MX2020013961A - Mutantes de hemaglutinina del virus de la influenza. - Google Patents
Mutantes de hemaglutinina del virus de la influenza.Info
- Publication number
- MX2020013961A MX2020013961A MX2020013961A MX2020013961A MX2020013961A MX 2020013961 A MX2020013961 A MX 2020013961A MX 2020013961 A MX2020013961 A MX 2020013961A MX 2020013961 A MX2020013961 A MX 2020013961A MX 2020013961 A MX2020013961 A MX 2020013961A
- Authority
- MX
- Mexico
- Prior art keywords
- influenza virus
- modified
- vlp
- particle
- production
- Prior art date
Links
- 101710154606 Hemagglutinin Proteins 0.000 title abstract 5
- 101710093908 Outer capsid protein VP4 Proteins 0.000 title abstract 5
- 101710135467 Outer capsid protein sigma-1 Proteins 0.000 title abstract 5
- 101710176177 Protein A56 Proteins 0.000 title abstract 5
- 239000000185 hemagglutinin Substances 0.000 title abstract 3
- 241000712461 unidentified influenza virus Species 0.000 title abstract 3
- 206010022000 influenza Diseases 0.000 abstract 4
- 239000002245 particle Substances 0.000 abstract 3
- 108010067390 Viral Proteins Proteins 0.000 abstract 2
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 238000006467 substitution reaction Methods 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/145—Orthomyxoviridae, e.g. influenza virus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
- C07K14/08—RNA viruses
- C07K14/11—Orthomyxoviridae, e.g. influenza virus
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
- C07K16/1018—Orthomyxoviridae, e.g. influenza virus
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
- C12N15/8257—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon
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- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
- C12N15/8257—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon
- C12N15/8258—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon for the production of oral vaccines (antigens) or immunoglobulins
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5258—Virus-like particles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16023—Virus like particles [VLP]
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16033—Use of viral protein as therapeutic agent other than vaccine, e.g. apoptosis inducing or anti-inflammatory
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16123—Virus like particles [VLP]
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16151—Methods of production or purification of viral material
- C12N2760/16152—Methods of production or purification of viral material relating to complementing cells and packaging systems for producing virus or viral particles
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Virology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biochemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Biomedical Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Pulmonology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Communicable Diseases (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Physics & Mathematics (AREA)
- Gastroenterology & Hepatology (AREA)
- Plant Pathology (AREA)
- Cell Biology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Oncology (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
