|
US1014946A
(en)
|
1910-06-16 |
1912-01-16 |
Us Sherardizing Company |
Alloy for coating with metal.
|
|
US1006439A
(en)
|
1911-03-11 |
1911-10-17 |
Clarence Cosby |
Can-shearing machine.
|
|
US5807715A
(en)
|
1984-08-27 |
1998-09-15 |
The Board Of Trustees Of The Leland Stanford Junior University |
Methods and transformed mammalian lymphocyte cells for producing functional antigen-binding protein including chimeric immunoglobulin
|
|
US5169939A
(en)
|
1985-05-21 |
1992-12-08 |
Massachusetts Institute Of Technology & Pres. & Fellows Of Harvard College |
Chimeric antibodies
|
|
US4720449A
(en)
|
1985-06-03 |
1988-01-19 |
Polaroid Corporation |
Thermal imaging method
|
|
GB8823869D0
(en)
|
1988-10-12 |
1988-11-16 |
Medical Res Council |
Production of antibodies
|
|
WO1991000906A1
(en)
|
1989-07-12 |
1991-01-24 |
Genetics Institute, Inc. |
Chimeric and transgenic animals capable of producing human antibodies
|
|
US6713610B1
(en)
|
1990-01-12 |
2004-03-30 |
Raju Kucherlapati |
Human antibodies derived from immunized xenomice
|
|
US6657103B1
(en)
|
1990-01-12 |
2003-12-02 |
Abgenix, Inc. |
Human antibodies derived from immunized xenomice
|
|
DE69120146T2
(de)
|
1990-01-12 |
1996-12-12 |
Cell Genesys Inc |
Erzeugung xenogener antikörper
|
|
US6673986B1
(en)
|
1990-01-12 |
2004-01-06 |
Abgenix, Inc. |
Generation of xenogeneic antibodies
|
|
US6300129B1
(en)
|
1990-08-29 |
2001-10-09 |
Genpharm International |
Transgenic non-human animals for producing heterologous antibodies
|
|
US5770429A
(en)
*
|
1990-08-29 |
1998-06-23 |
Genpharm International, Inc. |
Transgenic non-human animals capable of producing heterologous antibodies
|
|
US7041871B1
(en)
|
1995-10-10 |
2006-05-09 |
Genpharm International, Inc. |
Transgenic non-human animals capable of producing heterologous antibodies
|
|
US5633425A
(en)
*
|
1990-08-29 |
1997-05-27 |
Genpharm International, Inc. |
Transgenic non-human animals capable of producing heterologous antibodies
|
|
ATE158021T1
(de)
|
1990-08-29 |
1997-09-15 |
Genpharm Int |
Produktion und nützung nicht-menschliche transgentiere zur produktion heterologe antikörper
|
|
US5545806A
(en)
|
1990-08-29 |
1996-08-13 |
Genpharm International, Inc. |
Ransgenic non-human animals for producing heterologous antibodies
|
|
WO1993012227A1
(en)
|
1991-12-17 |
1993-06-24 |
Genpharm International, Inc. |
Transgenic non-human animals capable of producing heterologous antibodies
|
|
US6255458B1
(en)
|
1990-08-29 |
2001-07-03 |
Genpharm International |
High affinity human antibodies and human antibodies against digoxin
|
|
US7084260B1
(en)
|
1996-10-10 |
2006-08-01 |
Genpharm International, Inc. |
High affinity human antibodies and human antibodies against human antigens
|
|
WO1993004169A1
(en)
|
1991-08-20 |
1993-03-04 |
Genpharm International, Inc. |
Gene targeting in animal cells using isogenic dna constructs
|
|
ES2301158T3
(es)
|
1992-07-24 |
2008-06-16 |
Amgen Fremont Inc. |
Produccion de anticuerpos xenogenicos.
|
|
DK1621554T4
(da)
|
1992-08-21 |
2012-12-17 |
Univ Bruxelles |
Immunoglobuliner blottet for lette kæder
|
|
DE4228162C1
(de)
|
1992-08-25 |
1994-01-13 |
Rajewsky Klaus Dr |
Verfahren zum Ersetzen homologer Genabschnitte aus Säugern in der Keimbahn von nicht-menschlichen Säugern
|
|
US5565321A
(en)
|
1993-01-22 |
1996-10-15 |
Immunex Corporation |
Detection of mutations in a CD40 ligand gene
|
|
JPH08509612A
(ja)
|
1993-04-26 |
1996-10-15 |
ジェンファーム インターナショナル インコーポレイテッド |
異種抗体を産生することができるトランスジェニック非ヒト動物
|
|
DE4331162A1
(de)
|
1993-09-14 |
1995-03-16 |
Bayer Ag |
Verfahren zur Herstellung von Cyaninfarbstoffen
|
|
BE1007904A3
(nl)
|
1993-12-23 |
1995-11-14 |
Dsm Nv |
Werkwijze voor de bereiding van een alkanol en/of een alkanon.
