JP2016516415A - 植物におけるインフルエンザウイルス様粒子の生成 - Google Patents

植物におけるインフルエンザウイルス様粒子の生成 Download PDF

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JP2016516415A
JP2016516415A JP2016504431A JP2016504431A JP2016516415A JP 2016516415 A JP2016516415 A JP 2016516415A JP 2016504431 A JP2016504431 A JP 2016504431A JP 2016504431 A JP2016504431 A JP 2016504431A JP 2016516415 A JP2016516415 A JP 2016516415A
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cpmv
sequence
shows
protein
plant
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JP2016516415A5 (enExample
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マノン コーチャー,
マノン コーチャー,
マルク−アンドレ ダウスト,
マルク−アンドレ ダウスト,
ルイ−フィリップ ベジーナ,
ルイ−フィリップ ベジーナ,
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メディカゴ インコーポレイテッド
メディカゴ インコーポレイテッド
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JP2016504431A 2013-03-28 2014-03-28 植物におけるインフルエンザウイルス様粒子の生成 Pending JP2016516415A (ja)

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US201361806227P 2013-03-28 2013-03-28
US61/806,227 2013-03-28
US201461925852P 2014-01-10 2014-01-10
US61/925,852 2014-01-10
US201461971274P 2014-03-27 2014-03-27
US61/971,274 2014-03-27
PCT/CA2014/050326 WO2014153674A1 (en) 2013-03-28 2014-03-28 Influenza virus-like particle production in plants

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2019141061A (ja) * 2013-03-28 2019-08-29 メディカゴ インコーポレイテッド 植物におけるインフルエンザウイルス様粒子の生成

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI700368B (zh) 2011-09-30 2020-08-01 苜蓿股份有限公司 增加植物類病毒顆粒產率
US11390878B2 (en) 2011-09-30 2022-07-19 Medicago Inc. Increasing protein yield in plants
US12467058B2 (en) 2013-03-28 2025-11-11 Aramis Biotechnologies Inc. Influenza virus-like particle production in plants
BR112016015875A2 (pt) 2014-01-10 2017-09-19 Medicago Inc Elementos intensificadores de cpmv
AU2015234595B2 (en) 2014-03-27 2021-03-25 Medicago Inc. Modified CPMV enhancer elements
DK3134131T3 (en) 2014-04-23 2022-02-07 Modernatx Inc Nucleic acid vaccines
FR3054547B1 (fr) 2016-07-29 2020-06-05 Angany Inc. Particules pseudo-virales et leurs utilisations
GB201614485D0 (en) 2016-08-25 2016-10-12 Univ Oxford Innovation Ltd Immunogenic composition
CN106822887A (zh) * 2017-01-26 2017-06-13 中国科学院微生物研究所 一种流感病毒四价亚单位疫苗及其应用
JP7423875B6 (ja) 2018-03-14 2024-03-15 メディカゴ インコーポレイテッド 植物発現エンハンサ
AU2019295495B2 (en) 2018-06-27 2025-05-22 Aramis Biotechnologies Inc. Influenza virus hemagglutinin mutants
BR112021017899A2 (pt) * 2019-03-14 2021-12-21 Medicago Inc Intensificador de expressão vegetal endógeno
CN113249399B (zh) * 2021-05-27 2022-08-02 长沙诺合松生物科技合伙企业(有限合伙) pAM基因及其植物表达载体和应用
US20250325649A1 (en) * 2021-12-31 2025-10-23 Mynvax Private Limited Polypeptide fragments, immunogenic composition against influenza virus, and implementations thereof
WO2025102071A1 (en) * 2023-11-09 2025-05-15 The General Hospital Corporation Hemagglutinin polypeptides and uses thereof
WO2026027730A1 (en) * 2024-07-31 2026-02-05 Sanofi Modified h5 influenza hemagglutinin polypeptides and nucleic acids and uses thereof

