JP2009526082A5 - - Google Patents
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- Publication number
- JP2009526082A5 JP2009526082A5 JP2008554507A JP2008554507A JP2009526082A5 JP 2009526082 A5 JP2009526082 A5 JP 2009526082A5 JP 2008554507 A JP2008554507 A JP 2008554507A JP 2008554507 A JP2008554507 A JP 2008554507A JP 2009526082 A5 JP2009526082 A5 JP 2009526082A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- cell
- hybridoma
- hybridoma cell
- antigen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US77125106P | 2006-02-08 | 2006-02-08 | |
| US60/771,251 | 2006-02-08 | ||
| US77450006P | 2006-02-17 | 2006-02-17 | |
| US60/774,500 | 2006-02-17 | ||
| PCT/US2007/061874 WO2007092939A2 (en) | 2006-02-08 | 2007-02-08 | Antigenic gm-csf peptides and antibodies to gm-csf |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009526082A JP2009526082A (ja) | 2009-07-16 |
| JP2009526082A5 true JP2009526082A5 (https=) | 2010-04-02 |
| JP5210889B2 JP5210889B2 (ja) | 2013-06-12 |
Family
ID=38345964
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008554507A Expired - Fee Related JP5210889B2 (ja) | 2006-02-08 | 2007-02-08 | 抗原性gm−csfペプチドおよび抗gm−csf抗体 |
Country Status (18)
| Country | Link |
|---|---|
| US (5) | US7741450B2 (https=) |
| EP (2) | EP3181585A3 (https=) |
| JP (1) | JP5210889B2 (https=) |
| KR (2) | KR101395515B1 (https=) |
| CN (1) | CN101501070B (https=) |
| AU (1) | AU2007213716C1 (https=) |
| CA (2) | CA2961031C (https=) |
| CY (1) | CY1118709T1 (https=) |
| DK (1) | DK1981909T3 (https=) |
| ES (1) | ES2609088T3 (https=) |
| HR (1) | HRP20170024T1 (https=) |
| HU (1) | HUE032584T2 (https=) |
| IL (2) | IL193011A (https=) |
| LT (1) | LT1981909T (https=) |
| PL (1) | PL1981909T3 (https=) |
| PT (1) | PT1981909T (https=) |
| RS (1) | RS55526B1 (https=) |
| WO (1) | WO2007092939A2 (https=) |
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BRPI0608281B8 (pt) | 2005-04-18 | 2021-05-25 | Amgen Res Munich Gmbh | anticorpo monoclonal humano ou seu fragmento, seu uso no tratamento de doenças inflamatórias, bem como composição farmacêutica que o compreende |
| JP4736037B2 (ja) | 2005-10-26 | 2011-07-27 | 株式会社イーベック | ヒトgm−csfに結合するヒトのモノクローナル抗体並びにその抗原結合部分 |
| US7741450B2 (en) | 2006-02-08 | 2010-06-22 | Morphotek Inc. | Antibodies to GM-CSF |
| JP2009533072A (ja) * | 2006-04-17 | 2009-09-17 | モルフォテック、インク. | 細胞によるタンパク質および抗体収量を改善するために適用される全ゲノム進化技術 |
| US8398972B2 (en) | 2006-11-21 | 2013-03-19 | Kalobios Pharmaceuticals, Inc. | Methods of treating dementia using a GM-CSF antagonist |
| EP2101780B1 (en) * | 2006-11-21 | 2013-10-09 | Kalobios Pharmaceuticals, Inc. | Methods of treating chronic inflammatory diseases using a gm-csf antagonist |
| US20100255513A1 (en) * | 2007-03-30 | 2010-10-07 | Denson Lee A | Serological markers of inflammatory bowel disease phenotype and disease progression |
| JP5607530B2 (ja) | 2007-09-04 | 2014-10-15 | コンピュゲン エルティーディー. | ポリペプチド並びにポリヌクレオチド、並びに薬剤および生物製剤生産のための薬剤標的としてのその利用 |
| TW200918553A (en) * | 2007-09-18 | 2009-05-01 | Amgen Inc | Human GM-CSF antigen binding proteins |
| WO2009062238A1 (en) * | 2007-11-12 | 2009-05-22 | Crc For Asthma And Airways Ltd | Epitope for neutralizing antibodies |
| CN104072613A (zh) | 2007-11-13 | 2014-10-01 | Evec股份有限公司 | 与hGM-CSF结合的单克隆抗体及包含它的药物组合物 |
| JP5476310B2 (ja) * | 2008-02-14 | 2014-04-23 | 株式会社イーベック | hGM−CSFに結合するモノクローナル抗体および前記抗体を含む医薬組成物 |
