JP2016516415A5 - - Google Patents
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- Publication number
- JP2016516415A5 JP2016516415A5 JP2016504431A JP2016504431A JP2016516415A5 JP 2016516415 A5 JP2016516415 A5 JP 2016516415A5 JP 2016504431 A JP2016504431 A JP 2016504431A JP 2016504431 A JP2016504431 A JP 2016504431A JP 2016516415 A5 JP2016516415 A5 JP 2016516415A5
- Authority
- JP
- Japan
- Prior art keywords
- plant
- nucleic acid
- modified
- protein
- vlp
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 241000196324 Embryophyta Species 0.000 claims description 62
- 101710154606 Hemagglutinin Proteins 0.000 claims description 54
- 101710093908 Outer capsid protein VP4 Proteins 0.000 claims description 54
- 101710135467 Outer capsid protein sigma-1 Proteins 0.000 claims description 54
- 101710176177 Protein A56 Proteins 0.000 claims description 54
- 108020004707 nucleic acids Proteins 0.000 claims description 39
- 102000039446 nucleic acids Human genes 0.000 claims description 39
- 150000007523 nucleic acids Chemical class 0.000 claims description 39
- 239000000185 hemagglutinin Substances 0.000 claims description 32
- 238000000034 method Methods 0.000 claims description 27
- 239000002773 nucleotide Substances 0.000 claims description 27
- 125000003729 nucleotide group Chemical group 0.000 claims description 27
- 239000002253 acid Substances 0.000 claims description 17
- 206010022000 influenza Diseases 0.000 claims description 15
- 238000003776 cleavage reaction Methods 0.000 claims description 12
- 230000007017 scission Effects 0.000 claims description 12
- 230000002797 proteolythic effect Effects 0.000 claims description 10
- 108091005804 Peptidases Proteins 0.000 claims description 8
- 239000004365 Protease Substances 0.000 claims description 8
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 claims description 8
- 239000003623 enhancer Substances 0.000 claims description 8
- 230000001105 regulatory effect Effects 0.000 claims description 8
- 241000723655 Cowpea mosaic virus Species 0.000 claims description 6
- 238000003306 harvesting Methods 0.000 claims description 6
- 230000001965 increasing effect Effects 0.000 claims description 6
- 230000001939 inductive effect Effects 0.000 claims description 6
- 239000000203 mixture Substances 0.000 claims description 6
- 108091006146 Channels Proteins 0.000 claims description 4
- 102000034573 Channels Human genes 0.000 claims description 4
- 210000005220 cytoplasmic tail Anatomy 0.000 claims description 4
- 230000028993 immune response Effects 0.000 claims description 4
- 238000004519 manufacturing process Methods 0.000 claims description 4
- 239000002245 particle Substances 0.000 claims description 4
- 108091029795 Intergenic region Proteins 0.000 claims description 3
- 108010076504 Protein Sorting Signals Proteins 0.000 claims description 2
- 108090000631 Trypsin Proteins 0.000 claims description 2
- 102000004142 Trypsin Human genes 0.000 claims description 2
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 2
- 239000003937 drug carrier Substances 0.000 claims description 2
- 230000000694 effects Effects 0.000 claims description 2
- 230000036039 immunity Effects 0.000 claims description 2
- 208000037797 influenza A Diseases 0.000 claims description 2
- 208000037798 influenza B Diseases 0.000 claims description 2
- 208000037799 influenza C Diseases 0.000 claims description 2
- 150000002632 lipids Chemical class 0.000 claims description 2
- 102000004169 proteins and genes Human genes 0.000 claims description 2
- 108090000623 proteins and genes Proteins 0.000 claims description 2
- 230000001052 transient effect Effects 0.000 claims description 2
- 239000012588 trypsin Substances 0.000 claims description 2
- 241000712461 unidentified influenza virus Species 0.000 claims description 2
