JP2012527881A5 - - Google Patents
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- JP2012527881A5 JP2012527881A5 JP2012512407A JP2012512407A JP2012527881A5 JP 2012527881 A5 JP2012527881 A5 JP 2012527881A5 JP 2012512407 A JP2012512407 A JP 2012512407A JP 2012512407 A JP2012512407 A JP 2012512407A JP 2012527881 A5 JP2012527881 A5 JP 2012527881A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- ighv3
- igkv1
- collection
- germline protein
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 210000004602 germ cell Anatomy 0.000 claims 54
- 108090000623 proteins and genes Proteins 0.000 claims 54
- 235000018102 proteins Nutrition 0.000 claims 45
- 102000004169 proteins and genes Human genes 0.000 claims 45
- 239000012634 fragment Substances 0.000 claims 39
- 101000956889 Homo sapiens Immunoglobulin lambda variable 2-23 Proteins 0.000 claims 20
- 102100038430 Immunoglobulin lambda variable 2-23 Human genes 0.000 claims 20
- 101001037136 Homo sapiens Immunoglobulin heavy variable 3-15 Proteins 0.000 claims 19
- 102100040224 Immunoglobulin heavy variable 3-15 Human genes 0.000 claims 19
- 238000000034 method Methods 0.000 claims 19
- 101001037138 Homo sapiens Immunoglobulin heavy variable 3-11 Proteins 0.000 claims 15
- 102100040222 Immunoglobulin heavy variable 3-11 Human genes 0.000 claims 15
- 101001037141 Homo sapiens Immunoglobulin heavy variable 3-21 Proteins 0.000 claims 13
- 102100040217 Immunoglobulin heavy variable 3-21 Human genes 0.000 claims 13
- 101001047618 Homo sapiens Immunoglobulin kappa variable 3-15 Proteins 0.000 claims 12
- 102100022965 Immunoglobulin kappa variable 3-15 Human genes 0.000 claims 12
- 101001138128 Homo sapiens Immunoglobulin kappa variable 1-12 Proteins 0.000 claims 11
- 101001138123 Homo sapiens Immunoglobulin kappa variable 1-27 Proteins 0.000 claims 11
- 101001005360 Homo sapiens Immunoglobulin lambda variable 3-1 Proteins 0.000 claims 11
- 102100020773 Immunoglobulin kappa variable 1-12 Human genes 0.000 claims 11
- 102100020902 Immunoglobulin kappa variable 1-27 Human genes 0.000 claims 11
- 102100025921 Immunoglobulin lambda variable 3-1 Human genes 0.000 claims 11
- 101000839687 Homo sapiens Immunoglobulin heavy variable 3-74 Proteins 0.000 claims 10
- 102100028305 Immunoglobulin heavy variable 3-74 Human genes 0.000 claims 10
- 101000839660 Homo sapiens Immunoglobulin heavy variable 3-53 Proteins 0.000 claims 9
- 102100028317 Immunoglobulin heavy variable 3-53 Human genes 0.000 claims 9
- 101000998947 Homo sapiens Immunoglobulin heavy variable 1-46 Proteins 0.000 claims 7
- 101000989062 Homo sapiens Immunoglobulin heavy variable 5-51 Proteins 0.000 claims 7
- 101001138089 Homo sapiens Immunoglobulin kappa variable 1-39 Proteins 0.000 claims 7
- 101001054839 Homo sapiens Immunoglobulin lambda variable 1-51 Proteins 0.000 claims 7
- 102100036888 Immunoglobulin heavy variable 1-46 Human genes 0.000 claims 7
- 102100029414 Immunoglobulin heavy variable 5-51 Human genes 0.000 claims 7
- 102100020910 Immunoglobulin kappa variable 1-39 Human genes 0.000 claims 7