|
|
US7119248B1
(en)
|
1994-04-12 |
2006-10-10 |
Miltenyi Biotec Gmbh |
Antibodies against epitopes with homology to self antigens, methods of preparation and applications thereof
|
|
US6130364A
(en)
|
1995-03-29 |
2000-10-10 |
Abgenix, Inc. |
Production of antibodies using Cre-mediated site-specific recombination
|
|
AU3507297A
(en)
|
1996-06-26 |
1998-01-14 |
Baylor College Of Medicine |
Chromosomal rearrangement by insertion of two recombination substrates
|
|
ES2294799T3
(es)
|
1996-06-27 |
2008-04-01 |
Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw. |
Moleculas de anticuerpos que interactuan especificamente con el sitio activo o hendidura de una molecula diana.
|
|
CA2722378C
(en)
|
1996-12-03 |
2015-02-03 |
Amgen Fremont Inc. |
Human antibodies that bind tnf.alpha.
|
|
US6319906B1
(en)
|
1996-12-31 |
2001-11-20 |
Isis Pharmaceuticals |
Oligonucleotide compositions and methods for the modulation of the expression of B7 protein
|
|
ATE299938T1
(de)
|
1997-05-02 |
2005-08-15 |
Genentech Inc |
Ein verfahren zur herstellung multispezifischer antikörper die heteromultimere und gemeinsame komponenten besitzen
|
|
US20020088019A1
(en)
|
1997-09-02 |
2002-07-04 |
Oron Yacoby-Zeevi |
Methods of and pharmaceutical compositions for improving implantation of embryos
|
|
WO1999025821A1
(en)
|
1997-11-18 |
1999-05-27 |
Pioneer Hi-Bred International, Inc. |
Compositions and methods for genetic modification of plants
|
|
US6509156B1
(en)
|
1997-12-05 |
2003-01-21 |
Europaisches Laboratorium Fur Molekularoiologie (Embl) |
DNA cloning method relying on the E. coli recE/recT recombination system
|
|
EP0939120A1
(en)
|
1998-02-27 |
1999-09-01 |
Gesellschaft für biotechnologische Forschung mbH (GBF) |
Method for marker-free repetitive DNA expression cassette exchange in the genome of cells or parts of cells
|
|
GB9823930D0
(en)
|
1998-11-03 |
1998-12-30 |
Babraham Inst |
Murine expression of human ig\ locus
|
|
US6914128B1
(en)
*
|
1999-03-25 |
2005-07-05 |
Abbott Gmbh & Co. Kg |
Human antibodies that bind human IL-12 and methods for producing
|
|
WO2000071585A1
(en)
|
1999-05-03 |
2000-11-30 |
Medarex, Inc. |
Human antibodies to staphylococcus aureus
|
|
US6833268B1
(en)
|
1999-06-10 |
2004-12-21 |
Abgenix, Inc. |
Transgenic animals for producing specific isotypes of human antibodies via non-cognate switch regions
|
|
US6355412B1
(en)
|
1999-07-09 |
2002-03-12 |
The European Molecular Biology Laboratory |
Methods and compositions for directed cloning and subcloning using homologous recombination
|
|
US7605238B2
(en)
|
1999-08-24 |
2009-10-20 |
Medarex, Inc. |
Human CTLA-4 antibodies and their uses
|
|
CA2307503A1
(en)
|
2000-05-02 |
2001-11-02 |
Carlos F. Barbas Iii |
Peptides for use as a vaccine or treatment for hiv infection
|
|
BR0110927A
(pt)
*
|
2000-05-19 |
2003-03-11 |
Scancell Ltd |
Anticorpo, ácido nucléico, vetor, célula, método de fabricar um anticorpo, composição farmacêutica, uso de um anticorpo ou de um ácido nucleico, e, método para o tratamento ou profilaxia do câncer
|
|
BR0112633A
(pt)
|
2000-07-21 |
2003-09-16 |
Us Agriculture |
Método para substituir, translocar e empilhar dna em genomas eucarióticos
|
|
EA013564B1
(ru)
*
|
2000-08-03 |
2010-06-30 |
Терапеутик Хьюман Поликлоналз Инк. |
Гуманизированный иммуноглобулин и содержащая его фармацевтическая композиция
|
|
US8165246B1
(en)
*
|
