JP2010533001A5 - - Google Patents
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- Publication number
- JP2010533001A5 JP2010533001A5 JP2010516334A JP2010516334A JP2010533001A5 JP 2010533001 A5 JP2010533001 A5 JP 2010533001A5 JP 2010516334 A JP2010516334 A JP 2010516334A JP 2010516334 A JP2010516334 A JP 2010516334A JP 2010533001 A5 JP2010533001 A5 JP 2010533001A5
- Authority
- JP
- Japan
- Prior art keywords
- vlp
- plant
- composition
- influenza virus
- nucleic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 101710154606 Hemagglutinin Proteins 0.000 claims 6
- 101710093908 Outer capsid protein VP4 Proteins 0.000 claims 6
- 101710135467 Outer capsid protein sigma-1 Proteins 0.000 claims 6
- 101710176177 Protein A56 Proteins 0.000 claims 6
- 239000000185 hemagglutinin Substances 0.000 claims 5
- 238000000034 method Methods 0.000 claims 4
- 102000039446 nucleic acids Human genes 0.000 claims 4
- 108020004707 nucleic acids Proteins 0.000 claims 4
- 150000007523 nucleic acids Chemical class 0.000 claims 4
- 241000712461 unidentified influenza virus Species 0.000 claims 4
- 230000001939 inductive effect Effects 0.000 claims 3
- 206010022000 influenza Diseases 0.000 claims 3
- 239000002773 nucleotide Substances 0.000 claims 3
- 125000003729 nucleotide group Chemical group 0.000 claims 3
- 239000003937 drug carrier Substances 0.000 claims 2
- 230000028993 immune response Effects 0.000 claims 2
- 230000036039 immunity Effects 0.000 claims 2
- 239000002245 particle Substances 0.000 claims 2
- 230000009385 viral infection Effects 0.000 claims 2
- 235000015872 dietary supplement Nutrition 0.000 claims 1
- 150000002632 lipids Chemical class 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 230000001105 regulatory effect Effects 0.000 claims 1
Applications Claiming Priority (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US95941407P | 2007-07-13 | 2007-07-13 | |
| US60/959,414 | 2007-07-13 | ||
| US99060307P | 2007-11-27 | 2007-11-27 | |
| US60/990,603 | 2007-11-27 | ||
| US1327207P | 2007-12-12 | 2007-12-12 | |
| US61/013,272 | 2007-12-12 | ||
| CA002615372A CA2615372A1 (en) | 2007-07-13 | 2008-01-21 | Influenza virus-like particles (vlps) comprising hemagglutinin |
| CA2,615,372 | 2008-01-21 | ||
| US2277508P | 2008-01-22 | 2008-01-22 | |
| US61/022,775 | 2008-01-22 | ||
| PCT/CA2008/001281 WO2009009876A1 (en) | 2007-07-13 | 2008-07-11 | Influenza virus-like particles (vlps) comprising hemagglutinin produced within a plant |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010533001A JP2010533001A (ja) | 2010-10-21 |
| JP2010533001A5 true JP2010533001A5 (enExample) | 2013-08-29 |
| JP5624465B2 JP5624465B2 (ja) | 2014-11-12 |
Family
ID=40255124
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010516334A Active JP5624465B2 (ja) | 2007-07-13 | 2008-07-11 | 植物内で生成されるヘマグルチニンを含むインフルエンザウイルス様粒子（ｖｌｐ） |
Country Status (19)
| Country | Link |
|---|---|
| US (4) | US20100239610A1 (enExample) |
| EP (1) | EP2173886B1 (enExample) |
| JP (1) | JP5624465B2 (enExample) |
| KR (1) | KR101541330B1 (enExample) |
| CN (1) | CN101883856B (enExample) |
| AU (1) | AU2008278222B2 (enExample) |
| CA (2) | CA2615372A1 (enExample) |
