JP2010533001A5 - - Google Patents

Download PDF

Info

Publication number
JP2010533001A5
JP2010533001A5 JP2010516334A JP2010516334A JP2010533001A5 JP 2010533001 A5 JP2010533001 A5 JP 2010533001A5 JP 2010516334 A JP2010516334 A JP 2010516334A JP 2010516334 A JP2010516334 A JP 2010516334A JP 2010533001 A5 JP2010533001 A5 JP 2010533001A5
Authority
JP
Japan
Prior art keywords
vlp
plant
composition
influenza virus
nucleic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2010516334A
Other languages
English (en)
Japanese (ja)
Other versions
JP2010533001A (ja
JP5624465B2 (ja
Filing date
Publication date
Priority claimed from CA002615372A external-priority patent/CA2615372A1/en
Application filed filed Critical
Publication of JP2010533001A publication Critical patent/JP2010533001A/ja
Publication of JP2010533001A5 publication Critical patent/JP2010533001A5/ja
Application granted granted Critical
Publication of JP5624465B2 publication Critical patent/JP5624465B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2010516334A 2007-07-13 2008-07-11 植物内で生成されるヘマグルチニンを含むインフルエンザウイルス様粒子(vlp) Active JP5624465B2 (ja)

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US95941407P 2007-07-13 2007-07-13
US60/959,414 2007-07-13
US99060307P 2007-11-27 2007-11-27
US60/990,603 2007-11-27
US1327207P 2007-12-12 2007-12-12
US61/013,272 2007-12-12
CA002615372A CA2615372A1 (en) 2007-07-13 2008-01-21 Influenza virus-like particles (vlps) comprising hemagglutinin
CA2,615,372 2008-01-21
US2277508P 2008-01-22 2008-01-22
US61/022,775 2008-01-22
PCT/CA2008/001281 WO2009009876A1 (en) 2007-07-13 2008-07-11 Influenza virus-like particles (vlps) comprising hemagglutinin produced within a plant

Publications (3)

Publication Number Publication Date
JP2010533001A JP2010533001A (ja) 2010-10-21
JP2010533001A5 true JP2010533001A5 (enExample) 2013-08-29
JP5624465B2 JP5624465B2 (ja) 2014-11-12

Family

ID=40255124

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2010516334A Active JP5624465B2 (ja) 2007-07-13 2008-07-11 植物内で生成されるヘマグルチニンを含むインフルエンザウイルス様粒子(vlp)

Country Status (19)

Country Link
US (4) US20100239610A1 (enExample)
EP (1) EP2173886B1 (enExample)
JP (1) JP5624465B2 (enExample)
KR (1) KR101541330B1 (enExample)
CN (1) CN101883856B (enExample)
AU (1) AU2008278222B2 (enExample)
CA (2) CA2615372A1 (enExample)
CR (1) CR11209A (enExample)
DK (1) DK2173886T3 (enExample)
EA (1) EA018206B1 (enExample)
ES (1) ES2428384T3 (enExample)
MX (1) MX2010000525A (enExample)
MY (1) MY155236A (enExample)
NZ (1) NZ582360A (enExample)
PL (1) PL2173886T3 (enExample)
PT (1) PT2173886E (enExample)
SI (1) SI2173886T1 (enExample)
TN (1) TN2009000557A1 (enExample)
WO (1) WO2009009876A1 (enExample)

