|
US5618920A
(en)
|
1985-11-01 |
1997-04-08 |
Xoma Corporation |
Modular assembly of antibody genes, antibodies prepared thereby and use
|
|
US5258498A
(en)
|
1987-05-21 |
1993-11-02 |
Creative Biomolecules, Inc. |
Polypeptide linkers for production of biosynthetic proteins
|
|
ATE243754T1
(de)
|
1987-05-21 |
2003-07-15 |
Micromet Ag |
Multifunktionelle proteine mit vorbestimmter zielsetzung
|
|
US5091513A
(en)
|
1987-05-21 |
1992-02-25 |
Creative Biomolecules, Inc. |
Biosynthetic antibody binding sites
|
|
EP0436597B1
(en)
|
1988-09-02 |
1997-04-02 |
Protein Engineering Corporation |
Generation and selection of recombinant varied binding proteins
|
|
US5223409A
(en)
|
1988-09-02 |
1993-06-29 |
Protein Engineering Corp. |
Directed evolution of novel binding proteins
|
|
EP0368684B2
(en)
|
1988-11-11 |
2004-09-29 |
Medical Research Council |
Cloning immunoglobulin variable domain sequences.
|
|
WO1990014443A1
(en)
|
1989-05-16 |
1990-11-29 |
Huse William D |
Co-expression of heteromeric receptors
|
|
US6291159B1
(en)
|
1989-05-16 |
2001-09-18 |
Scripps Research Institute |
Method for producing polymers having a preselected activity
|
|
US6291158B1
(en)
|
1989-05-16 |
2001-09-18 |
Scripps Research Institute |
Method for tapping the immunological repertoire
|
|
US6291160B1
(en)
|
1989-05-16 |
2001-09-18 |
Scripps Research Institute |
Method for producing polymers having a preselected activity
|
|
US6291161B1
(en)
|
1989-05-16 |
2001-09-18 |
Scripps Research Institute |
Method for tapping the immunological repertiore
|
|
CA2016842A1
(en)
|
1989-05-16 |
1990-11-16 |
Richard A. Lerner |
Method for tapping the immunological repertoire
|
|
CA2016841C
(en)
|
1989-05-16 |
1999-09-21 |
William D. Huse |
A method for producing polymers having a preselected activity
|
|
US5859205A
(en)
|
1989-12-21 |
1999-01-12 |
Celltech Limited |
Humanised antibodies
|
|
WO1991010737A1
(en)
|
1990-01-11 |
1991-07-25 |
Molecular Affinities Corporation |
Production of antibodies using gene libraries
|
|
US5780225A
(en)
|
1990-01-12 |
1998-07-14 |
Stratagene |
Method for generating libaries of antibody genes comprising amplification of diverse antibody DNAs and methods for using these libraries for the production of diverse antigen combining molecules
|
|
DE4002897A1
(de)
|
1990-02-01 |
1991-08-08 |
Behringwerke Ag |
Herstellung und verwendung von genbanken synthetischer menschlicher antikoerper ("synthetische human-antikoerper-bibliotheken")
|
|
US5427908A
(en)
|
1990-05-01 |
1995-06-27 |
Affymax Technologies N.V. |
Recombinant library screening methods
|
|
EP0585287B1
(en)
|
1990-07-10 |
1999-10-13 |
Cambridge Antibody Technology Limited |
Methods for producing members of specific binding pairs
|
|
GB9015198D0
(en)
|
1990-07-10 |
1990-08-29 |
Brien Caroline J O |
Binding substance
|
|
WO1992015678A1
(en)
|
1991-03-01 |
1992-09-17 |
Stratagene |
Pcr generated dicistronic dna molecules for producing antibodies
|
|
EP0575485A1
(en)
|
1991-03-01 |
1993-12-29 |
Dyax Corp. |
Process for the development of binding mini-proteins
|
|
WO1993003151A1
(en)
|
1991-08-10 |
1993-02-18 |
Medical Research Council |
Treatment of cell populations
|
|
AU665025B2
(en)
|
1991-09-23 |
1995-12-14 |
Cambridge Antibody Technology Limited |
Production of chimeric antibodies - a combinatorial approach
|
|
ES2136092T3
(es)
|
1991-09-23 |
1999-11-16 |
Medical Res Council |
Procedimientos para la produccion de anticuerpos humanizados.
|
|
ES2341666T3
(es)
|
1991-12-02 |
2010-06-24 |
Medimmune Limited |
Produccion de autoanticuerpos de repertorios de segmentos de anticue rpos expresados en la superficie de fagos.