| JP2012105657A (ja) * | 2008-02-14 | 2012-06-07 | Evec Inc | hGM−CSFに結合するモノクローナル抗体および前記抗体を含む医薬組成物 |
| EP2282757B1 (en) * | 2008-04-07 | 2013-05-22 | Kalobios Pharmaceuticals, Inc. | Neutralization of gm-csf for the treatment of heart failure |
| WO2009134805A2 (en) * | 2008-04-28 | 2009-11-05 | Kalobios Pharmaceuticals, Inc. | Antibodies to granulocyte-macrophage colony-stimulating factor |
| CA2717987C (en) * | 2008-04-29 | 2018-11-13 | Micromet Ag | Inhibitors of gm-csf and il-17 for therapy |
| CA2747206C (en) * | 2008-12-22 | 2018-04-24 | The University Of Melbourne | Pain treatment |
| CN102271705A (zh) * | 2008-12-22 | 2011-12-07 | 墨尔本大学 | 骨关节炎治疗 |
| US8609101B2 (en) | 2009-04-23 | 2013-12-17 | Theraclone Sciences, Inc. | Granulocyte-macrophage colony-stimulating factor (GM-CSF) neutralizing antibodies |
| US20130046015A1 (en) * | 2010-02-11 | 2013-02-21 | Robert C. Axtell | Therapeutic Inhibition of Granulocyte Function in Demyelinating Disease |
| US9428574B2 (en) | 2011-06-30 | 2016-08-30 | Compugen Ltd. | Polypeptides and uses thereof for treatment of autoimmune disorders and infection |
| CN103827143A (zh) * | 2011-07-06 | 2014-05-28 | 莫弗系统股份公司 | 抗cd20抗体和抗gm-csf抗体的治疗性组合产品及其用途 |
| WO2013026059A1 (en) | 2011-08-18 | 2013-02-21 | New York University | Inhibition of oncogenic kras-induced gm-csf production and function |
| WO2013090989A1 (en) | 2011-12-22 | 2013-06-27 | Csl Limited | Method of treating inflammatory bowel disease |
| CA2848985A1 (en) | 2012-02-01 | 2013-08-08 | Compugen Ltd. | C10rf32 antibodies, and uses thereof for treatment of cancer |
| AR093297A1 (es) | 2012-10-31 | 2015-05-27 | Amgen Res Munich Gmbh | Formulacion liquida que comprende un compuesto neutralizante de gm-csf |
| WO2014068029A1 (en) | 2012-10-31 | 2014-05-08 | Takeda Gmbh | Lyophilized formulation comprising gm-csf neutralizing compound |
| CN104212760B (zh) * | 2013-05-29 | 2017-08-08 | 中国科学院上海生命科学研究院 | 肌肉干细胞体外培养方法及其应用 |
| US10745475B2 (en) | 2013-08-30 | 2020-08-18 | Takeda Gmbh | Antibodies neutralizing GM-CSF for use in the treatment of rheumatoid arthritis or as analgesics |
| KR102385802B1 (ko) | 2014-05-07 | 2022-04-13 | 다케다 야쿠힝 고교 가부시키가이샤 | Gm-csf 중화 화합물을 포함하는 액체 제제 |
| ES2626491B1 (es) | 2015-12-03 | 2018-06-25 | Consejo Superior De Investigaciones Científicas (Csic) | Anticuerpos monoclonales frente a bambi y uso para tratamiento de enfermedades inflamatorias |
| SG11201901789WA (en) | 2016-09-19 | 2019-03-28 | I Mab | Anti-gm-csf antibodies and uses thereof |
| CN107840886B (zh) * | 2016-09-19 | 2020-11-10 | 天境生物科技(上海)有限公司 | Gm-csf抗体及其用途 |
| US20180325931A1 (en) | 2017-01-21 | 2018-11-15 | Ningbo Zhiming Biotechnology Co., Ltd. | Use of paeoniflorin-6'-o-benzenesulfonate in treatment of sjögren's syndrome |
| EP3634487A4 (en) | 2017-06-09 | 2021-03-24 | The Regents Of The University Of Colorado, A Body Corporate, A Colorado Non-Profit | GM-CSF MIMETICS AND PROCESSES FOR THE PRODUCTION AND USE OF THEM |
| US11130805B2 (en) | 2017-10-02 | 2021-09-28 | Humanigen, Inc. | Methods of treating CART-T cell therapy-induced neuroinflammation using a GM-CSF antagonist |
| US10899831B2 (en) | 2017-10-02 | 2021-01-26 | Humanigen, Inc. | Method of reducing the level of non-GM-CSF cytokines/chemokines in immunotherapy-related toxicity |
| US10927168B2 (en) | 2017-10-02 | 2021-02-23 | Humanicen, Inc. | Method of reducing tumor relapse rate in immunotherapy by administration of lenzilumab |
