BR112020026620A8 - Mutantes de hemaglutinina do vírus influenza - Google Patents

Mutantes de hemaglutinina do vírus influenza

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Publication number
BR112020026620A8
BR112020026620A8 BR112020026620A BR112020026620A BR112020026620A8 BR 112020026620 A8 BR112020026620 A8 BR 112020026620A8 BR 112020026620 A BR112020026620 A BR 112020026620A BR 112020026620 A BR112020026620 A BR 112020026620A BR 112020026620 A8 BR112020026620 A8 BR 112020026620A8
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BR
Brazil
Prior art keywords
influenza virus
modified
influenza
vlp
production
Prior art date
Application number
BR112020026620A
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English (en)
Other versions
BR112020026620A2 (pt
Inventor
Alain Doucet
Aurélien Lorin
Manon Couture
MARC-ANDRé D'AOUST
Pierre-Olivier Lavoie
Original Assignee
Medicago Inc
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Publication date
Application filed by Medicago Inc filed Critical Medicago Inc
Publication of BR112020026620A2 publication Critical patent/BR112020026620A2/pt
Publication of BR112020026620A8 publication Critical patent/BR112020026620A8/pt

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/12Viral antigens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/12Viral antigens
    • A61K39/145Orthomyxoviridae, e.g. influenza virus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/16Antivirals for RNA viruses for influenza or rhinoviruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
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    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C07K14/08RNA viruses
    • C07K14/11Orthomyxoviridae, e.g. influenza virus
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    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
    • C07K16/1018Orthomyxoviridae, e.g. influenza virus
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    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8257Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon
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    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8257Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon
    • C12N15/8258Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon for the production of oral vaccines (antigens) or immunoglobulins
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    • C12P21/00Preparation of peptides or proteins
    • C12P21/02Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • AHUMAN NECESSITIES
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    • C12N2760/00011Details
    • C12N2760/16011Orthomyxoviridae
    • C12N2760/16023Virus like particles [VLP]
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    • C12N2760/00011Details
    • C12N2760/16011Orthomyxoviridae
    • C12N2760/16111Influenzavirus A, i.e. influenza A virus
    • C12N2760/16122New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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    • C12N2760/00011Details
    • C12N2760/16011Orthomyxoviridae
    • C12N2760/16111Influenzavirus A, i.e. influenza A virus
    • C12N2760/16123Virus like particles [VLP]
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    • C12N2760/00011Details
    • C12N2760/16011Orthomyxoviridae
    • C12N2760/16111Influenzavirus A, i.e. influenza A virus
    • C12N2760/16134Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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    • C12N2760/00011Details
    • C12N2760/16011Orthomyxoviridae
    • C12N2760/16111Influenzavirus A, i.e. influenza A virus
    • C12N2760/16151Methods of production or purification of viral material
    • C12N2760/16152Methods of production or purification of viral material relating to complementing cells and packaging systems for producing virus or viral particles

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  • Health & Medical Sciences (AREA)
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  • Genetics & Genomics (AREA)
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  • Biophysics (AREA)
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  • Plant Pathology (AREA)
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Abstract

mutantes de hemaglutinina do vírus influenza. a presente invenção refere-se à produção de proteínas virais de influenza modificadas em plantas. mais especificamente, a presente invenção se refere à produção e aumento da produção de partículas semelhantes ao vírus da gripe (vlp) em plantas, em que as vlps compreendem as proteínas virais da gripe modificadas, como a hemaglutinina da gripe modificada (ha). a proteína ha pode compreender uma sequência de aminoácidos compreendendo pelo menos uma substituição quando comparada a uma sequência de aminoácidos de tipo selvagem correspondente. além disso, são fornecidos ácidos nucleicos que codificam a proteína ha modificada. além disso, métodos de produção de uma partícula semelhante ao vírus da influenza (vlp) e métodos de aumento do rendimento de produção de uma partícula semelhante ao vírus da influenza (vlp) em uma planta, porção de uma planta ou célula vegetal também são fornecidos.
BR112020026620A 2018-06-27 2019-06-27 Mutantes de hemaglutinina do vírus influenza BR112020026620A8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862690780P 2018-06-27 2018-06-27
US62/690,780 2018-06-27
PCT/CA2019/050892 WO2020000100A1 (en) 2018-06-27 2019-06-27 Influenza virus hemagglutinin mutants