|
|
US5667988A
(en)
|
1992-01-27 |
1997-09-16 |
The Scripps Research Institute |
Methods for producing antibody libraries using universal or randomized immunoglobulin light chains
|
|
US5395750A
(en)
|
1992-02-28 |
1995-03-07 |
Hoffmann-La Roche Inc. |
Methods for producing proteins which bind to predetermined antigens
|
|
DE69333823T2
(de)
|
1992-03-24 |
2006-05-04 |
Cambridge Antibody Technology Ltd., Melbourn |
Verfahren zur herstellung von gliedern von spezifischen bindungspaaren
|
|
US5855885A
(en)
|
1993-01-22 |
1999-01-05 |
Smith; Rodger |
Isolation and production of catalytic antibodies using phage technology
|
|
WO1995011998A1
(en)
|
1993-10-26 |
1995-05-04 |
United Biomedical, Inc. |
Structured synthetic antigen libraries as diagnostics, vaccines and therapeutics
|
|
US20010049107A1
(en)
|
1994-01-31 |
2001-12-06 |
Boston University |
Polyclonal antibody libraries
|
|
US5605793A
(en)
|
1994-02-17 |
1997-02-25 |
Affymax Technologies N.V. |
Methods for in vitro recombination
|
|
CA2245835A1
(en)
|
1995-06-14 |
1997-01-03 |
The Regents Of The University Of California |
Novel high affinity human antibodies to tumor antigens
|
|
AU725609C
(en)
|
1995-08-18 |
2002-01-03 |
Morphosys Ag |
Protein/(poly)peptide libraries
|
|
US6696248B1
(en)
|
1995-08-18 |
2004-02-24 |
Morphosys Ag |
Protein/(poly)peptide libraries
|
|
GB9603507D0
(en)
|
1996-02-20 |
1996-04-17 |
Isis Innovation |
Antibody variants
|
|
CA2297070A1
(en)
|
1997-08-01 |
1999-02-11 |
Morphosys Ag |
Novel method and phage for the identification of nucleic acid sequences encoding members of a multimeric (poly)peptide complex
|
|
GB9722131D0
(en)
|
1997-10-20 |
1997-12-17 |
Medical Res Council |
Method
|
|
WO2000052054A2
(en)
|
1999-03-01 |
2000-09-08 |
Genentech, Inc. |
Antibodies for cancer therapy and diagnosis
|
|
ES2327382T3
(es)
|
1999-07-20 |
2009-10-29 |
Morphosys Ag |
Metodos para presentar (poli)peptidos/proteinas en particulas de bacteriofagos a traves de enlaces disulfuro.
|
|
IL136459A0
(en)
|
2000-05-30 |
2001-06-14 |
Galim Galil Immunology Ltd |
Antibody library
|
|
ES2430857T3
(es)
|
2000-12-18 |
2013-11-22 |
Dyax Corp. |
Bibliotecas focalizadas de paquetes genéticos
|
|
US7117096B2
(en)
|
2001-04-17 |
2006-10-03 |
Abmaxis, Inc. |
Structure-based selection and affinity maturation of antibody library
|
|
DK1438400T3
(da)
|
2001-10-01 |
2009-10-05 |
Dyax Corp |
Flerkædede eukaryote display-vektorer og anvendelser deraf
|
|
GB0130267D0
(en)
|
2001-12-19 |
2002-02-06 |
Neutec Pharma Plc |
Focussed antibody technology
|
|
EP1456237A2
(en)
|
2001-12-21 |
2004-09-15 |
Vlaams Interuniversitair Instituut voor Biotechnologie vzw. |
Method for cloning of variable domain sequences
|
|
US7244592B2
(en)
|
2002-03-07 |
2007-07-17 |
Dyax Corp. |
Ligand screening and discovery
|
|
US8206977B2
(en)
|
2002-07-30 |
2012-06-26 |
Morphosys Ag |
Tricistronic vectors and uses therefor
|
|
US8557743B2
(en)
|
2002-09-05 |
2013-10-15 |
Dyax Corp. |
Display library process
|
|
GB0309126D0
(en)
|
2003-04-17 |
2003-05-28 |
Neutec Pharma Plc |
Clostridium difficile focussed antibodies
|
|
US20120202710A1
(en)
|
2003-09-09 |
2012-08-09 |
Integrigen, Inc. |
Methods and compositions for generation of germline human antibody genes
|
|
TWI333977B
(en)
|
2003-09-18 |
2010-12-01 |
Symphogen As |
Method for linking sequences of interest
|
|