Families Citing this family (67)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI324181B (en) 2001-04-16 2010-05-01 Martek Biosciences Corp Product and process for transformation of thraustochytriales microorganisms
WO2005018539A2 (en) 2003-06-16 2005-03-03 Medimmune Vaccines, Inc. Influenza hemagglutinin and neuraminidase variants
ES2527503T3 (es) 2005-03-08 2015-01-26 Medimmune, Llc Virus influenza reordenantes
JP5683811B2 (ja) * 2006-07-27 2015-03-11 タケダ ヴァクシーンズ, インコーポレイテッド キメラインフルエンザウイルス様粒子
CA2615372A1 (en) 2007-07-13 2009-01-13 Marc-Andre D'aoust Influenza virus-like particles (vlps) comprising hemagglutinin
NZ587108A (en) 2007-11-27 2013-04-26 Medicago Inc Recombinant influenza virus-like particles (vlps) produced in transgenic plants expressing hemagglutinin
DK2294202T3 (en) 2008-07-08 2015-08-31 Medicago Inc SOLUBLE RECOMBINANT INFLUENZA ANTIGENES
RU2523587C2 (ru) * 2008-07-11 2014-07-20 МЕДИММЬЮН, ЭлЭлСи Варианты гемагглютинина и нейрамидазы вируса гриппа
AU2015202195B2 (en) * 2008-07-18 2017-10-12 Medicago Inc. New influenza virus immunizing epitope
KR101745925B1 (ko) * 2008-07-18 2017-06-12 메디카고 인코포레이티드 신규 인플루엔자 바이러스 면역화 에피토프
TWI504749B (zh) 2009-03-16 2015-10-21 Dsm Ip Assets Bv 於網黏菌門微生物中生產蛋白質之技術
JP2012521786A (ja) 2009-03-30 2012-09-20 モウント シナイ スクール オフ メディシネ インフルエンザウイルスワクチン及びその使用
US8933200B2 (en) 2009-04-09 2015-01-13 Alfa Biogene International B.V. Filtration of a liquid comprising a plant stress protein
SI2445928T1 (en) * 2009-06-24 2018-05-31 Medicago Inc. HYPER PARTICULARS, SIMILAR VIRUSES OF GRIPE, WHICH HAVE EXPOSED HEMAGLUTININE
PL222497B1 (pl) 2009-06-26 2016-08-31 Inst Biochemii I Biofizyki Pan Wektorowa cząsteczka wirusopodobna, sposób jej wytwarzania, kompozycja farmaceutyczna oraz zastosowanie wektorowej cząsteczki wirusopodobnej
AU2010266129B2 (en) 2009-07-02 2016-04-14 Massachusetts Institute Of Technology Compositions and methods for diagnosing and/or treating influenza infection
SG178918A1 (en) * 2009-09-22 2012-04-27 Medicago Inc Method of preparing plant-derived vlps
IN2012DN06277A (enExample) * 2009-12-28 2015-09-25 Dsm Ip Assets Bv
AR079767A1 (es) * 2009-12-28 2012-02-15 Merial Ltd Antigeno ndv (virus de la enfermedad de newcastle) recombinante y usos del mismo
EP2519636B8 (en) 2009-12-28 2017-08-09 DSM IP Assets B.V. Production of hemagglutinin-neuraminidase protein in microalgae
AU2015202267B2 (en) * 2010-01-26 2017-03-23 The Trustees Of The University Of Pennsylvania Influenza nucleic acid molecules and vaccines made therefrom
US8298820B2 (en) 2010-01-26 2012-10-30 The Trustees Of The University Of Pennsylvania Influenza nucleic acid molecules and vaccines made therefrom
US9701723B2 (en) 2010-02-18 2017-07-11 Icahn School Of Medicine At Mount Sinai Vaccines for use in the prophylaxis and treatment of influenza virus disease
MX2012011300A (es) 2010-03-30 2012-11-29 Sinai School Medicine Vacunas del virus de influenza y usos de las mismas.
CA2811023A1 (en) 2010-09-21 2012-03-29 Massachusetts Institute Of Technology Influenza treatment and/or characterization; human-adapted ha polypeptides; vaccines
MX2013003451A (es) 2010-09-30 2013-09-02 Franvax S R L Generacion de particulas de virosoma.
WO2012047941A2 (en) 2010-10-04 2012-04-12 Massachusetts Institute Of Technology Hemagglutinin polypeptides, and reagents and methods relating thereto
EP2632562B1 (en) * 2010-10-27 2020-08-05 Philip Morris Products S.a.s. Methods for capturing virus like particles from plants using expanded bed chromatography
ES2614527T3 (es) 2010-11-04 2017-05-31 Medicago Inc. Sistema de expresión en plantas
TWI526539B (zh) * 2010-12-22 2016-03-21 苜蓿股份有限公司 植物中生產類病毒顆粒(vlp)的方法及以該方法生產之vlp
EP2665817A1 (en) * 2011-01-17 2013-11-27 Philip Morris Products S.a.s. Vectors for nucleic acid expression in plants
TWI620816B (zh) 2011-03-23 2018-04-11 苜蓿股份有限公司 植物衍生蛋白回收方法