2000-08-28 |
2012-04-24 |
Alcatel Lucent |
Training sequence for low latency LMS implementation
|
|
US7105348B2
(en)
|
2000-10-31 |
2006-09-12 |
Regeneron Pharmaceuticals, Inc. |
Methods of modifying eukaryotic cells
|
|
US6586251B2
(en)
|
2000-10-31 |
2003-07-01 |
Regeneron Pharmaceuticals, Inc. |
Methods of modifying eukaryotic cells
|
|
US6596541B2
(en)
|
2000-10-31 |
2003-07-22 |
Regeneron Pharmaceuticals, Inc. |
Methods of modifying eukaryotic cells
|
|
AU2001297523B2
(en)
|
2000-11-17 |
2007-01-18 |
Sab, Llc |
Expression of xenogenous (human) immunoglobulins in cloned, transgenic ungulates
|
|
CA2430013C
(en)
|
2000-11-30 |
2011-11-22 |
Medarex, Inc. |
Transgenic transchromosomal rodents for making human antibodies
|
|
ES2389251T3
(es)
|
2000-12-19 |
2012-10-24 |
Altor Bioscience Corporation |
Animales transgénicos que comprenden un sistema inmunitario humanizado
|
|
ME00502B
(me)
*
|
2001-01-05 |
2011-10-10 |
Amgen Fremont Inc |
Antitjela za insulinu sličan receptor faktora i rasta
|
|
GB0115256D0
(en)
|
2001-06-21 |
2001-08-15 |
Babraham Inst |
Mouse light chain locus
|
|
FR2827302B1
(fr)
|
2001-07-13 |
2003-10-10 |
Genoway |
Cellule et animal transgenique modelisant la presentation antigenique humaine et leurs utilisations
|
|
US20030108925A1
(en)
|
2001-10-05 |
2003-06-12 |
U.S. Epa |
Genetic testing for male factor infertility
|
|
US20060199204A1
(en)
|
2001-10-05 |
2006-09-07 |
U.S. Epa |
Genetic testing for male factor infertility
|
|
US7390885B2
(en)
*
|
2001-11-26 |
2008-06-24 |
Cell Matrix, Inc. |
Humanized collagen antibodies and related methods
|
|
EP2319301B1
(en)
|
2001-11-30 |
2017-09-06 |
Amgen Fremont Inc. |
Transgenic animals bearing human Ig lambda light chain genes
|
|
WO2003061363A2
(en)
|
2002-01-17 |
2003-07-31 |
Albert Einstein College Of Medicine Of Yeshiva University |
Mutations caused by activation-induced cytidine deaminase
|
|
US8877901B2
(en)
|
2002-12-13 |
2014-11-04 |
Immunomedics, Inc. |
Camptothecin-binding moiety conjugates
|
|
DK2314629T4
(da)
|
2002-07-18 |
2023-02-06 |
Merus Nv |
Rekombinant produktion af blandinger af antistoffer
|
|
EP1539946A4
(en)
|
2002-09-09 |
2006-03-15 |
California Inst Of Techn |
METHOD AND COMPOSITIONS FOR PRODUCING HUMANIZED MICE
|
|
BRPI0315295C1
(pt)
*
|
2002-10-17 |
2021-05-25 |
Genmab As |
anticorpo monoclonal humano isolado, célula hospedeira procariótica, composição farmacêutica, molécula biespecífica, usos de um anticorpo, métodos in vitro de detectar a presença de antígeno de cd20 ou uma célula que expressa cd20 em uma amostra, kit, e, vetor de expressão
|
|
DE10251918A1
(de)
|
2002-11-08 |
2004-05-19 |
Horn, Carsten, Dipl.-Biochem. Dr. |
Systeme zur Erzeugung stabiler genomischer Transgen-Insertionen
|
|
US7700356B2
(en)
|
2002-11-08 |
2010-04-20 |
The United States Of America As Represented By The Secretary Of Agriculture |
System for gene targeting and producing stable genomic transgene insertions
|
|
WO2004041863A2
(en)
|
2002-11-08 |
2004-05-21 |
Ablynx N.V. |
Single domain antibodies directed against interferon- gamma and uses therefor
|
|
CL2003002461A1
(es)
|
2002-11-27 |
2005-01-07 |
Dow Chemical Company Agroscien |
Inmunoglobulina que comprende al menos un glicano afucosilado, composicion que la contiene, secuencia nucleotidica y vector que la comprende, procedimiento para producir dicha inmunoglobulina en plantas.