- 102100026922 Immunoglobulin lambda variable 1-51 Human genes 0.000 claims 7
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims 5
- 101000998950 Homo sapiens Immunoglobulin heavy variable 1-18 Proteins 0.000 claims 5
- 101001037139 Homo sapiens Immunoglobulin heavy variable 3-30 Proteins 0.000 claims 5
- 101001037143 Homo sapiens Immunoglobulin heavy variable 3-33 Proteins 0.000 claims 5
- 101000839679 Homo sapiens Immunoglobulin heavy variable 4-39 Proteins 0.000 claims 5
- 101001054837 Homo sapiens Immunoglobulin lambda variable 1-47 Proteins 0.000 claims 5
- 102100036884 Immunoglobulin heavy variable 1-18 Human genes 0.000 claims 5
- 102100040219 Immunoglobulin heavy variable 3-30 Human genes 0.000 claims 5
- 102100040236 Immunoglobulin heavy variable 3-33 Human genes 0.000 claims 5
- 102100028312 Immunoglobulin heavy variable 4-39 Human genes 0.000 claims 5
- 102100026809 Immunoglobulin lambda variable 1-47 Human genes 0.000 claims 5
- 102000039446 nucleic acids Human genes 0.000 claims 5
- 108020004707 nucleic acids Proteins 0.000 claims 5
- 150000007523 nucleic acids Chemical class 0.000 claims 5
- 210000002966 serum Anatomy 0.000 claims 5
- 241000283690 Bos taurus Species 0.000 claims 4
- 101001037147 Homo sapiens Immunoglobulin heavy variable 1-69 Proteins 0.000 claims 3
- 101000839662 Homo sapiens Immunoglobulin heavy variable 3-48 Proteins 0.000 claims 3
- 101001138126 Homo sapiens Immunoglobulin kappa variable 1-16 Proteins 0.000 claims 3
- 101001054843 Homo sapiens Immunoglobulin lambda variable 1-40 Proteins 0.000 claims 3
- 101000956884 Homo sapiens Immunoglobulin lambda variable 2-11 Proteins 0.000 claims 3
- 102100040232 Immunoglobulin heavy variable 1-69 Human genes 0.000 claims 3
- 102100028320 Immunoglobulin heavy variable 3-48 Human genes 0.000 claims 3
- 102100020946 Immunoglobulin kappa variable 1-16 Human genes 0.000 claims 3
- 102100026911 Immunoglobulin lambda variable 1-40 Human genes 0.000 claims 3
- 102100038432 Immunoglobulin lambda variable 2-11 Human genes 0.000 claims 3
- 210000003719 b-lymphocyte Anatomy 0.000 claims 3
- 239000012888 bovine serum Substances 0.000 claims 3
- 210000004027 cell Anatomy 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- 101000989060 Homo sapiens Immunoglobulin heavy variable 6-1 Proteins 0.000 claims 2
- 101000956885 Homo sapiens Immunoglobulin lambda variable 2-14 Proteins 0.000 claims 2
- 101001005365 Homo sapiens Immunoglobulin lambda variable 3-21 Proteins 0.000 claims 2
- 102100029416 Immunoglobulin heavy variable 6-1 Human genes 0.000 claims 2
- 102100038429 Immunoglobulin lambda variable 2-14 Human genes 0.000 claims 2
- 102100025934 Immunoglobulin lambda variable 3-21 Human genes 0.000 claims 2
- 239000002299 complementary DNA Substances 0.000 claims 2
- 241000588724 Escherichia coli Species 0.000 claims 1
- 101000998953 Homo sapiens Immunoglobulin heavy variable 1-2 Proteins 0.000 claims 1
- 101000998949 Homo sapiens Immunoglobulin heavy variable 1-24 Proteins 0.000 claims 1
- 101000998952 Homo sapiens Immunoglobulin heavy variable 1-3 Proteins 0.000 claims 1
