 | 2025-11-11 | Aramis Biotechnologies Inc. | Influenza virus-like particle production in plants |
| EP2978848B1 (en) | 2013-03-28 | 2020-05-06 | Medicago Inc. | Influenza virus-like particle production in plants |
| US11441150B2 (en) | 2014-01-10 | 2022-09-13 | Medicago Inc. | CPMV enhancer elements |
| CA2943796C (en) | 2014-03-27 | 2023-02-14 | Medicago Inc. | Modified cpmv enhancer elements |
| US11959088B2 (en) | 2014-07-11 | 2024-04-16 | Aramis Biotechnologies Inc. | Modifying protein production in plants |
| WO2016115630A1 (en) | 2015-01-23 | 2016-07-28 | Medicago Inc. | Rotavirus-like particle production in plants |
| US10736956B2 (en) | 2015-01-23 | 2020-08-11 | Icahn School Of Medicine At Mount Sinai | Influenza virus vaccination regimens |
| AU2016270979B2 (en) | 2015-06-02 | 2020-11-12 | Sanofi Pasteur Inc. | Engineered influenza antigenic polypeptides and immunogenic compositions thereof |
| CN107920487A (zh) | 2015-07-02 | 2018-04-17 | 莫迪卡戈公司 | 茉莉酸通路激活剂 |
| EP3464328A1 (en) | 2016-06-02 | 2019-04-10 | Sanofi Pasteur Inc. | Engineered influenza antigenic polypeptides and immunogenic compositions thereof |
| WO2017218624A1 (en) | 2016-06-15 | 2017-12-21 | Icahn School Of Medicine At Mount Sinai | Influenza virus hemagglutinin proteins and uses thereof |
| FR3054547B1 (fr) * | 2016-07-29 | 2020-06-05 | Angany Inc. | Particules pseudo-virales et leurs utilisations |
| CN110325208A (zh) * | 2016-09-16 | 2019-10-11 | 威克斯技术公司 | 针对流感的疫苗接种的组合物和方法 |
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| CN107058377A (zh) * | 2017-06-16 | 2017-08-18 | 深圳惠升生物科技有限公司 | 植物作为宿主在表达中东呼吸综合征的疫苗中的应用 |
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| BR112020018639A2 (pt) | 2018-03-14 | 2020-12-29 | Medicago Inc. | Potenciador de expressão vegetal |
| EP3810634A4 (en) | 2018-06-21 | 2022-07-27 | Icahn School of Medicine at Mount Sinai | Mosaic influenza virus hemagglutinin polypeptides and uses thereof |
| BR112020026620A8 (pt) | 2018-06-27 | 2022-01-25 | Medicago Inc | Mutantes de hemaglutinina do vírus influenza |
| JP2021534817A (ja) | 2018-08-17 | 2021-12-16 | サントル ナショナル ドゥ ラ ルシェルシュ シアンティフィック | 動物を病原性細菌から保護するならびに/または相利共生および片利共生細菌の有益な効果を促進するためのrnaベースの治療方法 |
| WO2020181354A1 (en) | 2019-03-14 | 2020-09-17 | Mitsubishi Tanabe Pharma Corporation | Endogenous plant expression enhancer |
| EP3959216A4 (en) | 2019-04-24 | 2023-01-11 | Icahn School of Medicine at Mount Sinai | ANTI-INFLUENZA B VIRUS NEURAMINIDASE ANTIBODIES AND USES THEREOF |
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