|
|
GB2398784B
(en)
|
2003-02-26 |
2005-07-27 |
Babraham Inst |
Removal and modification of the immunoglobulin constant region gene cluster of a non-human mammal
|
|
US20100069614A1
(en)
|
2008-06-27 |
2010-03-18 |
Merus B.V. |
Antibody producing non-human mammals
|
|
WO2004106375A1
(en)
|
2003-05-30 |
2004-12-09 |
Merus Biopharmaceuticals B.V. I.O. |
Fab library for the preparation of anti vegf and anti rabies virus fabs
|
|
US7205148B2
(en)
|
2003-06-11 |
2007-04-17 |
Regeneron Pharmaceuticals, Inc. |
Genome mutation by intron insertion into an embryonic stem cell genome
|
|
GB2403475B
(en)
|
2003-07-01 |
2008-02-06 |
Oxitec Ltd |
Stable integrands
|
|
ES2473596T3
(es)
*
|
2003-07-15 |
2014-07-07 |
Therapeutic Human Polyclonals, Inc. |
Loci de inmunoglobulina humanizada
|
|
US7663017B2
(en)
|
2003-07-30 |
2010-02-16 |
Institut Pasteur |
Transgenic mice having a human major histocompatability complex (MHC) phenotype, experimental uses and applications
|
|
US20050153392A1
(en)
|
2003-08-11 |
2005-07-14 |
Roland Buelow |
Transgenesis with humanized immunoglobulin loci
|
|
US7604994B2
(en)
|
2003-09-03 |
2009-10-20 |
Morphotek, Inc. |
Genetically altered antibody-producing cell lines with improved antibody characteristics
|
|
CA2445602C
(en)
|
2003-10-20 |
2014-01-14 |
Campusgen Gmbh |
Nucleotide sequence for creatinine deiminase and method of use
|
|
PL1691837T3
(pl)
|
2003-12-10 |
2012-11-30 |
Squibb & Sons Llc |
IP-10 przeciwciała i ich zastosowanie
|
|
US20050260679A1
(en)
|
2004-03-19 |
2005-11-24 |
Sirid-Aimee Kellerman |
Reducing the risk of human anti-human antibodies through V gene manipulation
|
|
US7625549B2
(en)
|
2004-03-19 |
2009-12-01 |
Amgen Fremont Inc. |
Determining the risk of human anti-human antibodies in transgenic mice
|
|
AU2005237494B2
(en)
*
|
2004-04-22 |
2010-06-10 |
Kyowa Hakko Kirin Co., Ltd |
Transgenic animals and uses thereof
|
|
JP2006029459A
(ja)
|
2004-07-16 |
2006-02-02 |
Kayaba Ind Co Ltd |
緩衝装置
|
|
KR101151957B1
(ko)
|
2004-07-22 |
2012-06-01 |
로저 킹돈 크레이그 |
결합 분자
|
|
FR2875239B1
(fr)
|
2004-09-10 |
2007-07-20 |
Inst Necker Ass Loi De 1901 |
Procede pour l'acceleration des mutations somatiques et son application en proteomique
|
|
WO2006029459A1
(en)
|
2004-09-13 |
2006-03-23 |
Evogenix, Inc |
Antibodies specific for hepatocellular carcinoma and other carcinomas and uses thereof
|
|
WO2006044492A2
(en)
|
2004-10-14 |
2006-04-27 |
Ingenious Targeting Laboratory, Inc. |
Methods for generating rat embryo-derived cell lines and genetic modification of rat genome
|
|
ES2463476T3
(es)
|
2004-10-19 |
2014-05-28 |
Regeneron Pharmaceuticals, Inc. |
Método para generar un ratón homocigótico para una modificación genética
|
|
WO2006055704A2
(en)
|
2004-11-17 |
2006-05-26 |
Curagen Corporation |
Antibodies directed to ten-m proteins and uses thereof
|
|
ZA200705695B
(en)
|
2004-12-21 |
2009-02-25 |
Astrazeneca Ab |
Antibodies directed to angiopoietin-2 and uses thereof
|
|
AU2006242854A1
(en)
|
2005-04-29 |
2006-11-09 |