- 101000998951 Homo sapiens Immunoglobulin heavy variable 1-8 Proteins 0.000 claims 1
- 101001037140 Homo sapiens Immunoglobulin heavy variable 3-23 Proteins 0.000 claims 1
- 101000839665 Homo sapiens Immunoglobulin heavy variable 3-43 Proteins 0.000 claims 1
- 101000839663 Homo sapiens Immunoglobulin heavy variable 3-49 Proteins 0.000 claims 1
- 101000839661 Homo sapiens Immunoglobulin heavy variable 3-64 Proteins 0.000 claims 1
- 101001037153 Homo sapiens Immunoglobulin heavy variable 3-7 Proteins 0.000 claims 1
- 101001037144 Homo sapiens Immunoglobulin heavy variable 3-9 Proteins 0.000 claims 1
- 101000839683 Homo sapiens Immunoglobulin heavy variable 4-28 Proteins 0.000 claims 1
- 101000839684 Homo sapiens Immunoglobulin heavy variable 4-31 Proteins 0.000 claims 1
- 101000839682 Homo sapiens Immunoglobulin heavy variable 4-34 Proteins 0.000 claims 1
- 101000839686 Homo sapiens Immunoglobulin heavy variable 4-4 Proteins 0.000 claims 1
- 101000839781 Homo sapiens Immunoglobulin heavy variable 4-59 Proteins 0.000 claims 1
- 101001138127 Homo sapiens Immunoglobulin kappa variable 1-13 Proteins 0.000 claims 1
- 101001138125 Homo sapiens Immunoglobulin kappa variable 1-17 Proteins 0.000 claims 1
- 101001138121 Homo sapiens Immunoglobulin kappa variable 1-33 Proteins 0.000 claims 1
- 101001138133 Homo sapiens Immunoglobulin kappa variable 1-5 Proteins 0.000 claims 1
- 101001138132 Homo sapiens Immunoglobulin kappa variable 1-6 Proteins 0.000 claims 1
- 101001138131 Homo sapiens Immunoglobulin kappa variable 1-8 Proteins 0.000 claims 1
- 101001138130 Homo sapiens Immunoglobulin kappa variable 1-9 Proteins 0.000 claims 1
- 101001008329 Homo sapiens Immunoglobulin kappa variable 1D-33 Proteins 0.000 claims 1
- 101001008255 Homo sapiens Immunoglobulin kappa variable 1D-8 Proteins 0.000 claims 1
- 101001047627 Homo sapiens Immunoglobulin kappa variable 2-28 Proteins 0.000 claims 1
- 101001047629 Homo sapiens Immunoglobulin kappa variable 2-30 Proteins 0.000 claims 1
- 101001008325 Homo sapiens Immunoglobulin kappa variable 2D-29 Proteins 0.000 claims 1
- 101001047617 Homo sapiens Immunoglobulin kappa variable 3-11 Proteins 0.000 claims 1
- 101001047619 Homo sapiens Immunoglobulin kappa variable 3-20 Proteins 0.000 claims 1
- 101000604674 Homo sapiens Immunoglobulin kappa variable 4-1 Proteins 0.000 claims 1
- 101001054844 Homo sapiens Immunoglobulin lambda variable 1-36 Proteins 0.000 claims 1
- 101001054838 Homo sapiens Immunoglobulin lambda variable 1-44 Proteins 0.000 claims 1
- 101000956888 Homo sapiens Immunoglobulin lambda variable 2-18 Proteins 0.000 claims 1
- 101000956887 Homo sapiens Immunoglobulin lambda variable 2-8 Proteins 0.000 claims 1
- 101001005361 Homo sapiens Immunoglobulin lambda variable 3-10 Proteins 0.000 claims 1
- 101001005336 Homo sapiens Immunoglobulin lambda variable 3-25 Proteins 0.000 claims 1
- 101001005337 Homo sapiens Immunoglobulin lambda variable 3-27 Proteins 0.000 claims 1
- 101001005332 Homo sapiens Immunoglobulin lambda variable 4-69 Proteins 0.000 claims 1
- 101000978133 Homo sapiens Immunoglobulin lambda variable 6-57 Proteins 0.000 claims 1