- 229960005486 vaccine Drugs 0.000 claims description 2
- 230000009385 viral infection Effects 0.000 claims description 2
- 235000010627 Phaseolus vulgaris Nutrition 0.000 claims 1
- 244000046052 Phaseolus vulgaris Species 0.000 claims 1
- 241000700605 Viruses Species 0.000 claims 1
- 241000577998 Bean yellow dwarf virus Species 0.000 description 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361806227P | 2013-03-28 | 2013-03-28 | |
| US61/806,227 | 2013-03-28 | ||
| US201461925852P | 2014-01-10 | 2014-01-10 | |
| US61/925,852 | 2014-01-10 | ||
| US201461971274P | 2014-03-27 | 2014-03-27 | |
| US61/971,274 | 2014-03-27 | ||
| PCT/CA2014/050326 WO2014153674A1 (en) | 2013-03-28 | 2014-03-28 | Influenza virus-like particle production in plants |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019067570A Division JP7065803B2 (ja) | 2013-03-28 | 2019-03-29 | 植物におけるインフルエンザウイルス様粒子の生成 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2016516415A JP2016516415A (ja) | 2016-06-09 |
| JP2016516415A5 true JP2016516415A5 (enExample) | 2017-03-09 |
Family
ID=51622327
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016504431A Pending JP2016516415A (ja) | 2013-03-28 | 2014-03-28 | 植物におけるインフルエンザウイルス様粒子の生成 |
| JP2019067570A Active JP7065803B2 (ja) | 2013-03-28 | 2019-03-29 | 植物におけるインフルエンザウイルス様粒子の生成 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019067570A Active JP7065803B2 (ja) | 2013-03-28 | 2019-03-29 | 植物におけるインフルエンザウイルス様粒子の生成 |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US10358652B2 (enExample) |
| EP (2) | EP3626827A1 (enExample) |
| JP (2) | JP2016516415A (enExample) |
| KR (1) | KR102199018B1 (enExample) |
| CN (2) | CN112592389A (enExample) |
| AU (1) | AU2014245779B2 (enExample) |
| CA (1) | CA2907591A1 (enExample) |
| ES (1) | ES2803508T3 (enExample) |
| IL (2) | IL295155A (enExample) |
| MX (1) | MX376138B (enExample) |
| PH (1) | PH12015502217B1 (enExample) |
| RU (2) | RU2705555C2 (enExample) |
| SG (1) | SG11201507928QA (enExample) |
| WO (1) | WO2014153674A1 (enExample) |
| ZA (1) | ZA201508327B (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI2760882T1 (sl) | 2011-09-30 | 2023-10-30 | Medicago Inc. | Povečanje količine virusom podobnih delcev v rastlinah |
| US11390878B2 (en) | 2011-09-30 | 2022-07-19 | Medicago Inc. | Increasing protein yield in plants |
| US12467058B2 (en) | 2013-03-28 | 2025-11-11 | Aramis Biotechnologies Inc. | Influenza virus-like particle production in plants |
| JP2016516415A (ja) | 2013-03-28 | 2016-06-09 | メディカゴ インコーポレイテッド | 植物におけるインフルエンザウイルス様粒子の生成 |
| EP3092309B1 (en) | 2014-01-10 | 2021-02-24 | Medicago Inc. | Cpmv enhancer elements |
| WO2015143567A1 (en) | 2014-03-27 | 2015-10-01 | Medicago Inc. | Modified cpmv enhancer elements |
| DK4023249T3 (da) | 2014-04-23 | 2025-01-13 | Modernatx Inc | Nukleinsyrevacciner |
| FR3054547B1 (fr) | 2016-07-29 | 2020-06-05 | Angany Inc. | Particules pseudo-virales et leurs utilisations |
| GB201614485D0 (en) | 2016-08-25 | 2016-10-12 | Univ Oxford Innovation Ltd | Immunogenic composition |
| CN106822887A (zh) * | 2017-01-26 | 2017-06-13 | 中国科学院微生物研究所 | 一种流感病毒四价亚单位疫苗及其应用 |
| AU2019233860B2 (en) * | 2018-03-14 | 2025-02-13 | Aramis Biotechnologies Inc. | Plant expression enhancer |
| MX2020013961A (es) * | 2018-06-27 | 2021-03-09 | Medicago Inc | Mutantes de hemaglutinina del virus de la influenza. |
| MX2021010974A (es) * | 2019-03-14 | 2021-10-13 | Mitsubishi Tanabe Pharma Corp | Potenciador de la expresion de plantas endogenas. |
| CN113249399B (zh) * | 2021-05-27 | 2022-08-02 | 长沙诺合松生物科技合伙企业(有限合伙) | pAM基因及其植物表达载体和应用 |
| AU2022425707A1 (en) * | 2021-12-31 | 2024-07-04 | Mynvax Private Limited | Polypeptide fragments, immunogenic composition against influenza virus, and implementations thereof |