La presente invención se refiere a la producción de proteínas virales de influenza modificadas en plantas. Más específicamente, la presente invención se refiere a producir y aumentar la producción de partículas similares al virus de la influenza (PSV) en plantas, en donde las PSV comprenden las proteínas virales de la influenza modificadas, tales como hemaglutinina (HA) de la influenza modificada. La proteína HA puede comprender una secuencia de aminoácidos que comprende por lo menos una sustitución en comparación con una secuencia de aminoácidos de tipo salvaje correspondiente. Se proporcionan además ácidos nucleicos que codifican la proteína HA modificada. Además, también se proporcionan métodos para producir una partícula similar al virus de la influenza (PSV) y métodos para aumentar el rendimiento de producción de una partícula similar al virus de la influenza (PSV) en una planta, porción de una planta o célula de una plantal.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862690780P | 2018-06-27 | 2018-06-27 | |
| PCT/CA2019/050893 WO2020000101A1 (en) | 2018-06-27 | 2019-06-27 | Influenza virus hemagglutinin mutants |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2020013961A true MX2020013961A (es) | 2021-03-09 |
Family
ID=68985311
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2020013957A MX2020013957A (es) | 2018-06-27 | 2019-06-27 | Mutantes de hemaglutinina del virus de la influenza. |
| MX2020013961A MX2020013961A (es) | 2018-06-27 | 2019-06-27 | Mutantes de hemaglutinina del virus de la influenza. |
| MX2020013959A MX2020013959A (es) | 2018-06-27 | 2019-06-27 | Mutantes de hemaglutinina del virus de la influenza. |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2020013957A MX2020013957A (es) | 2018-06-27 | 2019-06-27 | Mutantes de hemaglutinina del virus de la influenza. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2020013959A MX2020013959A (es) | 2018-06-27 | 2019-06-27 | Mutantes de hemaglutinina del virus de la influenza. |
Country Status (14)
| Country | Link |
|---|---|
| US (3) | US20210340184A1 (es) |
| EP (3) | EP3814507A4 (es) |
| JP (5) | JP2021528970A (es) |
| KR (3) | KR20210025627A (es) |
| CN (3) | CN112534056A (es) |
| AU (3) | AU2019295496A1 (es) |
| BR (3) | BR112020026537A2 (es) |
| CA (3) | CA3103840A1 (es) |
| IL (3) | IL279719A (es) |
| MX (3) | MX2020013957A (es) |
| PH (3) | PH12020552197A1 (es) |
| SG (3) | SG11202012349QA (es) |
| TW (3) | TW202017937A (es) |
| WO (3) | WO2020000099A1 (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3814507A4 (en) * | 2018-06-27 | 2022-07-06 | Medicago Inc. | INFLUENZA VIRUS HEMAGGLUTININ MUTANTS |
| EP3896077A1 (en) | 2020-04-16 | 2021-10-20 | Österreichische Agentur für Gesundheit und Ernährungssicherheit GmbH | Influenza virus-like particles (vlps) |
| WO2021249013A1 (en) * | 2020-06-10 | 2021-12-16 | Sichuan Clover Biopharmaceuticals, Inc. | Vaccine compositions, methods, and uses thereof |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU785148B2 (en) * | 1999-12-10 | 2006-10-05 | Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The | Use of recombinant parainfluenza viruses (PIVs) as vectors to protect against infection and disease caused by PIV and other human pathogens |
| CA2615372A1 (en) * | 2007-07-13 | 2009-01-13 | Marc-Andre D'aoust | Influenza virus-like particles (vlps) comprising hemagglutinin |
| EP2610345B1 (en) * | 2007-11-27 | 2015-08-19 | Medicago Inc. | Recombinant influenza virus-like particles (VLPS) produced in transgenic plants expressing hemagglutinin |
| KR101956910B1 (ko) * | 2008-01-21 | 2019-03-12 | 메디카고 인코포레이티드 | 헤마글루티닌을 발현하는 트랜스제닉 식물에서 생산된 재조합 인플루엔자 바이러스-유사 입자(ＶＬＰｓ) |
| PT2318530T (pt) * | 2008-07-18 | 2016-09-30 | Medicago Inc | Novo epítopo de imunização contra o vírus da gripe |
| PT2760882T (pt) * | 2011-09-30 | 2023-08-07 | Medicago Inc | Aumento do rendimento de partícula semelhante a vírus em plantas |
| WO2013130132A1 (en) * | 2011-10-07 | 2013-09-06 | Medimmune, Llc | Influenza hemagglutinin variants |
| US20130315955A1 (en) * | 2012-04-13 | 2013-11-28 | Protein Sciences Corporation | Stability and potency of hemagglutinin |
| CN104582714A (zh) * | 2012-05-23 | 2015-04-29 | 斯坦福大学托管董事会 | 流感疫苗构建体 |
