JP2016052331A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2016052331A5 JP2016052331A5 JP2016000233A JP2016000233A JP2016052331A5 JP 2016052331 A5 JP2016052331 A5 JP 2016052331A5 JP 2016000233 A JP2016000233 A JP 2016000233A JP 2016000233 A JP2016000233 A JP 2016000233A JP 2016052331 A5 JP2016052331 A5 JP 2016052331A5
- Authority
- JP
- Japan
- Prior art keywords
- nucleic acid
- signal peptide
- seq
- plant
- influenza
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 101710154606 Hemagglutinin Proteins 0.000 claims 12
- 101710093908 Outer capsid protein VP4 Proteins 0.000 claims 12
- 101710135467 Outer capsid protein sigma-1 Proteins 0.000 claims 12
- 101710176177 Protein A56 Proteins 0.000 claims 12
- 239000000185 hemagglutinin Substances 0.000 claims 12
- 108020004707 nucleic acids Proteins 0.000 claims 7
- 102000039446 nucleic acids Human genes 0.000 claims 7
- 150000007523 nucleic acids Chemical class 0.000 claims 6
- 239000002773 nucleotide Substances 0.000 claims 6
- 125000003729 nucleotide group Chemical group 0.000 claims 6
- 108010076504 Protein Sorting Signals Proteins 0.000 claims 5
- 241000196324 Embryophyta Species 0.000 claims 4
- 206010022000 influenza Diseases 0.000 claims 4
- 230000001105 regulatory effect Effects 0.000 claims 3
- 241000723655 Cowpea mosaic virus Species 0.000 claims 2
- 102000006010 Protein Disulfide-Isomerase Human genes 0.000 claims 2
- 239000002245 particle Substances 0.000 claims 2
- 108020003519 protein disulfide isomerase Proteins 0.000 claims 2
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US99060307P | 2007-11-27 | 2007-11-27 | |
| US1327207P | 2007-12-12 | 2007-12-12 | |
| US2277508P | 2008-01-22 | 2008-01-22 | |
| CAPCT/CA2008/001281 | 2008-07-11 | ||
| PCT/CA2008/001281 WO2009009876A1 (en) | 2007-07-13 | 2008-07-11 | Influenza virus-like particles (vlps) comprising hemagglutinin produced within a plant |
| CAPCT/CA2009/000032 | 2009-01-12 | ||
| PCT/CA2009/000032 WO2009076778A1 (en) | 2007-11-27 | 2009-01-12 | Recombinant influenza virus-like particles (vlps) produced in transgenic plants expressing hemagglutinin |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011516934A Division JP5921884B2 (ja) | 2008-07-11 | 2009-07-02 | 赤血球凝集素を含むインフルエンザウイルス様粒子（ｖｌｐｓ） |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016052331A JP2016052331A (ja) | 2016-04-14 |
| JP2016052331A5 true JP2016052331A5 (enExample) | 2016-06-30 |
| JP6215363B2 JP6215363B2 (ja) | 2017-10-18 |
Family
ID=40795157
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010542486A Pending JP2011509661A (ja) | 2007-11-27 | 2009-01-12 | ヘマグルチニンを発現するトランスジェニック植物において産生された組換え型インフルエンザウイルス様粒子（ｖｌｐ） |
| JP2014039035A Active JP5990207B2 (ja) | 2007-11-27 | 2014-02-28 | ヘマグルチニンを発現するトランスジェニック植物において産生された組換え型インフルエンザウイルス様粒子（ｖｌｐ） |
| JP2015231583A Withdrawn JP2016032477A (ja) | 2007-11-27 | 2015-11-27 | ヘマグルチニンを発現するトランスジェニック植物において産生された組換え型インフルエンザウイルス様粒子（ｖｌｐ） |
| JP2016000233A Active JP6215363B2 (ja) | 2007-11-27 | 2016-01-04 | 赤血球凝集素を含むインフルエンザウイルス様粒子（ＶＬＰｓ） |
Family Applications Before (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010542486A Pending JP2011509661A (ja) | 2007-11-27 | 2009-01-12 | ヘマグルチニンを発現するトランスジェニック植物において産生された組換え型インフルエンザウイルス様粒子（ｖｌｐ） |