US20140227322A1 (en) * 2011-06-13 2014-08-14 Medicago Inc. Rabies virus like particle production in plants
JP6113155B2 (ja) 2011-06-20 2017-04-12 ユニバーシティ オブ ピッツバーグ − オブ ザ コモンウェルス システム オブ ハイヤー エデュケイション 計算で最適化した広い反応性を示すh1n1インフルエンザの抗原
HK1200102A1 (en) 2011-09-20 2015-07-31 西奈山医学院 Influenza virus vaccines and uses thereof
US11390878B2 (en) 2011-09-30 2022-07-19 Medicago Inc. Increasing protein yield in plants
TWI700368B (zh) 2011-09-30 2020-08-01 苜蓿股份有限公司 增加植物類病毒顆粒產率
WO2013068593A1 (en) * 2011-11-11 2013-05-16 Philip Morris Products S.A. Influenza virus -like particles (vlps) comprising hemagglutinin produced nicotiana tabacum
US9234008B2 (en) 2012-02-07 2016-01-12 University of Pittsburgh—of the Commonwealth System of Higher Education Computationally optimized broadly reactive antigens for H3N2, H2N2, and B influenza viruses
US9566327B2 (en) 2012-02-13 2017-02-14 University of Pittsburgh—of the Commonwealth System of Higher Education Computationally optimized broadly reactive antigens for human and avian H5N1 influenza
US9364530B2 (en) 2012-03-22 2016-06-14 Fraunhofer Usa, Inc. Virus-like particles comprising a matrix protein from a plant enveloped virus and uses thereof
PL3597757T3 (pl) * 2012-05-11 2021-05-31 Medicago Inc. Wytwarzanie cząstek podobnych do rotawirusów w roślinach
AU2013312971B2 (en) * 2012-09-05 2019-04-18 Medicago Inc. Picornavirus-like particle production in plants
NZ627796A (en) 2012-12-18 2017-07-28 Icahn School Med Mount Sinai Influenza virus vaccines and uses thereof
US9908930B2 (en) 2013-03-14 2018-03-06 Icahn School Of Medicine At Mount Sinai Antibodies against influenza virus hemagglutinin and uses thereof
JP2016516415A (ja) * 2013-03-28 2016-06-09 メディカゴ インコーポレイテッド 植物におけるインフルエンザウイルス様粒子の生成
US12467058B2 (en) 2013-03-28 2025-11-11 Aramis Biotechnologies Inc. Influenza virus-like particle production in plants
WO2015034042A1 (ja) 2013-09-06 2015-03-12 三菱化学株式会社 植物を用いたタンパク質の製造方法
AU2015234595B2 (en) 2014-03-27 2021-03-25 Medicago Inc. Modified CPMV enhancer elements
WO2016004536A1 (en) 2014-07-11 2016-01-14 Medicago Inc. Modifying protein production in plants
HK1245333A1 (zh) 2015-01-23 2018-08-24 Medicago Inc. 在植物中产生轮状病毒样颗粒
EP3247389A4 (en) 2015-01-23 2019-10-30 Icahn School of Medicine at Mount Sinai INFLUENZAVIRUSSCHUTZIMPFPLÄNE
KR101637955B1 (ko) * 2015-05-18 2016-07-08 한국생명공학연구원 범용성 인플루엔자 바이러스 백신 조성물
RU2728472C2 (ru) 2015-07-02 2020-07-29 Медикаго Инк. Активатор сигнального пути жасмоновой кислоты
MX2018015755A (es) 2016-06-15 2019-08-29 Icahn School Med Mount Sinai Proteinas de hemaglutinina de virus de influenza y usos de las mismas.
CA3058652A1 (en) 2017-04-07 2018-10-11 Icahn School Of Medicine At Mount Sinai Anti-influenza b virus neuraminidase antibodies and uses thereof
JP7423875B6 (ja) 2018-03-14 2024-03-15 メディカゴ インコーポレイテッド 植物発現エンハンサ
KR101964044B1 (ko) * 2018-03-14 2019-04-02 인제대학교 산학협력단 재조합 아데노바이러스를 이용한 다가형 인플루엔자 생백신 플랫폼
US12364746B2 (en) 2018-06-21 2025-07-22 Icahn School Of Medicine At Mount Sinai Mosaic influenza virus hemagglutinin polypeptides and uses thereof
AU2019295495B2 (en) 2018-06-27 2025-05-22 Aramis Biotechnologies Inc. Influenza virus hemagglutinin mutants
CA3104392A1 (en) * 2018-07-04 2020-01-09 Probiogen Ag Method for purifying an enveloped virus
BR112021017899A2 (pt) 2019-03-14 2021-12-21 Medicago Inc Intensificador de expressão vegetal endógeno
CA3137160A1 (en) 2019-04-24 2020-10-29 Icahn School Of Medicine At Mount Sinai Anti-influenza b virus neuraminidase antibodies and uses thereof
CA3145200A1 (en) 2019-07-03 2021-01-07 Aillis Inc. Pharmaceutical composition for treating influenza virus infections
CN111122417B (zh) * 2020-02-22 2022-06-21 太原理工大学 一种测定含瓦斯煤开闭孔总体积膨胀率的装置及方法
EP4351320A1 (en) 2021-06-09 2024-04-17 ImmunityBio, Inc. Methods and systems for producing a protein of interest in a plant
CN115992101B (zh) * 2023-03-22 2023-07-28 深圳市卫光生物制品股份有限公司 一种流感病毒裂解疫苗原液的制备方法

