MA32439B1 - Particules pseudovirales (vlp) de la grippe recombinées produites dans des plantes transgéniques exprimant l'hémagglutinine - Google Patents

Particules pseudovirales (vlp) de la grippe recombinées produites dans des plantes transgéniques exprimant l'hémagglutinine

Info

Publication number
MA32439B1
MA32439B1 MA33088A MA33088A MA32439B1 MA 32439 B1 MA32439 B1 MA 32439B1 MA 33088 A MA33088 A MA 33088A MA 33088 A MA33088 A MA 33088A MA 32439 B1 MA32439 B1 MA 32439B1
Authority
MA
Morocco
Prior art keywords
vlps
influenza
produced
transgenic plants
plants expressing
Prior art date
Application number
MA33088A
Other languages
Arabic (ar)
English (en)
Inventor
Aoust Marc-André D
Manon Couture
Frédéric Ors
Sonia Trépanier
Pierre-Olivier Lavoie
Michèle Dargis
LOUIS-PHILIPPE VéZINA
Nathalie Landry
Original Assignee
Medicago Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CA002615372A external-priority patent/CA2615372A1/fr
Application filed by Medicago Inc filed Critical Medicago Inc
Publication of MA32439B1 publication Critical patent/MA32439B1/fr

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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8257—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon
    • C12N15/8258—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon for the production of oral vaccines (antigens) or immunoglobulins
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    • A61P31/12—Antivirals
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    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
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    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8257—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon
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    • A61K2039/525—Virus
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    • A—HUMAN NECESSITIES
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    • A61K2039/55588—Adjuvants of undefined constitution
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    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
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    • C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
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Abstract

L'invention concerne une méthode de synthèse de particules pseudovirales (VLP) de la grippe dans une plante ou une partie d'une plante. La méthode implique l'expression de HA de la grippe dans des plantes et la purification par chromatographie d'exclusion stérique. L'invention concerne également une VLP comprenant une protéine HA de la grippe et des lipides de plantes. L'invention concerne en outre un acide nucléique codant pour la protéine HA de la grippe ainsi que des vecteurs. Les VLP peuvent être utilisées pour préparer des vaccins antigrippaux ou peuvent être utilisées pour enrichir des vaccins existants.
MA33088A 2007-11-27 2010-08-13 Particules pseudovirales (vlp) de la grippe recombinées produites dans des plantes transgéniques exprimant l'hémagglutinine MA32439B1 (fr)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US99060307P 2007-11-27 2007-11-27
US1327207P 2007-12-12 2007-12-12
CA002615372A CA2615372A1 (fr) 2007-07-13 2008-01-21 Particules semblables au virus grippal a comprenant de l'hemagglutinine
US2277508P 2008-01-22 2008-01-22
PCT/CA2008/001281 WO2009009876A1 (fr) 2007-07-13 2008-07-11 Pseudo-particules du virus de la grippe (vlp) comprenant de l'hémagglutinine (ha) produit dans une plante
PCT/CA2009/000032 WO2009076778A1 (fr) 2007-11-27 2009-01-12 Particules pseudovirales (vlp) de la grippe recombinées produites dans des plantes transgéniques exprimant l'hémagglutinine

Publications (1)

Publication Number Publication Date
MA32439B1 true MA32439B1 (fr) 2011-07-03

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
MA33088A MA32439B1 (fr) 2007-11-27 2010-08-13 Particules pseudovirales (vlp) de la grippe recombinées produites dans des plantes transgéniques exprimant l'hémagglutinine

Country Status (19)

Country Link
US (4) US20100310604A1 (fr)
EP (2) EP2238253B1 (fr)
JP (4) JP2011509661A (fr)
KR (1) KR20100120157A (fr)
CN (2) CN101978066A (fr)
AU (1) AU2009202819B2 (fr)
CA (1) CA2707235C (fr)
CR (1) CR11612A (fr)
DK (1) DK2610345T3 (fr)
ES (1) ES2554703T3 (fr)
HK (1) HK1186207A1 (fr)
IL (1) IL206967A (fr)
IS (1) IS2982B (fr)
MA (1) MA32439B1 (fr)
MX (1) MX2010007962A (fr)
NZ (1) NZ587108A (fr)
PT (1) PT2610345E (fr)
WO (1) WO2009076778A1 (fr)
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