| JP2014039035A Active JP5990207B2 (ja) | 2007-11-27 | 2014-02-28 | ヘマグルチニンを発現するトランスジェニック植物において産生された組換え型インフルエンザウイルス様粒子（ｖｌｐ） |
| JP2015231583A Withdrawn JP2016032477A (ja) | 2007-11-27 | 2015-11-27 | ヘマグルチニンを発現するトランスジェニック植物において産生された組換え型インフルエンザウイルス様粒子（ｖｌｐ） |
Country Status (18)
| Country | Link |
|---|---|
| US (4) | US20100310604A1 (enExample) |
| EP (2) | EP2610345B1 (enExample) |
| JP (4) | JP2011509661A (enExample) |
| KR (1) | KR20100120157A (enExample) |
| CN (2) | CN103122354B (enExample) |
| AU (1) | AU2009202819B2 (enExample) |
| CA (1) | CA2707235C (enExample) |
| CR (1) | CR11612A (enExample) |
| DK (1) | DK2610345T3 (enExample) |
| ES (1) | ES2554703T3 (enExample) |
| IL (1) | IL206967A (enExample) |
| IS (1) | IS2982B (enExample) |
| MA (1) | MA32439B1 (enExample) |
| MX (1) | MX2010007962A (enExample) |
| NZ (1) | NZ587108A (enExample) |
| PT (1) | PT2610345E (enExample) |
| WO (1) | WO2009076778A1 (enExample) |
| ZA (1) | ZA201005917B (enExample) |
Families Citing this family (54)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2615372A1 (en) | 2007-07-13 | 2009-01-13 | Marc-Andre D'aoust | Influenza virus-like particles (vlps) comprising hemagglutinin |
| CN103122354B (zh) | 2007-11-27 | 2018-03-23 | 麦迪卡格公司 | 表达血凝素之转基因植物中生产的重组流感病毒样颗粒(vlp) |
| US8771703B2 (en) * | 2008-07-08 | 2014-07-08 | Medicago Inc. | Soluble recombinant influenza antigens |
| AU2009270404B2 (en) | 2008-07-18 | 2015-01-29 | Medicago Inc. | New influenza virus immunizing epitope |
| MX2011005604A (es) | 2008-11-28 | 2011-09-01 | Merial Ltd | Vacuna recombinante para influenza aviar y sus usos. |
| EP2413962A1 (en) | 2009-03-30 | 2012-02-08 | Mount Sinai School of Medicine | Influenza virus vaccines and uses thereof |
| CA2762042C (en) * | 2009-06-24 | 2012-11-20 | Medicago Inc. | Chimeric influenza virus-like particles comprising hemagglutinin |
| HRP20171564T1 (hr) | 2009-09-22 | 2017-11-17 | Medicago Inc. | Postupak za pripremu biljnih čestica sličnih virusu (vlp) |
| CN107746869A (zh) * | 2009-12-28 | 2018-03-02 | 赛诺菲疫苗技术公司 | 微藻中异源多肽的生产，微藻胞外体、组合物及其制备方法和用途 |
| WO2011090708A2 (en) | 2009-12-28 | 2011-07-28 | Merial Limited | Recombinant ndv antigen and uses thereof |
| AU2011217903B2 (en) | 2010-02-18 | 2017-03-02 | Mount Sinai School Of Medicine | Vaccines for use in the prophylaxis and treatment of influenza virus disease |
| US9345759B2 (en) | 2010-03-12 | 2016-05-24 | Merial, Inc. | Bluetongue virus recombinant vaccines and uses thereof |
| MX2012011300A (es) | 2010-03-30 | 2012-11-29 | Sinai School Medicine | Vacunas del virus de influenza y usos de las mismas. |
| WO2012041503A1 (en) | 2010-09-30 | 2012-04-05 | Franvax S.R.L. | Generation of virosome particles |
| US20130295609A1 (en) | 2010-11-04 | 2013-11-07 | Medicago Inc. | Plant expression system |
| TWI526539B (zh) * | 2010-12-22 | 2016-03-21 | 苜蓿股份有限公司 | 植物中生產類病毒顆粒(vlp)的方法及以該方法生產之vlp |
| TWI620816B (zh) | 2011-03-23 | 2018-04-11 | 苜蓿股份有限公司 | 植物衍生蛋白回收方法 |
| EP2700399B1 (en) | 2011-04-18 | 2017-05-31 | National Center of Neurology and Psychiatry | Drug delivery particles and method for producing same |
