JP2015083010A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2015083010A5 JP2015083010A5 JP2014255753A JP2014255753A JP2015083010A5 JP 2015083010 A5 JP2015083010 A5 JP 2015083010A5 JP 2014255753 A JP2014255753 A JP 2014255753A JP 2014255753 A JP2014255753 A JP 2014255753A JP 2015083010 A5 JP2015083010 A5 JP 2015083010A5
- Authority
- JP
- Japan
- Prior art keywords
- chain variable
- amino acid
- variable region
- acid sequence
- seq
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000003275 alpha amino acid group Chemical group 0.000 claims 22
- 239000000427 antigen Substances 0.000 claims 17
- 102000036639 antigens Human genes 0.000 claims 17
- 108091007433 antigens Proteins 0.000 claims 17
- 108091035707 Consensus sequence Proteins 0.000 claims 6
- 210000004443 dendritic cell Anatomy 0.000 claims 4
- 101100112922 Candida albicans CDR3 gene Proteins 0.000 claims 3
- 102100022430 Melanocyte protein PMEL Human genes 0.000 claims 3
- 102100028389 Melanoma antigen recognized by T-cells 1 Human genes 0.000 claims 3
- 239000012472 biological sample Substances 0.000 claims 3
- 230000002708 enhancing effect Effects 0.000 claims 3
- 230000001939 inductive effect Effects 0.000 claims 3
- 229910052757 nitrogen Inorganic materials 0.000 claims 3
- 229910052698 phosphorus Inorganic materials 0.000 claims 3
- 101100005713 Homo sapiens CD4 gene Proteins 0.000 claims 2
- 101000578784 Homo sapiens Melanoma antigen recognized by T-cells 1 Proteins 0.000 claims 2
- 101001094545 Homo sapiens Retrotransposon-like protein 1 Proteins 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 101800001271 Surface protein Proteins 0.000 claims 2
- 230000005867 T cell response Effects 0.000 claims 2
- 210000001744 T-lymphocyte Anatomy 0.000 claims 2
- 229940127089 cytotoxic agent Drugs 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 210000002919 epithelial cell Anatomy 0.000 claims 2
- 239000013604 expression vector Substances 0.000 claims 2
- 230000028993 immune response Effects 0.000 claims 2
- 230000003053 immunization Effects 0.000 claims 2
- 230000037361 pathway Effects 0.000 claims 2
- 108020003175 receptors Proteins 0.000 claims 2
- 102000005962 receptors Human genes 0.000 claims 2
- 230000008685 targeting Effects 0.000 claims 2
- 229940124597 therapeutic agent Drugs 0.000 claims 2
- SSOORFWOBGFTHL-OTEJMHTDSA-N (4S)-5-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-6-amino-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[2-[(2S)-2-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-6-amino-1-[[(2S)-1-[[(2S)-1-[[(2S,3S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-6-amino-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-5-amino-1-[[(2S)-1-[[(2S)-1-[[(2S)-6-amino-1-[[(2S)-6-amino-1-[[(2S)-1-[[(2S)-1-[[(2S)-5-amino-1-[[(2S)-5-carbamimidamido-1-[[(2S)-5-carbamimidamido-1-[[(1S)-4-carbamimidamido-1-carboxybutyl]amino]-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-1-oxohexan-2-yl]amino]-1-oxohexan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]amino]-1-oxohexan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-1-oxohexan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1-oxopropan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]carbamoyl]pyrrolidin-1-yl]-2-oxoethyl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-1-oxohexan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-(1H-imidazol-4-yl)-1-oxopropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-4-[[(2S)-2-[[(2S)-2-[[(2S)-2,6-diaminohexanoyl]amino]-3-methylbutanoyl]amino]propanoyl]amino]-5-oxopentanoic acid Chemical compound CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@@H](N)CCCCN)C(C)C)C(C)C)C(C)C)C(C)C)C(C)C)C(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O SSOORFWOBGFTHL-OTEJMHTDSA-N 0.000 claims 1
- LKKMLIBUAXYLOY-UHFFFAOYSA-N 3-Amino-1-methyl-5H-pyrido[4,3-b]indole Chemical compound N1C2=CC=CC=C2C2=C1C=C(N)N=C2C LKKMLIBUAXYLOY-UHFFFAOYSA-N 0.000 claims 1
- 102100023003 Ankyrin repeat domain-containing protein 30A Human genes 0.000 claims 1
- 102100025570 Cancer/testis antigen 1 Human genes 0.000 claims 1
- 101000757191 Homo sapiens Ankyrin repeat domain-containing protein 30A Proteins 0.000 claims 1
- 101000856237 Homo sapiens Cancer/testis antigen 1 Proteins 0.000 claims 1
- 101000914324 Homo sapiens Carcinoembryonic antigen-related cell adhesion molecule 5 Proteins 0.000 claims 1
- 101000914321 Homo sapiens Carcinoembryonic antigen-related cell adhesion molecule 7 Proteins 0.000 claims 1
- 101001018034 Homo sapiens Lymphocyte antigen 75 Proteins 0.000 claims 1
- 101000620359 Homo sapiens Melanocyte protein PMEL Proteins 0.000 claims 1
- 101000617725 Homo sapiens Pregnancy-specific beta-1-glycoprotein 2 Proteins 0.000 claims 1
- 101000880770 Homo sapiens Protein SSX2 Proteins 0.000 claims 1
- 101001012157 Homo sapiens Receptor tyrosine-protein kinase erbB-2 Proteins 0.000 claims 1