| CR (1) | CR11209A (enExample) |
| DK (1) | DK2173886T3 (enExample) |
| EA (1) | EA018206B1 (enExample) |
| ES (1) | ES2428384T3 (enExample) |
| MX (1) | MX2010000525A (enExample) |
| MY (1) | MY155236A (enExample) |
| NZ (1) | NZ582360A (enExample) |
| PL (1) | PL2173886T3 (enExample) |
| PT (1) | PT2173886E (enExample) |
| SI (1) | SI2173886T1 (enExample) |
| TN (1) | TN2009000557A1 (enExample) |
| WO (1) | WO2009009876A1 (enExample) |
Families Citing this family (66)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI324181B (en) | 2001-04-16 | 2010-05-01 | Martek Biosciences Corp | Product and process for transformation of thraustochytriales microorganisms |
| US7566458B2 (en) | 2003-06-16 | 2009-07-28 | Medimmune, Llc | Influenza hemagglutinin and neuraminidase variants |
| ES2527503T3 (es) | 2005-03-08 | 2015-01-26 | Medimmune, Llc | Virus influenza reordenantes |
| AU2007345768B2 (en) * | 2006-07-27 | 2013-08-01 | Ligocyte Pharmaceuticals, Inc. | Chimeric influenza virus-like particles |
| CA2615372A1 (en) | 2007-07-13 | 2009-01-13 | Marc-Andre D'aoust | Influenza virus-like particles (vlps) comprising hemagglutinin |
| KR20100120157A (ko) | 2007-11-27 | 2010-11-12 | 메디카고 인코포레이티드 | 헤마글루티닌을 발현하는 트랜스제닉 식물에서 생산된 재조합 인플루엔자 바이러스-유사 입자(ＶＬＰｓ) |
| EP2294202B1 (en) | 2008-07-08 | 2015-05-20 | Medicago Inc. | Soluble recombinant influenza antigens |
| CN102149405A (zh) * | 2008-07-11 | 2011-08-10 | 米迪缪尼股份有限公司 | 流感血凝素和神经氨酸酶变体 |
| DK2318530T3 (en) | 2008-07-18 | 2016-10-03 | Medicago Inc | Ny epitope to immunization against influenza |
| AU2015202195B2 (en) * | 2008-07-18 | 2017-10-12 | Medicago Inc. | New influenza virus immunizing epitope |
| ES2752196T3 (es) | 2009-03-16 | 2020-04-03 | Dsm Ip Assets Bv | Producción de proteínas en microorganismos del filo Labyrinthulomycota |
| US9051359B2 (en) | 2009-03-30 | 2015-06-09 | Icahn School Of Medicine At Mount Sinai | Influenza virus vaccines and uses thereof |
| DK2417153T3 (en) | 2009-04-09 | 2014-12-01 | Alfa Biogene Internat B V | Filtration of a liquid comprising a stress protein from a plant |
| HRP20180706T1 (hr) | 2009-06-24 | 2018-06-01 | Medicago Inc. | Kimerna gripa nalik čestici koja sadrži hemaglutinin |
| PL222497B1 (pl) | 2009-06-26 | 2016-08-31 | Inst Biochemii I Biofizyki Pan | Wektorowa cząsteczka wirusopodobna, sposób jej wytwarzania, kompozycja farmaceutyczna oraz zastosowanie wektorowej cząsteczki wirusopodobnej |
| AU2010266129B2 (en) | 2009-07-02 | 2016-04-14 | Massachusetts Institute Of Technology | Compositions and methods for diagnosing and/or treating influenza infection |
| CN102549148A (zh) * | 2009-09-22 | 2012-07-04 | 麦迪卡格公司 | 制备植物来源的vlp的方法 |
| CA2785867C (en) | 2009-12-28 | 2018-03-27 | Dsm Ip Assets B.V. | Production of hemagglutinin-neuraminidase protein in microalgae |
| US10633667B2 (en) * | 2009-12-28 | 2020-04-28 | Boehringer Ingelheim Animal Health USA Inc. | Recombinant NDV antigen and uses thereof |
| EP4130273B1 (en) * | 2009-12-28 | 2024-06-12 | Sanofi Vaccine Technologies, S.A.S. | Production of heterologous polypeptides in microalgae, microalgal extracellular bodies, compositions, and methods of making and uses thereof |