| WO2012145759A2 (en) * | 2011-04-21 | 2012-10-26 | Arizona Board Of Regents, A Body Corporate Of The State Of Arizona Acting For And On Behalf Of Arizona State University | Methods of protein production and compositions thereof |
| JP5846624B2 (ja) * | 2011-05-30 | 2016-01-20 | 公益財団法人ヒューマンサイエンス振興財団 | Ｈ５ｎ１型インフルエンザワクチン及び感染防御キット |
| MX350421B (es) * | 2011-06-13 | 2017-09-06 | Medicago Inc | Producción de partículas tipo virus de la rabia en plantas. |
| IN2014CN02114A (enExample) | 2011-09-20 | 2015-05-29 | Sinai School Medicine | |
| GB201116416D0 (en) * | 2011-09-23 | 2011-11-02 | Isis Innovation | Composition |
| US11390878B2 (en) * | 2011-09-30 | 2022-07-19 | Medicago Inc. | Increasing protein yield in plants |
| SI2760882T1 (sl) * | 2011-09-30 | 2023-10-30 | Medicago Inc. | Povečanje količine virusom podobnih delcev v rastlinah |
| TWI705139B (zh) * | 2012-05-11 | 2020-09-21 | 加拿大商苜蓿股份有限公司 | 產製植物中類輪狀病毒粒子 |
| EP4154907A1 (en) | 2012-12-18 | 2023-03-29 | Icahn School of Medicine at Mount Sinai | Influenza virus vaccines and uses thereof |
| WO2014159960A1 (en) | 2013-03-14 | 2014-10-02 | Icahn School Of Medicine At Mount Sinai | Antibodies against influenza virus hemagglutinin and uses thereof |
| JP2016516415A (ja) * | 2013-03-28 | 2016-06-09 | メディカゴ インコーポレイテッド | 植物におけるインフルエンザウイルス様粒子の生成 |
| US12467058B2 (en) | 2013-03-28 | 2025-11-11 | Aramis Biotechnologies Inc. | Influenza virus-like particle production in plants |
| EP3092309B1 (en) | 2014-01-10 | 2021-02-24 | Medicago Inc. | Cpmv enhancer elements |
| WO2015143567A1 (en) | 2014-03-27 | 2015-10-01 | Medicago Inc. | Modified cpmv enhancer elements |
| JP6788582B2 (ja) | 2014-07-11 | 2020-11-25 | メディカゴ インコーポレイテッド | 植物におけるタンパク質生産の改変 |
| JP2018504412A (ja) | 2015-01-23 | 2018-02-15 | アイカーン スクール オブ メディシン アット マウント サイナイ | インフルエンザウイルスワクチン接種レジメン |
| EA201791683A1 (ru) | 2015-01-23 | 2017-12-29 | Медикаго Инк. | Получение ротавирусоподобных частиц в растениях |
| CA2987939A1 (en) | 2015-06-02 | 2016-12-08 | Sanofi Pasteur Inc. | Engineered influenza antigenic polypeptides and immunogenic compositions thereof |
| CN107920487A (zh) | 2015-07-02 | 2018-04-17 | 莫迪卡戈公司 | 茉莉酸通路激活剂 |
| EP3464328A1 (en) | 2016-06-02 | 2019-04-10 | Sanofi Pasteur Inc. | Engineered influenza antigenic polypeptides and immunogenic compositions thereof |
| WO2017218624A1 (en) | 2016-06-15 | 2017-12-21 | Icahn School Of Medicine At Mount Sinai | Influenza virus hemagglutinin proteins and uses thereof |
| FR3054547B1 (fr) * | 2016-07-29 | 2020-06-05 | Angany Inc. | Particules pseudo-virales et leurs utilisations |
| CN110325208A (zh) * | 2016-09-16 | 2019-10-11 | 威克斯技术公司 | 针对流感的疫苗接种的组合物和方法 |
| US11254733B2 (en) | 2017-04-07 | 2022-02-22 | Icahn School Of Medicine At Mount Sinai | Anti-influenza B virus neuraminidase antibodies and uses thereof |
| GB201708866D0 (en) | 2017-06-02 | 2017-07-19 | Univ Cape Town | Expression of chaperone proteins in planta for increased expression of heterologous polypeptides of interest |
| CN107058377A (zh) * | 2017-06-16 | 2017-08-18 | 深圳惠升生物科技有限公司 | 植物作为宿主在表达中东呼吸综合征的疫苗中的应用 |