Family Cites Families (63)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0203177A4 (en) 1984-11-29 1987-04-28 Scripps Clinic Res POLYPEPTIDES AND ANTIBODIES ASSOCIATED WITH VIRAL GLUCOPROTEINS WITHOUT GLUCOSE.
US5232833A (en) * 1988-09-14 1993-08-03 Stressgen Biotechnologies Corporation Accumulation of heat shock proteins for evaluating biological damage due to chronic exposure of an organism to sublethal levels of pollutants
ATE142883T1 (de) * 1991-03-28 1996-10-15 Rooperol Na Nv Zusammensetzungen von phytosterolen mit phytosterolinen als immunmodulatoren
US6326470B1 (en) 1997-04-15 2001-12-04 The Penn State Research Foundation Enhancement of accessibility of cellulose by expansins
US5762939A (en) * 1993-09-13 1998-06-09 Mg-Pmc, Llc Method for producing influenza hemagglutinin multivalent vaccines using baculovirus
GB9414118D0 (en) 1994-07-13 1994-08-31 Axis Genetics Ltd Modified plant viruses as vectors of heterologous peptides
US6020169A (en) 1995-07-20 2000-02-01 Washington State University Research Foundation Production of secreted foreign polypeptides in plant cell culture
US6042832A (en) 1996-08-28 2000-03-28 Thomas Jefferson University Polypeptides fused with alfalfa mosaic virus or ilarvirus capsid proteins
US20010006950A1 (en) 1998-02-11 2001-07-05 Juha Punnonen Genetic vaccine vector engineering
US6489537B1 (en) 1998-08-07 2002-12-03 The Trustees Of The University Of Pennsylvania Phytochelatin synthases and uses therefor
MXPA01001445A (es) 1998-08-11 2002-11-29 Large Scale Biology Corp Metodo para recuperar proteinas a partir del fluido intersticial de tejidos de plantas.
US6392121B1 (en) 1998-10-07 2002-05-21 Boyce Thompson Institute For Plant Research Gemini virus vectors for gene expression in plants
US6287570B1 (en) * 1998-11-23 2001-09-11 Patricia L. Foley Vaccine against swine influenza virus
FR2791358B1 (fr) 1999-03-22 2003-05-16 Meristem Therapeutics Promoteurs chimeriques d'expression, cassettes d'expression, plasmides, vecteurs, plantes et semences transgeniques les contenant et leurs methodes d'obtention
ES2262514T3 (es) 1999-04-29 2006-12-01 Syngenta Limited Plantas resistentes a herbicidas.
US7125978B1 (en) 1999-10-04 2006-10-24 Medicago Inc. Promoter for regulating expression of foreign genes
US7449188B2 (en) 2001-01-18 2008-11-11 Vlaams Interuniversitair Instituut Voor Biotechnologie Recombinant oligometric protein complexes with enhanced immunogenic potential
CN1333370A (zh) * 2001-08-16 2002-01-30 深圳市三方圆信息技术有限公司 抗家禽病毒病的作物及其生产方法
AU2003219745B8 (en) * 2002-02-13 2008-10-09 Wisconsin Alumni Research Foundation Signal for packaging of influenza virus vectors
US7041500B2 (en) 2002-02-14 2006-05-09 Novavax, Inc. Insect cell line
EP2319935B1 (en) * 2002-03-19 2016-04-27 Stichting Dienst Landbouwkundig Onderzoek GnTIII (UDP-N-acetylglucosamine:Beta -D mannoside Beta (1,4)-N-acetylglucosaminyltransferase III) expression in plants.
ES2224792B1 (es) 2002-06-28 2007-02-16 Era Plantech, S.L. Produccion de peptidos y proteinas por acumulacion de cuerpos proteicos derivados de reticulos endoplasmico en plantas.
CU23202A1 (es) * 2003-01-31 2007-05-18 Ct Ingenieria Genetica Biotech ANTIGENOS RECOMBINANTES DEL VIRUS DE LA HEPATITIS A OBTENIDOS EN CéLULAS VEGETALES
CN1460718A (zh) * 2003-04-11 2003-12-10 浙江大学 表达传染性支气管炎病毒纤突蛋白的转基因马铃薯生产方法
NZ542933A (en) 2003-05-05 2009-08-28 Dow Agrosciences Llc Stable immunoprophylactic and therapeutic compositions derived from transgenic plant cells and methods for production
AU2004235813B2 (en) * 2003-05-05 2010-07-29 Boyce Thompson Institute For Plant Research Vectors and cells for preparing immunoprotective compositions derived from transgenic plants
WO2005018539A2 (en) * 2003-06-16 2005-03-03 Medimmune Vaccines, Inc. Influenza hemagglutinin and neuraminidase variants
US8592197B2 (en) 2003-07-11 2013-11-26 Novavax, Inc. Functional influenza virus-like particles (VLPs)