| AU2015202267B2 (en) * | 2010-01-26 | 2017-03-23 | The Trustees Of The University Of Pennsylvania | Influenza nucleic acid molecules and vaccines made therefrom |
| US8298820B2 (en) | 2010-01-26 | 2012-10-30 | The Trustees Of The University Of Pennsylvania | Influenza nucleic acid molecules and vaccines made therefrom |
| WO2011103453A2 (en) | 2010-02-18 | 2011-08-25 | Mount Sinai School Of Medicine | Vaccines for use in the prophylaxis and treatment of influenza virus disease |
| US9708373B2 (en) | 2010-03-30 | 2017-07-18 | Icahn School Of Medicine At Mount Sinai | Influenza virus vaccine and uses thereof |
| AU2011305371B2 (en) | 2010-09-21 | 2015-05-21 | Massachusetts Institute Of Technology | Human-adapted HA polypeptides, vaccines, and influenza treatment |
| JP2013542928A (ja) | 2010-09-30 | 2013-11-28 | フランバックス ソチエタ レスポンサビリタ リミテ | ビロソーム粒子の生成 |
| CN103328002B (zh) | 2010-10-04 | 2020-01-14 | 麻省理工学院 | 血球凝集素多肽以及与其相关的试剂和方法 |
| BR112013010385A2 (pt) * | 2010-10-27 | 2016-08-02 | Philip Morris Products Sa | métodos para capturar partículas semelhantes a vírus de plantas usando cromatografia expandida |
| US20130295609A1 (en) * | 2010-11-04 | 2013-11-07 | Medicago Inc. | Plant expression system |
| TWI526539B (zh) | 2010-12-22 | 2016-03-21 | 苜蓿股份有限公司 | 植物中生產類病毒顆粒(vlp)的方法及以該方法生產之vlp |
| CN103502455A (zh) * | 2011-01-17 | 2014-01-08 | 菲利普莫里斯生产公司 | 用于在植物中核酸表达的载体 |
| TWI620816B (zh) * | 2011-03-23 | 2018-04-11 | 苜蓿股份有限公司 | 植物衍生蛋白回收方法 |
| US20140227322A1 (en) * | 2011-06-13 | 2014-08-14 | Medicago Inc. | Rabies virus like particle production in plants |
| EP2721158B1 (en) | 2011-06-20 | 2017-05-03 | University of Pittsburgh - Of the Commonwealth System of Higher Education | Computationally optimized broadly reactive antigens for h1n1 influenza |
| WO2013043729A1 (en) | 2011-09-20 | 2013-03-28 | Mount Sinai School Of Medicine | Influenza virus vaccines and uses thereof |
| US11390878B2 (en) | 2011-09-30 | 2022-07-19 | Medicago Inc. | Increasing protein yield in plants |
| TWI700368B (zh) | 2011-09-30 | 2020-08-01 | 苜蓿股份有限公司 | 增加植物類病毒顆粒產率 |
| JP6390846B2 (ja) * | 2011-11-11 | 2018-09-19 | フィリップ・モーリス・プロダクツ・ソシエテ・アノニム | ニコチアナタバカムにおいて生成される血球凝集素を含むインフルエンザウイルス様粒子（ｖｌｐ） |
| AU2013217166B2 (en) | 2012-02-07 | 2017-04-06 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Computationally optimized broadly reactive antigens for H3N2, H2N2, and B influenza viruses |
| US9566327B2 (en) | 2012-02-13 | 2017-02-14 | University of Pittsburgh—of the Commonwealth System of Higher Education | Computationally optimized broadly reactive antigens for human and avian H5N1 influenza |
| BR112014019755B1 (pt) | 2012-03-22 | 2022-02-22 | Fraunhofer Usa, Inc | Partícula do tipo viral; método de produção das partículas do tipo viral; composição imunogênica e uso das partículas do tipo viral |
| ES2845698T3 (es) * | 2012-05-11 | 2021-07-27 | Medicago Inc | Producción de partículas de tipo rotavirus en plantas |
| NZ705488A (en) | 2012-09-05 | 2018-05-25 | Medicago Inc | Picornavirus-like particle production in plants |
| EP2934581B1 (en) | 2012-12-18 | 2022-09-14 | Icahn School of Medicine at Mount Sinai | Influenza virus vaccines and uses thereof |