| WO2025102071A1 (en) * | 2023-11-09 | 2025-05-15 | The General Hospital Corporation | Hemagglutinin polypeptides and uses thereof |
Family Cites Families (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5232833A (en) | 1988-09-14 | 1993-08-03 | Stressgen Biotechnologies Corporation | Accumulation of heat shock proteins for evaluating biological damage due to chronic exposure of an organism to sublethal levels of pollutants |
| AU6512299A (en) | 1998-10-07 | 2000-04-26 | Boyce Institute For Plant Research At Cornell University | Gemini virus vectors for gene expression in plants |
| US20020169306A1 (en) * | 1999-05-18 | 2002-11-14 | Kaio Kitazato | Envelope gene-deficient paramyxovirus vector |
| JP4972264B2 (ja) | 1999-12-06 | 2012-07-11 | ボード オブ トラスティーズ オブ ザ ユニバーシティ オブ イリノイ | 高親和性ｔｃｒタンパク質および方法 |
| DE10109354A1 (de) | 2001-02-27 | 2002-09-05 | Icon Genetics Ag | Rekombinante virale Schaltersysteme |
| US20030180756A1 (en) * | 2002-03-21 | 2003-09-25 | Yang Shi | Compositions and methods for suppressing eukaryotic gene expression |
| US8784335B2 (en) | 2002-04-19 | 2014-07-22 | Sanofi-Aventis Deutschland Gmbh | Body fluid sampling device with a capacitive sensor |
| JP2007526215A (ja) * | 2003-05-05 | 2007-09-13 | ダウ アグロサイエンス リミテッド ライアビリティー カンパニー | トランスジェニック植物細胞に由来する安定な免疫予防的および治療的組成物ならびにその産生方法 |
| DE602004028004D1 (de) | 2003-05-05 | 2010-08-19 | Thompson Boyce Plant Res | Vektoren und zellen zur herstellung von aus transgenen pflanzen gewonnenen immunprotektiven zusammensetzungen |
| US8080255B2 (en) | 2003-07-11 | 2011-12-20 | Novavax Inc. | Functional influenza virus like particles (VLPs) |
| WO2006119516A2 (en) | 2005-04-29 | 2006-11-09 | University Of Cape Town | Expression of viral proteins in plants |
| BRPI0617486A2 (pt) | 2005-10-18 | 2011-07-26 | Novavax Inc | vacina que compreende partÍculas similares a vÍrus da gripe funcionais (vlp) e uso de uma vlp de gripe |
| CA2642644A1 (en) | 2006-02-16 | 2007-09-07 | The Government Of The United States Of America, As Represented By The Se Cretary, Department Of Health And Human Services | Antiviral agents and vaccines against influenza |
| EP2476432B1 (en) * | 2006-03-07 | 2015-08-19 | Vaxinnate Corporation | Compositions that include hemagglutinin, methods of making and methods of use thereof |
| US7618815B2 (en) | 2006-03-08 | 2009-11-17 | University Of Kentucky Research Foundation | Viral vectors useful in soybean and methods of use |
| WO2007135480A1 (en) | 2006-05-22 | 2007-11-29 | Plant Bioscience Limited | Bipartite system, method and composition for the constitutive and inducible expression of high levels of foreign proteins in plants |
| JP2010500034A (ja) | 2006-08-09 | 2010-01-07 | メッドイミューン バクシーンズ，インコーポレイティド | インフルエンザ赤血球凝集素変異体およびノイラミニダーゼ変異体 |
| WO2008148104A1 (en) | 2007-05-25 | 2008-12-04 | Novavax, Inc. | Novel vlps derived from cells that do not express a viral matrix or core protein |
| RU2499053C2 (ru) | 2007-06-15 | 2013-11-20 | Медикаго Инк. | Способ синтеза белка с модифицированным профилем n-гликозилирования в растениях |
| CA2615372A1 (en) * | 2007-07-13 | 2009-01-13 | Marc-Andre D'aoust | Influenza virus-like particles (vlps) comprising hemagglutinin |
| CN103122354B (zh) * | 2007-11-27 | 2018-03-23 | 麦迪卡格公司 | 表达血凝素之转基因植物中生产的重组流感病毒样颗粒(vlp) |
| GB0800272D0 (en) | 2008-01-08 | 2008-02-13 | Plant Bioscience Ltd | Protein expression systems |
| KR101956910B1 (ko) | 2008-01-21 | 2019-03-12 | 메디카고 인코포레이티드 | 헤마글루티닌을 발현하는 트랜스제닉 식물에서 생산된 재조합 인플루엔자 바이러스-유사 입자(ＶＬＰｓ) |
| US8771703B2 (en) | 2008-07-08 | 2014-07-08 | Medicago Inc. | Soluble recombinant influenza antigens |
| AU2009270404B2 (en) | 2008-07-18 | 2015-01-29 | Medicago Inc. | New influenza virus immunizing epitope |