Inserm (Institut National De La Sante Et De La Recherche Medicale) |
Transgenic animals and methods of making recombinant antibodies
|
|
AU2005331864A1
(en)
|
2005-05-14 |
2006-11-23 |
Fudan University |
Piggybac as a tool for genetic manipulation and analysis in vertebrates
|
|
EP1780272A1
(en)
|
2005-10-27 |
2007-05-02 |
GSF-Forschungszentrum für Umwelt und Gesundheit GmbH |
Method for enhancing somatic hypermutation, gene conversion and class switch recombination
|
|
GB0601513D0
(en)
|
2006-01-25 |
2006-03-08 |
Univ Erasmus Medical Ct |
Binding molecules 3
|
|
AU2007219159B8
(en)
|
2006-01-25 |
2012-06-28 |
Roger Kingdon Craig |
Generation of heavy-chain only antibodies in transgenic animals
|
|
US7462759B2
(en)
|
2006-02-03 |
2008-12-09 |
Pioneer Hi-Bred International, Inc. |
Brittle stalk 2 gene family and related methods and uses
|
|
AU2007235496B2
(en)
*
|
2006-03-31 |
2013-11-21 |
E. R. Squibb & Sons, L.L.C. |
Transgenic animals expressing chimeric antibodies for use in preparing human antibodies
|
|
JP5307708B2
(ja)
|
2006-06-02 |
2013-10-02 |
リジェネロン・ファーマシューティカルズ・インコーポレイテッド |
ヒトｉｌ−６受容体に対する高親和性抗体
|
|
EP2409715A1
(en)
|
2006-06-27 |
2012-01-25 |
Sanofi Pasteur VaxDesign Corporation |
Models for vaccine assessment
|
|
EP1878342A1
(en)
|
2006-07-13 |
2008-01-16 |
Institut Pasteur |
Immunodeficient mice transgenic for HLA class I and HLA class II molecules and their uses
|
|
JP2010501165A
(ja)
|
2006-08-22 |
2010-01-21 |
ジーツー インフラメイション プロプライエタリー リミテッド |
抗体の作製方法
|
|
MY149079A
(en)
|
2006-10-02 |
2013-07-15 |
Regeneron Pharma |
High affinity human antibodies to human il-4 receptor
|
|
WO2008070367A2
(en)
|
2006-11-01 |
2008-06-12 |
Facet Biotech Corporation |
Mammalian cell-based immunoglobulin display libraries
|
|
RU2448979C2
(ru)
|
2006-12-14 |
2012-04-27 |
Ридженерон Фармасьютикалз, Инк. |
Антитела человека к дельта-подобному лиганду-4 человека
|
|
GB0700194D0
(en)
|
2007-01-05 |
2007-02-14 |
Univ Edinburgh |
Humanisation of animals
|
|
US20090075378A1
(en)
|
2007-02-20 |
2009-03-19 |
Anaptysbio, Inc. |
Somatic hypermutation systems
|
|
JP5642972B2
(ja)
|
2007-02-21 |
2014-12-17 |
ユニバーシティー オブ マサチューセッツＵｎｉｖｅｒｓｉｔｙ ｏｆ Ｍａｓｓａｃｈｕｓｅｔｔｓ |
Ｃ型肝炎ウイルス（ｈｃｖ）に対するヒト抗体およびその使用
|
|
CN101679974B
(zh)
|
2007-03-27 |
2015-09-30 |
航道生物技术有限责任公司 |
包含抗体替代轻链序列的构建体和文库
|
|
GB0706628D0
(en)
|
2007-04-04 |
2007-05-16 |
Univ Erasmus |
Germ-line manipulation 1
|
|
PL2602323T3
(pl)
*
|
2007-06-01 |
2018-06-29 |
Open Monoclonal Technology, Inc. |
Kompozycje i sposoby hamowania endogennych genów immunoglobin i wytwarzania transgenicznych ludzkich przeciwciał typu idiotypowego
|
|
WO2009013620A2
(en)
|
2007-06-11 |
2009-01-29 |
Erasmus University Medical Center Rotterdam |
Homologous recombination
|
|
MX2010000970A
(es)
|
2007-07-31 |
2010-03-09 |
Regeneron Pharma |
Anticuerpos humanos contra cd20 humano y metodo para utilizarlos.
|
|
MX2010001395A
(es)
|
2007-08-10 |
2010-03-10 |
Regeneron Pharma |
Anticuerpos humanos de alta afinidad de factor de crecimiento de nervio humano.