| WO2019049111A1 (en) * | 2017-09-11 | 2019-03-14 | R. J. Reynolds Tobacco Company | METHODS AND COMPOSITIONS FOR INCREASING THE EXPRESSION OF GENES OF INTEREST IN A PLANT BY CO-EXPRESSION WITH P21 |
| AU2019233860B2 (en) | 2018-03-14 | 2025-02-13 | Aramis Biotechnologies Inc. | Plant expression enhancer |
| EP3810634A4 (en) | 2018-06-21 | 2022-07-27 | Icahn School of Medicine at Mount Sinai | Mosaic influenza virus hemagglutinin polypeptides and uses thereof |
| MX2020013961A (es) | 2018-06-27 | 2021-03-09 | Medicago Inc | Mutantes de hemaglutinina del virus de la influenza. |
| CA3109666A1 (en) | 2018-08-17 | 2020-02-20 | Centre National De La Recherche Scientifique (Cnrs) | Rna-based therapeutic methods to protect animals against pathogenic bacteria and / or promote beneficial effects of symbiotic and commensal bacteria |
| MX2021010974A (es) | 2019-03-14 | 2021-10-13 | Mitsubishi Tanabe Pharma Corp | Potenciador de la expresion de plantas endogenas. |
| KR20220118421A (ko) * | 2019-12-18 | 2022-08-25 | 제네똥 | 식물 모상근으로부터 재조합 바이러스 벡터의 제조 |
| IL297465A (en) * | 2020-04-22 | 2022-12-01 | Medicago Inc | A superstructure containing modified influenza hemagglutinin with reduced interaction with sialic acid |
| WO2021215855A1 (ko) * | 2020-04-22 | 2021-10-28 | 포항공과대학교 산학협력단 | 삼량체를 형성하는 인플루엔자 바이러스 표면 단백질 유래 재조합 혈구응집소 단백질 및 이의 용도 |
| CN111888390B (zh) * | 2020-08-27 | 2021-12-14 | 广州白云山星群(药业)股份有限公司 | 夏桑菊提取物在抑制人类冠状病毒中的应用 |
Family Cites Families (75)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5428147A (en) | 1983-04-15 | 1995-06-27 | Mycogen Plant Science, Inc. | Octopine T-DNA promoters |
| US4945050A (en) | 1984-11-13 | 1990-07-31 | Cornell Research Foundation, Inc. | Method for transporting substances into living cells and tissues and apparatus therefor |
| US5100792A (en) | 1984-11-13 | 1992-03-31 | Cornell Research Foundation, Inc. | Method for transporting substances into living cells and tissues |
| US5036006A (en) | 1984-11-13 | 1991-07-30 | Cornell Research Foundation, Inc. | Method for transporting substances into living cells and tissues and apparatus therefor |
| WO1986003224A1 (en) | 1984-11-29 | 1986-06-05 | Scripps Clinic And Research Foundation | Polypeptides and antibodies related to deglycosylated viral glycoproteins |
| JPS61265086A (ja) | 1985-05-21 | 1986-11-22 | Mitsui Toatsu Chem Inc | プロトプラストの培養法 |
| US4962028A (en) | 1986-07-09 | 1990-10-09 | Dna Plant Technology Corporation | Plant promotors |
| US5232833A (en) * | 1988-09-14 | 1993-08-03 | Stressgen Biotechnologies Corporation | Accumulation of heat shock proteins for evaluating biological damage due to chronic exposure of an organism to sublethal levels of pollutants |
| US6403865B1 (en) | 1990-08-24 | 2002-06-11 | Syngenta Investment Corp. | Method of producing transgenic maize using direct transformation of commercially important genotypes |
| ATE142883T1 (de) * | 1991-03-28 | 1996-10-15 | Rooperol Na Nv | Zusammensetzungen von phytosterolen mit phytosterolinen als immunmodulatoren |
