JP2015083010A5 - - Google Patents
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- JP2015083010A5 JP2015083010A5 JP2014255753A JP2014255753A JP2015083010A5 JP 2015083010 A5 JP2015083010 A5 JP 2015083010A5 JP 2014255753 A JP2014255753 A JP 2014255753A JP 2014255753 A JP2014255753 A JP 2014255753A JP 2015083010 A5 JP2015083010 A5 JP 2015083010A5
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- chain variable
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- variable region
- acid sequence
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- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 125000003275 alpha amino acid group Chemical group 0.000 claims 22
- 239000000427 antigen Substances 0.000 claims 17
- 102000036639 antigens Human genes 0.000 claims 17
- 108091007433 antigens Proteins 0.000 claims 17
- 108091035707 Consensus sequence Proteins 0.000 claims 6
- 210000004443 dendritic cell Anatomy 0.000 claims 4
- 101100112922 Candida albicans CDR3 gene Proteins 0.000 claims 3
- 102100022430 Melanocyte protein PMEL Human genes 0.000 claims 3
- 102100028389 Melanoma antigen recognized by T-cells 1 Human genes 0.000 claims 3
- 239000012472 biological sample Substances 0.000 claims 3
- 230000002708 enhancing effect Effects 0.000 claims 3
- 230000001939 inductive effect Effects 0.000 claims 3
- 229910052757 nitrogen Inorganic materials 0.000 claims 3
- 229910052698 phosphorus Inorganic materials 0.000 claims 3
- 101100005713 Homo sapiens CD4 gene Proteins 0.000 claims 2
- 101000578784 Homo sapiens Melanoma antigen recognized by T-cells 1 Proteins 0.000 claims 2
- 101001094545 Homo sapiens Retrotransposon-like protein 1 Proteins 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 101800001271 Surface protein Proteins 0.000 claims 2
- 230000005867 T cell response Effects 0.000 claims 2
- 210000001744 T-lymphocyte Anatomy 0.000 claims 2
- 229940127089 cytotoxic agent Drugs 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 210000002919 epithelial cell Anatomy 0.000 claims 2
- 239000013604 expression vector Substances 0.000 claims 2
- 230000028993 immune response Effects 0.000 claims 2
- 230000003053 immunization Effects 0.000 claims 2
- 230000037361 pathway Effects 0.000 claims 2
- 108020003175 receptors Proteins 0.000 claims 2
- 102000005962 receptors Human genes 0.000 claims 2
- 230000008685 targeting Effects 0.000 claims 2
- 229940124597 therapeutic agent Drugs 0.000 claims 2
- SSOORFWOBGFTHL-OTEJMHTDSA-N (4S)-5-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-6-amino-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[2-[(2S)-2-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-6-amino-1-[[(2S)-1-[[(2S)-1-[[(2S,3S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-6-amino-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-5-amino-1-[[(2S)-1-[[(2S)-1-[[(2S)-6-amino-1-[[(2S)-6-amino-1-[[(2S)-1-[[(2S)-1-[[(2S)-5-amino-1-[[(2S)-5-carbamimidamido-1-[[(2S)-5-carbamimidamido-1-[[(1S)-4-carbamimidamido-1-carboxybutyl]amino]-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-1-oxohexan-2-yl]amino]-1-oxohexan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]amino]-1-oxohexan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-1-oxohexan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1-oxopropan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]carbamoyl]pyrrolidin-1-yl]-2-oxoethyl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-1-oxohexan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-(1H-imidazol-4-yl)-1-oxopropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-4-[[(2S)-2-[[(2S)-2-[[(2S)-2,6-diaminohexanoyl]amino]-3-methylbutanoyl]amino]propanoyl]amino]-5-oxopentanoic