JP2014531205A5 - - Google Patents
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- Publication number
- JP2014531205A5 JP2014531205A5 JP2014530196A JP2014530196A JP2014531205A5 JP 2014531205 A5 JP2014531205 A5 JP 2014531205A5 JP 2014530196 A JP2014530196 A JP 2014530196A JP 2014530196 A JP2014530196 A JP 2014530196A JP 2014531205 A5 JP2014531205 A5 JP 2014531205A5
- Authority
- JP
- Japan
- Prior art keywords
- sequence
- polypeptide
- seq
- glycoprotein
- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229920001184 polypeptide Polymers 0.000 claims 9
- 102000004196 processed proteins & peptides Human genes 0.000 claims 9
- 108090000765 processed proteins & peptides Proteins 0.000 claims 9
- 102000003886 Glycoproteins Human genes 0.000 claims 7
- 108090000288 Glycoproteins Proteins 0.000 claims 7
- 125000003275 alpha amino acid group Chemical group 0.000 claims 4
- 238000000034 method Methods 0.000 claims 4
- 102000040430 polynucleotide Human genes 0.000 claims 3
- 108091033319 polynucleotide Proteins 0.000 claims 3
- 239000002157 polynucleotide Substances 0.000 claims 3
- 102000005744 Glycoside Hydrolases Human genes 0.000 claims 2
- 108010031186 Glycoside Hydrolases Proteins 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 239000012634 fragment Substances 0.000 claims 2
- 150000004676 glycans Chemical class 0.000 claims 2
- 230000003301 hydrolyzing effect Effects 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 150000001413 amino acids Chemical class 0.000 claims 1
- 230000000295 complement effect Effects 0.000 claims 1
- 239000013604 expression vector Substances 0.000 claims 1
- 230000002068 genetic effect Effects 0.000 claims 1
- 230000013595 glycosylation Effects 0.000 claims 1
- 238000006206 glycosylation reaction Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1115841.7 | 2011-09-13 | ||
| GB201115841A GB201115841D0 (en) | 2011-09-13 | 2011-09-13 | Protein and method |
| PCT/EP2012/067841 WO2013037824A1 (en) | 2011-09-13 | 2012-09-12 | Endoglycosidase from streptococcus pyogenes and methods using it |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014531205A JP2014531205A (ja) | 2014-11-27 |
| JP2014531205A5 true JP2014531205A5 (enExample) | 2015-10-29 |
| JP6076349B2 JP6076349B2 (ja) | 2017-02-08 |
Family
ID=44908522
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014530196A Active JP6076349B2 (ja) | 2011-09-13 | 2012-09-12 | ストレプトコッカス・ピオゲネス由来のエンドグリコシダーゼ及びその使用方法 |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US9493752B2 (enExample) |
| EP (1) | EP2756077B1 (enExample) |
| JP (1) | JP6076349B2 (enExample) |
| KR (1) | KR102001427B1 (enExample) |
| CN (1) | CN103946377B (enExample) |
| AU (1) | AU2012307461B2 (enExample) |
| BR (1) | BR112014005816A2 (enExample) |
| CA (1) | CA2848230C (enExample) |
| DK (1) | DK2756077T3 (enExample) |
| EA (1) | EA028490B8 (enExample) |
| ES (1) | ES2627334T3 (enExample) |
| GB (2) | GB201115841D0 (enExample) |
| IL (1) | IL231410A0 (enExample) |
| IN (1) | IN2014CN02163A (enExample) |
| MX (1) | MX347727B (enExample) |