- 102100031413 L-dopachrome tautomerase Human genes 0.000 claims 1
- 101710093778 L-dopachrome tautomerase Proteins 0.000 claims 1
- 108010010995 MART-1 Antigen Proteins 0.000 claims 1
- 102000043129 MHC class I family Human genes 0.000 claims 1
- 108091054437 MHC class I family Proteins 0.000 claims 1
- 102000043131 MHC class II family Human genes 0.000 claims 1
- 108091054438 MHC class II family Proteins 0.000 claims 1
- 102000000440 Melanoma-associated antigen Human genes 0.000 claims 1
- 108050008953 Melanoma-associated antigen Proteins 0.000 claims 1
- 102000003735 Mesothelin Human genes 0.000 claims 1
- 108090000015 Mesothelin Proteins 0.000 claims 1
- 102100034256 Mucin-1 Human genes 0.000 claims 1
- 108010008707 Mucin-1 Proteins 0.000 claims 1
- 102100022019 Pregnancy-specific beta-1-glycoprotein 2 Human genes 0.000 claims 1
- 102100037686 Protein SSX2 Human genes 0.000 claims 1
- 102100030086 Receptor tyrosine-protein kinase erbB-2 Human genes 0.000 claims 1
- 101710173694 Short transient receptor potential channel 2 Proteins 0.000 claims 1
- 108010017842 Telomerase Proteins 0.000 claims 1
- 102000003425 Tyrosinase Human genes 0.000 claims 1
- 108060008724 Tyrosinase Proteins 0.000 claims 1
- 102000040856 WT1 Human genes 0.000 claims 1
- 108700020467 WT1 Proteins 0.000 claims 1
- 101150084041 WT1 gene Proteins 0.000 claims 1
- 239000013566 allergen Substances 0.000 claims 1
- 125000000539 amino acid group Chemical group 0.000 claims 1
- 230000030741 antigen processing and presentation Effects 0.000 claims 1
- 239000002246 antineoplastic agent Substances 0.000 claims 1
- 210000003719 b-lymphocyte Anatomy 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 239000002254 cytotoxic agent Substances 0.000 claims 1
- 231100000599 cytotoxic agent Toxicity 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 239000003018 immunosuppressive agent Substances 0.000 claims 1
- 229940125721 immunosuppressive agent Drugs 0.000 claims 1
- 230000021633 leukocyte mediated immunity Effects 0.000 claims 1
- 230000001404 mediated effect Effects 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 claims 1
- 244000052769 pathogen Species 0.000 claims 1
- 230000001717 pathogenic effect Effects 0.000 claims 1
- 230000002093 peripheral effect Effects 0.000 claims 1
- 230000004044 response Effects 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 238000002198 surface plasmon resonance spectroscopy Methods 0.000 claims 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US225307P | 2007-11-07 | 2007-11-07 | |
| US61/002,253 | 2007-11-07 | ||
| US19155108P | 2008-09-10 | 2008-09-10 | |
| US61/191,551 | 2008-09-10 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010532344A Division JP5701606B2 (ja) | 2007-11-07 | 2008-11-07 | ヒト樹状細胞および上皮細胞２０５（ｄｅｃ−２０５）に結合する抗体 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016137221A Division JP2017014218A (ja) | 2007-11-07 | 2016-07-12 | ヒト樹状細胞および上皮細胞２０５（ｄｅｃ−２０５）に結合する抗体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015083010A JP2015083010A (ja) | 2015-04-30 |
| JP2015083010A5 true JP2015083010A5 (enExample) | 2015-11-12 |
| JP6067667B2 JP6067667B2 (ja) | 2017-01-25 |
Family
ID=40257038
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010532344A Expired - Fee Related JP5701606B2 (ja) | 2007-11-07 | 2008-11-07 | ヒト樹状細胞および上皮細胞２０５（ｄｅｃ−２０５）に結合する抗体 |
| JP2014255753A Expired - Fee Related JP6067667B2 (ja) | 2007-11-07 | 2014-12-18 | ヒト樹状細胞および上皮細胞２０５（ｄｅｃ−２０５）に結合する抗体 |
| JP2016137221A Pending JP2017014218A (ja) | 2007-11-07 | 2016-07-12 | ヒト樹状細胞および上皮細胞２０５（ｄｅｃ−２０５）に結合する抗体 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010532344A Expired - Fee Related JP5701606B2 (ja) | 2007-11-07 | 2008-11-07 | ヒト樹状細胞および上皮細胞２０５（ｄｅｃ−２０５）に結合する抗体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016137221A Pending JP2017014218A (ja) | 2007-11-07 | 2016-07-12 | ヒト樹状細胞および上皮細胞２０５（ｄｅｃ−２０５）に結合する抗体 |
Country Status (17)
| Country | Link |
|---|---|
| US (4) | US8236318B2 (enExample) |
| EP (2) | EP2570137A3 (enExample) |
| JP (3) | JP5701606B2 (enExample) |
| KR (2) | KR101811965B1 (enExample) |
| CN (1) | CN101888856B (enExample) |
| AU (1) | AU2008323848B2 (enExample) |
| BR (1) | BRPI0820270A2 (enExample) |
| CA (1) | CA2704583A1 (enExample) |
| DK (1) | DK2224954T3 (enExample) |
| EA (2) | EA201692127A1 (enExample) |
| ES (1) | ES2445755T3 (enExample) |
| IL (1) | IL205393A (enExample) |
| MX (1) | MX2010005022A (enExample) |
| NZ (2) | NZ599777A (enExample) |
| SG (2) | SG10201605208QA (enExample) |
| WO (1) | WO2009061996A2 (enExample) |
| ZA (1) | ZA201003101B (enExample) |
Families Citing this family (73)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1641927B1 (en) | 2003-02-18 | 2015-07-08 | Baylor College of Medicine | Induced activation in dendritic cells |
| EP2460534A1 (en) | 2004-12-22 | 2012-06-06 | Cleveland Clinic Foundation | Flagellin related polypeptides and uses thereof |
