|
DE670584C
(de)
*
|
1936-07-09 |
1939-01-20 |
I G Farbenindustrie Akt Ges |
Verfahren zur Herstellung von o-Aminophenolen
|
|
DE1108213B
(de)
|
1959-02-28 |
1961-06-08 |
Frantisek Sorm Dr Ing |
Verfahren zur Herstellung von 2, 2-Dimethyl-3-phenylcyclopropan-carbonsaeuren
|
|
SE370866B
(enExample)
*
|
1968-03-21 |
1974-11-04 |
Ciba Geigy Ag |
|
|
JPS4825500B1
(enExample)
*
|
1970-12-29 |
1973-07-30 |
|
|
|
US3850931A
(en)
*
|
1971-06-25 |
1974-11-26 |
American Home Prod |
4-(substituted anilino)-2-phenyl-5-pyrimidinecarboxylic acid esters
|
|
GB2079480B
(en)
|
1980-07-08 |
1984-05-16 |
Kodak Ltd |
Heat-activated photographic and thermal recording processes employing precursor compounds
|
|
NO156828C
(no)
*
|
1980-11-10 |
1987-12-02 |
Otsuka Pharma Co Ltd |
Analogifremgangsm te for fremstilling av antibakterielt virksomme benzoheterocykliske forbindelser.
|
|
JPS57102887A
(en)
|
1980-12-18 |
1982-06-26 |
Otsuka Pharmaceut Co Ltd |
Preparation of benzo(ij)quinolizine-2-carboxylic acid derivative
|
|
JPS5853916A
(ja)
|
1981-09-09 |
1983-03-30 |
チバ−ガイギ−・アクチエンゲゼルシヤフト |
熱硬化性エポキシド樹脂組成物
|
|
US4404356A
(en)
*
|
1981-09-09 |
1983-09-13 |
Ciba-Geigy Corporation |
Heat-curable epoxide resin compositions
|
|
US5525727A
(en)
|
1982-05-18 |
1996-06-11 |
University Of Florida |
Brain-specific drug delivery
|
|
DE3511110A1
(de)
*
|
1985-03-27 |
1986-10-02 |
Dr. Karl Thomae Gmbh, 7950 Biberach |
Neue pyridazinone, ihre herstellung und diese verbindungen enthaltende arzneimittel
|
|
GB8508588D0
(en)
|
1985-04-02 |
1985-05-09 |
Akzo Nv |
Indene & napthalene derivatives
|
|
NZ219974A
(en)
|
1986-04-22 |
1989-08-29 |
Goedecke Ag |
N-(2'-aminophenyl)-benzamide derivatives, process for their preparation and their use in the control of neoplastic diseases
|
|
IT1231413B
(it)
*
|
1987-09-23 |
1991-12-04 |
Angeli Inst Spa |
Derivati dell'acido benzimidazolin-2-osso-1-carbossilico utili come antagonisti dei recettori 5-ht
|
|
US5994392A
(en)
|
1988-02-26 |
1999-11-30 |
Neuromedica, Inc. |
Antipsychotic prodrugs comprising an antipsychotic agent coupled to an unsaturated fatty acid
|
|
DE3830054A1
(de)
|
1988-09-03 |
1990-03-15 |
Boehringer Mannheim Gmbh |
Phenylamide - verfahren zu ihrer herstellung sowie diese verbindungen enthaltende arzneimittel
|
|
JPH03232868A
(ja)
*
|
1990-02-05 |
1991-10-16 |
Nippon Telegr & Teleph Corp <Ntt> |
新規光学活性化合物及び液晶組成物
|
|
US5177064A
(en)
|
1990-07-13 |
1993-01-05 |
University Of Florida |
Targeted drug delivery via phosphonate derivatives
|
|
JP3507486B2
(ja)
|
1991-03-15 |
2004-03-15 |
アムジエン・インコーポレーテツド |
顆粒球コロニー刺激因子の肺内投与
|
|
JPH06122669A
(ja)
|
1991-12-28 |
1994-05-06 |
Ishihara Sangyo Kaisha Ltd |
ジアミノベンゼン誘導体を含有するホスホリパーゼa2阻害剤
|
|
DE4323916A1
(de)
*
|
1993-07-16 |
1995-01-19 |
Basf Ag |
Substituierte 2-Phenylpyridine
|
|
US5451569A
(en)
|
1994-04-19 |
1995-09-19 |
Hong Kong University Of Science And Technology R & D Corporation Limited |
Pulmonary drug delivery system
