JP2019141061A5 - - Google Patents
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- Publication number
- JP2019141061A5 JP2019141061A5 JP2019067570A JP2019067570A JP2019141061A5 JP 2019141061 A5 JP2019141061 A5 JP 2019141061A5 JP 2019067570 A JP2019067570 A JP 2019067570A JP 2019067570 A JP2019067570 A JP 2019067570A JP 2019141061 A5 JP2019141061 A5 JP 2019141061A5
- Authority
- JP
- Japan
- Prior art keywords
- plant
- modified influenza
- type
- influenza
- nucleic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 101710154606 Hemagglutinin Proteins 0.000 claims 30
- 101710093908 Outer capsid protein VP4 Proteins 0.000 claims 30
- 101710135467 Outer capsid protein sigma-1 Proteins 0.000 claims 30
- 101710176177 Protein A56 Proteins 0.000 claims 30
- 239000000185 hemagglutinin Substances 0.000 claims 26
- 206010022000 influenza Diseases 0.000 claims 19
- 108020004707 nucleic acids Proteins 0.000 claims 9
- 102000039446 nucleic acids Human genes 0.000 claims 9
- 150000007523 nucleic acids Chemical class 0.000 claims 9
- 238000000034 method Methods 0.000 claims 7
- 238000003776 cleavage reaction Methods 0.000 claims 4
- 230000007017 scission Effects 0.000 claims 4
- 108091005804 Peptidases Proteins 0.000 claims 3
- 239000004365 Protease Substances 0.000 claims 3
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 claims 3
- 239000003623 enhancer Substances 0.000 claims 3
- 230000014509 gene expression Effects 0.000 claims 3
- 230000028993 immune response Effects 0.000 claims 3
- 239000002245 particle Substances 0.000 claims 3
- 230000002797 proteolythic effect Effects 0.000 claims 3
- 108091026898 Leader sequence (mRNA) Proteins 0.000 claims 2
- 108091036066 Three prime untranslated region Proteins 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 208000037798 influenza B Diseases 0.000 claims 2
- 230000001105 regulatory effect Effects 0.000 claims 2
- 230000010474 transient expression Effects 0.000 claims 2
- 108090000317 Chymotrypsin Proteins 0.000 claims 1
- 241000588724 Escherichia coli Species 0.000 claims 1
- 102000004961 Furin Human genes 0.000 claims 1
- 108090001126 Furin Proteins 0.000 claims 1
- 102100038946 Proprotein convertase subtilisin/kexin type 6 Human genes 0.000 claims 1
- 101710135785 Subtilisin-like protease Proteins 0.000 claims 1
- 108090000631 Trypsin Proteins 0.000 claims 1
- 102000004142 Trypsin Human genes 0.000 claims 1
- 125000003275 alpha amino acid group Chemical group 0.000 claims 1
- 229960002376 chymotrypsin Drugs 0.000 claims 1
- 230000036039 immunity Effects 0.000 claims 1
- 150000002632 lipids Chemical class 0.000 claims 1
- 239000000463 material Substances 0.000 claims 1
- 239000012588 trypsin Substances 0.000 claims 1
- 108010015530 tryptase Clara Proteins 0.000 claims 1
- 241000712461 unidentified influenza virus Species 0.000 claims 1
- 229960005486 vaccine Drugs 0.000 claims 1
- 230000009385 viral infection Effects 0.000 claims 1
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361806227P | 2013-03-28 | 2013-03-28 | |
| US61/806,227 | 2013-03-28 | ||
| US201461925852P | 2014-01-10 | 2014-01-10 | |
| US61/925,852 | 2014-01-10 | ||
| US201461971274P | 2014-03-27 | 2014-03-27 | |
| US61/971,274 | 2014-03-27 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016504431A Division JP2016516415A (ja) | 2013-03-28 | 2014-03-28 | 植物におけるインフルエンザウイルス様粒子の生成 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019141061A JP2019141061A (ja) | 2019-08-29 |