| UA48104C2 (uk) | 1991-10-04 | 2002-08-15 | Новартіс Аг | Фрагмент днк, який містить послідовність,що кодує інсектицидний протеїн, оптимізовану для кукурудзи,фрагмент днк, який забезпечує направлену бажану для серцевини стебла експресію зв'язаного з нею структурного гена в рослині, фрагмент днк, який забезпечує специфічну для пилку експресію зв`язаного з нею структурного гена в рослині, рекомбінантна молекула днк, спосіб одержання оптимізованої для кукурудзи кодуючої послідовності інсектицидного протеїну, спосіб захисту рослин кукурудзи щонайменше від однієї комахи-шкідника |
| US6326470B1 (en) | 1997-04-15 | 2001-12-04 | The Penn State Research Foundation | Enhancement of accessibility of cellulose by expansins |
| US5762939A (en) * | 1993-09-13 | 1998-06-09 | Mg-Pmc, Llc | Method for producing influenza hemagglutinin multivalent vaccines using baculovirus |
| GB9414118D0 (en) * | 1994-07-13 | 1994-08-31 | Axis Genetics Ltd | Modified plant viruses as vectors of heterologous peptides |
| WO1997004122A1 (en) | 1995-07-20 | 1997-02-06 | Washington State University Research Foundation | Production of secreted foreign polypeptides in plant cell culture |
| US5773695A (en) | 1996-01-26 | 1998-06-30 | North Carolina State University | Plant nuclear scaffold attachment region and method for increasing gene expression in transgenic cells |
| US6042832A (en) | 1996-08-28 | 2000-03-28 | Thomas Jefferson University | Polypeptides fused with alfalfa mosaic virus or ilarvirus capsid proteins |
| US20010006950A1 (en) | 1998-02-11 | 2001-07-05 | Juha Punnonen | Genetic vaccine vector engineering |
| US6489537B1 (en) | 1998-08-07 | 2002-12-03 | The Trustees Of The University Of Pennsylvania | Phytochelatin synthases and uses therefor |
| AU759813B2 (en) | 1998-08-11 | 2003-05-01 | Kentucky Bioprocessing, Llc | Method for recovering proteins from the interstitial fluid of plant tissues |
| US6287570B1 (en) | 1998-11-23 | 2001-09-11 | Patricia L. Foley | Vaccine against swine influenza virus |
| FR2791358B1 (fr) | 1999-03-22 | 2003-05-16 | Meristem Therapeutics | Promoteurs chimeriques d'expression, cassettes d'expression, plasmides, vecteurs, plantes et semences transgeniques les contenant et leurs methodes d'obtention |
| MXPA01010921A (es) | 1999-04-29 | 2003-06-24 | Syngenta Ltd | Plantas resistentes a herbicidas. |
| US7125978B1 (en) | 1999-10-04 | 2006-10-24 | Medicago Inc. | Promoter for regulating expression of foreign genes |
| JP2003512821A (ja) | 1999-10-04 | 2003-04-08 | メディカゴ インコーポレイテッド | 外来性遺伝子の転写調節方法 |
| ATE433491T1 (de) | 2001-01-18 | 2009-06-15 | Vlaams Interuniv Inst Biotech | Oligomerische komplexe von chimären proteinen mit verbessertem immunogenen potential |
| HUE050222T2 (hu) * | 2002-02-13 | 2020-11-30 | Wisconsin Alumni Res Found | Szignál influenzavírus-vektorok pakolására |
| WO2003068163A2 (en) | 2002-02-14 | 2003-08-21 | Novavax, Inc. | Optimization of gene sequences of chimeric virus-like particles for expression in insect cells |
| EP1485492B1 (en) * | 2002-03-19 | 2011-12-21 | Stichting Dienst Landbouwkundig Onderzoek | Gntiii (udp-n-acetylglucosamine:beta-d mannoside beta(1,4)-n-acetylglucosaminyltransferase iii) expression in plants |