|
|
JPH11503110A
(ja)
*
|
1995-02-17 |
1999-03-23 |
スミスクライン・ビーチャム・コーポレイション |
Il−8受容体拮抗剤
|
|
US5635503A
(en)
*
|
1995-06-07 |
1997-06-03 |
Bristol-Myers Squibb Company |
Dihydropyridine npy antagonists: piperazine derivatives
|
|
US6051227A
(en)
|
1995-07-25 |
2000-04-18 |
The Regents Of The University Of California, Office Of Technology Transfer |
Blockade of T lymphocyte down-regulation associated with CTLA-4 signaling
|
|
US5855887A
(en)
|
1995-07-25 |
1999-01-05 |
The Regents Of The University Of California |
Blockade of lymphocyte down-regulation associated with CTLA-4 signaling
|
|
US5811097A
(en)
|
1995-07-25 |
1998-09-22 |
The Regents Of The University Of California |
Blockade of T lymphocyte down-regulation associated with CTLA-4 signaling
|
|
JPH09227495A
(ja)
*
|
1996-02-16 |
1997-09-02 |
Tanabe Seiyaku Co Ltd |
フェノール誘導体及びその製法
|
|
EP1014962A4
(en)
|
1997-06-26 |
2007-06-27 |
Lilly Co Eli |
ANTITHROMBOTIC AGENTS
|
|
US6682736B1
(en)
|
1998-12-23 |
2004-01-27 |
Abgenix, Inc. |
Human monoclonal antibodies to CTLA-4
|
|
JP4390024B2
(ja)
|
1999-04-23 |
2009-12-24 |
アステラス製薬株式会社 |
新規なジアゼパン誘導体又はその塩
|
|
US6653309B1
(en)
|
1999-04-26 |
2003-11-25 |
Vertex Pharmaceuticals Incorporated |
Inhibitors of IMPDH enzyme technical field of the invention
|
|
NZ517202A
(en)
|
1999-08-24 |
2004-05-28 |
Medarex Inc |
Human CTLA-4 antibodies and their uses
|
|
US7605238B2
(en)
|
1999-08-24 |
2009-10-20 |
Medarex, Inc. |
Human CTLA-4 antibodies and their uses
|
|
US6713454B1
(en)
|
1999-09-13 |
2004-03-30 |
Nobex Corporation |
Prodrugs of etoposide and etoposide analogs
|
|
AU2001233027A1
(en)
|
2000-01-27 |
2001-08-07 |
Genetics Institute, Llc |
Antibodies against ctla4 (cd152), conjugates comprising same, and uses thereof
|
|
FR2805741B1
(fr)
*
|
2000-03-06 |
2003-06-20 |
Oreal |
Composition de teinture d'oxydation des fibres keratiniques avec un derive particulier de la paraphenylenediamine et un colorant direct particulier
|
|
JP2003528074A
(ja)
*
|
2000-03-24 |
2003-09-24 |
メチルジーン インコーポレイテッド |
ヒストン脱アセチル化酵素の阻害剤
|
|
DE10038007A1
(de)
*
|
2000-08-04 |
2002-02-14 |
Bayer Ag |
Neue Amino-und Amido-Diphenylether für Arzneimittel
|
|
US20020173507A1
(en)
|
2000-08-15 |
2002-11-21 |
Vincent Santora |
Urea compounds and methods of uses
|
|
US6645990B2
(en)
*
|
2000-08-15 |
2003-11-11 |
Amgen Inc. |
Thiazolyl urea compounds and methods of uses
|
|
CA2417432C
(en)
|
2000-09-01 |
2010-11-02 |
The Center For Blood Research, Inc. |
Modified polypeptides stabilized in a desired conformation and methods for producing same
|
|
AU3950802A
(en)
|
2000-12-07 |
2002-06-18 |
Cv Therapeutics Inc |
Abca-1 elevating compounds
|
|
JP4183923B2
(ja)
|
2001-03-29 |
2008-11-19 |
富士フイルム株式会社 |
熱現像感光材料
|
|
EP1379511B1
(en)
*
|
2001-04-12 |
2005-07-20 |
F. Hoffmann-La Roche Ag |
DIHYDRO-BENZO (b) (1, 4) DIAZEPIN-2-ONE DERIVATIVES AS MGLUR2 ANTAGONISTS II
|
|
AR034897A1
(es)
|
2001-08-07 |
2004-03-24 |