| JP2019141061A5 true JP2019141061A5 (enExample) | 2020-02-13 |
| JP7065803B2 JP7065803B2 (ja) | 2022-05-12 |
Family
ID=51622327
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016504431A Pending JP2016516415A (ja) | 2013-03-28 | 2014-03-28 | 植物におけるインフルエンザウイルス様粒子の生成 |
| JP2019067570A Active JP7065803B2 (ja) | 2013-03-28 | 2019-03-29 | 植物におけるインフルエンザウイルス様粒子の生成 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016504431A Pending JP2016516415A (ja) | 2013-03-28 | 2014-03-28 | 植物におけるインフルエンザウイルス様粒子の生成 |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US10358652B2 (enExample) |
| EP (2) | EP2978848B1 (enExample) |
| JP (2) | JP2016516415A (enExample) |
| KR (1) | KR102199018B1 (enExample) |
| CN (2) | CN105247059B (enExample) |
| AU (1) | AU2014245779B2 (enExample) |
| ES (1) | ES2803508T3 (enExample) |
| IL (2) | IL241692B2 (enExample) |
| MX (1) | MX376138B (enExample) |
| PH (1) | PH12015502217A1 (enExample) |
| RU (2) | RU2742607C1 (enExample) |
| SG (1) | SG11201507928QA (enExample) |
| WO (1) | WO2014153674A1 (enExample) |
| ZA (1) | ZA201508327B (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11390878B2 (en) | 2011-09-30 | 2022-07-19 | Medicago Inc. | Increasing protein yield in plants |
| CN103930435A (zh) | 2011-09-30 | 2014-07-16 | 麦迪卡格公司 | 增加植物中病毒样颗粒的产率 |
| US12467058B2 (en) | 2013-03-28 | 2025-11-11 | Aramis Biotechnologies Inc. | Influenza virus-like particle production in plants |
| WO2014153674A1 (en) * | 2013-03-28 | 2014-10-02 | Medicago Inc. | Influenza virus-like particle production in plants |
| DK3092309T3 (da) | 2014-01-10 | 2021-04-12 | Medicago Inc | Cpmv-forstærkerelementer |
| US10563213B2 (en) | 2014-03-27 | 2020-02-18 | Medicago Inc. | Modified CPMV enhancer elements |
| PT3981437T (pt) | 2014-04-23 | 2025-01-15 | Modernatx Inc | Vacinas de ácidos nucleicos |
| FR3054547B1 (fr) | 2016-07-29 | 2020-06-05 | Angany Inc. | Particules pseudo-virales et leurs utilisations |
| GB201614485D0 (en) | 2016-08-25 | 2016-10-12 | Univ Oxford Innovation Ltd | Immunogenic composition |
| CN106822887A (zh) * | 2017-01-26 | 2017-06-13 | 中国科学院微生物研究所 | 一种流感病毒四价亚单位疫苗及其应用 |
| RU2020132255A (ru) | 2018-03-14 | 2022-04-15 | Медикаго Инк. | Энхансер экспрессии в растениях |
| CN112639100A (zh) * | 2018-06-27 | 2021-04-09 | 麦迪卡格公司 | 流感病毒血凝素突变体 |
| CA3133166A1 (en) * | 2019-03-14 | 2020-09-17 | Mitsubishi Tanabe Pharma Corporation | Endogenous plant expression enhancer |
| CN113249399B (zh) * | 2021-05-27 | 2022-08-02 | 长沙诺合松生物科技合伙企业(有限合伙) | pAM基因及其植物表达载体和应用 |
| AU2022425707A1 (en) * | 2021-12-31 | 2024-07-04 | Mynvax Private Limited | Polypeptide fragments, immunogenic composition against influenza virus, and implementations thereof |
| WO2025102071A1 (en) * | 2023-11-09 | 2025-05-15 | The General Hospital Corporation | Hemagglutinin polypeptides and uses thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US5232833A (en) | 1988-09-14 | 1993-08-03 | Stressgen Biotechnologies Corporation | Accumulation of heat shock proteins for evaluating biological damage due to chronic exposure of an organism to sublethal levels of pollutants |
| WO2000020557A2 (en) | 1998-10-07 | 2000-04-13 | Boyce Institute For Plant Research At Cornell University | Gemini virus vectors for gene expression in plants |
| US20020169306A1 (en) * | 1999-05-18 | 2002-11-14 | Kaio Kitazato | Envelope gene-deficient paramyxovirus vector |