| ES2224792B1 (es) | 2002-06-28 | 2007-02-16 | Era Plantech, S.L. | Produccion de peptidos y proteinas por acumulacion de cuerpos proteicos derivados de reticulos endoplasmico en plantas. |
| JP2007526215A (ja) * | 2003-05-05 | 2007-09-13 | ダウ アグロサイエンス リミテッド ライアビリティー カンパニー | トランスジェニック植物細胞に由来する安定な免疫予防的および治療的組成物ならびにその産生方法 |
| DE602004028004D1 (de) | 2003-05-05 | 2010-08-19 | Thompson Boyce Plant Res | Vektoren und zellen zur herstellung von aus transgenen pflanzen gewonnenen immunprotektiven zusammensetzungen |
| CA2816222A1 (en) | 2003-06-16 | 2005-03-03 | Medimmune Vaccines, Inc. | Influenza hemagglutinin and neuraminidase variants |
| US8592197B2 (en) * | 2003-07-11 | 2013-11-26 | Novavax, Inc. | Functional influenza virus-like particles (VLPs) |
| US7226781B1 (en) | 2003-07-24 | 2007-06-05 | Belyaev Alexander S | Chaperone expression genomes |
| US7901691B2 (en) | 2004-08-13 | 2011-03-08 | Council Of Scientific And Indistrial Research | Chimeric G protein based rabies vaccine |
| US9155483B2 (en) | 2004-12-03 | 2015-10-13 | The Invention Science Fund I, Llc | Vision modification with reflected image |
| WO2006119516A2 (en) | 2005-04-29 | 2006-11-09 | University Of Cape Town | Expression of viral proteins in plants |
| CN100410378C (zh) * | 2005-05-09 | 2008-08-13 | 中国农业科学院生物技术研究所 | 编码禽流感血凝素的基因及其植物表达载体和应用 |
| MX2008000890A (es) | 2005-07-19 | 2008-03-18 | Dow Global Technologies Inc | Vacunas de influenza (flu) recombinantes. |
| US7871626B2 (en) | 2005-08-04 | 2011-01-18 | St. Jude Children's Research Hospital | Modified influenza virus for monitoring and improving vaccine efficiency |
| WO2007022425A2 (en) | 2005-08-16 | 2007-02-22 | Hawaii Biotech, Inc. | Influenza recombinant subunit vaccine |
| BRPI0617486A2 (pt) | 2005-10-18 | 2011-07-26 | Novavax Inc | vacina que compreende partÍculas similares a vÍrus da gripe funcionais (vlp) e uso de uma vlp de gripe |
| WO2007081447A2 (en) | 2005-11-22 | 2007-07-19 | Novartis Vaccines And Diagnostics, Inc. | Norovirus and sapovirus antigens |
| AU2007215080A1 (en) | 2006-02-13 | 2007-08-23 | Fraunhofer Usa, Inc. | Influenza antigens, vaccine compositions, and related methods |
| CA2642644A1 (en) | 2006-02-16 | 2007-09-07 | The Government Of The United States Of America, As Represented By The Se Cretary, Department Of Health And Human Services | Antiviral agents and vaccines against influenza |
| EP2010210A4 (en) | 2006-04-21 | 2010-07-21 | Dow Agrosciences Llc | VACCINE AGAINST BIRD FLUID AND METHOD OF APPLICATION THEREFOR |
| WO2007130327A2 (en) | 2006-05-01 | 2007-11-15 | Technovax, Inc. | Influenza virus-like particle (vlp) compositions |
| CA2657849A1 (en) | 2006-05-18 | 2008-05-08 | Pharmexa Inc. | Inducing immune responses to influenza virus using polypeptide and nucleic acid compositions |
| WO2007135480A1 (en) | 2006-05-22 | 2007-11-29 | Plant Bioscience Limited | Bipartite system, method and composition for the constitutive and inducible expression of high levels of foreign proteins in plants |
| US20070286873A1 (en) * | 2006-05-23 | 2007-12-13 | Williams John V | Recombinant Influenza H5 Hemagluttinin Protein And Nucleic Acid Coding Therefor |