WO2005094159A2
(en)
|
2003-11-12 |
2005-10-13 |
Oncomab Gmbh |
Methods of identifying neoplasm-specific antibodies and uses thereof
|
|
WO2005071112A2
(en)
|
2004-01-26 |
2005-08-04 |
Isis Innovation Ltd |
Molecular analysis
|
|
DE502005011243D1
(de)
|
2004-05-26 |
2011-05-26 |
Fraunhofer Ges Forschung |
Isolation allergen-spezifischer immunoglobulin-gene aus humanen b-zellen von atopikern
|
|
CA2572961C
(en)
|
2004-07-06 |
2016-08-16 |
Bioren, Inc. |
Universal antibody libraries
|
|
US7977050B2
(en)
|
2004-09-02 |
2011-07-12 |
Bioarray Solutions, Ltd. |
Nucleic acid amplification with integrated multiplex detection
|
|
US20060078898A1
(en)
|
2004-10-12 |
2006-04-13 |
Curry Bo U |
Methods and compositions for reducing label variation in array-based comparative genome hybridization assays II
|
|
US8551920B2
(en)
|
2005-02-01 |
2013-10-08 |
Morpho Sys AG |
Libraries and methods for isolating antibodies
|
|
RU2311927C2
(ru)
*
|
2005-08-15 |
2007-12-10 |
Федеральное государственное унитарное учреждение науки "Государственный научный центр вирусологии и биотехнологии "Вектор" Федеральной службы по надзору в сфере защиты прав потребителей и благополучия человека" |
КОМБИНАТОРНАЯ ФАГМИДНАЯ БИБЛИОТЕКА ОДНОЦЕПОЧЕЧНЫХ АНТИТЕЛ ЧЕЛОВЕКА, ОБОГАЩЕННАЯ АНТИТЕЛАМИ ПРОТИВ ВИРУСА ОСПОВАКЦИНЫ, РЕКОМБИНАНТНАЯ ФАГМИДНАЯ ДНК pHEN-2A8, СОДЕРЖАЩАЯ УНИКАЛЬНЫЙ ГЕН ОДНОЦЕПОЧЕЧНОГО АНТИТЕЛА ЧЕЛОВЕКА, СПОСОБНОГО НЕЙТРАЛИЗОВАТЬ ВИРУС ОСПОВАКЦИНЫ И ВИРУС ОСПЫ КОРОВ, И ИСКУССТВЕННОЕ ОДНОЦЕПОЧЕЧНОЕ АНТИТЕЛО ЧЕЛОВЕКА 2A8, СПОСОБНОЕ НЕЙТРАЛИЗОВАТЬ ВИРУС ОСПОВАКЦИНЫ И ВИРУС ОСПЫ КОРОВ
|
|
EP1957531B1
(en)
|
2005-11-07 |
2016-04-13 |
Genentech, Inc. |
Binding polypeptides with diversified and consensus vh/vl hypervariable sequences
|
|
EP1979378B1
(en)
|
2005-12-20 |
2012-07-25 |
MorphoSys AG |
Novel collection of hcdr3 regions and uses therefor
|
|
WO2007130520A2
(en)
|
2006-05-04 |
2007-11-15 |
Abmaxis Inc. |
Cross-species and multi-species display systems
|
|
EP1918302A3
(en)
*
|
2006-05-18 |
2009-11-18 |
AvantGen, Inc. |
Methods for the identification and the isolation of epitope specific antibodies
|
|
CN101772574B
(zh)
|
2007-08-21 |
2016-01-06 |
莫佛塞斯公司 |
改良的用于二硫键形成的方法
|
|
US8691730B2
(en)
|
2007-09-14 |
2014-04-08 |
Adimab, Llc |
Rationally designed, synthetic antibody libraries and uses therefor
|
|
JP2011507519A
(ja)
|
2007-12-19 |
2011-03-10 |
セントコア・オーソ・バイオテツク・インコーポレーテツド |
ｐＩＸ又はｐＶＩＩへの融合を介したヒトデノボｐＩＸファージディスプレイライブラリの設計及び作製、ベクター、抗体、及び方法
|
|
EP2088432A1
(en)
*
|
2008-02-11 |
2009-08-12 |
MorphoSys AG |
Methods for identification of an antibody or a target
|
|
US9873957B2
(en)
|
2008-03-13 |
2018-01-23 |
Dyax Corp. |
Libraries of genetic packages comprising novel HC CDR3 designs
|
|
EP2100970B1
(en)
|
2008-03-13 |
2017-05-10 |
National Institute of Immunology |
Ig genes specific oligonucleotides and uses thereof
|
|
EP2331570B1
(en)
|
2008-09-10 |
2014-08-27 |
Philochem AG |
Display library for antibody selection
|
|
DK2356270T3
(da)
|
2008-11-07 |
2016-12-12 |
Fabrus Llc |
Kombinatoriske antistofbiblioteker og anvendelser deraf
|
|
WO2010130824A2
(en)
*
|
2009-05-15 |
2010-11-18 |
Morphosys Ag |
Collections and uses thereof
|
|
SG175407A1
(en)
|
2009-05-29 |
2011-11-28 |
Morphosys Ag |
A collection and methods for its use
|
|
EP2528944B1
(en)
|
2010-01-29 |
2015-08-12 |
MorphoSys AG |
Rodent combinatorial antibody libraries
|