|
|
JP5588866B2
(ja)
|
2007-08-10 |
2014-09-10 |
メダレックス エル．エル．シー． |
Ｈｃｏ３２およびｈｃｏ２７、ならびに関連実施例
|
|
PT2592148T
(pt)
|
2007-10-12 |
2018-11-12 |
Hoffmann La Roche |
Expressão proteica de múltiplos ácidos nucleicos
|
|
KR20100103810A
(ko)
|
2007-12-10 |
2010-09-28 |
알리바 바이오파마수티컬스, 아이엔씨. |
동종 재조합에 의한 표적화된 영역의 순차적인 치환 방법
|
|
US8227577B2
(en)
|
2007-12-21 |
2012-07-24 |
Hoffman-La Roche Inc. |
Bivalent, bispecific antibodies
|
|
EP2252659A2
(en)
|
2008-01-25 |
2010-11-24 |
Cabot Corporation |
Method of preparing modified colored pigments
|
|
EP2271207A2
(en)
|
2008-03-26 |
2011-01-12 |
ITI Scotland Limited |
Efficient insertion of dna into embryonic stem cells
|
|
US8012714B2
(en)
|
2008-04-14 |
2011-09-06 |
Innovative Targeting Solutions, Inc. |
Sequence diversity generation in immunoglobulins
|
|
EP2669298A3
(en)
|
2008-05-23 |
2014-02-26 |
Ablexis, LLC |
Single variable immunoglobulin domain comprising VL-DH-JL
|
|
EP2147594B1
(en)
|
2008-06-27 |
2013-11-13 |
Merus B.V. |
Antibody producing non-human mammals
|
|
AU2009298458B2
(en)
|
2008-09-30 |
2015-10-08 |
Ablexis, Llc |
Non-human mammals for the production of chimeric antibodies
|
|
JO3672B1
(ar)
|
2008-12-15 |
2020-08-27 |
Regeneron Pharma |
أجسام مضادة بشرية عالية التفاعل الكيماوي بالنسبة لإنزيم سبتيليسين كنفرتيز بروبروتين / كيكسين نوع 9 (pcsk9).
|
|
JP5827127B2
(ja)
|
2008-12-18 |
2015-12-02 |
エラスムス・ユニヴァーシティ・メディカル・センター・ロッテルダム |
ヒト化抗体を発現する非ヒトトランスジェニック動物及びその使用
|
|
WO2010091182A2
(en)
|
2009-02-04 |
2010-08-12 |
Molecular Innovations |
Methods for screening candidate agents for modulating prorenin and renin, assays for detecting prorenin, and antibodies used therein
|
|
CA2753287A1
(en)
|
2009-02-24 |
2010-09-02 |
Glaxo Group Limited |
Antigen-binding constructs
|
|
GB0905023D0
(en)
|
2009-03-24 |
2009-05-06 |
Univ Erasmus Medical Ct |
Binding molecules
|
|
EP2414507B1
(en)
|
2009-04-03 |
2014-07-02 |
Medical Research Council |
Mutants of activation-induced cytidine deaminase (aid) and methods of use
|
|
CA2764729C
(en)
|
2009-06-26 |
2019-04-02 |
Sea Lane Biotechnologies, Llc |
Expression of surrogate light chains
|
|
US9445581B2
(en)
|
2012-03-28 |
2016-09-20 |
Kymab Limited |
Animal models and therapeutic molecules
|
|
DK3622815T3
(da)
|
2009-07-08 |
2023-06-26 |
Kymab Ltd |
Gnavermodeller og terapeutiske molekyler
|
|
US9273118B2
(en)
|
2009-07-15 |
2016-03-01 |
Aimm Therapeutics B.V. |
Means and methods for producing high affinity antibodies
|
|
JO3182B1
(ar)
|
2009-07-29 |
2018-03-08 |
Regeneron Pharma |
مضادات حيوية بشرية عالية الالفة مع تولد الاوعية البشرية - 2
|
|
US8586526B2
(en)
|
2010-05-17 |
2013-11-19 |
Sangamo Biosciences, Inc. |
DNA-binding proteins and uses thereof
|
|
AU2010282508B2
(en)
|
2009-08-13 |
2015-05-28 |
Crystal Bioscience Inc. |
Transgenic animal for production of antibodies having minimal CDRs
|
|
CN102050877B
(zh)
*
|
2009-10-30 |
2014-05-07 |
上海抗体药物国家工程研究中心有限公司 |
抗人cd20人源化抗体、其制备方法及用途
|
|
US20120251552A1
(en)
|
2009-11-05 |
2012-10-04 |
Anaptysbio, Inc. |
Methods of generating improved antigen-binding agents using chain shuffling and optionally somatic hypermutation
|
|
EP2502993B1
(en)
|
2009-11-17 |
2017-07-26 |
Sanford Applied Biosciences L.L.C. |
Human artificial chromosome vector
|
|
US8961967B2
(en)