acid Chemical compound CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@@H](N)CCCCN)C(C)C)C(C)C)C(C)C)C(C)C)C(C)C)C(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O SSOORFWOBGFTHL-OTEJMHTDSA-N 0.000 claims 1
- LKKMLIBUAXYLOY-UHFFFAOYSA-N 3-Amino-1-methyl-5H-pyrido[4,3-b]indole Chemical compound N1C2=CC=CC=C2C2=C1C=C(N)N=C2C LKKMLIBUAXYLOY-UHFFFAOYSA-N 0.000 claims 1
- 102100023003 Ankyrin repeat domain-containing protein 30A Human genes 0.000 claims 1
- 102100025570 Cancer/testis antigen 1 Human genes 0.000 claims 1
- 101000757191 Homo sapiens Ankyrin repeat domain-containing protein 30A Proteins 0.000 claims 1
- 101000856237 Homo sapiens Cancer/testis antigen 1 Proteins 0.000 claims 1
- 101000914324 Homo sapiens Carcinoembryonic antigen-related cell adhesion molecule 5 Proteins 0.000 claims 1
- 101000914321 Homo sapiens Carcinoembryonic antigen-related cell adhesion molecule 7 Proteins 0.000 claims 1
- 101001018034 Homo sapiens Lymphocyte antigen 75 Proteins 0.000 claims 1
- 101000620359 Homo sapiens Melanocyte protein PMEL Proteins 0.000 claims 1
- 101000617725 Homo sapiens Pregnancy-specific beta-1-glycoprotein 2 Proteins 0.000 claims 1
- 101000880770 Homo sapiens Protein SSX2 Proteins 0.000 claims 1
- 101001012157 Homo sapiens Receptor tyrosine-protein kinase erbB-2 Proteins 0.000 claims 1
- 102100031413 L-dopachrome tautomerase Human genes 0.000 claims 1
- 101710093778 L-dopachrome tautomerase Proteins 0.000 claims 1
- 108010010995 MART-1 Antigen Proteins 0.000 claims 1
- 102000043129 MHC class I family Human genes 0.000 claims 1
- 108091054437 MHC class I family Proteins 0.000 claims 1
- 102000043131 MHC class II family Human genes 0.000 claims 1
- 108091054438 MHC class II family Proteins 0.000 claims 1
- 102000000440 Melanoma-associated antigen Human genes 0.000 claims 1
- 108050008953 Melanoma-associated antigen Proteins 0.000 claims 1
- 102000003735 Mesothelin Human genes 0.000 claims 1
- 108090000015 Mesothelin Proteins 0.000 claims 1
- 102100034256 Mucin-1 Human genes 0.000 claims 1
- 108010008707 Mucin-1 Proteins 0.000 claims 1
- 102100022019 Pregnancy-specific beta-1-glycoprotein 2 Human genes 0.000 claims 1
- 102100037686 Protein SSX2 Human genes 0.000 claims 1
- 102100030086 Receptor tyrosine-protein kinase erbB-2 Human genes 0.000 claims 1
- 101710173694 Short transient receptor potential channel 2 Proteins 0.000 claims 1
- 108010017842 Telomerase Proteins 0.000 claims 1
- 102000003425 Tyrosinase Human genes 0.000 claims 1
- 108060008724 Tyrosinase Proteins 0.000 claims 1
- 102000040856 WT1 Human genes 0.000 claims 1
- 108700020467 WT1 Proteins 0.000 claims 1
- 101150084041 WT1 gene Proteins 0.000 claims 1
- 239000013566 allergen Substances 0.000 claims 1
- 125000000539 amino acid group Chemical group 0.000 claims 1
- 230000030741 antigen processing and presentation Effects 0.000 claims 1
- 239000002246 antineoplastic agent Substances 0.000 claims 1
- 210000003719 b-lymphocyte Anatomy 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 239000002254 cytotoxic agent Substances 0.000 claims 1