| US9908930B2 (en) | 2013-03-14 | 2018-03-06 | Icahn School Of Medicine At Mount Sinai | Antibodies against influenza virus hemagglutinin and uses thereof |
| US12467058B2 (en) | 2013-03-28 | 2025-11-11 | Aramis Biotechnologies Inc. | Influenza virus-like particle production in plants |
| IL295155A (en) | 2013-03-28 | 2022-09-01 | Medicago Inc | Production of influenza virus-like particles in plants |
| JP6358257B2 (ja) | 2013-09-06 | 2018-07-18 | 三菱ケミカル株式会社 | 植物を用いたタンパク質の製造方法 |
| AU2015234595B2 (en) | 2014-03-27 | 2021-03-25 | Medicago Inc. | Modified CPMV enhancer elements |
| AU2015286165B2 (en) * | 2014-07-11 | 2021-03-11 | Medicago Inc. | Modifying protein production in plants |
| CA2974438A1 (en) | 2015-01-23 | 2016-07-28 | Medicago Inc. | Rotavirus-like particle production in plants |
| AU2016209032A1 (en) | 2015-01-23 | 2017-08-10 | Icahn School Of Medicine At Mount Sinai | Influenza virus vaccination regimens |
| KR101637955B1 (ko) * | 2015-05-18 | 2016-07-08 | 한국생명공학연구원 | 범용성 인플루엔자 바이러스 백신 조성물 |
| MX2017016366A (es) | 2015-07-02 | 2018-05-22 | Medicago Inc | Activador del ciclo de acido jasmonico. |
| EP3471767A4 (en) | 2016-06-15 | 2020-01-15 | Icahn School of Medicine at Mount Sinai | Influenza virus hemagglutinin proteins and uses thereof |
| EP3606555A4 (en) | 2017-04-07 | 2021-08-04 | Icahn School of Medicine at Mount Sinai | INFLUENZA VIRUS TYPE B ANTI-NEURAMINIDASE ANTIBODIES AND THEIR USES |
| CA3093592A1 (en) | 2018-03-14 | 2019-09-19 | Medicago Inc. | Plant expression enhancer |
| KR101964044B1 (ko) * | 2018-03-14 | 2019-04-02 | 인제대학교 산학협력단 | 재조합 아데노바이러스를 이용한 다가형 인플루엔자 생백신 플랫폼 |
| EP3810634A4 (en) | 2018-06-21 | 2022-07-27 | Icahn School of Medicine at Mount Sinai | Mosaic influenza virus hemagglutinin polypeptides and uses thereof |
| US12139511B2 (en) * | 2018-06-27 | 2024-11-12 | Aramis Biotechnologies Inc. | Influenza virus hemagglutinin mutants |
| JP2021528999A (ja) * | 2018-07-04 | 2021-10-28 | プロバイオジェン アーゲー | エンベロープウイルスの精製方法 |
| JP7512546B2 (ja) | 2019-03-14 | 2024-07-09 | アラミス バイオテクノロジーズ インコーポレイテッド | 内因性植物発現エンハンサー |
| US12245754B2 (en) | 2019-07-03 | 2025-03-11 | Aillis Inc. | Pharmaceutical composition for treating influenza virus infections |
| CN111122417B (zh) * | 2020-02-22 | 2022-06-21 | 太原理工大学 | 一种测定含瓦斯煤开闭孔总体积膨胀率的装置及方法 |
| EP4351320A1 (en) | 2021-06-09 | 2024-04-17 | ImmunityBio, Inc. | Methods and systems for producing a protein of interest in a plant |
| CN115992101B (zh) * | 2023-03-22 | 2023-07-28 | 深圳市卫光生物制品股份有限公司 | 一种流感病毒裂解疫苗原液的制备方法 |
Family Cites Families (63)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0203177A4 (en) | 1984-11-29 | 1987-04-28 | Scripps Clinic Res | POLYPEPTIDES AND ANTIBODIES AGAINST DEGGLYCOSILIZED VIRAL GLYCOPROTEINS. |
| US5232833A (en) * | 1988-09-14 | 1993-08-03 | Stressgen Biotechnologies Corporation | Accumulation of heat shock proteins for evaluating biological damage due to chronic exposure of an organism to sublethal levels of pollutants |
| EP0509656B1 (en) * | 1991-03-28 | 1996-09-18 | Rooperol (Na) Nv | Compositions of phytosterols and phytosterolins as immunmodulators |