| AU2018345751A1 (en) | 2017-10-02 | 2020-05-07 | Humanigen, Inc. | Methods of treating immunotherapy-related toxicity using a GM-CSF antagonist |
| US11655293B2 (en) | 2018-02-22 | 2023-05-23 | Universitat Zurich | Ligands to GM-CSF or GM-CSF-receptor for use in leukemia in a patient having undergone allo-HCT |
| JP7603580B2 (ja) | 2018-10-15 | 2024-12-20 | エリクシロン・イミュノセラピューティクス・(ホンコン)・リミテッド | 顆粒球マクロファージコロニー刺激因子に対する抗体及びそれらの使用 |
| WO2020092850A1 (en) * | 2018-10-31 | 2020-05-07 | Humanigen, Inc. | Materials and methods for treating cancer |
| WO2021207667A1 (en) * | 2020-04-10 | 2021-10-14 | Kinevant Sciences Gmbh | Compositions and methods for treating lung injury or acute respiratory distress syndrome (ards) |
| CN117384856B (zh) * | 2023-09-04 | 2024-04-16 | 广州医科大学 | 一种永生化copd人支气管上皮细胞株及其构建方法和应用 |
| CN120399067B (zh) * | 2025-07-02 | 2025-09-30 | 武汉伊莱瑞特生物科技股份有限公司 | 一种与人gm-csf特异性结合的单克隆抗体及其检测试剂盒和应用 |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU594014B2 (en) | 1984-03-21 | 1990-03-01 | Research Corporation Technologies, Inc. | Recombinant DNA molecules |
| US5908763A (en) | 1984-07-06 | 1999-06-01 | Novartis Corporation | DNA encoding GM-CSF and a method of producing GM-CSF protein |
| NZ218336A (en) * | 1985-12-09 | 1991-08-27 | Kirin Amgen Inc | Monoclonal antibodies to human pluripotent granulocyte colony stimulating factor (hpg-csf) |
| US6013619A (en) | 1988-01-06 | 2000-01-11 | The Scripps Research Institute | Pulmonary surfactants and therapeutic uses, including pulmonary lavage |
| US5164369A (en) | 1988-01-06 | 1992-11-17 | The Scripps Research Institute | Pulmonary surfactant protein and related polypeptide |
| US6613734B2 (en) | 1988-01-06 | 2003-09-02 | The Scripps Research Institute | Peptides-containing liposomal surfactants |
| US5260273A (en) | 1988-01-06 | 1993-11-09 | The Scripps Research Institute | Pulmonary surfactant protein and related polypeptide |
| EP0482086A1 (en) | 1989-07-14 | 1992-04-29 | Schering Corporation | Antagonists of gm-csf derived from the carboxyl terminus |
| CA2060741A1 (en) * | 1991-02-11 | 1992-08-12 | Robert S. Greenfield | Gm-csf inhibiting oligopeptides |
| BR9205151A (pt) | 1992-08-17 | 1994-03-01 | Praxair Technology Inc | Dissolucao aumentada de gas |
| AU2322097A (en) | 1996-03-27 | 1997-10-17 | Ortho Pharmaceutical Corporation | Lyophilized pulmonary surfactant peptide compositions |
| US6120795A (en) | 1996-03-27 | 2000-09-19 | Ortho Pharmaceutical Corp. | Manufacture of liposomes and lipid-protein complexes by ethanolic injection and thin film evaporation |
| US6013764A (en) | 1996-07-17 | 2000-01-11 | Ortho Pharmaceutical Corp. | Liquid phase peptide synthesis of KL-4 pulmonary surfactant |
| EP0959136A1 (en) | 1998-05-20 | 1999-11-24 | Introgene B.V. | Targeted delivery through a cationic amino acid transporter |
| US7108852B2 (en) | 2000-03-20 | 2006-09-19 | Warner-Lambert Company Llc | Methods of treating inflammation using antibodies to M-CSF |
| US7455836B2 (en) | 2000-05-08 | 2008-11-25 | The University Of Melbourne | Method of treatment and agents useful for same |
| CA2430013C (en) * | 2000-11-30 | 2011-11-22 | Medarex, Inc. | Transgenic transchromosomal rodents for making human antibodies |
| KR20030082962A (ko) | 2001-03-08 | 2003-10-23 | 메르크 파텐트 게엠베하 | 감소된 면역원성을 갖는 개질된과립구대식세포집락자극인자(gm-csf) |