| US8513397B2 (en) | 2008-08-27 | 2013-08-20 | The Arizona Board Of Regents For And On Behalf Of Arizona State University | DNA replicon system for high-level rapid production of vaccines and monoclonal antibody therapeutics in plants |
| EP2413962A1 (en) * | 2009-03-30 | 2012-02-08 | Mount Sinai School of Medicine | Influenza virus vaccines and uses thereof |
| CA2762042C (en) | 2009-06-24 | 2012-11-20 | Medicago Inc. | Chimeric influenza virus-like particles comprising hemagglutinin |
| FR2947875B1 (fr) | 2009-07-10 | 2011-07-08 | Raymond A & Cie | Dispositif de fixation a elements de fixation multiples dont l'un est flottant |
| WO2011011390A1 (en) | 2009-07-20 | 2011-01-27 | Novavax, Inc. | Purified recombinant influenza virus ha proteins |
| CN102753700A (zh) | 2009-09-04 | 2012-10-24 | 先正达参股股份有限公司 | 增加植物中多肽表达的翻译增强子元件堆叠 |
| HRP20171564T1 (hr) * | 2009-09-22 | 2017-11-17 | Medicago Inc. | Postupak za pripremu biljnih čestica sličnih virusu (vlp) |
| US9352031B2 (en) | 2010-02-18 | 2016-05-31 | Technovax, Inc. | Universal virus-like particle (VLP) influenza vaccines |
| AU2011312178B2 (en) * | 2010-10-04 | 2016-05-12 | Massachusetts Institute Of Technology | Hemagglutinin polypeptides, and reagents and methods relating thereto |
| US20130295609A1 (en) | 2010-11-04 | 2013-11-07 | Medicago Inc. | Plant expression system |
| TWI526539B (zh) | 2010-12-22 | 2016-03-21 | 苜蓿股份有限公司 | 植物中生產類病毒顆粒(vlp)的方法及以該方法生產之vlp |
| TWI620816B (zh) * | 2011-03-23 | 2018-04-11 | 苜蓿股份有限公司 | 植物衍生蛋白回收方法 |
| MX350421B (es) | 2011-06-13 | 2017-09-06 | Medicago Inc | Producción de partículas tipo virus de la rabia en plantas. |
| PL220281B1 (pl) | 2011-09-23 | 2015-09-30 | Inst Biochemii I Biofizyki Polskiej Akademii Nauk | Szczepionka DNA, sposób indukowania odpowiedzi immunologicznej, przeciwciała specyficznie rozpoznające białko hemaglutyniny H5 wirusa grypy i zastosowanie szczepionki DNA |
| US11390878B2 (en) * | 2011-09-30 | 2022-07-19 | Medicago Inc. | Increasing protein yield in plants |
| SI2760882T1 (sl) | 2011-09-30 | 2023-10-30 | Medicago Inc. | Povečanje količine virusom podobnih delcev v rastlinah |
| CN104010655B (zh) | 2011-11-11 | 2018-06-22 | 菲利普莫里斯生产公司 | 普通烟草中产生的包含血凝素的流感病毒样颗粒(vlp) |
| WO2014017493A1 (ja) * | 2012-07-23 | 2014-01-30 | 有限会社生物資源研究所 | ワクチン |
| JP2016516415A (ja) | 2013-03-28 | 2016-06-09 | メディカゴ インコーポレイテッド | 植物におけるインフルエンザウイルス様粒子の生成 |
-
2014
- 2014-03-28 JP JP2016504431A patent/JP2016516415A/ja active Pending
- 2014-03-28 RU RU2015146097A patent/RU2705555C2/ru active
- 2014-03-28 MX MX2015013700A patent/MX376138B/es active IP Right Grant
- 2014-03-28 CN CN202011519705.6A patent/CN112592389A/zh active Pending
- 2014-03-28 EP EP19206629.8A patent/EP3626827A1/en active Pending
- 2014-03-28 CA CA2907591A patent/CA2907591A1/en active Pending
- 2014-03-28 ES ES14773061T patent/ES2803508T3/es active Active
- 2014-03-28 WO PCT/CA2014/050326 patent/WO2014153674A1/en not_active Ceased
- 2014-03-28 US US14/779,423 patent/US10358652B2/en active Active
- 2014-03-28 KR KR1020157030865A patent/KR102199018B1/ko active Active
- 2014-03-28 CN CN201480029001.7A patent/CN105247059B/zh active Active
- 2014-03-28 SG SG11201507928QA patent/SG11201507928QA/en unknown
- 2014-03-28 IL IL295155A patent/IL295155A/en unknown
- 2014-03-28 AU AU2014245779A patent/AU2014245779B2/en active Active
- 2014-03-28 IL IL241692A patent/IL241692B2/en unknown
- 2014-03-28 EP EP14773061.8A patent/EP2978848B1/en active Active
- 2014-03-28 RU RU2019135043A patent/RU2742607C1/ru active
-
2015
- 2015-09-23 PH PH12015502217A patent/PH12015502217B1/en unknown
- 2015-10-26 ZA ZA2015/08327A patent/ZA201508327B/en unknown
-
2019
- 2019-03-29 JP JP2019067570A patent/JP7065803B2/ja active Active
- 2019-07-19 US US16/516,802 patent/US11085049B2/en active Active
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