JP2009526082A5 - - Google Patents

Download PDF

Info

Publication number
JP2009526082A5
JP2009526082A5 JP2008554507A JP2008554507A JP2009526082A5 JP 2009526082 A5 JP2009526082 A5 JP 2009526082A5 JP 2008554507 A JP2008554507 A JP 2008554507A JP 2008554507 A JP2008554507 A JP 2008554507A JP 2009526082 A5 JP2009526082 A5 JP 2009526082A5
Authority
JP
Japan
Prior art keywords
antibody
cell
hybridoma
hybridoma cell
antigen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2008554507A
Other languages
English (en)
Japanese (ja)
Other versions
JP2009526082A (ja
JP5210889B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2007/061874 external-priority patent/WO2007092939A2/en
Publication of JP2009526082A publication Critical patent/JP2009526082A/ja
Publication of JP2009526082A5 publication Critical patent/JP2009526082A5/ja
Application granted granted Critical
Publication of JP5210889B2 publication Critical patent/JP5210889B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2008554507A 2006-02-08 2007-02-08 抗原性ｇｍ−ｃｓｆペプチドおよび抗ｇｍ−ｃｓｆ抗体 Expired - Fee Related JP5210889B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US77125106P 2006-02-08 2006-02-08
US60/771,251 2006-02-08
US77450006P 2006-02-17 2006-02-17
US60/774,500 2006-02-17
PCT/US2007/061874 WO2007092939A2 (en) 2006-02-08 2007-02-08 Antigenic gm-csf peptides and antibodies to gm-csf

Publications (3)

Publication Number Publication Date
JP2009526082A JP2009526082A (ja) 2009-07-16
JP2009526082A5 true JP2009526082A5 (https=) 2010-04-02
JP5210889B2 JP5210889B2 (ja) 2013-06-12

Family

ID=38345964

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2008554507A Expired - Fee Related JP5210889B2 (ja) 2006-02-08 2007-02-08 抗原性ｇｍ−ｃｓｆペプチドおよび抗ｇｍ−ｃｓｆ抗体

Country Status (18)