CN1926238A (zh) * 2004-02-27 2007-03-07 陶氏化学公司 植物细胞中的高效肽生产
WO2006016380A2 (en) 2004-08-13 2006-02-16 Council Of Scientific And Industrial Research A chimeric g protein based rabies vaccine
ES2662118T3 (es) 2005-04-29 2018-04-05 University Of Cape Town Expresión de proteínas virales en las plantas
CN100410378C (zh) 2005-05-09 2008-08-13 中国农业科学院生物技术研究所 编码禽流感血凝素的基因及其植物表达载体和应用
CA2615658A1 (en) 2005-07-19 2007-01-25 Dow Global Technolgies Inc. Recombinant flu vaccines
US7871626B2 (en) 2005-08-04 2011-01-18 St. Jude Children's Research Hospital Modified influenza virus for monitoring and improving vaccine efficiency
EP1945250A4 (en) 2005-08-16 2010-05-19 Hawaii Biotech Inc RECOMBINANT SUBUNIT VACCINE AGAINST INFLUENZA
RU2483751C2 (ru) * 2005-10-18 2013-06-10 Новавакс, Инк. ФУНКЦИОНАЛЬНЫЕ ВИРУСОПОДОБНЫЕ ЧАСТИЦЫ ГРИППА (VLPs)
AU2006335256B2 (en) 2005-11-22 2012-10-18 Novartis Vaccines And Diagnostics, Inc. Norovirus and sapovirus antigens
EP1984405A4 (en) 2006-02-13 2010-06-30 Fraunhofer Usa Inc INFLUENZA ANTIGENES, VACCINE COMPOSITIONS AND RELATED METHODS
KR20080109094A (ko) 2006-04-21 2008-12-16 다우 아그로사이언시즈 엘엘씨 조류 인플루엔자 백신 및 이용방법
US8778353B2 (en) 2006-05-01 2014-07-15 Technovax, Inc. Influenza virus-like particle (VLP) compositions
WO2008054540A2 (en) 2006-05-18 2008-05-08 Pharmexa Inc. Inducing immune responses to influenza virus using polypeptide and nucleic acid compositions
US20070286873A1 (en) * 2006-05-23 2007-12-13 Williams John V Recombinant Influenza H5 Hemagluttinin Protein And Nucleic Acid Coding Therefor
US7730950B2 (en) 2007-01-19 2010-06-08 Halliburton Energy Services, Inc. Methods for treating intervals of a subterranean formation having variable permeability
CN104962579A (zh) 2007-06-15 2015-10-07 麦迪卡格公司 修饰植物中的糖蛋白产生
KR100964462B1 (ko) 2007-07-10 2010-06-16 성균관대학교산학협력단 형질전환 식물 유래의 조류독감 바이러스 백신 및 그 제조방법
CA2615372A1 (en) * 2007-07-13 2009-01-13 Marc-Andre D'aoust Influenza virus-like particles (vlps) comprising hemagglutinin
CA2696764A1 (en) 2007-08-20 2009-02-26 Fraunhofer Usa, Inc. Prophylactic and therapeutic influenza vaccines, antigens, compositions, and methods
NZ587108A (en) * 2007-11-27 2013-04-26 Medicago Inc Recombinant influenza virus-like particles (vlps) produced in transgenic plants expressing hemagglutinin
CN101909454A (zh) 2007-12-28 2010-12-08 荷兰联合利华有限公司 从茶回收香味化合物的方法
GB0800272D0 (en) 2008-01-08 2008-02-13 Plant Bioscience Ltd Protein expression systems
SG187500A1 (en) 2008-01-21 2013-02-28 Medicago Inc Recombinant influenza virus-like particles (vlps) produced in transgenic plants expressing hemagglutinin
DK2294202T3 (en) 2008-07-08 2015-08-31 Medicago Inc SOLUBLE RECOMBINANT INFLUENZA ANTIGENES
KR101745925B1 (ko) 2008-07-18 2017-06-12 메디카고 인코포레이티드 신규 인플루엔자 바이러스 면역화 에피토프
CA2736796A1 (en) 2008-08-27 2010-03-04 Arizona Board Of Regents For And On Behalf Of Arizona State University A dna replicon system for high-level rapid production of vaccines and monoclonal antibody therapeutics in plants
WO2010025235A1 (en) 2008-08-29 2010-03-04 Regents Of The University Of Michigan Selective ligands for the dopamine 3 (d3) receptor and methods of using the same
WO2010077712A1 (en) 2008-12-09 2010-07-08 Novavax, Inc. Bovine respiratory syncytial virus virus-like particle (vlps)
SI2445928T1 (en) * 2009-06-24 2018-05-31 Medicago Inc. HYPER PARTICULARS, SIMILAR VIRUSES OF GRIPE, WHICH HAVE EXPOSED HEMAGLUTININE
WO2011011390A1 (en) 2009-07-20 2011-01-27 Novavax, Inc. Purified recombinant influenza virus ha proteins
SG178918A1 (en) 2009-09-22 2012-04-27 Medicago Inc Method of preparing plant-derived vlps
CA2789945A1 (en) 2010-02-18 2011-08-25 Technovax, Inc. Universal virus-like particle (vlp) influenza vaccines
ES2614527T3 (es) 2010-11-04 2017-05-31 Medicago Inc. Sistema de expresión en plantas
CA2817005C (en) 2010-11-05 2018-09-11 Novavax Inc. Rabies glycoprotein virus-like particles (vlps)
TWI526539B (zh) 2010-12-22 2016-03-21 苜蓿股份有限公司 植物中生產類病毒顆粒(vlp)的方法及以該方法生產之vlp