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012157367A (ja) * 2005-10-18 2012-08-23 Novavax Inc 機能的インフルエンザウイルス様粒子(vlp)
WO2012126123A1 (en) * 2011-03-23 2012-09-27 Medicago Inc. Method of recovering plant-derived proteins
JP2012530499A (ja) * 2009-06-24 2012-12-06 メディカゴ インコーポレイテッド ヘマグルチニンを含むキメラインフルエンザウイルス様粒子
WO2013044390A1 (en) * 2011-09-30 2013-04-04 Medicago Inc. Increasing virus-like particle yield in plants

Family Cites Families (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5232833A (en) 1988-09-14 1993-08-03 Stressgen Biotechnologies Corporation Accumulation of heat shock proteins for evaluating biological damage due to chronic exposure of an organism to sublethal levels of pollutants
US6392121B1 (en) 1998-10-07 2002-05-21 Boyce Thompson Institute For Plant Research Gemini virus vectors for gene expression in plants
US20020169306A1 (en) * 1999-05-18 2002-11-14 Kaio Kitazato Envelope gene-deficient paramyxovirus vector
AU5076301A (en) 1999-12-06 2001-07-09 Board Of Trustees Of The University Of Illinois, The High affinity tcr proteins and methods
DE10109354A1 (de) 2001-02-27 2002-09-05 Icon Genetics Ag Rekombinante virale Schaltersysteme
US20030180756A1 (en) * 2002-03-21 2003-09-25 Yang Shi Compositions and methods for suppressing eukaryotic gene expression
US8784335B2 (en) 2002-04-19 2014-07-22 Sanofi-Aventis Deutschland Gmbh Body fluid sampling device with a capacitive sensor
AU2004235813B2 (en) 2003-05-05 2010-07-29 Boyce Thompson Institute For Plant Research Vectors and cells for preparing immunoprotective compositions derived from transgenic plants
NZ542933A (en) * 2003-05-05 2009-08-28 Dow Agrosciences Llc Stable immunoprophylactic and therapeutic compositions derived from transgenic plant cells and methods for production
US8080255B2 (en) 2003-07-11 2011-12-20 Novavax Inc. Functional influenza virus like particles (VLPs)
ES2662118T3 (es) 2005-04-29 2018-04-05 University Of Cape Town Expresión de proteínas virales en las plantas
CN101484466A (zh) 2006-02-16 2009-07-15 美国国有健康与人类服务部(马里兰州) 针对流感病毒的抗病毒剂和疫苗
ES2555544T3 (es) * 2006-03-07 2016-01-04 Vaxinnate Corporation Composiciones que incluyen hemaglutinina, métodos de preparación y métodos de uso de las mismas
US7618815B2 (en) 2006-03-08 2009-11-17 University Of Kentucky Research Foundation Viral vectors useful in soybean and methods of use
EP2029755A1 (en) 2006-05-22 2009-03-04 Plant Bioscience Limited Bipartite system, method and composition for the constitutive and inducible expression of high levels of foreign proteins in plants
JP2010500034A (ja) 2006-08-09 2010-01-07 メッドイミューン バクシーンズ,インコーポレイティド インフルエンザ赤血球凝集素変異体およびノイラミニダーゼ変異体
WO2008148104A1 (en) 2007-05-25 2008-12-04 Novavax, Inc. Novel vlps derived from cells that do not express a viral matrix or core protein
CN104962579A (zh) 2007-06-15 2015-10-07 麦迪卡格公司 修饰植物中的糖蛋白产生
CA2615372A1 (en) * 2007-07-13 2009-01-13 Marc-Andre D'aoust Influenza virus-like particles (vlps) comprising hemagglutinin
NZ587108A (en) * 2007-11-27 2013-04-26 Medicago Inc Recombinant influenza virus-like particles (vlps) produced in transgenic plants expressing hemagglutinin