Country Link
US (5) US7741450B2 (https=)
EP (2) EP3181585A3 (https=)
JP (1) JP5210889B2 (https=)
KR (2) KR101395515B1 (https=)
CN (1) CN101501070B (https=)
AU (1) AU2007213716C1 (https=)
CA (2) CA2641169C (https=)
CY (1) CY1118709T1 (https=)
DK (1) DK1981909T3 (https=)
ES (1) ES2609088T3 (https=)
HR (1) HRP20170024T1 (https=)
HU (1) HUE032584T2 (https=)
IL (2) IL193011A (https=)
LT (1) LT1981909T (https=)
PL (1) PL1981909T3 (https=)
PT (1) PT1981909T (https=)
RS (1) RS55526B1 (https=)
WO (1) WO2007092939A2 (https=)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2468774A3 (en) 2005-04-18 2013-01-02 Amgen Research (Munich) GmbH Antibody neutralizers of human granulocyte macrophage colony stimulating factor
JP4736037B2 (ja) 2005-10-26 2011-07-27 株式会社イーベック ヒトｇｍ−ｃｓｆに結合するヒトのモノクローナル抗体並びにその抗原結合部分
CA2641169C (en) 2006-02-08 2017-05-02 Morphotek, Inc. Antigenic gm-csf peptides and antibodies to gm-csf
EP2013620A2 (en) * 2006-04-17 2009-01-14 Morphotek, Inc. Whole genome evolution technology applied to improve protein and antibody yields by cells
US8398972B2 (en) 2006-11-21 2013-03-19 Kalobios Pharmaceuticals, Inc. Methods of treating dementia using a GM-CSF antagonist
US20080206241A1 (en) * 2006-11-21 2008-08-28 Kalobios Pharmaceuticals Inc. Methods of Treating Chronic Inflammatory Diseases Using a GM-CSF Antagonist
US20100255513A1 (en) * 2007-03-30 2010-10-07 Denson Lee A Serological markers of inflammatory bowel disease phenotype and disease progression
WO2009032845A2 (en) 2007-09-04 2009-03-12 Compugen, Ltd. Polypeptides and polynucleotides, and uses thereof as a drug target for producing drugs and biologics
TW200918553A (en) * 2007-09-18 2009-05-01 Amgen Inc Human GM-CSF antigen binding proteins
EP2217626A4 (en) * 2007-11-12 2011-06-22 Crc For Asthma And Airways Ltd EPITOP FOR NEUTRALIZING ANTIBODIES
PE20091420A1 (es) * 2007-11-13 2009-10-17 Evec Inc ANTICUERPOS MONOCLONALES ANTI hGM-CSF
JP2012105657A (ja) * 2008-02-14 2012-06-07 Evec Inc ｈＧＭ−ＣＳＦに結合するモノクローナル抗体および前記抗体を含む医薬組成物
JP5476310B2 (ja) * 2008-02-14 2014-04-23 株式会社イーベック ｈＧＭ−ＣＳＦに結合するモノクローナル抗体および前記抗体を含む医薬組成物
US8075885B2 (en) 2008-04-07 2011-12-13 Kalobios Pharmaceuticals, Inc. Methods of treating heart failure using an anti-GM-CSF antibody
NZ588850A (en) * 2008-04-28 2012-12-21 Kalobios Pharmaceuticals Inc Antibodies to granulocyte-macrophage colony-stimulating factor
KR101681331B1 (ko) * 2008-04-29 2016-12-01 암젠 리서치 (뮌헨) 게엠베하 치료를 위한 ｇｍ-ｃｓｆ 및 ｉｌ-17의 억제제
RU2630969C2 (ru) 2008-12-22 2017-09-15 Де Юниверсити Оф Мельбурн Лечение боли
EP3056217B1 (en) * 2008-12-22 2021-06-30 The University of Melbourne Osteoarthritis treatment
CN102459340A (zh) * 2009-04-23 2012-05-16 特罗科隆科学有限公司 粒性白血细胞-巨噬细胞菌落-刺激因子(gm-csf)中和抗体
WO2011100637A1 (en) 2010-02-11 2011-08-18 The Board Of Trustees Of The Leland Stanford Junior University Markers for determination of patient responsiveness
WO2013001517A1 (en) 2011-06-30 2013-01-03 Compugen Ltd. Polypeptides and uses thereof for treatment of autoimmune disorders and infection
EP2729498A1 (en) * 2011-07-06 2014-05-14 MorphoSys AG Therapeutic combinations of anti -cd20 and anti - gm - csf antibodies and uses thereof
WO2013026059A1 (en) 2011-08-18 2013-02-21 New York University Inhibition of oncogenic kras-induced gm-csf production and function
WO2013090989A1 (en) 2011-12-22 2013-06-27 Csl Limited Method of treating inflammatory bowel disease
KR20140126357A (ko) 2012-02-01 2014-10-30 컴퓨젠 엘티디. C1orf32 항체 및 이의 암 치료를 위한 용도
EP2914289B1 (en) 2012-10-31 2019-05-22 Takeda GmbH Lyophilized formulation comprising gm-csf neutralizing compound
AR093297A1 (es) 2012-10-31 2015-05-27 Amgen Res Munich Gmbh Formulacion liquida que comprende un compuesto neutralizante de gm-csf
CN104212760B (zh) * 2013-05-29 2017-08-08 中国科学院上海生命科学研究院 肌肉干细胞体外培养方法及其应用
US10745475B2 (en) 2013-08-30 2020-08-18 Takeda Gmbh Antibodies neutralizing GM-CSF for use in the treatment of rheumatoid arthritis or as analgesics
EP3139960B1 (en) 2014-05-07 2024-01-17 Takeda Pharmaceutical Company Limited Liquid formulation comprising gm-csf neutralizing compound
ES2626491B1 (es) * 2015-12-03 2018-06-25 Consejo Superior De Investigaciones Científicas (Csic) Anticuerpos monoclonales frente a bambi y uso para tratamiento de enfermedades inflamatorias
MX2019003019A (es) 2016-09-19 2019-09-19 I Mab Anticuerpos anti-gm-csf y usos de los mismos.
CN107840886B (zh) * 2016-09-19 2020-11-10 天境生物科技(上海)有限公司 Gm-csf抗体及其用途
US20180325931A1 (en) 2017-01-21 2018-11-15 Ningbo Zhiming Biotechnology Co., Ltd. Use of paeoniflorin-6'-o-benzenesulfonate in treatment of sjögren's syndrome
US11267859B2 (en) 2017-06-09 2022-03-08 The Regents Of The University Of Colorado, A Body Corporate GM-CSF mimetics and methods of making and using same
EP3691663A4 (en) 2017-10-02 2021-08-18 Humanigen, Inc. METHODS OF TREATMENT OF TOXICITY ASSOCIATED WITH IMMUNOTHERAPIES USING A GM-CSF ANTAGONIST
US10927168B2 (en) 2017-10-02 2021-02-23 Humanicen, Inc. Method of reducing tumor relapse rate in immunotherapy by administration of lenzilumab
US10899831B2 (en) 2017-10-02 2021-01-26 Humanigen, Inc. Method of reducing the level of non-GM-CSF cytokines/chemokines in immunotherapy-related toxicity
US11130805B2 (en) 2017-10-02 2021-09-28 Humanigen, Inc. Methods of treating CART-T cell therapy-induced neuroinflammation using a GM-CSF antagonist
US11655293B2 (en) 2018-02-22 2023-05-23 Universitat Zurich Ligands to GM-CSF or GM-CSF-receptor for use in leukemia in a patient having undergone allo-HCT
CN112805301B (zh) * 2018-10-15 2023-07-21 安立玺荣生医(香港)有限公司 粒细胞-巨噬细胞集落刺激因子的抗体及其用途
SG11202103589XA (en) * 2018-10-31 2021-05-28 Humanigen Inc Materials and methods for treating cancer
WO2021207667A1 (en) * 2020-04-10 2021-10-14 Kinevant Sciences Gmbh Compositions and methods for treating lung injury or acute respiratory distress syndrome (ards)
CN117384856B (zh) * 2023-09-04 2024-04-16 广州医科大学 一种永生化copd人支气管上皮细胞株及其构建方法和应用
CN120399067B (zh) * 2025-07-02 2025-09-30 武汉伊莱瑞特生物科技股份有限公司 一种与人gm-csf特异性结合的单克隆抗体及其检测试剂盒和应用