|
2009-11-30 |
2015-02-24 |
Janssen Biotech, Inc. |
Antibody Fc mutants with ablated effector functions
|
|
WO2011071957A1
(en)
|
2009-12-07 |
2011-06-16 |
Sea Lane Biotechnologies, Llc |
Conjugates comprising an antibody surrogate scaffold with improved pharmacokinetic properties
|
|
ES2724975T3
(es)
|
2009-12-10 |
2019-09-18 |
Regeneron Pharma |
Ratones que producen anticuerpos de cadena pesada
|
|
JO3274B1
(ar)
*
|
2009-12-24 |
2018-09-16 |
Regeneron Pharma |
أجسام مضادة بشرية للبروتين 4 المشابه لأجيوبيوتين البشري
|
|
US20120021409A1
(en)
|
2010-02-08 |
2012-01-26 |
Regeneron Pharmaceuticals, Inc. |
Common Light Chain Mouse
|
|
SMT202600080T1
(it)
|
2010-02-08 |
2026-03-09 |
Regeneron Pharma |
Topo con catena leggera comune
|
|
CN103228130B
(zh)
|
2010-06-17 |
2016-03-16 |
科马布有限公司 |
动物模型及治疗分子
|
|
PT3034608T
(pt)
|
2010-06-22 |
2019-05-28 |
Regeneron Pharma |
Ratinhos expressando uma cadeia leve híbrida de imunoglobulina com uma região variável humana
|
|
SMT201700023T1
(it)
|
2010-08-02 |
2017-03-08 |
Regeneron Pharma |
Topi che producono proteine leganti vl
|
|
CN103261220B
(zh)
|
2010-08-16 |
2016-06-15 |
诺夫免疫股份有限公司 |
用于生成多特异性和多价抗体的方法
|
|
JO3375B1
(ar)
|
2010-11-08 |
2019-03-13 |
Regeneron Pharma |
أجسام مضادة بشرية للجين a1 الشبيه بعامل النخر الورمي (tl1a)
|
|
CN103261230A
(zh)
|
2010-12-22 |
2013-08-21 |
霍夫曼-拉罗奇有限公司 |
抗pcsk9抗体及使用方法
|
|
ME02106B
(me)
|
2011-02-25 |
2015-10-20 |
Regeneron Pharma |
Miševi sa adam6
|
|
HUE047278T2
(hu)
|
2011-08-05 |
2020-04-28 |
Regeneron Pharma |
Humanizált univerzális könnyûláncú egerek
|
|
BR112014006394A2
(pt)
|
2011-09-19 |
2017-03-28 |
Kymab Ltd |
manipulação de diversidade genética de imunoglobulina e terapêuticos multi-anticorpos
|
|
EP2758534B1
(en)
|
2011-09-19 |
2020-04-29 |
Kymab Limited |
Animals, repertoires & methods for the production of human antibodies
|
|
WO2013045916A1
(en)
|
2011-09-26 |
2013-04-04 |
Kymab Limited |
Chimaeric surrogate light chains (slc) comprising human vpreb
|
|
SG11201401181YA
(en)
|
2011-10-17 |
2014-04-28 |
Regeneron Pharma |
Restricted immunoglobulin heavy chain mice
|
|
KR102024958B1
(ko)
|
2011-10-20 |
2019-09-24 |
쓰리엠 이노베이티브 프로퍼티즈 컴파니 |
아포다이징된 광대역 부분 반사기
|
|
US20130102031A1
(en)
|
2011-10-25 |
2013-04-25 |
Anaptysbio, Inc. |
Use of somatic hypermutation to create insertion and deletion mutations in vitro
|
|
GB2496375A
(en)
|
2011-10-28 |
2013-05-15 |
Kymab Ltd |
A non-human assay vertebrate comprising human antibody loci and human epitope knock-in, and uses thereof
|
|
US9253965B2
(en)
|
2012-03-28 |
2016-02-09 |
Kymab Limited |
Animal models and therapeutic molecules
|
|
GB201122047D0
(en)
|
2011-12-21 |
2012-02-01 |
Kymab Ltd |
Transgenic animals
|
|
US20180295821A1
(en)
|
2011-12-02 |
2018-10-18 |
Kymab Limited |
Transgenic Animals
|
|
SG10201605675WA
(en)
|
2011-12-20 |
2016-09-29 |
Regeneron Pharma |
Humanized light chain mice
|
|
EP3597038B1
(en)
|
2012-02-01 |
2021-04-21 |
Regeneron Pharmaceuticals, Inc. |
Humanized rodents that express heavy chains containing vl domains
|
|
AR090219A1
(es)
|
2012-03-02 |
2014-10-29 |
Regeneron Pharma |
Anticuerpos humanos frente a toxinas de clostridium difficile
|
|
MX353278B
(es)
|
2012-03-06 |
2018-01-05 |
Regeneron Pharma |
Raton con cadena ligera comun.