| US7730950B2 (en) | 2007-01-19 | 2010-06-08 | Halliburton Energy Services, Inc. | Methods for treating intervals of a subterranean formation having variable permeability |
| WO2008148104A1 (en) | 2007-05-25 | 2008-12-04 | Novavax, Inc. | Novel vlps derived from cells that do not express a viral matrix or core protein |
| RU2499053C2 (ru) | 2007-06-15 | 2013-11-20 | Медикаго Инк. | Способ синтеза белка с модифицированным профилем n-гликозилирования в растениях |
| KR100964462B1 (ko) * | 2007-07-10 | 2010-06-16 | 성균관대학교산학협력단 | 형질전환 식물 유래의 조류독감 바이러스 백신 및 그 제조방법 |
| CA2615372A1 (en) | 2007-07-13 | 2009-01-13 | Marc-Andre D'aoust | Influenza virus-like particles (vlps) comprising hemagglutinin |
| CA2696764A1 (en) | 2007-08-20 | 2009-02-26 | Fraunhofer Usa, Inc. | Prophylactic and therapeutic influenza vaccines, antigens, compositions, and methods |
| CN103122354B (zh) | 2007-11-27 | 2018-03-23 | 麦迪卡格公司 | 表达血凝素之转基因植物中生产的重组流感病毒样颗粒(vlp) |
| JP2011508034A (ja) | 2007-12-28 | 2011-03-10 | ユニリーバー・ナームローゼ・ベンノートシヤープ | 茶から香気成分を回収する方法 |
| GB0800272D0 (en) | 2008-01-08 | 2008-02-13 | Plant Bioscience Ltd | Protein expression systems |
| KR101956910B1 (ko) | 2008-01-21 | 2019-03-12 | 메디카고 인코포레이티드 | 헤마글루티닌을 발현하는 트랜스제닉 식물에서 생산된 재조합 인플루엔자 바이러스-유사 입자(ＶＬＰｓ) |
| US8771703B2 (en) | 2008-07-08 | 2014-07-08 | Medicago Inc. | Soluble recombinant influenza antigens |
| AU2009270404B2 (en) | 2008-07-18 | 2015-01-29 | Medicago Inc. | New influenza virus immunizing epitope |
| US8513397B2 (en) | 2008-08-27 | 2013-08-20 | The Arizona Board Of Regents For And On Behalf Of Arizona State University | DNA replicon system for high-level rapid production of vaccines and monoclonal antibody therapeutics in plants |
| US20100167376A1 (en) | 2008-10-06 | 2010-07-01 | Genvault Corporation | Methods for providing cellular lysates from cell wall-containing samples |
| WO2010077712A1 (en) | 2008-12-09 | 2010-07-08 | Novavax, Inc. | Bovine respiratory syncytial virus virus-like particle (vlps) |
| EP2413962A1 (en) | 2009-03-30 | 2012-02-08 | Mount Sinai School of Medicine | Influenza virus vaccines and uses thereof |
| CA2762042C (en) * | 2009-06-24 | 2012-11-20 | Medicago Inc. | Chimeric influenza virus-like particles comprising hemagglutinin |
| WO2011011390A1 (en) | 2009-07-20 | 2011-01-27 | Novavax, Inc. | Purified recombinant influenza virus ha proteins |
| HRP20171564T1 (hr) | 2009-09-22 | 2017-11-17 | Medicago Inc. | Postupak za pripremu biljnih čestica sličnih virusu (vlp) |
| US9352031B2 (en) | 2010-02-18 | 2016-05-31 | Technovax, Inc. | Universal virus-like particle (VLP) influenza vaccines |
| US20130295609A1 (en) * | 2010-11-04 | 2013-11-07 | Medicago Inc. | Plant expression system |
| PT2635257T (pt) | 2010-11-05 | 2017-08-16 | Novavax Inc | Partículas semelhantes a vírus de glicoproteína de raiva (vlps) |
| TWI526539B (zh) | 2010-12-22 | 2016-03-21 | 苜蓿股份有限公司 | 植物中生產類病毒顆粒(vlp)的方法及以該方法生產之vlp |
| CN108611793B (zh) | 2018-05-18 | 2020-11-20 | 北京化工大学 | 一种高强度静电纺丝聚丙烯腈基纳米碳纤维毡的制备方法 |
-
2009
- 2009-01-12 CN CN201310021693.8A patent/CN103122354B/zh active Active
- 2009-01-12 PT PT121838544T patent/PT2610345E/pt unknown