Hoffmann La Roche |
Derivados n-monoacilados de o-fenilendiaminas, sus analogos heterociclicos de seis miembros y su uso como agentes farmaceuticos
|
|
US6949542B2
(en)
*
|
2002-02-06 |
2005-09-27 |
Hoffman-La Roche Inc. |
Dihydro-benzo[b][1,4]diazepin-2-one derivatives
|
|
TWI319387B
(en)
|
2002-04-05 |
2010-01-11 |
Astrazeneca Ab |
Benzamide derivatives
|
|
NZ536420A
(en)
|
2002-04-12 |
2008-04-30 |
Medarex Inc |
Methods of treatment using CTLA-4 antibodies
|
|
EP1402888A1
(en)
*
|
2002-09-18 |
2004-03-31 |
Jerini AG |
The use of substituted carbocyclic compounds as rotamases inhibitors
|
|
US7244751B2
(en)
|
2003-02-14 |
2007-07-17 |
Shenzhen Chipscreen Biosciences Ltd. |
Histone deacetylase inhibitors of novel benzamide derivatives with potent differentiation and anti-proliferation activity
|
|
JP2006517960A
(ja)
|
2003-02-18 |
2006-08-03 |
ファイザー インコーポレイテッド |
C型肝炎ウイルスの阻害剤、それを使用する組成物および治療法
|
|
WO2005025557A1
(en)
|
2003-09-16 |
2005-03-24 |
Monash University |
An agent for plasminogen-activation and matrix metalloproteinase associated conditions and methods of use
|
|
AU2004276337B2
(en)
|
2003-09-24 |
2009-11-12 |
Methylgene Inc. |
Inhibitors of histone deacetylase
|
|
WO2005033562A2
(en)
|
2003-10-02 |
2005-04-14 |
Jesel, Inc. |
Double roller cam follower
|
|
AU2004280264A1
(en)
|
2003-10-09 |
2005-04-21 |
Merck Hdac Research, Llc |
Thiophene and benzothiophene hydroxamic acid derivatives
|
|
US20080070954A1
(en)
|
2003-10-27 |
2008-03-20 |
S*Bio Pte Ltd. |
Acylurea Connected And Sulfonylurea Connected Hydroxamates
|
|
US20050137234A1
(en)
|
2003-12-19 |
2005-06-23 |
Syrrx, Inc. |
Histone deacetylase inhibitors
|
|
EP1753740A2
(en)
|
2004-05-21 |
2007-02-21 |
Merck & Co., Inc. |
Amino cyclopentyl heterocyclic and carbocyclic modulators of chemokine receptor activity
|
|
US20060008517A1
(en)
|
2004-07-09 |
2006-01-12 |
Lynch Marina A |
Treatment of age-related memory impairment
|
|
CN101001851B
(zh)
*
|
2004-08-09 |
2011-04-20 |
安斯泰来制药有限公司 |
具有作为组蛋白脱乙酰酶(hdac)抑制剂的活性的羟基酰胺化合物
|
|
JPWO2006028161A1
(ja)
*
|
2004-09-09 |
2008-05-08 |
財団法人乙卯研究所 |
セロトニン5−ht3受容体作動薬
|
|
AU2006262166A1
(en)
|
2005-06-24 |
2007-01-04 |
Merck Sharp & Dohme Corp. |
Modified malonate derivatives
|
|
KR101704734B1
(ko)
|
2005-07-01 |
2017-02-09 |
이. 알. 스퀴부 앤드 선즈, 엘.엘.씨. |
예정 사멸 리간드 1 (피디-엘1)에 대한 인간 모노클로날 항체
|
|
AU2007208495A1
(en)
|
2006-01-12 |
2007-08-02 |
Merck Sharp & Dohme Corp. |
Hydroxyalkylarylamide derivatives
|
|
CA2648804C
(en)
*
|
2006-04-07 |
2014-05-27 |
Methylgene Inc. |
Benzamide derivatives as inhibitors of histone deacetylase
|
|
WO2008075196A1
(en)
|
2006-12-15 |
2008-06-26 |
Pfizer Products Inc. |
Benzimidazole derivatives
|
|
CA2670645A1
(en)
|
2006-12-19 |
2008-07-03 |
Genentech, Inc. |
Pyrimidine kinase inhibitors
|
|
CA2673870A1
(en)
|
2006-12-27 |
2008-07-10 |
Emory University |
Compositions and methods for the treatment of infections and tumors
|
|
CN103087043A
(zh)
|