| US8691210B2 (en) * | 2006-10-19 | 2014-04-08 | David M Spencer | Methods and compositions for generating an immune response by inducing CD40 and pattern recognition receptors and adaptors thereof |
| CA2715044A1 (en) * | 2007-02-02 | 2008-08-14 | Baylor Research Institute | Vaccines based on targeting antigen to dcir expressed an antigen-presenting cells |
| WO2008104803A2 (en) | 2007-02-26 | 2008-09-04 | Oxford Genome Sciences (Uk) Limited | Proteins |
| EA201692127A1 (ru) | 2007-11-07 | 2017-08-31 | Селлдекс Терапьютикс Инк. | Антитела, связывающиеся с человеческим dec-205 |
| EP2320948B1 (en) | 2008-08-01 | 2013-03-06 | Cleveland Biolabs, Inc. | Methods for treating reperfusion injuries |
| WO2010033949A1 (en) | 2008-09-22 | 2010-03-25 | Baylor College Of Medicine | Methods and compositions for generating an immune response by inducing cd40 and pattern recognition receptor adapters |
| CN105131112A (zh) | 2009-08-29 | 2015-12-09 | Abbvie公司 | 治疗用dll4结合蛋白 |
| BR112012005713A2 (pt) | 2009-09-14 | 2019-09-24 | Baylor Res Institute | vacinas direcionadas a célula langerhans. |
| CA2813494A1 (en) * | 2009-10-08 | 2011-04-14 | President And Fellows Of Harvard College | Methods and compositions for amelioration of autoimmune disease using fusion proteins of anti-dendritic cell receptor antibody to peptide sequences |
| US8846872B2 (en) | 2009-11-18 | 2014-09-30 | Mannkind Corporation | Monoclonal antibodies and diagnostic uses thereof |
| AU2011223919B2 (en) | 2010-03-02 | 2015-03-19 | Abbvie Inc. | Therapeutic DLL4 binding proteins |
| EA201690310A1 (ru) | 2010-04-13 | 2016-12-30 | Селлдекс Терапьютикс Инк. | Антитела, связывающие cd27 человека, и их применение |
| AU2011239569B2 (en) * | 2010-04-16 | 2014-07-24 | Baylor College Of Medicine | Method for treating solid tumors |
| US9089520B2 (en) | 2010-05-21 | 2015-07-28 | Baylor College Of Medicine | Methods for inducing selective apoptosis |
| DE102010039019B4 (de) | 2010-08-06 | 2014-08-07 | Technische Universität Dresden | Antikörper gegen 6-sulfo LacNAc positive humane dendritische Zellen und deren Verwendung |
| WO2012021834A1 (en) * | 2010-08-13 | 2012-02-16 | Baylor Research Institute | Novel vaccine adjuvants based on targeting adjuvants to antibodies directly to antigen-presenting cells |
| US11291483B2 (en) | 2010-10-20 | 2022-04-05 | 206 Ortho, Inc. | Method and apparatus for treating bone fractures, and/or for fortifying and/or augmenting bone, including the provision and use of composite implants |
| WO2015095745A1 (en) | 2010-10-20 | 2015-06-25 | 206 Ortho, Inc. | Method and apparatus for treating bone fractures, and/or for fortifying and/or augmenting bone, including the provision and use of composite implants, and novel composite structures which may be used for medical and non-medical applications |
| US11207109B2 (en) | 2010-10-20 | 2021-12-28 | 206 Ortho, Inc. | Method and apparatus for treating bone fractures, and/or for fortifying and/or augmenting bone, including the provision and use of composite implants, and novel composite structures which may be used for medical and non-medical applications |
| US11484627B2 (en) | 2010-10-20 | 2022-11-01 | 206 Ortho, Inc. | Method and apparatus for treating bone fractures, and/or for fortifying and/or augmenting bone, including the provision and use of composite implants, and novel composite structures which may be used for medical and non-medical applications |
| WO2012097012A1 (en) | 2011-01-10 | 2012-07-19 | Cleveland Biolabs, Inc. | Use of toll-like receptor agonist for treating cancer |
| JP5828909B2 (ja) * | 2011-01-10 | 2015-12-09 | シーティー アトランティック リミテッド | 腫瘍関連抗原結合抗体を含む併用療法 |
| WO2013009841A1 (en) * | 2011-07-11 | 2013-01-17 | Baylor Research Institute | Subsets of antigen-presenting cells (apc's) in the human vagina and their distinct functions |
| US20130028915A1 (en) * | 2011-07-27 | 2013-01-31 | Baylor Research Institute | Dendritic cell (dc)-vaccine therapy for pancreatic cancer |
| KR102367723B1 (ko) * | 2012-03-28 | 2022-02-28 | 사노피 | 브라디키닌 b1 수용체 리간드에 대한 항체 |
| GB201220010D0 (en) * | 2012-11-07 | 2012-12-19 | Oxford Biotherapeutics Ltd | Therapeutic amd diagnostic target |
| CN103044552B (zh) * | 2012-12-11 | 2019-01-29 | 中国医学科学院病原生物学研究所 | 人源化的抗树突状细胞表面dec-205分子的单克隆抗体 |
| US9434935B2 (en) | 2013-03-10 | 2016-09-06 | Bellicum Pharmaceuticals, Inc. | Modified caspase polypeptides and uses thereof |
| WO2014151960A2 (en) | 2013-03-14 | 2014-09-25 | Bellicum Pharmaceuticals, Inc. | Methods for controlling t cell proliferation |
| US20140302037A1 (en) * | 2013-03-15 | 2014-10-09 | Amgen Inc. | BISPECIFIC-Fc MOLECULES |
| WO2014197638A2 (en) | 2013-06-05 | 2014-12-11 | Bellicum Pharmaceuticals, Inc. | Methods for inducing partial apoptosis using caspase polypeptides |