| US6326470B1 (en) | 1997-04-15 | 2001-12-04 | The Penn State Research Foundation | Enhancement of accessibility of cellulose by expansins |
| US5762939A (en) * | 1993-09-13 | 1998-06-09 | Mg-Pmc, Llc | Method for producing influenza hemagglutinin multivalent vaccines using baculovirus |
| GB9414118D0 (en) | 1994-07-13 | 1994-08-31 | Axis Genetics Ltd | Modified plant viruses as vectors of heterologous peptides |
| AU6504796A (en) | 1995-07-20 | 1997-02-18 | Washington State University Research Foundation | Production of secreted foreign polypeptides in plant cell culture |
| US6042832A (en) | 1996-08-28 | 2000-03-28 | Thomas Jefferson University | Polypeptides fused with alfalfa mosaic virus or ilarvirus capsid proteins |
| US20010006950A1 (en) | 1998-02-11 | 2001-07-05 | Juha Punnonen | Genetic vaccine vector engineering |
| US6489537B1 (en) | 1998-08-07 | 2002-12-03 | The Trustees Of The University Of Pennsylvania | Phytochelatin synthases and uses therefor |
| NZ510358A (en) | 1998-08-11 | 2002-09-27 | Large Scale Biology Corp | Method for recovering proteins from the interstitial fluid of plant tissues |
| US6392121B1 (en) | 1998-10-07 | 2002-05-21 | Boyce Thompson Institute For Plant Research | Gemini virus vectors for gene expression in plants |
| US6287570B1 (en) * | 1998-11-23 | 2001-09-11 | Patricia L. Foley | Vaccine against swine influenza virus |
| FR2791358B1 (fr) | 1999-03-22 | 2003-05-16 | Meristem Therapeutics | Promoteurs chimeriques d'expression, cassettes d'expression, plasmides, vecteurs, plantes et semences transgeniques les contenant et leurs methodes d'obtention |
| AU4134000A (en) | 1999-04-29 | 2000-11-17 | Syngenta Limited | Herbicide resistant plants |
| US7125978B1 (en) | 1999-10-04 | 2006-10-24 | Medicago Inc. | Promoter for regulating expression of foreign genes |
| DK1362109T3 (da) | 2001-01-18 | 2009-07-27 | Vlaams Interuniv Inst Biotech | Rekombinante oligomere protein-komplekser med foröget immunogent potentiale |
| CN1333370A (zh) * | 2001-08-16 | 2002-01-30 | 深圳市三方圆信息技术有限公司 | 抗家禽病毒病的作物及其生产方法 |
| HUE050222T2 (hu) * | 2002-02-13 | 2020-11-30 | Wisconsin Alumni Res Found | Szignál influenzavírus-vektorok pakolására |
| WO2003068804A2 (en) | 2002-02-14 | 2003-08-21 | Novavax, Inc. | Novel insect cell line |
| AU2003219402B2 (en) * | 2002-03-19 | 2008-05-08 | Stichting Dienst Landbouwkundig Onderzoek | GnTIII (UDP-n-acethylglucosamine:beta-D mannoside beta (1,4)-N-acethylglucosaminy ltransferase III) expression in plants |
| ES2224792B1 (es) | 2002-06-28 | 2007-02-16 | Era Plantech, S.L. | Produccion de peptidos y proteinas por acumulacion de cuerpos proteicos derivados de reticulos endoplasmico en plantas. |
| CU23202A1 (es) * | 2003-01-31 | 2007-05-18 | Ct Ingenieria Genetica Biotech | ANTIGENOS RECOMBINANTES DEL VIRUS DE LA HEPATITIS A OBTENIDOS EN CéLULAS VEGETALES |
| CN1460718A (zh) * | 2003-04-11 | 2003-12-10 | 浙江大学 | 表达传染性支气管炎病毒纤突蛋白的转基因马铃薯生产方法 |
| JP2007526215A (ja) | 2003-05-05 | 2007-09-13 | ダウ アグロサイエンス リミテッド ライアビリティー カンパニー | トランスジェニック植物細胞に由来する安定な免疫予防的および治療的組成物ならびにその産生方法 |
| ZA200508930B (en) * | 2003-05-05 | 2007-03-28 | Thompson Boyce Inst Plant Research | Vectors and cells for preparing immunoprotective compositions derived from transgenic plants |