GB0800272D0 (en) 2008-01-08 2008-02-13 Plant Bioscience Ltd Protein expression systems
SG187500A1 (en) * 2008-01-21 2013-02-28 Medicago Inc Recombinant influenza virus-like particles (vlps) produced in transgenic plants expressing hemagglutinin
DK2294202T3 (en) 2008-07-08 2015-08-31 Medicago Inc SOLUBLE RECOMBINANT INFLUENZA ANTIGENES
KR101745925B1 (ko) 2008-07-18 2017-06-12 메디카고 인코포레이티드 신규 인플루엔자 바이러스 면역화 에피토프
CA2736796A1 (en) 2008-08-27 2010-03-04 Arizona Board Of Regents For And On Behalf Of Arizona State University A dna replicon system for high-level rapid production of vaccines and monoclonal antibody therapeutics in plants
JP2012521786A (ja) * 2009-03-30 2012-09-20 モウント シナイ スクール オフ メディシネ インフルエンザウイルスワクチン及びその使用
FR2947875B1 (fr) 2009-07-10 2011-07-08 Raymond A & Cie Dispositif de fixation a elements de fixation multiples dont l'un est flottant
WO2011011390A1 (en) 2009-07-20 2011-01-27 Novavax, Inc. Purified recombinant influenza virus ha proteins
KR20120093193A (ko) 2009-09-04 2012-08-22 신젠타 파티서페이션즈 아게 식물 폴리펩티드 발현 증가를 위한 번역 향상제 요소의 적층
SG178918A1 (en) * 2009-09-22 2012-04-27 Medicago Inc Method of preparing plant-derived vlps
CA2789945A1 (en) 2010-02-18 2011-08-25 Technovax, Inc. Universal virus-like particle (vlp) influenza vaccines
WO2012047941A2 (en) * 2010-10-04 2012-04-12 Massachusetts Institute Of Technology Hemagglutinin polypeptides, and reagents and methods relating thereto
ES2614527T3 (es) 2010-11-04 2017-05-31 Medicago Inc. Sistema de expresión en plantas
TWI526539B (zh) 2010-12-22 2016-03-21 苜蓿股份有限公司 植物中生產類病毒顆粒(vlp)的方法及以該方法生產之vlp
US20140227322A1 (en) 2011-06-13 2014-08-14 Medicago Inc. Rabies virus like particle production in plants
PL220281B1 (pl) 2011-09-23 2015-09-30 Inst Biochemii I Biofizyki Polskiej Akademii Nauk Szczepionka DNA, sposób indukowania odpowiedzi immunologicznej, przeciwciała specyficznie rozpoznające białko hemaglutyniny H5 wirusa grypy i zastosowanie szczepionki DNA
US11390878B2 (en) * 2011-09-30 2022-07-19 Medicago Inc. Increasing protein yield in plants
WO2013068593A1 (en) 2011-11-11 2013-05-16 Philip Morris Products S.A. Influenza virus -like particles (vlps) comprising hemagglutinin produced nicotiana tabacum
EP2876161B1 (en) 2012-07-23 2018-12-05 The Institute of Biological Resources Vaccine
JP2016516415A (ja) 2013-03-28 2016-06-09 メディカゴ インコーポレイテッド 植物におけるインフルエンザウイルス様粒子の生成

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012157367A (ja) * 2005-10-18 2012-08-23 Novavax Inc 機能的インフルエンザウイルス様粒子(vlp)
JP2012530499A (ja) * 2009-06-24 2012-12-06 メディカゴ インコーポレイテッド ヘマグルチニンを含むキメラインフルエンザウイルス様粒子
WO2012126123A1 (en) * 2011-03-23 2012-09-27 Medicago Inc. Method of recovering plant-derived proteins
WO2013044390A1 (en) * 2011-09-30 2013-04-04 Medicago Inc. Increasing virus-like particle yield in plants

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
TRENDS IN MICROBIOLOGY, vol. 1994, Vol.2, No.2, JPN6019021051, pages 39 - 43, ISSN: 0004049673 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2019141061A (ja) * 2013-03-28 2019-08-29 メディカゴ インコーポレイテッド 植物におけるインフルエンザウイルス様粒子の生成
JP7065803B2 (ja) 2013-03-28 2022-05-12 メディカゴ インコーポレイテッド 植物におけるインフルエンザウイルス様粒子の生成

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