| MX346878B (es) | 2013-06-26 | 2017-03-28 | Univ Nac Autónoma De México | Nuevos anticuerpos monoclonales contra el receptor dec-205 de celulas dendriticas de pollo. |
| CN103409451A (zh) * | 2013-06-28 | 2013-11-27 | 扬州维克斯生物科技有限公司 | 一种向树突状细胞dc靶向加载肿瘤抗原肽的方法 |
| ES2859604T3 (es) * | 2013-10-11 | 2021-10-04 | Oxford Bio Therapeutics Ltd | Anticuerpos conjugados contra LY75 para el tratamiento del cáncer |
| CN111849912B (zh) | 2014-02-14 | 2024-03-15 | 贝里坤制药股份有限公司 | 用诱导型嵌合多肽活化t细胞的方法 |
| KR20170031251A (ko) | 2014-07-30 | 2017-03-20 | 클리브랜드 바이오랩스, 아이엔씨. | 플라젤린 조성물 및 용도 |
| US10888608B2 (en) | 2014-09-02 | 2021-01-12 | Bellicum Pharmaceuticals, Inc. | Costimulation of chimeric antigen receptors by MyD88 and CD40 polypeptides |
| US10183056B2 (en) | 2014-10-16 | 2019-01-22 | Cleveland Biolabs, Inc. | Methods and compositions for the treatment of radiation-related disorders |
| JP6718444B2 (ja) | 2014-11-03 | 2020-07-08 | アカデミッシュ ザイケンホイス レイデン （エイチ．オー．ディー．エヌ． エルユーエムシー） | Ｂｏｂ１に対して指向されるＴ細胞レセプターおよびその使用 |
| EP3268037B1 (en) | 2015-03-09 | 2022-08-31 | Celldex Therapeutics, Inc. | Cd27 agonists |
| CN107056932B (zh) * | 2016-12-24 | 2021-04-09 | 深圳大学 | 一种氨基酸序列、含ova表位的融合蛋白及其制备方法和应用 |
| GB201703876D0 (en) | 2017-03-10 | 2017-04-26 | Berlin-Chemie Ag | Pharmaceutical combinations |
| CA3058966A1 (en) | 2017-04-14 | 2018-10-18 | Tollnine, Inc. | Immunomodulating polynucleotides, antibody conjugates thereof, and methods of their use |
| ES2864013T3 (es) * | 2017-10-14 | 2021-10-13 | Abbvie Inc | Conjugados de fármaco y anticuerpo activable anti-CD71 y métodos de uso de los mismos |
| EP3700557A4 (en) * | 2017-10-27 | 2021-07-28 | Indian Institute of Science | VACCINE TARGETING DENDRITIC CELLS |
| MX2020010913A (es) | 2018-04-17 | 2021-01-08 | Celldex Therapeutics Inc | Anticuerpos anti-cd27 y anti-pd-l1 y constructos biespecíficos. |
| GB201809746D0 (en) | 2018-06-14 | 2018-08-01 | Berlin Chemie Ag | Pharmaceutical combinations |
| WO2019244973A1 (ja) * | 2018-06-20 | 2019-12-26 | 中外製薬株式会社 | 標的細胞に対する免疫反応を活性化する方法およびその組成物 |
| CN112368613B (zh) | 2018-06-29 | 2022-10-21 | 日本瑞翁株式会社 | 识别介质、真实性判定方法以及物品 |
| US20220016168A1 (en) | 2018-12-11 | 2022-01-20 | Celldex Therapeutics, Inc. | Methods of using cd27 antibodies as conditioning treatment for adoptive cell therapy |
| US20220010008A1 (en) * | 2018-12-12 | 2022-01-13 | Shanghai Pharmaexplorer Co., Ltd. | Anti-human interleukin 5(il-5) monoclonal antibody and use thereof |
| CA3162518A1 (en) * | 2019-11-26 | 2021-06-03 | Cedars-Sinai Medical Center | Compositions and methods for treating diseases and conditions by depletion of mitochondrial or genomic dna from circulation |
| JP2023505311A (ja) * | 2019-12-05 | 2023-02-08 | デンドロサイト バイオテック ピーティーワイ リミテッド | 抗原負荷 |
| JP7735291B2 (ja) | 2020-02-21 | 2025-09-08 | エーアールエス ファーマシューティカルズ、インコーポレイテッド | ネクチン－４抗体コンジュゲートおよびその使用 |
| CN115427458A (zh) | 2020-02-28 | 2022-12-02 | 塔拉克治疗公司 | 转谷氨酰胺酶介导的缀合 |
| WO2022006327A1 (en) | 2020-07-01 | 2022-01-06 | Silverback Therapeutics, Inc. | Anti-asgr1 antibody conjugates and uses thereof |
| US20240417459A1 (en) | 2021-04-09 | 2024-12-19 | Celldex Therapeutics, Inc. | Antibodies against ilt4, bispecific anti-ilt4/pd-l1 antibody and uses thereof |
| BR112023023831A2 (pt) | 2021-05-26 | 2024-01-30 | Oxford Biotherapeutics Ltd | Métodos, combinação farmacêutica, anticorpo ou porção de ligação ao antígeno do mesmo |
| WO2023077521A1 (en) | 2021-11-08 | 2023-05-11 | Celldex Therapeutics, Inc | Anti-ilt4 and anti-pd-1 bispecific constructs |
| US20250073346A1 (en) | 2021-11-18 | 2025-03-06 | Oxford Bio Therapeutics Ltd | Pharmaceutical combinations |
| CN114949191A (zh) * | 2022-06-21 | 2022-08-30 | 苏州工业园区唯可达生物科技有限公司 | 一种肿瘤疫苗及其制备方法 |
| CN114887047A (zh) * | 2022-06-21 | 2022-08-12 | 苏州工业园区唯可达生物科技有限公司 | 基于ny-eso-1肿瘤抗原的疫苗及制备方法 |
| CN115028741A (zh) * | 2022-06-21 | 2022-09-09 | 苏州工业园区唯可达生物科技有限公司 | 一种肿瘤抗原抗体复合物及制备方法和应用 |
| CN114989311A (zh) * | 2022-06-21 | 2022-09-02 | 苏州工业园区唯可达生物科技有限公司 | 3g9-lnm抗体偶联蛋白及其制备方法和应用 |
| WO2024040195A1 (en) | 2022-08-17 | 2024-02-22 | Capstan Therapeutics, Inc. | Conditioning for in vivo immune cell engineering |
| US12311033B2 (en) | 2023-05-31 | 2025-05-27 | Capstan Therapeutics, Inc. | Lipid nanoparticle formulations and compositions |
| WO2025076113A1 (en) | 2023-10-05 | 2025-04-10 | Capstan Therapeutics, Inc. | Ionizable cationic lipids with conserved spacing and lipid nanoparticles |
| WO2025076127A1 (en) | 2023-10-05 | 2025-04-10 | Capstan Therapeutics, Inc. | Constrained ionizable cationic lipids and lipid nanoparticles |
| US20250302763A1 (en) | 2024-02-22 | 2025-10-02 | Capstan Therapeutics, Inc. | Immune engineering amplification |
| WO2025217454A2 (en) | 2024-04-11 | 2025-10-16 | Capstan Therapeutics, Inc. | Ionizable cationic lipids and lipid nanoparticles |
| WO2025217452A1 (en) | 2024-04-11 | 2025-10-16 | Capstan Therapeutics, Inc. | Constrained ionizable cationic lipids and lipid nanoparticles |