- 231100000599 cytotoxic agent Toxicity 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 239000003018 immunosuppressive agent Substances 0.000 claims 1
- 229940125721 immunosuppressive agent Drugs 0.000 claims 1
- 230000021633 leukocyte mediated immunity Effects 0.000 claims 1
- 230000001404 mediated effect Effects 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 claims 1
- 244000052769 pathogen Species 0.000 claims 1
- 230000001717 pathogenic effect Effects 0.000 claims 1
- 230000002093 peripheral effect Effects 0.000 claims 1
- 230000004044 response Effects 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 238000002198 surface plasmon resonance spectroscopy Methods 0.000 claims 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US225307P | 2007-11-07 | 2007-11-07 | |
| US61/002,253 | 2007-11-07 | ||
| US19155108P | 2008-09-10 | 2008-09-10 | |
| US61/191,551 | 2008-09-10 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010532344A Division JP5701606B2 (ja) | 2007-11-07 | 2008-11-07 | ヒト樹状細胞および上皮細胞２０５（ｄｅｃ−２０５）に結合する抗体 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016137221A Division JP2017014218A (ja) | 2007-11-07 | 2016-07-12 | ヒト樹状細胞および上皮細胞２０５（ｄｅｃ−２０５）に結合する抗体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015083010A JP2015083010A (ja) | 2015-04-30 |
| JP2015083010A5 true JP2015083010A5 (enExample) | 2015-11-12 |
| JP6067667B2 JP6067667B2 (ja) | 2017-01-25 |
Family
ID=40257038
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010532344A Expired - Fee Related JP5701606B2 (ja) | 2007-11-07 | 2008-11-07 | ヒト樹状細胞および上皮細胞２０５（ｄｅｃ−２０５）に結合する抗体 |
| JP2014255753A Expired - Fee Related JP6067667B2 (ja) | 2007-11-07 | 2014-12-18 | ヒト樹状細胞および上皮細胞２０５（ｄｅｃ−２０５）に結合する抗体 |
| JP2016137221A Pending JP2017014218A (ja) | 2007-11-07 | 2016-07-12 | ヒト樹状細胞および上皮細胞２０５（ｄｅｃ−２０５）に結合する抗体 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010532344A Expired - Fee Related JP5701606B2 (ja) | 2007-11-07 | 2008-11-07 | ヒト樹状細胞および上皮細胞２０５（ｄｅｃ−２０５）に結合する抗体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016137221A Pending JP2017014218A (ja) | 2007-11-07 | 2016-07-12 | ヒト樹状細胞および上皮細胞２０５（ｄｅｃ−２０５）に結合する抗体 |
Country Status (17)
| Country | Link |
|---|---|
| US (4) | US8236318B2 (enExample) |
| EP (2) | EP2224954B1 (enExample) |
| JP (3) | JP5701606B2 (enExample) |
| KR (2) | KR101811965B1 (enExample) |
| CN (1) | CN101888856B (enExample) |
| AU (1) | AU2008323848B2 (enExample) |
| BR (1) | BRPI0820270A2 (enExample) |
| CA (1) | CA2704583A1 (enExample) |
| DK (1) | DK2224954T3 (enExample) |
| EA (2) | EA026990B1 (enExample) |
| ES (1) | ES2445755T3 (enExample) |
| IL (1) | IL205393A (enExample) |
| MX (1) | MX2010005022A (enExample) |
| NZ (2) | NZ585556A (enExample) |
| SG (2) | SG187482A1 (enExample) |
| WO (1) | WO2009061996A2 (enExample) |
| ZA (1) | ZA201003101B (enExample) |
Families Citing this family (73)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1641927B1 (en) * | 2003-02-18 | 2015-07-08 | Baylor College of Medicine | Induced activation in dendritic cells |
| JP5285278B2 (ja) | 2004-12-22 | 2013-09-11 | クリーブランド クリニック ファウンデイション | フラゲリン関連ポリペプチドおよびその使用 |
| WO2008049113A2 (en) * | 2006-10-19 | 2008-04-24 | Baylor College Of Medicine | Generating an immune response by inducing cd40 and pattern recognition receptors |