| CA2406668C (en) | 1999-12-06 | 2015-11-24 | Board Of Trustees Of The University Of Illinois | High affinity tcr proteins and methods |
| DE10109354A1 (de) | 2001-02-27 | 2002-09-05 | Icon Genetics Ag | Rekombinante virale Schaltersysteme |
| US20030180756A1 (en) * | 2002-03-21 | 2003-09-25 | Yang Shi | Compositions and methods for suppressing eukaryotic gene expression |
| US8784335B2 (en) | 2002-04-19 | 2014-07-22 | Sanofi-Aventis Deutschland Gmbh | Body fluid sampling device with a capacitive sensor |
| US7132291B2 (en) | 2003-05-05 | 2006-11-07 | Dow Agro Sciences Llc | Vectors and cells for preparing immunoprotective compositions derived from transgenic plants |
| AU2004235800B2 (en) * | 2003-05-05 | 2010-02-18 | Dow Agrosciences Llc | Stable immunoprophylactic and therapeutic compositions derived from transgenic plant cells and methods for production |
| US8080255B2 (en) | 2003-07-11 | 2011-12-20 | Novavax Inc. | Functional influenza virus like particles (VLPs) |
| ES2381200T3 (es) | 2005-04-29 | 2012-05-24 | University Of Cape Town | Expresión de proteínas virales en las plantas |
| CN103865892B (zh) * | 2005-10-18 | 2017-04-12 | 诺瓦瓦克斯股份有限公司 | 功能性流感病毒样颗粒(vlp) |
| WO2007100584A2 (en) | 2006-02-16 | 2007-09-07 | The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Antiviral agents and vaccines against influenza |
| EP1991264B1 (en) * | 2006-03-07 | 2015-01-07 | Vaxinnate Corporation | Compositions that include hemagglutinin, methods of making and methods of use thereof |
| US7618815B2 (en) | 2006-03-08 | 2009-11-17 | University Of Kentucky Research Foundation | Viral vectors useful in soybean and methods of use |
| WO2007135480A1 (en) | 2006-05-22 | 2007-11-29 | Plant Bioscience Limited | Bipartite system, method and composition for the constitutive and inducible expression of high levels of foreign proteins in plants |
| AU2007286161B2 (en) | 2006-08-09 | 2013-05-02 | Medimmune, Llc | Influenza hemagglutinin and neuraminidase variants |
| US8697088B2 (en) | 2007-05-25 | 2014-04-15 | Novavax, Inc. | VLPs derived from cells that do not express a viral matrix or core protein |
| MX2009013665A (es) | 2007-06-15 | 2010-06-02 | Medicago Inc | Produccion modificada de glicoproteinas en plantas. |
| CA2615372A1 (en) * | 2007-07-13 | 2009-01-13 | Marc-Andre D'aoust | Influenza virus-like particles (vlps) comprising hemagglutinin |
| ES2554703T3 (es) * | 2007-11-27 | 2015-12-22 | Medicago Inc. | Partículas recombinantes semejantes al virus de la influenza (VLP) producidas en plantas transgénicas que expresan hemaglutinina |
| GB0800272D0 (en) | 2008-01-08 | 2008-02-13 | Plant Bioscience Ltd | Protein expression systems |
| SG187500A1 (en) * | 2008-01-21 | 2013-02-28 | Medicago Inc | Recombinant influenza virus-like particles (vlps) produced in transgenic plants expressing hemagglutinin |
| CN105753948A (zh) | 2008-07-08 | 2016-07-13 | 麦迪卡格公司 | 可溶性重组流感抗原 |
| CA2730668C (en) | 2008-07-18 | 2020-04-28 | Medicago Inc. | New influenza virus immunizing epitope |
| CA2736796A1 (en) | 2008-08-27 | 2010-03-04 | Arizona Board Of Regents For And On Behalf Of Arizona State University | A dna replicon system for high-level rapid production of vaccines and monoclonal antibody therapeutics in plants |
| EP3009145A1 (en) * | 2009-03-30 | 2016-04-20 | Mount Sinai School of Medicine of New York University | Influenza virus vaccines and uses thereof |
| EP2445928B1 (en) * | 2009-06-24 | 2018-03-28 | Medicago Inc. | Chimeric influenza virus-like particles comprising hemagglutinin |