Family Cites Families (124)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2857090A (en) | 1955-06-02 | 1958-10-21 | Crown Zellerbach Corp | Container for heavy articles |
| US2887389A (en) | 1955-06-03 | 1959-05-19 | Creath Q Linville | Cartons |
| US3164316A (en) | 1962-05-21 | 1965-01-05 | Weyerhaeuser Co | Carton |
| US3353740A (en) | 1965-12-28 | 1967-11-21 | Int Paper Co | Reclosable carton |
| US3447735A (en) | 1967-07-03 | 1969-06-03 | Western Kraft Corp | Easy-opening container |
| US3552633A (en) | 1969-10-27 | 1971-01-05 | Inland Container Corp | Pallet case |
| US3698548A (en) | 1970-06-15 | 1972-10-17 | Robert N Stenzel | Box for dispensing flexible sheet material |
| US3883067A (en) | 1972-12-15 | 1975-05-13 | Continental Can Co | Carton corner construction |
| US4267959A (en) | 1979-10-22 | 1981-05-19 | Westvaco Corporation | Hinged paperboard container |
| US4475196A (en) | 1981-03-06 | 1984-10-02 | Zor Clair G | Instrument for locating faults in aircraft passenger reading light and attendant call control system |
| US4447233A (en) | 1981-04-10 | 1984-05-08 | Parker-Hannifin Corporation | Medication infusion pump |
| US4474893A (en) | 1981-07-01 | 1984-10-02 | The University of Texas System Cancer Center | Recombinant monoclonal antibodies |
| US4439196A (en) | 1982-03-18 | 1984-03-27 | Merck & Co., Inc. | Osmotic drug delivery system |
| US4436727A (en) | 1982-05-26 | 1984-03-13 | Ribi Immunochem Research, Inc. | Refined detoxified endotoxin product |
| US4866034A (en) | 1982-05-26 | 1989-09-12 | Ribi Immunochem Research Inc. | Refined detoxified endotoxin |
| US4522811A (en) | 1982-07-08 | 1985-06-11 | Syntex (U.S.A.) Inc. | Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides |
| US4447224A (en) | 1982-09-20 | 1984-05-08 | Infusaid Corporation | Variable flow implantable infusion apparatus |
| US4487603A (en) | 1982-11-26 | 1984-12-11 | Cordis Corporation | Implantable microinfusion pump system |
| US4486194A (en) | 1983-06-08 | 1984-12-04 | James Ferrara | Therapeutic device for administering medicaments through the skin |
| GB8422238D0 (en) | 1984-09-03 | 1984-10-10 | Neuberger M S | Chimeric proteins |
| US4596556A (en) | 1985-03-25 | 1986-06-24 | Bioject, Inc. | Hypodermic injection apparatus |
| US5374548A (en) | 1986-05-02 | 1994-12-20 | Genentech, Inc. | Methods and compositions for the attachment of proteins to liposomes using a glycophospholipid anchor |
| MX9203291A (es) | 1985-06-26 | 1992-08-01 | Liposome Co Inc | Metodo para acoplamiento de liposomas. |
| GB8601597D0 (en) | 1986-01-23 | 1986-02-26 | Wilson R H | Nucleotide sequences |
| US4877611A (en) | 1986-04-15 | 1989-10-31 | Ribi Immunochem Research Inc. | Vaccine containing tumor antigens and adjuvants |
| US4954617A (en) | 1986-07-07 | 1990-09-04 | Trustees Of Dartmouth College | Monoclonal antibodies to FC receptors for immunoglobulin G on human mononuclear phagocytes |
| US4946778A (en) | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
| US5260203A (en) | 1986-09-02 | 1993-11-09 | Enzon, Inc. | Single polypeptide chain binding molecules |
| WO1988009344A1 (en) | 1987-05-21 | 1988-12-01 | Creative Biomolecules, Inc. | Targeted multifunctional proteins |
| US4941880A (en) | 1987-06-19 | 1990-07-17 | Bioject, Inc. | Pre-filled ampule and non-invasive hypodermic injection device assembly |
| US4790824A (en) | 1987-06-19 | 1988-12-13 | Bioject, Inc. | Non-invasive hypodermic injection device |
| GB8717430D0 (en) | 1987-07-23 | 1987-08-26 | Celltech Ltd | Recombinant dna product |
| ES2012739T5 (es) | 1987-11-18 | 2001-12-01 | Chiron Corp | Diagnosticos para nanbv. |
| US5804381A (en) | 1996-10-03 | 1998-09-08 | Cornell Research Foundation | Isolated nucleic acid molecule encoding an esophageal cancer associated antigen, the antigen itself, and uses thereof |
| GB8809129D0 (en) | 1988-04-18 | 1988-05-18 | Celltech Ltd | Recombinant dna methods vectors and host cells |
| US4912094B1 (en) | 1988-06-29 | 1994-02-15 | Ribi Immunochem Research Inc. | Modified lipopolysaccharides and process of preparation |
| US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
| GB8823869D0 (en) | 1988-10-12 | 1988-11-16 | Medical Res Council | Production of antibodies |
| US5108921A (en) | 1989-04-03 | 1992-04-28 | Purdue Research Foundation | Method for enhanced transmembrane transport of exogenous molecules |
| US5064413A (en) | 1989-11-09 | 1991-11-12 | Bioject, Inc. | Needleless hypodermic injection device |
| US5312335A (en) | 1989-11-09 | 1994-05-17 | Bioject Inc. | Needleless hypodermic injection device |
| SG46445A1 (en) * | 1990-01-26 | 1998-02-20 | Immunomedics Inc | Vaccines against cancer and infectious diseases |
| US5427908A (en) | 1990-05-01 | 1995-06-27 | Affymax Technologies N.V. | Recombinant library screening methods |
| US6172197B1 (en) | 1991-07-10 | 2001-01-09 | Medical Research Council | Methods for producing members of specific binding pairs |
| GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
| US5789650A (en) | 1990-08-29 | 1998-08-04 | Genpharm International, Inc. | Transgenic non-human animals for producing heterologous antibodies |
| US5877397A (en) | 1990-08-29 | 1999-03-02 | Genpharm International Inc. | Transgenic non-human animals capable of producing heterologous antibodies of various isotypes |
| US5545806A (en) | 1990-08-29 | 1996-08-13 | Genpharm International, Inc. | Ransgenic non-human animals for producing heterologous antibodies |
| US6300129B1 (en) | 1990-08-29 | 2001-10-09 | Genpharm International | Transgenic non-human animals for producing heterologous antibodies |
| US5625126A (en) | 1990-08-29 | 1997-04-29 | Genpharm International, Inc. | Transgenic non-human animals for producing heterologous antibodies |
| US5661016A (en) | 1990-08-29 | 1997-08-26 | Genpharm International Inc. | Transgenic non-human animals capable of producing heterologous antibodies of various isotypes |
| US5633425A (en) | 1990-08-29 | 1997-05-27 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| US5814318A (en) | 1990-08-29 | 1998-09-29 | Genpharm International Inc. | Transgenic non-human animals for producing heterologous antibodies |
| ES2246502T3 (es) | 1990-08-29 | 2006-02-16 | Genpharm International, Inc. | Animales no humanos transgenicos capaces de producir anticuerpos heterologos. |
| US5770429A (en) | 1990-08-29 | 1998-06-23 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| US5874299A (en) | 1990-08-29 | 1999-02-23 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| AU9040591A (en) | 1990-11-06 | 1992-05-26 | Children's Medical Center Corporation | Soluble mannose receptor peptides |
| US6235525B1 (en) | 1991-05-23 | 2001-05-22 | Ludwig Institute For Cancer Research | Isolated nucleic acid molecules coding for tumor rejection antigen precursor MAGE-3 and uses thereof |
| JP4124480B2 (ja) | 1991-06-14 | 2008-07-23 | ジェネンテック・インコーポレーテッド | 免疫グロブリン変異体 |
| AU2235992A (en) | 1991-06-14 | 1993-01-12 | Genpharm International, Inc. | Transgenic immunodeficient non-human animals |
| DE69224906T2 (de) | 1991-07-08 | 1998-10-29 | Univ Massachusetts | Thermotropes flüssig-kristallines segment-blockcopolymer |
| DE4123760C2 (de) | 1991-07-18 | 2000-01-20 | Dade Behring Marburg Gmbh | Seroreaktive Bereiche auf den HPV 16 Proteinen E1 und E2 |
| GB9117522D0 (en) | 1991-08-14 | 1991-10-02 | Medical Res Council | Ligands for dendritic cells, their uses and production |
| DK1024191T3 (da) | 1991-12-02 | 2008-12-08 | Medical Res Council | Fremstilling af autoantistoffer fremvist på fag-overflader ud fra antistofsegmentbiblioteker |
| CA2124967C (en) | 1991-12-17 | 2008-04-08 | Nils Lonberg | Transgenic non-human animals capable of producing heterologous antibodies |
| US5383851A (en) | 1992-07-24 | 1995-01-24 | Bioject Inc. | Needleless hypodermic injection device |
| GB9223377D0 (en) | 1992-11-04 | 1992-12-23 | Medarex Inc | Humanized antibodies to fc receptors for immunoglobulin on human mononuclear phagocytes |
| US5620886A (en) | 1993-03-18 | 1997-04-15 | Ludwig Institute For Cancer Research | Isolated nucleic acid sequence coding for a tumor rejection antigen precursor processed to at least one tumor rejection antigen presented by HLA-A2 |
| EP0754225A4 (en) | 1993-04-26 | 2001-01-31 | Genpharm Int | HETEROLOGIC ANTIBODY-PRODUCING TRANSGENIC NON-HUMAN ANIMALS |
| WO1995012409A1 (en) | 1993-11-04 | 1995-05-11 | Canterbury Health Limited | Dendritic cell-specific antibodies and methods for their preparation |
| WO1995015340A1 (en) | 1993-12-03 | 1995-06-08 | The Board Of Trustees Of Leland Stanford Junior University | Monoclonal antibodies to antigens expressed by human dendritic cells |
| US5541110A (en) | 1994-05-17 | 1996-07-30 | Bristol-Myers Squibb | Cloning and expression of a gene encoding bryodin 1 from Bryonia dioica |
| US6194388B1 (en) | 1994-07-15 | 2001-02-27 | The University Of Iowa Research Foundation | Immunomodulatory oligonucleotides |
| US5698679A (en) | 1994-09-19 | 1997-12-16 | National Jewish Center For Immunology And Respiratory Medicine | Product and process for targeting an immune response |
| WO2001072329A1 (en) | 2000-03-29 | 2001-10-04 | The Trustees Of The University Of Pennsylvania | Compositions and methods for enhancing immunogenicity of antigens |
| JPH10513350A (ja) | 1995-01-31 | 1998-12-22 | ザ ロックフェラー ユニヴァーシティ | ＤＥＣ（樹状細胞及び上皮細胞、２０５ ｋＤａ）の同定、Ｃ型レクチンドメインを有するレセプター、ＤＥＣをコードする核酸、及びこれらの使用 |
| US20020187131A1 (en) | 1995-01-31 | 2002-12-12 | Daniel Hawiger | Enhanced antigen delivery and modulation of the immune response therefrom |
| US20040258688A1 (en) * | 1995-01-31 | 2004-12-23 | Daniel Hawiger | Enhanced antigen delivery and modulation of the immune response therefrom |
| US5840306A (en) | 1995-03-22 | 1998-11-24 | Merck & Co., Inc. | DNA encoding human papillomavirus type 18 |