| NZ578696A (en) * | 2007-02-02 | 2012-01-12 | Baylor Res Inst | Vaccines based on targeting antigen to dcir expressed an antigen-presenting cells |
| WO2008104803A2 (en) | 2007-02-26 | 2008-09-04 | Oxford Genome Sciences (Uk) Limited | Proteins |
| EP2224954B1 (en) | 2007-11-07 | 2014-01-08 | Celldex Therapeutics, Inc. | Antibodies that bind human dendritic and epithelial cell 205 (dec-205) |
| JP5577337B2 (ja) | 2008-08-01 | 2014-08-20 | クリーブランド バイオラブス， インコーポレイテッド | 再灌流傷害を治療するための方法 |
| ES2633470T3 (es) * | 2008-09-22 | 2017-09-21 | Baylor College Of Medicine | Métodos y composiciones de generación de una respuesta inmune mediante la inducción de CD40 y adaptadores de receptores de reconocimiento de patrones |
| TWI465250B (zh) | 2009-08-29 | 2014-12-21 | Abbvie Inc | 治療用之ｄｌｌ４結合蛋白質 |
| AU2010291939B2 (en) | 2009-09-14 | 2012-11-15 | Baylor Research Institute | Vaccines directed to Langerhans cells |
| CA2813494A1 (en) * | 2009-10-08 | 2011-04-14 | President And Fellows Of Harvard College | Methods and compositions for amelioration of autoimmune disease using fusion proteins of anti-dendritic cell receptor antibody to peptide sequences |
| CA2781248A1 (en) * | 2009-11-18 | 2011-05-26 | Mannkind Corporation | Monoclonal antibodies and diagnostic uses thereof |
| CN105037543B (zh) | 2010-03-02 | 2020-11-03 | Abbvie 公司 | 治疗性dll4结合蛋白 |
| AU2011239706B2 (en) | 2010-04-13 | 2015-08-20 | Celldex Therapeutics Inc. | Antibodies that bind human CD27 and uses thereof |
| CA2795947A1 (en) * | 2010-04-16 | 2011-10-20 | Bellicum Pharmaceuticals, Inc. | Method for treating solid tumors |
| WO2011146862A1 (en) | 2010-05-21 | 2011-11-24 | Bellicum Pharmaceuticals, Inc. | Methods for inducing selective apoptosis |
| DE102010039019B4 (de) | 2010-08-06 | 2014-08-07 | Technische Universität Dresden | Antikörper gegen 6-sulfo LacNAc positive humane dendritische Zellen und deren Verwendung |
| RU2013110889A (ru) * | 2010-08-13 | 2014-09-20 | Бейлор Рисёч Инститьют | Новые вакцинные адъюванты на основе адъювантов-антител, нацеливающих непосредственно на антигенпрезентирующие клетки |
| US11207109B2 (en) | 2010-10-20 | 2021-12-28 | 206 Ortho, Inc. | Method and apparatus for treating bone fractures, and/or for fortifying and/or augmenting bone, including the provision and use of composite implants, and novel composite structures which may be used for medical and non-medical applications |
| US11291483B2 (en) | 2010-10-20 | 2022-04-05 | 206 Ortho, Inc. | Method and apparatus for treating bone fractures, and/or for fortifying and/or augmenting bone, including the provision and use of composite implants |
| US11484627B2 (en) | 2010-10-20 | 2022-11-01 | 206 Ortho, Inc. | Method and apparatus for treating bone fractures, and/or for fortifying and/or augmenting bone, including the provision and use of composite implants, and novel composite structures which may be used for medical and non-medical applications |
| WO2015095745A1 (en) | 2010-10-20 | 2015-06-25 | 206 Ortho, Inc. | Method and apparatus for treating bone fractures, and/or for fortifying and/or augmenting bone, including the provision and use of composite implants, and novel composite structures which may be used for medical and non-medical applications |
| EP2663580B1 (en) * | 2011-01-10 | 2016-12-07 | CT Atlantic Ltd. | Combination therapy including tumor associated antigen binding antibodies |
