BR112015024790A2 - produção de partícula semelhante a vírus influenza em plantas - Google Patents

produção de partícula semelhante a vírus influenza em plantas

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Publication number
BR112015024790A2
BR112015024790A2 BR112015024790A BR112015024790A BR112015024790A2 BR 112015024790 A2 BR112015024790 A2 BR 112015024790A2 BR 112015024790 A BR112015024790 A BR 112015024790A BR 112015024790 A BR112015024790 A BR 112015024790A BR 112015024790 A2 BR112015024790 A2 BR 112015024790A2
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Brazil
Prior art keywords
plant
modified
vlp
particle
virus
Prior art date
Application number
BR112015024790A
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English (en)
Other versions
BR112015024790B1 (pt
Inventor
Vezina Louis-Philippe
Couture Manon
D'aoust Marc-Andre
Original Assignee
Medicago Inc
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Publication date
Application filed by Medicago Inc filed Critical Medicago Inc
Publication of BR112015024790A2 publication Critical patent/BR112015024790A2/pt
Publication of BR112015024790B1 publication Critical patent/BR112015024790B1/pt

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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8257—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon
    • C12N15/8258—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon for the production of oral vaccines (antigens) or immunoglobulins
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/145—Orthomyxoviridae, e.g. influenza virus
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
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    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8257—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon
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    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C12P19/28—N-glycosides
    • C12P19/30—Nucleotides
    • C12P19/34—Polynucleotides, e.g. nucleic acids, oligoribonucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5258—Virus-like particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
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    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
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    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
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    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16211—Influenzavirus B, i.e. influenza B virus
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  • Biophysics (AREA)
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  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
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  • Pulmonology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
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  • Proteomics, Peptides & Aminoacids (AREA)
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Abstract

resumo patente de invenção: “produção de partícula semelhante a vírus influenza em plantas”. a presente invenção se refere a um método de produção de uma partícula semelhante a vírus (vlp) em uma planta compreendendo hemaglutinina modificada. o método compreende a introdução de um ácido nucleico compreendendo uma região reguladora ativa na planta e operativamente ligada a uma sequência de nucleotídeos codificando uma proteína hemaglutinina (ha) de influenza modificada na planta, ou porção da planta, a proteína ha modificada compreende um laço proteolítico modificado. seguido por incubação da planta ou porção da planta, sob condições que permitam a expressão dos ácidos nucleicos, desse modo, produzindo a vlp. o laço proteolítico modificado pode compreender um ou mais sítios de clivagem de protease, exibindo clivagem por uma protease reduzida ou abolida. a sequência de nucleotídeos, codificando a ha, pode ser selecionada do grupo consistindo em b ha, c, h1, h2, h3, h4, h5, h6, h7, h8, h9, h10, h11, h12, h13, h14, h15, e h16. também é descrita uma partícula semelhante a vírus (vlp) produzida pelo método, e plantas expressando a vlp. a partícula semelhante a vírus (vlp) pode compreender n-glicanos específicos de planta, ou n-glicanos modificados.
BR112015024790-3A 2013-03-28 2014-03-28 Ácido nucleico, método de produção de partícula semelhante a vírus influenza (vlp) em plantas, vlp, seu uso, método de produção de uma proteína ha modificada, ha modificada de influenza e composição BR112015024790B1 (pt)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201361806227P 2013-03-28 2013-03-28
US61/806,227 2013-03-28
US201461925852P 2014-01-10 2014-01-10
US61/925,852 2014-01-10
US201461971274P 2014-03-27 2014-03-27
US61/971,274 2014-03-27
PCT/CA2014/050326 WO2014153674A1 (en) 2013-03-28 2014-03-28 Influenza virus-like particle production in plants

Publications (2)

Publication Number Publication Date
BR112015024790A2 true BR112015024790A2 (pt) 2017-10-10
BR112015024790B1 BR112015024790B1 (pt) 2024-04-16

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Also Published As

Publication number Publication date
ES2803508T3 (es) 2021-01-27
MX2015013700A (es) 2016-02-29
EP3626827A1 (en) 2020-03-25
US20200255849A1 (en) 2020-08-13
JP2016516415A (ja) 2016-06-09
SG11201507928QA (en) 2015-10-29
IL241692B1 (en) 2023-08-01
RU2742607C1 (ru) 2021-02-09
CN105247059A (zh) 2016-01-13
US11085049B2 (en) 2021-08-10
IL295155A (en) 2022-09-01
RU2015146097A (ru) 2017-05-04
US10358652B2 (en) 2019-07-23
RU2705555C2 (ru) 2019-11-07
IL241692A (pt) 2015-11-30
JP2019141061A (ja) 2019-08-29
EP2978848A4 (en) 2016-11-16
EP2978848B1 (en) 2020-05-06
CN105247059B (zh) 2021-07-06
KR102199018B1 (ko) 2021-01-07
IL241692B2 (en) 2023-12-01
CA2907591A1 (en) 2014-10-02
AU2014245779A1 (en) 2015-10-22
US20160122777A1 (en) 2016-05-05
PH12015502217A1 (en) 2016-02-01
EP2978848A1 (en) 2016-02-03
HK1220729A1 (zh) 2017-05-12
JP7065803B2 (ja) 2022-05-12
WO2014153674A1 (en) 2014-10-02
CN112592389A (zh) 2021-04-02
AU2014245779B2 (en) 2020-02-06
PH12015502217B1 (en) 2016-02-01
KR20150134423A (ko) 2015-12-01
ZA201508327B (en) 2022-08-31
NZ712752A (en) 2021-06-25

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