- 101000978132 Homo sapiens Immunoglobulin lambda variable 7-43 Proteins 0.000 claims 1
- 101000978127 Homo sapiens Immunoglobulin lambda variable 7-46 Proteins 0.000 claims 1
- 101000978129 Homo sapiens Immunoglobulin lambda variable 9-49 Proteins 0.000 claims 1
- 101000989063 Homo sapiens Probable non-functional immunoglobulin heavy variable 7-81 Proteins 0.000 claims 1
- 102100036887 Immunoglobulin heavy variable 1-2 Human genes 0.000 claims 1
- 102100036890 Immunoglobulin heavy variable 1-24 Human genes 0.000 claims 1
- 102100036886 Immunoglobulin heavy variable 1-3 Human genes 0.000 claims 1
- 102100036885 Immunoglobulin heavy variable 1-8 Human genes 0.000 claims 1
- 102100040220 Immunoglobulin heavy variable 3-23 Human genes 0.000 claims 1
- 102100028315 Immunoglobulin heavy variable 3-43 Human genes 0.000 claims 1
- 102100028319 Immunoglobulin heavy variable 3-49 Human genes 0.000 claims 1
- 102100028321 Immunoglobulin heavy variable 3-64 Human genes 0.000 claims 1
- 102100040231 Immunoglobulin heavy variable 3-7 Human genes 0.000 claims 1
- 102100040234 Immunoglobulin heavy variable 3-9 Human genes 0.000 claims 1
- 102100028311 Immunoglobulin heavy variable 4-28 Human genes 0.000 claims 1
- 102100028310 Immunoglobulin heavy variable 4-31 Human genes 0.000 claims 1
- 102100028306 Immunoglobulin heavy variable 4-34 Human genes 0.000 claims 1
- 102100028308 Immunoglobulin heavy variable 4-4 Human genes 0.000 claims 1
- 102100028405 Immunoglobulin heavy variable 4-59 Human genes 0.000 claims 1
- 102100020772 Immunoglobulin kappa variable 1-13 Human genes 0.000 claims 1
- 102100020945 Immunoglobulin kappa variable 1-17 Human genes 0.000 claims 1
- 102100020901 Immunoglobulin kappa variable 1-33 Human genes 0.000 claims 1
- 102100020769 Immunoglobulin kappa variable 1-5 Human genes 0.000 claims 1
- 102100020768 Immunoglobulin kappa variable 1-6 Human genes 0.000 claims 1
- 102100020771 Immunoglobulin kappa variable 1-8 Human genes 0.000 claims 1
- 102100020770 Immunoglobulin kappa variable 1-9 Human genes 0.000 claims 1
- 102100027464 Immunoglobulin kappa variable 1D-33 Human genes 0.000 claims 1
- 102100027406 Immunoglobulin kappa variable 1D-8 Human genes 0.000 claims 1
- 102100022950 Immunoglobulin kappa variable 2-28 Human genes 0.000 claims 1
- 102100022952 Immunoglobulin kappa variable 2-30 Human genes 0.000 claims 1
- 102100027458 Immunoglobulin kappa variable 2D-29 Human genes 0.000 claims 1
- 102100022955 Immunoglobulin kappa variable 3-11 Human genes 0.000 claims 1
- 102100022964 Immunoglobulin kappa variable 3-20 Human genes 0.000 claims 1
- 102100038198 Immunoglobulin kappa variable 4-1 Human genes 0.000 claims 1
- 102100026916 Immunoglobulin lambda variable 1-36 Human genes 0.000 claims 1
- 102100026921 Immunoglobulin lambda variable 1-44 Human genes 0.000 claims 1
- 102100038431 Immunoglobulin lambda variable 2-18 Human genes 0.000 claims 1
- 102100038428 Immunoglobulin lambda variable 2-8 Human genes 0.000 claims 1
- 102100025919 Immunoglobulin lambda variable 3-10 Human genes 0.000 claims 1