| JP6041444B2 (ja) | 2011-01-10 | 2016-12-07 | クリーブランド バイオラブズ，インコーポレイテッド | 癌を治療するためのＴｏｌｌ様受容体アゴニストの使用 |
| WO2013009841A1 (en) * | 2011-07-11 | 2013-01-17 | Baylor Research Institute | Subsets of antigen-presenting cells (apc's) in the human vagina and their distinct functions |
| KR20140054140A (ko) * | 2011-07-27 | 2014-05-08 | 베일러 리서치 인스티튜트 | 췌장암에 대한 수지상 세포(ｄｃ) - 백신 치료요법 |
| SI2831113T1 (en) * | 2012-03-28 | 2018-08-31 | Sanofi | Antibodies to bradykinin b1 receptor ligands |
| GB201220010D0 (en) * | 2012-11-07 | 2012-12-19 | Oxford Biotherapeutics Ltd | Therapeutic amd diagnostic target |
| CN103044552B (zh) * | 2012-12-11 | 2019-01-29 | 中国医学科学院病原生物学研究所 | 人源化的抗树突状细胞表面dec-205分子的单克隆抗体 |
| US9434935B2 (en) | 2013-03-10 | 2016-09-06 | Bellicum Pharmaceuticals, Inc. | Modified caspase polypeptides and uses thereof |
| SG11201506974XA (en) | 2013-03-14 | 2015-10-29 | Bellicum Pharmaceuticals Inc | Methods for controlling t cell proliferation |
| US20140302037A1 (en) * | 2013-03-15 | 2014-10-09 | Amgen Inc. | BISPECIFIC-Fc MOLECULES |
| DK3004329T3 (da) | 2013-06-05 | 2020-05-18 | Bellicum Pharmaceuticals Inc | Fremgangsmåder til induktion af delvis apoptose under anvendelse af caspasepolypeptider |
| MX346878B (es) | 2013-06-26 | 2017-03-28 | Univ Nac Autónoma De México | Nuevos anticuerpos monoclonales contra el receptor dec-205 de celulas dendriticas de pollo. |
| CN103409451A (zh) * | 2013-06-28 | 2013-11-27 | 扬州维克斯生物科技有限公司 | 一种向树突状细胞dc靶向加载肿瘤抗原肽的方法 |
| US10081682B2 (en) * | 2013-10-11 | 2018-09-25 | Oxford Bio Therapeutics Ltd. | Conjugated antibodies against LY75 for the treatment of cancer |
| CN111849912B (zh) | 2014-02-14 | 2024-03-15 | 贝里坤制药股份有限公司 | 用诱导型嵌合多肽活化t细胞的方法 |
| JP6940916B2 (ja) | 2014-07-30 | 2021-09-29 | ゲノム プロテクション，インコーポレイテッド | フラジェリン組成物および使用 |
| US10888608B2 (en) | 2014-09-02 | 2021-01-12 | Bellicum Pharmaceuticals, Inc. | Costimulation of chimeric antigen receptors by MyD88 and CD40 polypeptides |
| US10183056B2 (en) | 2014-10-16 | 2019-01-22 | Cleveland Biolabs, Inc. | Methods and compositions for the treatment of radiation-related disorders |
| US10189880B2 (en) | 2014-11-03 | 2019-01-29 | Leiden University Medical Center | T cell receptors directed against Bob1 and uses thereof |
| WO2016145085A2 (en) | 2015-03-09 | 2016-09-15 | Celldex Therapeutics, Inc. | Cd27 agonists |
| CN107056932B (zh) * | 2016-12-24 | 2021-04-09 | 深圳大学 | 一种氨基酸序列、含ova表位的融合蛋白及其制备方法和应用 |
| GB201703876D0 (en) | 2017-03-10 | 2017-04-26 | Berlin-Chemie Ag | Pharmaceutical combinations |
| MX2019012295A (es) | 2017-04-14 | 2020-02-07 | Tollnine Inc | Polinucleotidos inmunomoduladores, conjugados de anticuerpos de los mismos y metodos para su uso. |
| MD3691692T2 (ro) * | 2017-10-14 | 2021-05-31 | Abbvie Inc | Conjugaţi medicament anticorp activabili anti-CD71 și metode de utilizare a acestora |
| WO2019082208A1 (en) * | 2017-10-27 | 2019-05-02 | Indian Institute Of Science | Dendritic cells-targeting vaccine |
| JP7466459B2 (ja) | 2018-04-17 | 2024-04-12 | セルデックス セラピューティクス インコーポレイテッド | 抗ｃｄ２７および抗ｐｄ－ｌ１抗体ならびに二重特異性構築物 |
| GB201809746D0 (en) | 2018-06-14 | 2018-08-01 | Berlin Chemie Ag | Pharmaceutical combinations |
| JPWO2019244973A1 (ja) * | 2018-06-20 | 2021-07-08 | 中外製薬株式会社 | 標的細胞に対する免疫反応を活性化する方法およびその組成物 |
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