| JP2006500905A (ja) | 2002-02-13 | 2006-01-12 | ルードヴィッヒ インスティテュート フォー キャンサー リサーチ | ヒト化gm−csf抗体 |
| JP4555089B2 (ja) * | 2002-11-15 | 2010-09-29 | モーフオテク・インコーポレーテツド | invitro免疫感作により創製されたハイブリドーマからの抗体の高生産量の生成方法 |
| US7396915B2 (en) | 2003-02-28 | 2008-07-08 | Mitsubishi Pharma Corporation | Monoclonal antibody and gene encoding the same, hybridoma, pharmaceutical composition, and diagnostic reagent |
| JP2005040126A (ja) * | 2003-02-28 | 2005-02-17 | Mitsubishi Pharma Corp | モノクローナル抗体およびそれをコードする遺伝子、ハイブリドーマ、医薬組成物ならびに診断試薬 |
| WO2005014652A1 (en) | 2003-08-05 | 2005-02-17 | Morphotek, Inc. | A variant cell surface molecule associated with cancer |
| JP2005176792A (ja) | 2003-12-24 | 2005-07-07 | Atex Co Ltd | 乗用草刈機 |
| ATE435238T1 (de) | 2004-05-05 | 2009-07-15 | Micromet Ag | Herstellung eines einkettigen fv antikörperfragments |
| US20060257359A1 (en) | 2005-02-28 | 2006-11-16 | Cedric Francois | Modifying macrophage phenotype for treatment of disease |
| BRPI0608281B8 (pt) * | 2005-04-18 | 2021-05-25 | Amgen Res Munich Gmbh | anticorpo monoclonal humano ou seu fragmento, seu uso no tratamento de doenças inflamatórias, bem como composição farmacêutica que o compreende |
| RU2447085C2 (ru) * | 2005-05-18 | 2012-04-10 | МорфоСис АГ | Анти-gm-csf антитела и их применение |
| JP4736037B2 (ja) * | 2005-10-26 | 2011-07-27 | 株式会社イーベック | ヒトgm−csfに結合するヒトのモノクローナル抗体並びにその抗原結合部分 |
| US7741450B2 (en) | 2006-02-08 | 2010-06-22 | Morphotek Inc. | Antibodies to GM-CSF |
-
2007
- 2007-02-08 US US11/672,902 patent/US7741450B2/en active Active
- 2007-02-08 RS RS20161183A patent/RS55526B1/sr unknown
- 2007-02-08 ES ES07763514.2T patent/ES2609088T3/es active Active
- 2007-02-08 HU HUE07763514A patent/HUE032584T2/en unknown
- 2007-02-08 CN CN2007800048460A patent/CN101501070B/zh active Active
- 2007-02-08 CA CA2961031A patent/CA2961031C/en active Active
- 2007-02-08 KR KR1020087021791A patent/KR101395515B1/ko not_active Expired - Fee Related
- 2007-02-08 KR KR1020137029090A patent/KR101486183B1/ko not_active Expired - Fee Related
- 2007-02-08 LT LTEP07763514.2T patent/LT1981909T/lt unknown
- 2007-02-08 DK DK07763514.2T patent/DK1981909T3/en active
- 2007-02-08 HR HRP20170024TT patent/HRP20170024T1/hr unknown
- 2007-02-08 AU AU2007213716A patent/AU2007213716C1/en not_active Ceased
- 2007-02-08 EP EP16192629.0A patent/EP3181585A3/en not_active Withdrawn
- 2007-02-08 PL PL07763514T patent/PL1981909T3/pl unknown
- 2007-02-08 EP EP07763514.2A patent/EP1981909B1/en active Active
- 2007-02-08 JP JP2008554507A patent/JP5210889B2/ja not_active Expired - Fee Related
- 2007-02-08 CA CA2641169A patent/CA2641169C/en active Active
- 2007-02-08 PT PT77635142T patent/PT1981909T/pt unknown
- 2007-02-08 WO PCT/US2007/061874 patent/WO2007092939A2/en not_active Ceased
-
2008
- 2008-07-24 IL IL193011A patent/IL193011A/en active IP Right Grant
-
2010
- 2010-04-16 US US12/761,464 patent/US8318168B2/en active Active
-
2012
- 2012-10-24 US US13/659,165 patent/US8623364B2/en not_active Expired - Fee Related
-
2013
- 2013-11-26 US US14/091,028 patent/US9422367B2/en active Active
-
2014
- 2014-10-07 IL IL235050A patent/IL235050A/en active IP Right Grant
-
2016
- 2016-07-18 US US15/212,779 patent/US10023632B2/en active Active
-
2017
- 2017-01-04 CY CY20171100011T patent/CY1118709T1/el unknown
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