| PL (1) | PL2756077T3 (enExample) |
| PT (1) | PT2756077T (enExample) |
| SG (1) | SG11201400505YA (enExample) |
| WO (1) | WO2013037824A1 (enExample) |
| ZA (1) | ZA201401840B (enExample) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2307564T3 (es) * | 2000-12-21 | 2008-12-01 | Id Biomedical Corporation | Antigenos de streptococcus pyrogenes y fragmentos de adn correspondientes. |
| HUE038285T2 (hu) | 2012-10-23 | 2018-10-29 | Synaffix Bv | Módosított antitest, antitest-konjugátum és eljárás ezek elõállítására |
| SI2991683T1 (sl) | 2013-05-02 | 2020-01-31 | Glykos Finland Oy | Konjugati glikoproteina ali glikana s toksično obremenitvijo |
| JP2016538878A (ja) | 2013-10-14 | 2016-12-15 | シンアフィックス ビー．ブイ． | 糖鎖工学的に操作された抗体、抗体コンジュゲート、及びそれらの調製方法 |
| WO2015057064A1 (en) | 2013-10-14 | 2015-04-23 | Synaffix B.V. | Modified glycoprotein, protein-conjugate and process for the preparation thereof |
| US10072096B2 (en) | 2013-10-14 | 2018-09-11 | Synaffix B.V. | Modified glycoprotein, protein-conjugate and process for the preparation thereof |
| US20160235861A1 (en) | 2013-10-14 | 2016-08-18 | SynAffix. B.V. | Glycoengineered antibody, antibody-conjugate and methods for their preparation |
| GB201318490D0 (en) * | 2013-10-18 | 2013-12-04 | Genovis Ab | Method |
| CN106660967A (zh) | 2014-01-24 | 2017-05-10 | 西纳福克斯股份有限公司 | (杂)芳基1，3‑偶极化合物与(杂)环炔的环加成方法 |
| EP3682904A1 (en) | 2014-06-30 | 2020-07-22 | Glykos Finland Oy | Saccharide derivative of a toxic payload and antibody conjugates thereof |
| GB201413240D0 (en) * | 2014-07-25 | 2014-09-10 | Hansa Medical Ab | Method |
| EP3177633B1 (en) | 2014-08-04 | 2022-07-20 | SynAffix B.V. | Process for the modification of a glycoprotein using a beta-(1,4)-n-acetylgalactosaminyltransferase or a mutant thereof |
| GB201502306D0 (en) | 2015-02-12 | 2015-04-01 | Hansa Medical Ab | Protein |
| GB201502305D0 (en) * | 2015-02-12 | 2015-04-01 | Hansa Medical Ab | Protein |
| HRP20180439T1 (hr) | 2015-04-23 | 2018-07-13 | Synaffix B.V. | Postupak modificiranja glikoproteina glikoziltransferazom koja je ili je derivat beta-(1,4)-n-acetilgalaktozaminil transferaze |
| WO2017124084A1 (en) * | 2016-01-15 | 2017-07-20 | University Of Maryland, College Park | Endo-s2 mutants as glycosynthases, method of making and use for glycoengineering of glycoproteins |
| AU2017214441B2 (en) * | 2016-02-04 | 2021-08-19 | Genovis Ab | New Streptococcal proteases |
| TWI706035B (zh) * | 2016-08-24 | 2020-10-01 | 醣基生醫股份有限公司 | 利用醣苷內切酶突變體重塑醣蛋白及其使用方法 |
| CN111183220B (zh) | 2017-05-26 | 2024-03-22 | 杰诺维斯公司 | 用于聚糖分析的工具 |
| US20210228738A1 (en) | 2017-07-17 | 2021-07-29 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Compositions and methods for increasing or enhancing transduction of gene therapy vectors and for removing or reducing immunoglobulins |
| US20210402002A1 (en) | 2018-06-19 | 2021-12-30 | Glykos Biomedical Oy | Conjugate |
| CA3102155A1 (en) | 2018-06-29 | 2020-01-02 | Glykos Biomedical Oy | Conjugates |
| US20230038373A1 (en) | 2019-12-18 | 2023-02-09 | Glykos Biomedical Oy | Stabile conjugate |