| US5869057A (en) | 1995-06-07 | 1999-02-09 | Rock; Edwin P. | Recombinant vaccines to break self-tolerance |
| US6440418B1 (en) | 1995-11-07 | 2002-08-27 | Idec Pharmaceuticals Corporation | Methods of treating autoimmune diseases with gp39-specific antibodies |
| US6080409A (en) | 1995-12-28 | 2000-06-27 | Dendreon Corporation | Immunostimulatory method |
| US6117977A (en) | 1996-04-24 | 2000-09-12 | Genentech, Inc. | Type C lectins |
| WO1997045449A1 (en) | 1996-05-29 | 1997-12-04 | Derek Nigel John Hart | Dendritic cell receptor |
| US5922845A (en) | 1996-07-11 | 1999-07-13 | Medarex, Inc. | Therapeutic multispecific compounds comprised of anti-Fcα receptor antibodies |
| US5856462A (en) | 1996-09-10 | 1999-01-05 | Hybridon Incorporated | Oligonucleotides having modified CpG dinucleosides |
| US6069233A (en) | 1996-10-03 | 2000-05-30 | Memorial Sloan-Kettering Cancer Center | Isolated nucleic acid molecule encoding an esophageal cancer associated antigen, the antigen itself, and uses thereof |
| JP2001502670A (ja) | 1996-10-09 | 2001-02-27 | カンタベリー ヘルス リミテッド | 樹状細胞に特異的な抗体 |
| AR014891A1 (es) | 1997-07-09 | 2001-04-11 | Schering Corp | Genes aislados de proteinas de membranas de mamiferos; reactivos relacionados |
| AU754065B2 (en) | 1997-09-29 | 2002-11-07 | Macfarlane Burnet Institute For Medical Research And Public Health Ltd | Mannose receptor bearing cell line and antigen composition |
| AU1457199A (en) | 1997-11-12 | 1999-05-31 | University Of Pittsburgh | Isolation, characterization, and identification of dendritic like cells and methods of using same |
| GB9727262D0 (en) | 1997-12-24 | 1998-02-25 | Smithkline Beecham Biolog | Vaccine |
| JP2002506645A (ja) | 1998-03-17 | 2002-03-05 | シェーリング コーポレイション | 単離された哺乳動物膜タンパク質遺伝子および関連試薬 |
| AU746163B2 (en) | 1998-04-09 | 2002-04-18 | Smithkline Beecham Biologicals (Sa) | Adjuvant compositions |
| CA2327505A1 (en) | 1998-04-28 | 1999-11-04 | Smithkline Beecham Corporation | Monoclonal antibodies with reduced immunogenicity |
| JP2002514420A (ja) | 1998-05-11 | 2002-05-21 | ミクロメット・アクチェンゲゼルシャフト | 樹状細胞に対する抗体およびヒト樹状細胞集団およびその使用 |
| AU4954899A (en) | 1998-06-26 | 2000-01-17 | Trustees Of Dartmouth College | Methods and compositions for modulating antigen-specific immunological (humoral)responses by targeting such antigen to apcs in conjunction with anti-cd40 ligan d administration |
| KR100295558B1 (ko) | 1998-06-27 | 2001-07-12 | 김기태 | 1차면역세포들중덴드리틱세포(dendriticcell)표면에특이하게작용하는단클론항체3-6-a |
| EP0997476A3 (en) | 1998-09-25 | 2000-07-19 | Schering-Plough | Antibodies to a mammalian Langerhans cell antigen and their uses |
| WO2000048994A1 (en) * | 1999-02-18 | 2000-08-24 | F. Hoffmann-La Roche Ag | Thioamide derivatives |
| EP1046651A1 (en) | 1999-04-19 | 2000-10-25 | Koninklijke Universiteit Nijmegen | Composition and method for modulating dendritic cell-T interaction |
| US6794132B2 (en) | 1999-10-02 | 2004-09-21 | Biosite, Inc. | Human antibodies |
| US6774226B1 (en) | 1999-11-30 | 2004-08-10 | Ludwig Institute For Cancer Research | Isolated nucleic acid molecules encoding cancer associated antigens, the antigens per se, and uses thereof |
| EP1274852A2 (en) | 2000-04-12 | 2003-01-15 | University Of Rochester | Targeted vaccine delivery systems |
| US7201714B2 (en) | 2000-04-27 | 2007-04-10 | Graphic Packaging International, Inc. | Paperboard cartons with laminated reinforcing ribbons and method of printing same |
| MXPA02010869A (es) | 2000-05-08 | 2003-04-14 | Medarex Inc | Anticuerpos monoclonales humanos para celulas dendriticas. |
| US7560534B2 (en) | 2000-05-08 | 2009-07-14 | Celldex Research Corporation | Molecular conjugates comprising human monoclonal antibodies to dendritic cells |
| GB0105360D0 (en) | 2001-03-03 | 2001-04-18 | Glaxo Group Ltd | Chimaeric immunogens |
| US6794501B2 (en) | 2001-05-04 | 2004-09-21 | Ludwig Institute For Cancer Research | Colon cancer antigen panel |
| CA2468878A1 (en) | 2001-11-30 | 2003-06-05 | Crucell Holland B.V. | Antigen presenting cell targeting conjugate, an antigen presenting cell contacted with such conjugate, their use for vaccination or as medicament, and methods for their productionor generation |
| US8029803B2 (en) | 2002-06-20 | 2011-10-04 | Paladin Labs, Inc. | Chimeric antigens for eliciting an immune response |
| WO2004026326A2 (en) | 2002-09-20 | 2004-04-01 | Stichting Katholieke Universiteit | Antigen uptake receptor for candida albicans on dendritic cells |
| US20040146948A1 (en) * | 2002-10-18 | 2004-07-29 | Centenary Institute Of Cancer Medicine And Cell Biology | Compositions and methods for targeting antigen-presenting cells with antibody single-chain variable region fragments |
| WO2004074432A2 (en) | 2003-01-31 | 2004-09-02 | Celldex Therapeutics, Inc. | Antibody vaccine conjugates and uses therefor |