- 102100025876 Immunoglobulin lambda variable 3-25 Human genes 0.000 claims 1
- 102100025874 Immunoglobulin lambda variable 3-27 Human genes 0.000 claims 1
- 102100025863 Immunoglobulin lambda variable 4-69 Human genes 0.000 claims 1
- 102100023747 Immunoglobulin lambda variable 6-57 Human genes 0.000 claims 1
- 102100023746 Immunoglobulin lambda variable 7-43 Human genes 0.000 claims 1
- 102100023751 Immunoglobulin lambda variable 7-46 Human genes 0.000 claims 1
- 102100023754 Immunoglobulin lambda variable 9-49 Human genes 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 238000012408 PCR amplification Methods 0.000 claims 1
- 102100029413 Probable non-functional immunoglobulin heavy variable 7-81 Human genes 0.000 claims 1
- 210000001744 T-lymphocyte Anatomy 0.000 claims 1
- 238000010367 cloning Methods 0.000 claims 1
- 235000018417 cysteine Nutrition 0.000 claims 1
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims 1
- 235000006109 methionine Nutrition 0.000 claims 1
- 150000002742 methionines Chemical class 0.000 claims 1
- 230000004481 post-translational protein modification Effects 0.000 claims 1
- 238000012163 sequencing technique Methods 0.000 claims 1
- 230000002194 synthesizing effect Effects 0.000 claims 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US18235009P | 2009-05-29 | 2009-05-29 | |
| US61/182,350 | 2009-05-29 | ||
| EP09162724.0 | 2009-06-15 | ||
| EP09162724 | 2009-06-15 | ||
| US29940110P | 2010-01-29 | 2010-01-29 | |
| US61/299,401 | 2010-01-29 | ||
| PCT/EP2010/057507 WO2010136598A1 (en) | 2009-05-29 | 2010-05-29 | A collection and methods for its use |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012527881A JP2012527881A (ja) | 2012-11-12 |
| JP2012527881A5 true JP2012527881A5 (https=) | 2014-04-24 |
| JP5804521B2 JP5804521B2 (ja) | 2015-11-04 |
Family
ID=41210731
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012512407A Active JP5804521B2 (ja) | 2009-05-29 | 2010-05-29 | コレクション及びその使用方法 |
Country Status (17)
| Country | Link |
|---|---|
| US (3) | US8685896B2 (https=) |
| EP (1) | EP2435568B1 (https=) |
| JP (1) | JP5804521B2 (https=) |
| KR (1) | KR101805202B1 (https=) |
| CN (1) | CN102449149B (https=) |
| AU (1) | AU2010252939B2 (https=) |
| CA (1) | CA2758356C (https=) |
| DK (1) | DK2435568T3 (https=) |
| ES (1) | ES2511051T3 (https=) |
| IL (1) | IL216536B (https=) |
| MX (1) | MX2011012696A (https=) |
| NZ (1) | NZ596603A (https=) |
| PT (1) | PT2435568E (https=) |
| RU (1) | RU2569187C2 (https=) |
| SG (1) | SG175407A1 (https=) |
| WO (1) | WO2010136598A1 (https=) |
| ZA (1) | ZA201107652B (https=) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20100069614A1 (en) | 2008-06-27 | 2010-03-18 | Merus B.V. | Antibody producing non-human mammals |
| SG175407A1 (en) | 2009-05-29 | 2011-11-28 | Morphosys Ag | A collection and methods for its use |
| SI2501817T2 (sl) | 2010-02-08 | 2021-09-30 | Regeneron Pharmaceuticals, Inc. | Miš z navadno lahko verigo |
| US20120021409A1 (en) * | 2010-02-08 | 2012-01-26 | Regeneron Pharmaceuticals, Inc. | Common Light Chain Mouse |