2007-03-16 |
2013-05-08 |
中国人民解放军军事医学科学院放射与辐射医学研究所 |
具有抗增殖活性的苯甲酰胺类衍生物及其药用制剂
|
|
PT2170959E
(pt)
|
2007-06-18 |
2014-01-07 |
Merck Sharp & Dohme |
Anticorpos para o receptor humano de morte programada pd-1
|
|
WO2009002534A1
(en)
|
2007-06-26 |
2008-12-31 |
Gilead Colorado, Inc. |
Imidazopyridinyl thiazolyl histone deacetylase inhibitors
|
|
WO2009002495A1
(en)
*
|
2007-06-27 |
2008-12-31 |
Merck & Co., Inc. |
4-carboxybenzylamino derivatives as histone deacetylase inhibitors
|
|
US8138168B1
(en)
|
2007-09-26 |
2012-03-20 |
Takeda Pharmaceutical Company Limited |
Renin inhibitors
|
|
AU2008315651B2
(en)
|
2007-10-22 |
2012-12-13 |
Orchid Research Laboratories Limited |
Histone deacetylase inhibitors
|
|
BRPI0817897A2
(pt)
|
2007-11-02 |
2019-09-24 |
Methylgene Inc |
composto, composição, e, métodos de inibição da atividade hdac, e de tratamento de uma doença responsiva a um inibidor de atividade hdac
|
|
WO2009076234A2
(en)
|
2007-12-07 |
2009-06-18 |
University Of Maryland, Baltimore |
Synthesis methods of histone deacetylase inhibitors (hdacis)
|
|
US8138138B2
(en)
|
2008-01-04 |
2012-03-20 |
Ecolab Usa Inc. |
Solidification matrix using a polycarboxylic acid polymer
|
|
PL2254873T3
(pl)
|
2008-02-22 |
2014-10-31 |
Otsuka Pharma Co Ltd |
Związek benzodiazepinowy i kompozycja farmaceutyczna
|
|
US8093000B2
(en)
|
2008-05-09 |
2012-01-10 |
The Regents Of The University Of California |
Methods for predicting and treating tumors resistant to drug, immunotherapy, and radiation
|
|
JP5640005B2
(ja)
|
2008-07-14 |
2014-12-10 |
ギリアード サイエンシーズ, インコーポレイテッド |
Hdacおよび/またはcdk阻害剤としてのイミダゾシルピリジン化合物
|
|
WO2010014054A1
(en)
|
2008-07-28 |
2010-02-04 |
The Regents Of The University Of California |
Inhibitors of protein prenyltransferases
|
|
WO2010014784A2
(en)
|
2008-08-01 |
2010-02-04 |
Bristol-Myers Squibb Company |
Combination of anti-ctla4 antibody with diverse therapeutic regimens for the synergistic treatment of proliferative diseases
|
|
EA201500417A1
(ru)
|
2008-08-25 |
2015-11-30 |
Эмплиммьюн, Инк. |
Композиции антагонистов pd-1 и способы применения
|
|
AU2009289649B2
(en)
|
2008-09-03 |
2016-05-05 |
Biomarin Pharmaceutical Inc. |
Compositions including 6-aminohexanoic acid derivatives as HDAC inhibitors
|
|
WO2010036959A2
(en)
|
2008-09-26 |
2010-04-01 |
Dana-Farber Cancer Institute |
Human anti-pd-1, pd-l1, and pd-l2 antibodies and uses therefor
|
|
WO2010042433A1
(en)
|
2008-10-06 |
2010-04-15 |
Bristol-Myers Squibb Company |
Combination of cd137 antibody and ctla-4 antibody for the treatment of proliferative diseases
|
|
US8232409B2
(en)
*
|
2008-10-15 |
2012-07-31 |
Janssen Pharmaceutica N.V. |
Heterocyclic benzimidazoles as TRPM8 modulators
|
|
JP2012510512A
(ja)
|
2008-12-03 |
2012-05-10 |
マサチューセッツ インスティテュート オブ テクノロジー |
記憶を推進するためのhdac2の阻害
|
|
MX356367B
(es)
|
2008-12-09 |
2018-05-25 |
Genentech Inc |
Anticuerpos anti-pd-l1 y su uso para mejorar la funcion de celulas t.