| EP1605974B1 (en) * | 2003-03-04 | 2014-11-12 | Alexion Pharmaceuticals, Inc. | Method of treating autoimmune disease by inducing antigen presentation by tolerance inducing antigen presenting cells |
| US6834793B2 (en) | 2003-05-31 | 2004-12-28 | Graphic Packaging International, Inc. | Enclosed container carton convertible into a tray |
| CN1893925B (zh) * | 2003-08-21 | 2011-04-27 | 利普泰克有限公司 | 树突细胞的体内靶向 |
| KR100918746B1 (ko) * | 2004-09-06 | 2009-09-24 | 교와 핫꼬 기린 가부시키가이샤 | 항 ａ３３ 항체 |
| EP1926665B1 (en) | 2005-09-21 | 2015-11-11 | Graphic Packaging International, Inc. | Carton and method of forming a carton |
| SG177194A1 (en) * | 2005-12-08 | 2012-01-30 | Medarex Inc | Human monoclonal antibodies to protein tyrosine kinase 7 (ptk7) and methods for using anti-ptk7 antibodies |
| BRPI0620601A2 (pt) * | 2005-12-08 | 2011-11-16 | Medarex Inc | anticorpo monoclonal humano isolado ou uma porção ligante ao antìgeno do mesmo, composição, imunoconjugado, molécula de ácido nucléico isolada, vetor de expressão, célula hospedeira, método para preparar um anticorpo anti-o8e e método para tratar ou prevenir uma doença definida pelo crescimento de células tumorais expressando o8e |
| EA201692127A1 (ru) | 2007-11-07 | 2017-08-31 | Селлдекс Терапьютикс Инк. | Антитела, связывающиеся с человеческим dec-205 |
| JP6136343B2 (ja) | 2012-06-12 | 2017-05-31 | 株式会社リコー | 情報処理システム、情報処理方法、プログラム、及び記録媒体 |
| KR102264548B1 (ko) | 2014-11-21 | 2021-06-16 | 삼성전자주식회사 | 반도체 패키지 및 그 제조 방법 |
-
2008
- 2008-11-07 EA EA201692127A patent/EA201692127A1/ru unknown
- 2008-11-07 CN CN200880119337.7A patent/CN101888856B/zh not_active Expired - Fee Related
- 2008-11-07 ES ES08848354.0T patent/ES2445755T3/es active Active
- 2008-11-07 SG SG10201605208QA patent/SG10201605208QA/en unknown
- 2008-11-07 CA CA2704583A patent/CA2704583A1/en not_active Abandoned
- 2008-11-07 US US12/266,745 patent/US8236318B2/en not_active Expired - Fee Related
- 2008-11-07 AU AU2008323848A patent/AU2008323848B2/en not_active Ceased
- 2008-11-07 JP JP2010532344A patent/JP5701606B2/ja not_active Expired - Fee Related
- 2008-11-07 NZ NZ599777A patent/NZ599777A/xx not_active IP Right Cessation
- 2008-11-07 EP EP12196330.0A patent/EP2570137A3/en not_active Withdrawn
- 2008-11-07 MX MX2010005022A patent/MX2010005022A/es active IP Right Grant
- 2008-11-07 DK DK08848354.0T patent/DK2224954T3/en active
- 2008-11-07 WO PCT/US2008/082745 patent/WO2009061996A2/en not_active Ceased
- 2008-11-07 BR BRPI0820270-2A patent/BRPI0820270A2/pt not_active IP Right Cessation
- 2008-11-07 NZ NZ585556A patent/NZ585556A/en not_active IP Right Cessation
- 2008-11-07 KR KR1020167002430A patent/KR101811965B1/ko not_active Expired - Fee Related
- 2008-11-07 SG SG2013003413A patent/SG187482A1/en unknown
- 2008-11-07 KR KR1020107012364A patent/KR101624751B1/ko not_active Expired - Fee Related
- 2008-11-07 EA EA201000770A patent/EA026990B1/ru not_active IP Right Cessation
- 2008-11-07 EP EP08848354.0A patent/EP2224954B1/en active Active
-
2009
- 2009-05-05 US US12/387,654 patent/US8362214B2/en not_active Expired - Fee Related
-
2010
- 2010-04-28 IL IL205393A patent/IL205393A/en not_active IP Right Cessation
- 2010-05-04 ZA ZA2010/03101A patent/ZA201003101B/en unknown
-
2012
- 2012-07-06 US US13/542,909 patent/US8586720B2/en not_active Expired - Fee Related
- 2012-12-17 US US13/716,973 patent/US9624300B2/en not_active Expired - Fee Related
-
2014
- 2014-12-18 JP JP2014255753A patent/JP6067667B2/ja not_active Expired - Fee Related
-
2016
- 2016-07-12 JP JP2016137221A patent/JP2017014218A/ja active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2015083010A5 (enExample) | ||
| JP2017014218A5 (enExample) | ||
| JP7542870B2 (ja) | 免疫療法のためのナノ粒子組成物及び方法 | |
| Safarzadeh Kozani et al. | Nanobody-based CAR-T cells for cancer immunotherapy | |
| TWI828625B (zh) | 引導及導航控制蛋白質以及彼之製造及使用方法 | |
| JP2011503014A5 (enExample) | ||
| JP2021518103A5 (enExample) | ||
| RU2018107802A (ru) | Полностью человеческие антитела к мезотелину и иммунные эффекторные клетки, нацеленные на мезотелин | |
| JP2015535691A5 (enExample) | ||
| JP2013531970A5 (enExample) | ||
| JP2014039548A5 (enExample) | ||
| JP2019510733A5 (enExample) | ||
| HRP20171315T1 (hr) | Optimizacija humanih antitijela koja vezuju limfocitni aktivacijski gen-3 (lag-3), i njihove primjene | |
| JP2019512207A5 (enExample) | ||
| TW202003037A (zh) | 引導及導航控制蛋白及其製備和使用方法 | |
| JP2015535689A5 (enExample) | ||
| IL295398B2 (en) | Antibody/T-cell receptor chimeric constructs and their uses | |
| JP2018527919A5 (enExample) | ||
| JP2019506865A (ja) | 改善された内部移行特性を有する多重特異性抗原結合分子 | |
| JPWO2019175218A5 (enExample) | ||
| TW201100096A (en) | Antigen presenting cell targeted anti-viral vaccines | |
| JP2018509163A5 (enExample) | ||
| JP2018506961A5 (enExample) | ||
| ES2820729T3 (es) | Redirectores de células T específicas de antígenos | |
| Ma et al. | Targeting of antigens to B lymphocytes via CD19 as a means for tumor vaccine development |