| US7566458B2 (en) * | 2003-06-16 | 2009-07-28 | Medimmune, Llc | Influenza hemagglutinin and neuraminidase variants |
| US8592197B2 (en) | 2003-07-11 | 2013-11-26 | Novavax, Inc. | Functional influenza virus-like particles (VLPs) |
| CN1926238A (zh) * | 2004-02-27 | 2007-03-07 | 陶氏化学公司 | 植物细胞中的高效肽生产 |
| WO2006016380A2 (en) | 2004-08-13 | 2006-02-16 | Council Of Scientific And Industrial Research | A chimeric g protein based rabies vaccine |
| US8535930B2 (en) | 2005-04-29 | 2013-09-17 | University Of Cape Town | Expression of proteins in plants |
| CN100410378C (zh) | 2005-05-09 | 2008-08-13 | 中国农业科学院生物技术研究所 | 编码禽流感血凝素的基因及其植物表达载体和应用 |
| WO2007011904A2 (en) | 2005-07-19 | 2007-01-25 | Dow Global Technologies Inc. | Recombinant flu vaccines |
| US7871626B2 (en) | 2005-08-04 | 2011-01-18 | St. Jude Children's Research Hospital | Modified influenza virus for monitoring and improving vaccine efficiency |
| CN101605558A (zh) | 2005-08-16 | 2009-12-16 | 夏威夷生物技术公司 | 流感重组亚单位疫苗 |
| JP5714799B2 (ja) * | 2005-10-18 | 2015-05-07 | ノババックス インコーポレイテッド | 機能的インフルエンザウイルス様粒子（ｖｌｐ） |
| WO2007081447A2 (en) | 2005-11-22 | 2007-07-19 | Novartis Vaccines And Diagnostics, Inc. | Norovirus and sapovirus antigens |
| KR20080106433A (ko) | 2006-02-13 | 2008-12-05 | 프라운호퍼 유에스에이, 인코포레이티드 | 인플루엔자 항원, 백신 조성물 및 관련 방법 |
| BRPI0710689A2 (pt) | 2006-04-21 | 2012-02-22 | Dow Agrosciences Llc | método para preparação de uma vacina de aiv feita de planta e a referida vacina |
| WO2007130327A2 (en) | 2006-05-01 | 2007-11-15 | Technovax, Inc. | Influenza virus-like particle (vlp) compositions |
| US9511134B2 (en) | 2006-05-18 | 2016-12-06 | Epimmune Inc. | Inducing immune responses to influenza virus using polypeptide and nucleic acid compositions |
| US20070286873A1 (en) * | 2006-05-23 | 2007-12-13 | Williams John V | Recombinant Influenza H5 Hemagluttinin Protein And Nucleic Acid Coding Therefor |
| US7730950B2 (en) | 2007-01-19 | 2010-06-08 | Halliburton Energy Services, Inc. | Methods for treating intervals of a subterranean formation having variable permeability |
| KR101385050B1 (ko) | 2007-06-15 | 2014-05-13 | 메디카고 인코포레이티드 | 식물에서 당단백질 생산의 변형 |
| KR100964462B1 (ko) | 2007-07-10 | 2010-06-16 | 성균관대학교산학협력단 | 형질전환 식물 유래의 조류독감 바이러스 백신 및 그 제조방법 |
| CA2615372A1 (en) | 2007-07-13 | 2009-01-13 | Marc-Andre D'aoust | Influenza virus-like particles (vlps) comprising hemagglutinin |
| CN101820903A (zh) | 2007-08-20 | 2010-09-01 | 美国弗劳恩霍夫股份有限公司 | 预防性和治疗性流感疫苗、抗原、组合物和方法 |
| KR20100120157A (ko) | 2007-11-27 | 2010-11-12 | 메디카고 인코포레이티드 | 헤마글루티닌을 발현하는 트랜스제닉 식물에서 생산된 재조합 인플루엔자 바이러스-유사 입자(ＶＬＰｓ) |
| WO2009083420A1 (en) | 2007-12-28 | 2009-07-09 | Unilever Plc | Process for recovering aroma from tea |
| GB0800272D0 (en) | 2008-01-08 | 2008-02-13 | Plant Bioscience Ltd | Protein expression systems |
| SG187500A1 (en) | 2008-01-21 | 2013-02-28 | Medicago Inc | Recombinant influenza virus-like particles (vlps) produced in transgenic plants expressing hemagglutinin |
| EP2294202B1 (en) | 2008-07-08 | 2015-05-20 | Medicago Inc. | Soluble recombinant influenza antigens |