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU594014B2 (en) 1984-03-21 1990-03-01 Research Corporation Technologies, Inc. Recombinant DNA molecules
US5908763A (en) 1984-07-06 1999-06-01 Novartis Corporation DNA encoding GM-CSF and a method of producing GM-CSF protein
NZ218336A (en) * 1985-12-09 1991-08-27 Kirin Amgen Inc Monoclonal antibodies to human pluripotent granulocyte colony stimulating factor (hpg-csf)
US6013619A (en) 1988-01-06 2000-01-11 The Scripps Research Institute Pulmonary surfactants and therapeutic uses, including pulmonary lavage
US6613734B2 (en) 1988-01-06 2003-09-02 The Scripps Research Institute Peptides-containing liposomal surfactants
US5260273A (en) 1988-01-06 1993-11-09 The Scripps Research Institute Pulmonary surfactant protein and related polypeptide
US5164369A (en) 1988-01-06 1992-11-17 The Scripps Research Institute Pulmonary surfactant protein and related polypeptide
AU630496B2 (en) 1989-07-14 1992-10-29 Schering Corporation Antagonists of gm-csf derived from the carboxyl terminus
CA2060741A1 (en) * 1991-02-11 1992-08-12 Robert S. Greenfield Gm-csf inhibiting oligopeptides
BR9205151A (pt) 1992-08-17 1994-03-01 Praxair Technology Inc Dissolucao aumentada de gas
WO1997035882A1 (en) 1996-03-27 1997-10-02 Ortho Pharmaceutical Corporation Lyophilized pulmonary surfactant peptide compositions
AU2066897A (en) 1996-03-27 1997-10-17 Ortho Pharmaceutical Corporation Manufacture of liposomes and lipid-protein complexes by ethanolic injection and thin film evaporation
US6013764A (en) 1996-07-17 2000-01-11 Ortho Pharmaceutical Corp. Liquid phase peptide synthesis of KL-4 pulmonary surfactant
EP0959136A1 (en) * 1998-05-20 1999-11-24 Introgene B.V. Targeted delivery through a cationic amino acid transporter
US7108852B2 (en) 2000-03-20 2006-09-19 Warner-Lambert Company Llc Methods of treating inflammation using antibodies to M-CSF
US7455836B2 (en) * 2000-05-08 2008-11-25 The University Of Melbourne Method of treatment and agents useful for same
CN1487996B (zh) * 2000-11-30 2010-06-16 米德列斯公司 用于生产人类抗体的转基因转染色体啮齿动物
MXPA03008032A (es) 2001-03-08 2003-12-04 Merck Patent Gmbh Factor de estimulacion de colonias de granulocitos- macrofagos modificado con inmunogenicidad reducida.
US7381801B2 (en) * 2002-02-13 2008-06-03 Ludwig Institute For Cancer Research Chimerized GM-CSF antibodies
CA2506127C (en) * 2002-11-15 2013-07-09 Morphotek, Inc. Methods of generating high-production of antibodies from hybridomas created by in vitro immunization
JP2005040126A (ja) * 2003-02-28 2005-02-17 Mitsubishi Pharma Corp モノクローナル抗体およびそれをコードする遺伝子、ハイブリドーマ、医薬組成物ならびに診断試薬
CA2515389A1 (en) * 2003-02-28 2004-09-10 Mitsubishi Pharma Corporation Monoclonal antibody and gene encoding the same, hybridoma, pharmaceutical compostion, and diagnostic reagent
JP2007525971A (ja) 2003-08-05 2007-09-13 モルフォテック、インク． 癌に関連する変異体細胞表面分子
JP2005176792A (ja) 2003-12-24 2005-07-07 Atex Co Ltd 乗用草刈機
EP1593690B1 (en) * 2004-05-05 2009-07-01 Micromet AG Preparation of ScFv antibody fragments
US20060257359A1 (en) 2005-02-28 2006-11-16 Cedric Francois Modifying macrophage phenotype for treatment of disease
EP2468774A3 (en) * 2005-04-18 2013-01-02 Amgen Research (Munich) GmbH Antibody neutralizers of human granulocyte macrophage colony stimulating factor
EP3620171B1 (en) 2005-05-18 2022-04-20 MorphoSys AG Anti-gm-csf antibodies and uses therefor
JP4736037B2 (ja) * 2005-10-26 2011-07-27 株式会社イーベック ヒトｇｍ−ｃｓｆに結合するヒトのモノクローナル抗体並びにその抗原結合部分
CA2641169C (en) 2006-02-08 2017-05-02 Morphotek, Inc. Antigenic gm-csf peptides and antibodies to gm-csf

