CA2816558C - A collection and methods for its use - Google Patents

A collection and methods for its use Download PDF

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Publication number
CA2816558C
CA2816558C CA2816558A CA2816558A CA2816558C CA 2816558 C CA2816558 C CA 2816558C CA 2816558 A CA2816558 A CA 2816558A CA 2816558 A CA2816558 A CA 2816558A CA 2816558 C CA2816558 C CA 2816558C
Authority
CA
Canada
Prior art keywords
seq
antibodies
light chain
pairs
heavy chain
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2816558A
Other languages
English (en)
French (fr)
Other versions
CA2816558A1 (en
Inventor
Stefanie Urlinger
Thomas Tiller
Ingrid Schuster
Yvonne Stark
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Morphosys AG
Original Assignee
Morphosys AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Morphosys AG filed Critical Morphosys AG
Publication of CA2816558A1 publication Critical patent/CA2816558A1/en
Application granted granted Critical
Publication of CA2816558C publication Critical patent/CA2816558C/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/005—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies constructed by phage libraries
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1037—Screening libraries presented on the surface of microorganisms, e.g. phage display, E. coli display
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854—Immunoglobulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/06—Libraries containing nucleotides or polynucleotides, or derivatives thereof
    • C40B40/08—Libraries containing RNA or DNA which encodes proteins, e.g. gene libraries

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Virology (AREA)
  • Physics & Mathematics (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Plant Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CA2816558A 2010-11-19 2011-11-18 A collection and methods for its use Active CA2816558C (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US41536710P 2010-11-19 2010-11-19
EP10191910 2010-11-19
US61/415,367 2010-11-19
EP10191910.8 2010-11-19
US201161494452P 2011-06-08 2011-06-08
US61/494,452 2011-06-08
PCT/EP2011/070473 WO2012066129A1 (en) 2010-11-19 2011-11-18 A collection and methods for its use

Publications (2)

Publication Number Publication Date
CA2816558A1 CA2816558A1 (en) 2012-05-24
CA2816558C true CA2816558C (en) 2020-12-29

Family

ID=44041472

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2816558A Active CA2816558C (en) 2010-11-19 2011-11-18 A collection and methods for its use

Country Status (18)

Country Link
US (3) US8728981B2 (https=)
EP (1) EP2640742B1 (https=)
JP (1) JP6253986B2 (https=)
KR (1) KR101938021B1 (https=)
CN (1) CN103237809B (https=)
AU (1) AU2011331129B2 (https=)
CA (1) CA2816558C (https=)
DK (1) DK2640742T3 (https=)
ES (1) ES2696548T3 (https=)
HR (1) HRP20181811T1 (https=)
IL (1) IL226364B (https=)
MX (1) MX353795B (https=)
NZ (1) NZ609707A (https=)
PL (1) PL2640742T3 (https=)
RU (1) RU2603080C2 (https=)
SG (2) SG189950A1 (https=)
WO (1) WO2012066129A1 (https=)
ZA (1) ZA201303566B (https=)

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CN102993305B (zh) * 2012-11-16 2015-05-13 上海赛伦生物技术有限公司 人源抗人表皮生长因子受体抗体及其编码基因与应用
MY191512A (en) * 2013-09-18 2022-06-28 Regeneron Pharma Histidine engineered light chain antibodies and genetically modified non-human animals for generating the same
EP3080158A4 (en) * 2013-12-09 2018-03-21 Adimab, LLC Polyclonal mixtures of antibodies, and methods of making and using them
BR112016014824A2 (pt) * 2013-12-27 2017-09-19 Chugai Pharmaceutical Co Ltd Método para purificar anticorpo que tem ponto isoelétrico baixo
CA3014842A1 (en) 2016-02-19 2017-08-24 Morphosys Ag Antibodies for il-17c
ES2996699T3 (en) * 2016-04-12 2025-02-13 Medimmune Llc Immune repertoire mining
EP3538552B1 (en) 2016-11-14 2023-09-13 MorphoSys AG Fab molecules with a rodent hinge region and a non-rodent ch1 region
WO2019099454A2 (en) 2017-11-15 2019-05-23 Philippe Valadon Highly functional antibody libraries
KR20210013090A (ko) 2018-05-16 2021-02-03 모르포시스 아게 당단백질 vi를 표적으로 하는 항체
KR102115300B1 (ko) * 2018-06-01 2020-05-26 재단법인 목암생명과학연구소 항체 라이브러리 및 이를 이용한 항체 스크리닝 방법
US20230183675A1 (en) 2020-05-20 2023-06-15 Institut Curie Synthetic Single Domain Library
WO2021250017A1 (en) 2020-06-08 2021-12-16 Immundiagnostik Ag Improved method and test system for in-vitro determination of drug antibodies in blood
US20230357398A1 (en) 2020-09-24 2023-11-09 Morphosys Ag Novel human antibodies binding to human cd3 epsilon
US20250206819A1 (en) 2022-03-22 2025-06-26 Morphosys Ag Deimmunized antibodies specific for cd3
WO2024236163A1 (en) 2023-05-17 2024-11-21 Morphosys Ag T cell receptor beta constant region 2 (trbc2) antibodies
WO2025003511A1 (en) 2023-06-30 2025-01-02 Morphosys Ag Dual-targeting of flt3 and cd123 co-expressing tumor cells by functional complementation of cycat® halfbody molecules
WO2025082777A1 (en) 2023-10-17 2025-04-24 Morphosys Ag Dual-targeting of muc16 and mesothelin co-expressing tumor cells by functional complementation of cycat® halfbody molecules

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Also Published As

Publication number Publication date
RU2013126025A (ru) 2014-12-27
RU2603080C2 (ru) 2016-11-20
ZA201303566B (en) 2014-07-30
US8728981B2 (en) 2014-05-20
HRP20181811T1 (hr) 2018-12-28
MX353795B (es) 2018-01-30
EP2640742A1 (en) 2013-09-25
SG10201509257VA (en) 2015-12-30
US20130236902A1 (en) 2013-09-12
US20120129717A1 (en) 2012-05-24
MX2013005614A (es) 2013-11-21
SG189950A1 (en) 2013-06-28
AU2011331129A1 (en) 2013-05-23
US9541559B2 (en) 2017-01-10
US8367586B2 (en) 2013-02-05
WO2012066129A1 (en) 2012-05-24
JP6253986B2 (ja) 2017-12-27
IL226364A0 (en) 2013-07-31
NZ609707A (en) 2014-12-24
CN103237809A (zh) 2013-08-07
KR101938021B1 (ko) 2019-01-11
PL2640742T3 (pl) 2019-01-31
DK2640742T3 (en) 2018-12-03
CN103237809B (zh) 2016-09-07
CA2816558A1 (en) 2012-05-24
AU2011331129B2 (en) 2016-10-06
JP2014500725A (ja) 2014-01-16
IL226364B (en) 2020-11-30
EP2640742B1 (en) 2018-08-15
US20140206575A1 (en) 2014-07-24
ES2696548T3 (es) 2019-01-16
KR20140015274A (ko) 2014-02-06

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