| DK2318530T3 (en) * | 2008-07-18 | 2016-10-03 | Medicago Inc | Ny epitope to immunization against influenza |
| AU2009285667B2 (en) | 2008-08-27 | 2015-05-28 | Arizona Board Of Regents For And On Behalf Of Arizona State University | A DNA replicon system for high-level rapid production of vaccines and monoclonal antibody therapeutics in plants |
| WO2010025235A1 (en) | 2008-08-29 | 2010-03-04 | Regents Of The University Of Michigan | Selective ligands for the dopamine 3 (d3) receptor and methods of using the same |
| WO2010077712A1 (en) | 2008-12-09 | 2010-07-08 | Novavax, Inc. | Bovine respiratory syncytial virus virus-like particle (vlps) |
| HRP20180706T1 (hr) * | 2009-06-24 | 2018-06-01 | Medicago Inc. | Kimerna gripa nalik čestici koja sadrži hemaglutinin |
| WO2011011390A1 (en) | 2009-07-20 | 2011-01-27 | Novavax, Inc. | Purified recombinant influenza virus ha proteins |
| CN102549148A (zh) | 2009-09-22 | 2012-07-04 | 麦迪卡格公司 | 制备植物来源的vlp的方法 |
| EP2536428B1 (en) | 2010-02-18 | 2018-12-05 | Technovax, Inc. | Universal virus-like particle (vlp) influenza vaccines |
| US20130295609A1 (en) | 2010-11-04 | 2013-11-07 | Medicago Inc. | Plant expression system |
| HUE034247T2 (en) | 2010-11-05 | 2018-02-28 | Novavax Inc | RABIES GLYCOPROTEIN VIRUS-LIKE PARTICLES (VLPs) |
| TWI526539B (zh) | 2010-12-22 | 2016-03-21 | 苜蓿股份有限公司 | 植物中生產類病毒顆粒(vlp)的方法及以該方法生產之vlp |
-
2008
- 2008-01-21 CA CA002615372A patent/CA2615372A1/en not_active Abandoned
- 2008-07-11 JP JP2010516334A patent/JP5624465B2/ja active Active
- 2008-07-11 DK DK08783201.0T patent/DK2173886T3/da active
- 2008-07-11 EP EP08783201.0A patent/EP2173886B1/en active Active
- 2008-07-11 PT PT87832010T patent/PT2173886E/pt unknown
- 2008-07-11 MX MX2010000525A patent/MX2010000525A/es active IP Right Grant
- 2008-07-11 CA CA2693956A patent/CA2693956C/en active Active
- 2008-07-11 US US12/669,033 patent/US20100239610A1/en not_active Abandoned
- 2008-07-11 SI SI200831024T patent/SI2173886T1/sl unknown
- 2008-07-11 MY MYPI2010000142A patent/MY155236A/en unknown
- 2008-07-11 EA EA201000195A patent/EA018206B1/ru not_active IP Right Cessation
- 2008-07-11 WO PCT/CA2008/001281 patent/WO2009009876A1/en not_active Ceased
- 2008-07-11 AU AU2008278222A patent/AU2008278222B2/en active Active
- 2008-07-11 KR KR1020107002538A patent/KR101541330B1/ko active Active
- 2008-07-11 PL PL08783201T patent/PL2173886T3/pl unknown
- 2008-07-11 ES ES08783201T patent/ES2428384T3/es active Active
- 2008-07-11 NZ NZ582360A patent/NZ582360A/en unknown
- 2008-07-11 CN CN2008801070729A patent/CN101883856B/zh active Active
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2009
- 2009-07-02 US US13/003,570 patent/US9492528B2/en active Active
- 2009-12-31 TN TNP2009000557A patent/TN2009000557A1/fr unknown
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2010
- 2010-01-11 CR CR11209A patent/CR11209A/es not_active Application Discontinuation
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2013
- 2013-01-04 US US13/734,886 patent/US9452210B2/en active Active
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2022
- 2022-07-27 US US17/815,503 patent/US20230044454A1/en not_active Abandoned
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