|
|
WO2013138681A1
(en)
|
2012-03-16 |
2013-09-19 |
Regeneron Pharmaceuticals, Inc. |
Mice that produce antigen-binding proteins with ph-dependent binding characteristics
|
|
SG11201405059XA
(en)
|
2012-03-28 |
2014-09-26 |
Kymab Ltd |
Transgenic non-human vertebrate for the expression of class - switched, fully human, antibodies
|
|
GB2502127A
(en)
|
2012-05-17 |
2013-11-20 |
Kymab Ltd |
Multivalent antibodies and in vivo methods for their production
|
|
US10251377B2
(en)
|
2012-03-28 |
2019-04-09 |
Kymab Limited |
Transgenic non-human vertebrate for the expression of class-switched, fully human, antibodies
|
|
JO3820B1
(ar)
|
2012-05-03 |
2021-01-31 |
Regeneron Pharma |
أجسام مضادة بشرية لـ fel d1وطرق لاستخدامها
|
|
AU2013266968B2
(en)
|
2012-05-25 |
2017-06-29 |
Emmanuelle CHARPENTIER |
Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription
|
|
ME03551B
(me)
|
2012-06-12 |
2020-07-20 |
Regeneron Pharma |
Humanizovane nehumane živoтinje sa ograničenim lokusima imunoglobulinskog тeškog lanca
|
|
US8962913B2
(en)
|
2012-06-18 |
2015-02-24 |
Regeneron Pharmaceuticals, Inc. |
Humanized IL-7 rodents
|
|
EP3031921B1
(en)
|
2012-12-12 |
2025-03-12 |
The Broad Institute, Inc. |
Delivery, engineering and optimization of systems, methods and compositions for sequence manipulation and therapeutic applications
|
|
MY178882A
(en)
|
2013-02-20 |
2020-10-21 |
Regeneron Pharma |
Non-human animals with modified immunoglobulin heavy chain sequences
|
|
WO2014141192A1
(en)
|
2013-03-15 |
2014-09-18 |
Erasmus University Medical Center |
Generation of heavy chain-only antibodies
|
|
US9788534B2
(en)
|
2013-03-18 |
2017-10-17 |
Kymab Limited |
Animal models and therapeutic molecules
|
|
US9783618B2
(en)
|
2013-05-01 |
2017-10-10 |
Kymab Limited |
Manipulation of immunoglobulin gene diversity and multi-antibody therapeutics
|
|
US20150033372A1
(en)
|
2013-05-01 |
2015-01-29 |
Kymab Limited |
Human VpreB & Chimaeric Surrogate Light Chains in Transgenic Non-Human Vertebrates
|
|
US11707056B2
(en)
|
2013-05-02 |
2023-07-25 |
Kymab Limited |
Animals, repertoires and methods
|
|
US9783593B2
(en)
|
2013-05-02 |
2017-10-10 |
Kymab Limited |
Antibodies, variable domains and chains tailored for human use
|
|
US20140331339A1
(en)
|
2013-05-03 |
2014-11-06 |
Kymab Limited |
Transgenic Non-Human Assay Vertebrates, Assays and Kits
|
|
US20140331344A1
(en)
|
2013-05-03 |
2014-11-06 |
Kymab Ltd. |
Transgenic Animals
|
|
AU2014330922A1
(en)
|
2013-10-01 |
2016-03-03 |
Kymab Limited |
Animal models and therapeutic molecules
|
|
GB201710984D0
(en)
|
2017-07-07 |
2017-08-23 |
Kymab Ltd |
Cells, vertebrates, populations & methods
|