Similar Documents

Publication Publication Date Title
JP2009526082A5 (https=)
JP7844685B2 (ja) 胸線間質性リンパ球増殖因子に結合可能な抗体およびその使用
TWI845767B (zh) 抗人Claudin18.2抗體及其應用
CN112625136B (zh) 针对冠状病毒具有中和活性的双特异性抗体及其用途
AU2016228196B2 (en) Express humanization of antibodies
ES2828627T3 (es) Anticuerpo multivalente estable
CN104271602B (zh) 双特异性抗体
CN103819561A (zh) 抗cd24单克隆抗体、其可变区序列及其应用
TW201942130A (zh) 結合至ssea4的單株抗體及其用途
JP6731702B2 (ja) 親和性成熟化ヒト抗体の同定
JP2018148915A (ja) 抗ｖａｓａ抗体、ならびにその産生法および使用法
JP2021518168A (ja) 拮抗的抗原結合タンパク質
CN118510805A (zh) 一种gprc5d抗体及其应用
CN116848147A (zh) Cd19人源化抗体及其应用
CN102482699A (zh) Toll样受体3拮抗剂
CN115536747B (zh) 一种结合trop2的抗体及靶向trop2和cd3的双特异性抗体及其制备方法与应用
CN101389791A (zh) 融合蛋白文库的产生和筛选方法及其应用
WO2024017326A1 (zh) 抗gprc5d纳米抗体及其应用
US20240124575A1 (en) Human cd33 antibody and use thereof
CN105646712B (zh) 单克隆抗体及其应用
WO2025131127A1 (zh) 抗cd5单域抗体及其应用
JP2023535233A (ja) グリコシル化ｃｅａｃａｍ５に特異的に結合した抗体
CN103588876B (zh) 一种生产人源化抗体或抗原结合片段的方法
CN118359724A (zh) 靶向gpc3的抗体、其抗原结合片段及其应用
CN105646713B (zh) 一种单克隆抗体及其应用