| CN111044731B (zh) * | 2019-12-19 | 2021-05-07 | 北京科技大学 | 脉冲温育免疫反应分离富集多肽药物中肽类杂质的方法 |
| TW202140075A (zh) | 2020-01-09 | 2021-11-01 | 美商梅爾莎納醫療公司 | 具有含肽之連接子的位置特異性抗體－藥物共軛體 |
| GB202002072D0 (en) * | 2020-02-14 | 2020-04-01 | Hansa Biopharma AB | immunoglobulin detection and associated therapies |
| US20230374083A1 (en) * | 2020-09-21 | 2023-11-23 | Shanghai Bao Pharmaceuticals Co., Ltd. | Pharmaceutical combination and use thereof |
| CA3203721A1 (en) | 2021-01-04 | 2022-07-07 | Timothy B. Lowinger | B7h4-targeted antibody-drug conjugates and methods of use thereof |
| EP4079848A1 (en) | 2021-04-22 | 2022-10-26 | Genovis Ab | Immunoglobulin cleaving enzyme |
| CN115873833B (zh) * | 2022-11-08 | 2024-08-16 | 上海泰昶生物技术有限公司 | 生产免疫球蛋白g降解酶的工程菌株和工艺 |
| CN117165643B (zh) * | 2023-08-17 | 2025-10-28 | 山东大学 | 一种糖苷内切酶在水解高甘露糖型n-糖蛋白中的应用 |
| WO2025098484A1 (zh) * | 2023-11-10 | 2025-05-15 | 上海齐鲁制药研究中心有限公司 | 新型Endo S2突变体酶 |
| WO2025248500A1 (en) | 2024-05-31 | 2025-12-04 | Janssen Biotech, Inc. | Antibody drug conjugates that target enpp3 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0130228D0 (en) | 2001-12-18 | 2002-02-06 | Hansa Medica Ab | Protein |
| GB0624874D0 (en) | 2006-12-13 | 2007-01-24 | Hansa Medical Ab | Treatment |
| CN102584989B (zh) * | 2007-09-14 | 2015-05-13 | 季诺维斯公司 | 用于解离Fcgamma-受体-IgG复合物及纯化与检测IgG的方法和试剂盒 |
| GB0821100D0 (en) | 2008-11-18 | 2008-12-24 | Hansa Medical Ab | Antibodies |
| JP2013506404A (ja) * | 2009-10-02 | 2013-02-28 | ロシュ グリクアート アーゲー | 抗体における非フコシル化の検出法 |
-
2011
- 2011-09-13 GB GB201115841A patent/GB201115841D0/en not_active Ceased
-
2012
- 2012-09-12 ES ES12756523.2T patent/ES2627334T3/es active Active
- 2012-09-12 GB GB1406321.8A patent/GB2509284A/en not_active Withdrawn
- 2012-09-12 CN CN201280044106.0A patent/CN103946377B/zh active Active
- 2012-09-12 JP JP2014530196A patent/JP6076349B2/ja active Active
- 2012-09-12 CA CA2848230A patent/CA2848230C/en active Active
- 2012-09-12 MX MX2014002906A patent/MX347727B/es active IP Right Grant
- 2012-09-12 PT PT127565232T patent/PT2756077T/pt unknown
- 2012-09-12 EA EA201490447A patent/EA028490B8/ru not_active IP Right Cessation
- 2012-09-12 BR BR112014005816-4A patent/BR112014005816A2/pt not_active IP Right Cessation
- 2012-09-12 WO PCT/EP2012/067841 patent/WO2013037824A1/en not_active Ceased
- 2012-09-12 KR KR1020147009205A patent/KR102001427B1/ko active Active
- 2012-09-12 US US14/343,938 patent/US9493752B2/en active Active
- 2012-09-12 PL PL12756523T patent/PL2756077T3/pl unknown
- 2012-09-12 AU AU2012307461A patent/AU2012307461B2/en active Active
- 2012-09-12 IN IN2163CHN2014 patent/IN2014CN02163A/en unknown
- 2012-09-12 EP EP12756523.2A patent/EP2756077B1/en active Active
- 2012-09-12 SG SG11201400505YA patent/SG11201400505YA/en unknown
- 2012-09-12 DK DK12756523.2T patent/DK2756077T3/en active
-
2014
- 2014-03-09 IL IL231410A patent/IL231410A0/en unknown
- 2014-03-12 ZA ZA2014/01840A patent/ZA201401840B/en unknown
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