| US20130045492A1 (en) | 2010-02-08 | 2013-02-21 | Regeneron Pharmaceuticals, Inc. | Methods For Making Fully Human Bispecific Antibodies Using A Common Light Chain |
| US9796788B2 (en) | 2010-02-08 | 2017-10-24 | Regeneron Pharmaceuticals, Inc. | Mice expressing a limited immunoglobulin light chain repertoire |
| RU2603080C2 (ru) | 2010-11-19 | 2016-11-20 | МорфоСис АГ | Коллекция и способы ее применения |
| EP2698431B1 (en) | 2011-03-30 | 2020-09-09 | Chugai Seiyaku Kabushiki Kaisha | Retention of antigen-binding molecules in blood plasma and method for modifying immunogenicity |
| PT3415619T (pt) * | 2011-04-28 | 2021-03-22 | Univ Leland Stanford Junior | Identificação de polinucleótidos associados a uma amostra |
| EA032929B1 (ru) | 2011-05-17 | 2019-08-30 | Дзе Рокфеллер Юниверсити | Нейтрализующее вирус иммунодефицита человека антитело и способы его применения |
| RS59728B1 (sr) | 2011-08-05 | 2020-02-28 | Regeneron Pharma | Humanizovani miševi univerzalnog lakog lanca |
| CN103890246A (zh) * | 2011-08-18 | 2014-06-25 | 亲和生物科学公司 | 可溶性多肽 |
| CA2791109C (en) | 2011-09-26 | 2021-02-16 | Merus B.V. | Generation of binding molecules |
| JP6322411B2 (ja) | 2011-09-30 | 2018-05-09 | 中外製薬株式会社 | 複数の生理活性を有する抗原の消失を促進する抗原結合分子 |
| RU2732151C2 (ru) | 2011-09-30 | 2020-09-11 | Чугаи Сейяку Кабусики Кайся | Библиотека зависимых от концентрации ионов связывающих молекул |
| TW201945034A (zh) | 2011-09-30 | 2019-12-01 | 日商中外製藥股份有限公司 | 包含依離子濃度之條件對抗原之結合活性會改變之抗原結合分域、及於pH中性之條件下對FcRn有結合活性之FcRn結合分域、且誘導對標的抗原的免疫反應之抗原結合分子 |
| US9764038B2 (en) | 2011-12-23 | 2017-09-19 | Innate Pharma | Enzymatic conjugation of antibodies |
| KR102228296B1 (ko) | 2012-03-16 | 2021-03-17 | 리제너론 파마슈티칼스 인코포레이티드 | 히스티딘 공학처리된 경쇄 항체 및 그것을 생성하기 위한 유전자 변형된 비-사람 동물 |
| SG10201700360VA (en) | 2012-03-16 | 2017-03-30 | Regeneron Pharma | Non-human animals expressing ph-sensitive immunoglobulin sequences |
| WO2014009426A2 (en) | 2012-07-13 | 2014-01-16 | Innate Pharma | Screening of conjugated antibodies |
| US10036010B2 (en) | 2012-11-09 | 2018-07-31 | Innate Pharma | Recognition tags for TGase-mediated conjugation |
| AU2014220306A1 (en) * | 2013-02-20 | 2015-08-27 | Affinity Biosciences Pty Ltd | Cytoplasmic expression of Fab proteins |
| EP2968582B1 (en) | 2013-03-15 | 2020-07-01 | Innate Pharma | Solid phase tgase-mediated conjugation of antibodies |
| EP3010547B1 (en) | 2013-06-20 | 2021-04-21 | Innate Pharma | Enzymatic conjugation of polypeptides |
| JP6744212B2 (ja) | 2013-06-21 | 2020-08-19 | イナート・ファルマ・ソシエテ・アノニムＩｎｎａｔｅ Ｐｈａｒｍａ Ｐｈａｒｍａ Ｓ．Ａ． | ポリペプチドの酵素的結合 |
| KR102453188B1 (ko) * | 2013-06-24 | 2022-10-07 | 넥스이뮨, 인크. | 면역요법을 위한 조성물 및 방법 |
| US20150011405A1 (en) | 2013-07-03 | 2015-01-08 | Atreca, Inc. | Use of Nanoexpression to Interrogate Antigen Repertoires |
| KR102276752B1 (ko) | 2014-03-21 | 2021-07-13 | 리제너론 파마슈티칼스 인코포레이티드 | 단일 도메인 결합 단백질을 생산하는 비-인간 동물 |
| EP3271403A1 (en) | 2015-03-19 | 2018-01-24 | Regeneron Pharmaceuticals, Inc. | Non-human animals that select for light chain variable regions that bind antigen |
| EP3347051A4 (en) * | 2015-09-10 | 2019-04-24 | Affigen, Inc. | SEQUENCING SELECTING TUMOR THEROSTICAS |