- 2009-01-12 ES ES12183854.4T patent/ES2554703T3/es active Active
- 2009-01-12 EP EP12183854.4A patent/EP2610345B1/en active Active
- 2009-01-12 JP JP2010542486A patent/JP2011509661A/ja active Pending
- 2009-01-12 KR KR1020107018343A patent/KR20100120157A/ko not_active Ceased
- 2009-01-12 AU AU2009202819A patent/AU2009202819B2/en active Active
- 2009-01-12 US US12/863,772 patent/US20100310604A1/en not_active Abandoned
- 2009-01-12 CA CA2707235A patent/CA2707235C/en active Active
- 2009-01-12 WO PCT/CA2009/000032 patent/WO2009076778A1/en not_active Ceased
- 2009-01-12 NZ NZ587108A patent/NZ587108A/xx unknown
- 2009-01-12 DK DK12183854.4T patent/DK2610345T3/en active
- 2009-01-12 EP EP09700061A patent/EP2238253B1/en active Active
- 2009-01-12 CN CN2009801097815A patent/CN101978066A/zh active Pending
- 2009-01-12 MX MX2010007962A patent/MX2010007962A/es active IP Right Grant
-
2010
- 2010-07-13 IL IL206967A patent/IL206967A/en active IP Right Grant
- 2010-07-29 CR CR11612A patent/CR11612A/es not_active Application Discontinuation
- 2010-08-04 IS IS8919A patent/IS2982B/is unknown
- 2010-08-13 MA MA33088A patent/MA32439B1/fr unknown
- 2010-08-19 ZA ZA2010/05917A patent/ZA201005917B/en unknown
-
2013
- 2013-01-23 US US13/748,531 patent/US9458470B2/en active Active
-
2014
- 2014-02-28 JP JP2014039035A patent/JP5990207B2/ja active Active
-
2015
- 2015-11-27 JP JP2015231583A patent/JP2016032477A/ja not_active Withdrawn
-
2016
- 2016-01-04 JP JP2016000233A patent/JP6215363B2/ja active Active
- 2016-09-02 US US15/256,119 patent/US10190132B2/en active Active
-
2018
- 2018-12-13 US US16/219,306 patent/US11434497B2/en active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2016052331A5 (enExample) | ||
| Elliott et al. | Emerging phleboviruses | |
| WO2013044203A3 (en) | Novel influenza hemagglutinin protein-based vaccines | |
| EA201890220A1 (ru) | Вакцина против rsv | |
| PH12018501912A1 (en) | Vaccine against rsv | |
| NZ587108A (en) | Recombinant influenza virus-like particles (vlps) produced in transgenic plants expressing hemagglutinin | |
| IL253187B (en) | Novel multivalent nanoparticle-based vaccines | |
| JP2012095652A5 (enExample) | ||
| JP2016516415A5 (enExample) | ||
| JP2015119730A5 (enExample) | ||
| JP2016034981A5 (enExample) | ||
| ZA202100386B (en) | Influenza virus hemagglutinin mutants | |
| JP2015096070A5 (enExample) | ||
| JP2019530462A5 (enExample) | ||
| JP2014531205A5 (enExample) | ||
| EA201001198A1 (ru) | Рекомбинантные вирусоподобные частицы (вч), схожие с вирусом гриппа, производящиеся в трансгенных растениях, экспрессирующих гемагглютинин | |
| WO2006119516A3 (en) | Expression of viral proteins in plants | |
| JP2010088434A5 (enExample) | ||
| JP2014507146A5 (enExample) | ||
| JP2014506785A5 (enExample) | ||
| FI2760882T3 (fi) | Viruksen kaltaisen partikkelin saantojen lisääminen kasveissa | |
| HRP20200012T1 (hr) | Atenuirani virusi i cjepiva gripe | |
| JP2016520534A5 (enExample) | ||
| MX390966B (es) | Vacunas contra el dengue | |
| FI3511015T9 (fi) | Geneettisesti stabiili elävä heikennetty respiratory syncytial -virusrokote ja sen tuottaminen |