Similar Documents

Publication Publication Date Title
Tariq et al. Virus-like particles: revolutionary platforms for developing vaccines against emerging infectious diseases
Vahdat et al. Hepatitis B core-based virus-like particles: A platform for vaccine development in plants
Chen et al. Plant-derived virus-like particles as vaccines
Hadj Hassine et al. Virus‐like particles as powerful vaccination strategy against human viruses
Hemmati et al. Plant-derived VLP: a worthy platform to produce vaccine against SARS-CoV-2
MX2010003202A (es) Metodo para producir virus de la gripe.
MY161965A (en) New influenza virus immunizing epitope
EP3199545A3 (en) Computationally optimized broadly reactive antigens for h1n1 influenza
WO2010003225A8 (en) Influenza virus-like particles (vlps) comprising hemagglutinin
JP2016516415A5 (enExample)
JP2013216685A5 (enExample)
RU2015146097A (ru) Получение вирусоподобных частиц вируса гриппа в растениях
JP2011182797A5 (enExample)
WO2010148511A8 (en) Chimeric influenza virus-like particles comprising hemagglutinin
TN2009000557A1 (en) Influenza virus-like particles (vlps) comprising hemagglutinin produced within a plant
JP2010533737A5 (enExample)
NZ587108A (en) Recombinant influenza virus-like particles (vlps) produced in transgenic plants expressing hemagglutinin
MX394097B (es) Producción de partículas similares a virus en plantas.
RU2014116371A (ru) Повышение выхода вирусоподобных частиц в растениях
WO2008085147A3 (en) Novel plant virus particles and methods of inactivation thereof
CN104232594B (zh) 重组类禽型h1n1流感病毒灭活疫苗株(js40/pr8)及其制备方法和应用
RU2013154698A (ru) Получение вирусоподобной частицы вируса бешенства в растениях
MX2014000753A (es) Procedimiento para producir antigeno viral y vacunas.
JP2009225809A5 (enExample)
EP2261364A3 (en) Chloroplasts engineered to express pharmaceutical proteins