| HUE061840T2 (hu) | 2017-07-12 | 2023-08-28 | Nouscom Ag | Egy univerzális vakcina, amely közös tumor neoantigéneken alapul a mikroszatellita-instabilitás (MSI) rákos megbetegedések megelõzésére és kezelésére |
| US20210130440A1 (en) * | 2019-10-03 | 2021-05-06 | Janssen Biotech, Inc. | Methods for producing biotherapeutics with increased stability by sequence optimization |
| JP7772379B2 (ja) * | 2020-03-27 | 2025-11-18 | ディーディーバイオ．カンパニー、リミテッド | 抗原特異的結合ポリペプチド遺伝子ディスプレイベクターの構築方法および用途 |
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| US5618920A (en) | 1985-11-01 | 1997-04-08 | Xoma Corporation | Modular assembly of antibody genes, antibodies prepared thereby and use |
| WO1988008673A1 (en) | 1987-05-14 | 1988-11-17 | Commonwealth Scientific And Industrial Research Or | Whey protein fractions |
| US5258498A (en) | 1987-05-21 | 1993-11-02 | Creative Biomolecules, Inc. | Polypeptide linkers for production of biosynthetic proteins |
| ATE243754T1 (de) | 1987-05-21 | 2003-07-15 | Micromet Ag | Multifunktionelle proteine mit vorbestimmter zielsetzung |
| US5091513A (en) | 1987-05-21 | 1992-02-25 | Creative Biomolecules, Inc. | Biosynthetic antibody binding sites |
| EP0436597B1 (en) | 1988-09-02 | 1997-04-02 | Protein Engineering Corporation | Generation and selection of recombinant varied binding proteins |
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| WO1990014443A1 (en) | 1989-05-16 | 1990-11-29 | Huse William D | Co-expression of heteromeric receptors |
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| US6291158B1 (en) | 1989-05-16 | 2001-09-18 | Scripps Research Institute | Method for tapping the immunological repertoire |
| CA2016842A1 (en) | 1989-05-16 | 1990-11-16 | Richard A. Lerner | Method for tapping the immunological repertoire |
| CA2016841C (en) | 1989-05-16 | 1999-09-21 | William D. Huse | A method for producing polymers having a preselected activity |
| US6291161B1 (en) | 1989-05-16 | 2001-09-18 | Scripps Research Institute | Method for tapping the immunological repertiore |
| US6291160B1 (en) | 1989-05-16 | 2001-09-18 | Scripps Research Institute | Method for producing polymers having a preselected activity |
| US5859205A (en) | 1989-12-21 | 1999-01-12 | Celltech Limited | Humanised antibodies |
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| WO1991010737A1 (en) | 1990-01-11 | 1991-07-25 | Molecular Affinities Corporation | Production of antibodies using gene libraries |
| DE4002897A1 (de) | 1990-02-01 | 1991-08-08 | Behringwerke Ag | Herstellung und verwendung von genbanken synthetischer menschlicher antikoerper ("synthetische human-antikoerper-bibliotheken") |
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| GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
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| WO1992015678A1 (en) | 1991-03-01 | 1992-09-17 | Stratagene | Pcr generated dicistronic dna molecules for producing antibodies |
| EP0575485A1 (en) | 1991-03-01 | 1993-12-29 | Dyax Corp. | Process for the development of binding mini-proteins |
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