| CN112592389A (zh) * | 2013-03-28 | 2021-04-02 | 莫迪卡戈公司 | 植物中流感样病毒颗粒的产生 |
| CN107074912B (zh) * | 2014-07-10 | 2021-10-29 | 扬森疫苗与预防公司 | 流行性感冒病毒疫苗及其用途 |
| WO2017191258A1 (en) * | 2016-05-04 | 2017-11-09 | Curevac Ag | Influenza mrna vaccines |
| WO2018073340A1 (en) * | 2016-10-19 | 2018-04-26 | Redbiotec Ag | Influenza virus vaccine |
| KR20190093816A (ko) * | 2016-10-26 | 2019-08-26 | 큐어백 아게 | 지질 나노입자 mRNA 백신 |
| EP3814507A4 (en) * | 2018-06-27 | 2022-07-06 | Medicago Inc. | INFLUENZA VIRUS HEMAGGLUTININ MUTANTS |
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2019
- 2019-06-27 EP EP19825330.4A patent/EP3814507A4/en active Pending
- 2019-06-27 CN CN201980038609.9A patent/CN112534056A/zh active Pending
- 2019-06-27 JP JP2020571749A patent/JP2021528970A/ja active Pending
- 2019-06-27 WO PCT/CA2019/050891 patent/WO2020000099A1/en active Application Filing
- 2019-06-27 KR KR1020217002765A patent/KR20210025627A/ko unknown
- 2019-06-27 AU AU2019295496A patent/AU2019295496A1/en active Pending
- 2019-06-27 WO PCT/CA2019/050893 patent/WO2020000101A1/en active Application Filing
- 2019-06-27 CN CN201980038608.4A patent/CN112654707A/zh active Pending
- 2019-06-27 EP EP19825331.2A patent/EP3814508A4/en active Pending
- 2019-06-27 US US17/255,517 patent/US20210340184A1/en active Pending
- 2019-06-27 AU AU2019295495A patent/AU2019295495A1/en active Pending
- 2019-06-27 JP JP2020571812A patent/JP2021528972A/ja active Pending
- 2019-06-27 CN CN201980038607.XA patent/CN112639100A/zh active Pending
- 2019-06-27 SG SG11202012349QA patent/SG11202012349QA/en unknown
- 2019-06-27 CA CA3103840A patent/CA3103840A1/en active Pending
- 2019-06-27 WO PCT/CA2019/050892 patent/WO2020000100A1/en active Application Filing
- 2019-06-27 TW TW108122683A patent/TW202017937A/zh unknown
- 2019-06-27 SG SG11202012398UA patent/SG11202012398UA/en unknown
- 2019-06-27 BR BR112020026537-3A patent/BR112020026537A2/pt unknown
- 2019-06-27 SG SG11202012314YA patent/SG11202012314YA/en unknown
- 2019-06-27 AU AU2019295497A patent/AU2019295497A1/en active Pending
- 2019-06-27 TW TW108122682A patent/TW202016308A/zh unknown
- 2019-06-27 MX MX2020013957A patent/MX2020013957A/es unknown
- 2019-06-27 TW TW108122684A patent/TW202016309A/zh unknown
- 2019-06-27 MX MX2020013961A patent/MX2020013961A/es unknown
- 2019-06-27 BR BR112020026638-8A patent/BR112020026638A2/pt unknown
- 2019-06-27 CA CA3103849A patent/CA3103849A1/en active Pending
- 2019-06-27 US US17/255,526 patent/US20210221853A1/en active Pending
- 2019-06-27 CA CA3103842A patent/CA3103842A1/en active Pending
- 2019-06-27 JP JP2020571750A patent/JP2021528971A/ja active Pending
- 2019-06-27 EP EP19826960.7A patent/EP3814509A4/en active Pending
- 2019-06-27 BR BR112020026620A patent/BR112020026620A8/pt unknown
- 2019-06-27 KR KR1020217002764A patent/KR20210025626A/ko unknown
- 2019-06-27 US US17/255,520 patent/US20210371472A1/en active Pending
- 2019-06-27 MX MX2020013959A patent/MX2020013959A/es unknown
- 2019-06-27 KR KR1020217002699A patent/KR20210024625A/ko unknown
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2020
- 2020-12-17 PH PH12020552197A patent/PH12020552197A1/en unknown
- 2020-12-18 PH PH12020552219A patent/PH12020552219A1/en unknown
- 2020-12-22 PH PH12020552252A patent/PH12020552252A1/en unknown
- 2020-12-23 IL IL279719A patent/IL279719A/en unknown
- 2020-12-23 IL IL279729A patent/IL279729A/en unknown
- 2020-12-23 IL IL279726A patent/IL279726A/en unknown
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2024
- 2024-01-19 JP JP2024007046A patent/JP2024050650A/ja active Pending
- 2024-01-19 JP JP2024007064A patent/JP2024050651A/ja active Pending
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