Publications (2)

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BR112020026620A2 BR112020026620A2 (pt) 2021-04-06
BR112020026620A8 true BR112020026620A8 (pt) 2022-01-25

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BR112020026638-8A BR112020026638A2 (pt) 2018-06-27 2019-06-27 Mutantes de hemaglutinina do vírus influenza
BR112020026620A BR112020026620A8 (pt) 2018-06-27 2019-06-27 Mutantes de hemaglutinina do vírus influenza
BR112020026537-3A BR112020026537A2 (pt) 2018-06-27 2019-06-27 Mutantes de hemaglutinina do vírus influenza

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Country Status (14)

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US (3) US20210340184A1 (pt)
EP (3) EP3814508A4 (pt)
JP (5) JP2021528972A (pt)
KR (3) KR20210024625A (pt)
CN (3) CN112639100A (pt)
AU (3) AU2019295497A1 (pt)
BR (3) BR112020026638A2 (pt)
CA (3) CA3103842A1 (pt)
IL (3) IL279729A (pt)
MX (3) MX2020013961A (pt)
PH (3) PH12020552197A1 (pt)
SG (3) SG11202012349QA (pt)
TW (3) TW202016308A (pt)
WO (3) WO2020000101A1 (pt)

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CN112654707A (zh) 2021-04-13
BR112020026638A2 (pt) 2021-04-06
MX2020013957A (es) 2021-03-09
SG11202012314YA (en) 2021-01-28
CA3103840A1 (en) 2020-01-02
EP3814509A4 (en) 2022-07-27
IL279719A (en) 2021-03-01
PH12020552219A1 (en) 2021-06-28
KR20210024625A (ko) 2021-03-05
CA3103842A1 (en) 2020-01-02
US12104196B2 (en) 2024-10-01
US20210221853A1 (en) 2021-07-22
CA3103849A1 (en) 2020-01-02
PH12020552252A1 (en) 2021-06-07
AU2019295496A1 (en) 2020-11-26
IL279729A (en) 2021-03-01
MX2020013959A (es) 2021-03-09
JP2024050651A (ja) 2024-04-10
PH12020552197A1 (en) 2021-06-28
AU2019295497A1 (en) 2020-11-26
SG11202012349QA (en) 2021-01-28
SG11202012398UA (en) 2021-01-28
KR20210025627A (ko) 2021-03-09
TW202017937A (zh) 2020-05-16
JP2021528970A (ja) 2021-10-28
EP3814507A1 (en) 2021-05-05
EP3814508A1 (en) 2021-05-05
EP3814508A4 (en) 2022-07-27
WO2020000100A1 (en) 2020-01-02
WO2020000099A1 (en) 2020-01-02
EP3814507A4 (en) 2022-07-06
WO2020000101A1 (en) 2020-01-02
BR112020026620A2 (pt) 2021-04-06
TW202016309A (zh) 2020-05-01
US20210340184A1 (en) 2021-11-04
TW202016308A (zh) 2020-05-01
MX2020013961A (es) 2021-03-09
US20210371472A1 (en) 2021-12-02
JP2024050650A (ja) 2024-04-10
CN112534056A (zh) 2021-03-19
JP2021528971A (ja) 2021-10-28
BR112020026537A2 (pt) 2021-04-06
AU2019295495A1 (en) 2020-11-26
JP2021528972A (ja) 2021-10-28
KR20210025626A (ko) 2021-03-09
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IL279726A (en) 2021-03-01
CN112639100A (zh) 2021-04-09

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