|
|
WO2010089411A2
(en)
|
2009-02-09 |
2010-08-12 |
Universite De La Mediterranee |
Pd-1 antibodies and pd-l1 antibodies and uses thereof
|
|
WO2010094678A1
(en)
*
|
2009-02-23 |
2010-08-26 |
F. Hoffmann-La Roche Ag |
Novel ortho-aminoamides for the treatment of cancer
|
|
WO2010135524A1
(en)
*
|
2009-05-22 |
2010-11-25 |
Exelixis, Inc. |
Benzoxazepines based p13k/mt0r inhibitors against proliferative diseases
|
|
US8211901B2
(en)
|
2009-05-22 |
2012-07-03 |
Shenzhen Chipscreen Biosciences Ltd. |
Naphthamide derivatives as multi-target protein kinase inhibitors and histone deacetylase inhibitors
|
|
US8835648B2
(en)
|
2009-06-11 |
2014-09-16 |
Siena Biotech S.P.A. |
Hedgehog pathway antagonists and therapeutic applications thereof
|
|
US8354419B2
(en)
*
|
2009-07-16 |
2013-01-15 |
Vertex Pharmaceuticals Incorporated |
Benzimidazole analogues for the treatment or prevention of flavivirus infections
|
|
WO2011053876A1
(en)
*
|
2009-10-30 |
2011-05-05 |
Massachusetts Institute Of Technology |
The use of ci-994 and dinaline for the treatment of memory/cognition and anxiety disorders
|
|
EP2504028A4
(en)
|
2009-11-24 |
2014-04-09 |
Amplimmune Inc |
SIMULTANEOUS INHIBITION OF PD-L1 / PD-L2
|
|
US8952037B2
(en)
*
|
2010-05-13 |
2015-02-10 |
Amgen Inc. |
Heteroaryloxycarbocyclyl compounds as PDE10 inhibitors
|
|
WO2012112447A2
(en)
|
2011-02-14 |
2012-08-23 |
Dana-Farber Cancer Institute, Inc. |
Histone deacetylase inhibitors and methods of use thereof
|
|
WO2012118782A1
(en)
|
2011-02-28 |
2012-09-07 |
Repligen Corporation |
Histone deacetylase inhibitors
|
|
US8957066B2
(en)
|
2011-02-28 |
2015-02-17 |
Biomarin Pharmaceutical Inc. |
Histone deacetylase inhibitors
|
|
RU2013140975A
(ru)
|
2011-02-28 |
2015-04-10 |
Дженентек, Инк. |
Биологические маркеры и способы прогнозирования восприимчивости к антагонистам в-клеток
|
|
WO2012149540A1
(en)
|
2011-04-28 |
2012-11-01 |
The Broad Institute Inc |
Inhibitors of histone deacetylase
|
|
CN102775356B
(zh)
|
2011-05-13 |
2015-07-22 |
江苏恒谊药业有限公司 |
4-氨基喹唑啉衍生物及其应用
|
|
WO2013043569A1
(en)
|
2011-09-20 |
2013-03-28 |
Vical Incorporated |
Synergistic anti-tumor efficacy using alloantigen combination immunotherapy
|
|
WO2013059582A2
(en)
|
2011-10-20 |
2013-04-25 |
Nupotential, Inc. |
Small molecule inhibitors of histone deacteylases
|
|
WO2013067391A1
(en)
|
2011-11-02 |
2013-05-10 |
The Broad Institute, Inc. |
Fluorescent substrates for determining lysine modifying enzyme activity
|
|
CA2759407A1
(en)
|
2011-12-02 |
2013-06-02 |
Marrett Alexander GREEN |
Grey water recycling systems and valves
|
|
WO2013132317A1
(en)
|
2012-03-07 |
2013-09-12 |
Aurigene Discovery Technologies Limited |
Peptidomimetic compounds as immunomodulators
|
|
US9856320B2
(en)
|
2012-05-15 |
2018-01-02 |
Bristol-Myers Squibb Company |
Cancer immunotherapy by disrupting PD-1/PD-L1 signaling
|
|
EP2877444B1
(en)
|
2012-07-27 |
2020-09-02 |
The Broad Institute, Inc. |
Inhibitors of histone deacetylase
|
|
US9914717B2
(en)
|
2012-12-20 |
2018-03-13 |
The Broad Institute, Inc. |
Cycloalkenyl hydroxamic acid derivatives and their use as histone deacetylase inhibitors
|
|
US9988343B2
(en)
|
2013-11-05 |
2018-06-05 |
Dana-Farber Cancer Institute, Inc. |
Inhibitors of histone deacetylase
|
|
JP2017508798A
(ja)
|
2014-03-07 |
2017-03-30 |
ザ ジョンズ ホプキンス ユニバーシティ |
ヒストンリジン特異的デメチラーゼ(lsd1)およびヒストンデアセチラーゼ(hdac)の阻害剤
|
|
SG11201702401RA
(en)
|
2014-10-14 |
2017-04-27 |
Novartis Ag |
Antibody molecules to pd-l1 and uses thereof
|
|
PT3328894T
(pt)
|
2015-08-06 |
2019-02-13 |
Agency Science Tech & Res |
Anticorpos de cadeia comum gama/il2rbeta
|
|
TWI794171B
(zh)
|
2016-05-11 |
2023-03-01 |
美商滬亞生物國際有限公司 |
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