| FR2947875B1 (fr) | 2009-07-10 | 2011-07-08 | Raymond A & Cie | Dispositif de fixation a elements de fixation multiples dont l'un est flottant |
| WO2011011390A1 (en) | 2009-07-20 | 2011-01-27 | Novavax, Inc. | Purified recombinant influenza virus ha proteins |
| US20120185969A1 (en) | 2009-09-04 | 2012-07-19 | Syngenta Participations Ag | Stacking of translational enhancer elements to increase polypeptide expression in plants |
| MX2012003372A (es) * | 2009-09-22 | 2012-05-29 | Medicago Inc | Metodo para preparar proteina derivada de vegetales. |
| WO2011102900A1 (en) | 2010-02-18 | 2011-08-25 | Technovax, Inc. | Universal virus-like particle (vlp) influenza vaccines |
| SG189236A1 (en) * | 2010-10-04 | 2013-05-31 | Massachusetts Inst Technology | Hemagglutinin polypeptides, and reagents and methods relating thereto |
| CA2815887C (en) | 2010-11-04 | 2013-12-10 | Medicago Inc. | Plant expression system |
| TWI526539B (zh) | 2010-12-22 | 2016-03-21 | 苜蓿股份有限公司 | 植物中生產類病毒顆粒(vlp)的方法及以該方法生產之vlp |
| TWI620816B (zh) | 2011-03-23 | 2018-04-11 | 苜蓿股份有限公司 | 植物衍生蛋白回收方法 |
| BR112013032033A2 (pt) | 2011-06-13 | 2017-05-30 | Medicago Inc | produção de partícula simular ao vírus da raiva em plantas |
| PL220281B1 (pl) * | 2011-09-23 | 2015-09-30 | Inst Biochemii I Biofizyki Polskiej Akademii Nauk | Szczepionka DNA, sposób indukowania odpowiedzi immunologicznej, przeciwciała specyficznie rozpoznające białko hemaglutyniny H5 wirusa grypy i zastosowanie szczepionki DNA |
| CN103930435A (zh) * | 2011-09-30 | 2014-07-16 | 麦迪卡格公司 | 增加植物中病毒样颗粒的产率 |
| US11390878B2 (en) * | 2011-09-30 | 2022-07-19 | Medicago Inc. | Increasing protein yield in plants |
| JP6390846B2 (ja) | 2011-11-11 | 2018-09-19 | フィリップ・モーリス・プロダクツ・ソシエテ・アノニム | ニコチアナタバカムにおいて生成される血球凝集素を含むインフルエンザウイルス様粒子(vlp) |
| EP2876161B1 (en) * | 2012-07-23 | 2018-12-05 | The Institute of Biological Resources | Vaccine |
| WO2014153674A1 (en) * | 2013-03-28 | 2014-10-02 | Medicago Inc. | Influenza virus-like particle production in plants |
-
2014
- 2014-03-28 WO PCT/CA2014/050326 patent/WO2014153674A1/en not_active Ceased
- 2014-03-28 KR KR1020157030865A patent/KR102199018B1/ko active Active
- 2014-03-28 JP JP2016504431A patent/JP2016516415A/ja active Pending
- 2014-03-28 RU RU2019135043A patent/RU2742607C1/ru active
- 2014-03-28 CN CN201480029001.7A patent/CN105247059B/zh active Active
- 2014-03-28 SG SG11201507928QA patent/SG11201507928QA/en unknown
- 2014-03-28 US US14/779,423 patent/US10358652B2/en active Active
- 2014-03-28 RU RU2015146097A patent/RU2705555C2/ru active
- 2014-03-28 AU AU2014245779A patent/AU2014245779B2/en active Active
- 2014-03-28 IL IL241692A patent/IL241692B2/en unknown
- 2014-03-28 MX MX2015013700A patent/MX376138B/es active IP Right Grant
- 2014-03-28 EP EP14773061.8A patent/EP2978848B1/en active Active
- 2014-03-28 ES ES14773061T patent/ES2803508T3/es active Active
- 2014-03-28 IL IL295155A patent/IL295155A/en unknown
- 2014-03-28 EP EP19206629.8A patent/EP3626827A1/en active Pending
- 2014-03-28 CN CN202011519705.6A patent/CN112592389A/zh active Pending
-
2015
- 2015-09-23 PH PH12015502217A patent/PH12015502217A1/en unknown
- 2015-10-26 ZA ZA2015/08327A patent/ZA201508327B/en unknown
-
2019
- 2019-03-29 JP JP2019067570A patent/JP7065803B2/ja active Active
- 2019-07-19 US US16/516,802 patent/US11085049B2/en active Active
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