JP2014523857A5 - - Google Patents

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JP2014523857A5
JP2014523857A5 JP2014508179A JP2014508179A JP2014523857A5 JP 2014523857 A5 JP2014523857 A5 JP 2014523857A5 JP 2014508179 A JP2014508179 A JP 2014508179A JP 2014508179 A JP2014508179 A JP 2014508179A JP 2014523857 A5 JP2014523857 A5 JP 2014523857A5
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alkyl
ring
independently
halogen
hydrogen
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JP6240063B2 (ja
JP2014523857A (ja
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Priority claimed from PCT/US2012/035814 external-priority patent/WO2012149540A1/en
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JP2014508179A 2011-04-28 2012-04-30 ヒストンデアセチラーゼ阻害剤 Active JP6240063B2 (ja)

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JP2017212845A JP6974120B2 (ja) 2011-04-28 2017-11-02 ヒストンデアセチラーゼ阻害剤

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US201161480133P 2011-04-28 2011-04-28
US61/480,133 2011-04-28
PCT/US2012/035814 WO2012149540A1 (en) 2011-04-28 2012-04-30 Inhibitors of histone deacetylase

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JP2014523857A JP2014523857A (ja) 2014-09-18
JP2014523857A5 true JP2014523857A5 (enExample) 2016-06-09
JP6240063B2 JP6240063B2 (ja) 2017-11-29

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JP2017212845A Active JP6974120B2 (ja) 2011-04-28 2017-11-02 ヒストンデアセチラーゼ阻害剤
JP2019185842A Active JP7042244B2 (ja) 2011-04-28 2019-10-09 ヒストンデアセチラーゼ阻害剤

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JP2019185842A Active JP7042244B2 (ja) 2011-04-28 2019-10-09 ヒストンデアセチラーゼ阻害剤

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US (5) US9365498B2 (enExample)
EP (2) EP2701699B1 (enExample)
JP (3) JP6240063B2 (enExample)
CA (1) CA2834548C (enExample)
WO (1) WO2012149540A1 (enExample)

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2553337Y2 (ja) 1993-06-30 1997-11-05 住友重機械工業株式会社 電気集塵装置
EP2701699B1 (en) 2011-04-28 2019-10-16 The Broad Institute, Inc. Inhibitors of histone deacetylase
JP6337255B2 (ja) 2012-07-27 2018-06-06 ザ ブロード インスティテュート, インコーポレーテッドThe Broad Institute, Inc. ヒストンデアセチラーゼの阻害剤
US9872919B2 (en) 2012-09-19 2018-01-23 The Research Foundation For The State University Of New York Prodrugs for selective anticancer therapy
US9914717B2 (en) 2012-12-20 2018-03-13 The Broad Institute, Inc. Cycloalkenyl hydroxamic acid derivatives and their use as histone deacetylase inhibitors
CA2895808A1 (en) 2012-12-21 2014-06-26 Quanticel Pharmaceuticals, Inc. Histone demethylase inhibitors
WO2014121062A1 (en) 2013-02-01 2014-08-07 Acetylon Pharmaceuticals, Inc. Selective hdac3 inhibitors
US9139583B2 (en) 2013-02-01 2015-09-22 Acetylon Pharmaceuticals, Inc. Selective HDAC3 inhibitors
JP6371851B2 (ja) 2013-08-27 2018-08-08 ブリストル−マイヤーズ スクイブ カンパニーBristol−Myers Squibb Company Ido阻害剤
MX375219B (es) 2014-06-25 2025-03-06 Celgene Quanticel Res Inc Inhibidores de histona demetilasa.
US9981920B2 (en) 2014-06-26 2018-05-29 Rodin Therapeutics, Inc. Inhibitors of histone deacetylase
WO2016031815A1 (ja) 2014-08-26 2016-03-03 武田薬品工業株式会社 複素環化合物
CA2978698A1 (en) 2015-03-06 2016-09-15 Colorado State University Research Foundation Method for preparing largazole analogs and uses thereof
AU2016230008B2 (en) 2015-03-06 2020-08-27 Colorado State University Research Foundation Synthesis and utility of new capgroup largazole analogs
LT3319959T (lt) * 2015-07-06 2021-12-27 Alkermes, Inc. Histono deacetilazės hetero-halogeno inhibitoriai
US10421756B2 (en) 2015-07-06 2019-09-24 Rodin Therapeutics, Inc. Heterobicyclic N-aminophenyl-amides as inhibitors of histone deacetylase
EP3327019A4 (en) 2015-07-17 2019-04-03 Takeda Pharmaceutical Company Limited HETEROCYCLIC CONNECTION
CN108026088B (zh) 2015-07-17 2021-02-12 武田药品工业株式会社 用作hdac抑制剂的噁二唑衍生物
US10406146B2 (en) 2015-08-25 2019-09-10 Takeda Pharmaceutical Company Limited Heterocyclic compound
EP3386493B1 (en) 2015-12-09 2024-11-20 Brandeis University Dbh inhibitors for treating or preventing memory loss
KR20180101404A (ko) * 2015-12-17 2018-09-12 메사추세츠 인스티튜트 오브 테크놀로지 폴리히드록실화된 벤조페논의 조성물 및 신경변성 장애의 치료 방법
HUE054857T2 (hu) * 2016-07-01 2021-10-28 Pfizer 5,7-dihidro-pirrolo-piridinszármazékok neurológiai és neurodegeneratív betegségek kezelésére
MY200068A (en) * 2016-08-26 2023-12-06 Dong A St Co Ltd Novel salt of (r)-(1-methylpyrrolidine-3-yl)methyl(3'-chloro-4'-fluoro-[1,1'-biphenyl]-2-yl)carbamate and a crystal form thereof
KR102239776B1 (ko) * 2016-08-26 2021-04-13 동아에스티 주식회사 (r)-(1-메틸피롤리딘-3-일)메틸(3'-클로로-4'-플루오로-[1,1'-비페닐]-2-일)카바메이트의 신규염 및 이의 결정형
ES2909086T3 (es) 2017-01-11 2022-05-05 Alkermes Inc Inhibidores bicíclicos de histona desacetilasa
US20200039938A1 (en) 2017-03-30 2020-02-06 Albert-Ludwigs-University Freiburg Kdm4 inhibitors
EP3661931A1 (en) 2017-07-31 2020-06-10 Takeda Pharmaceutical Company Limited Heterocyclic compound
SG11202000970WA (en) 2017-08-07 2020-02-27 Rodin Therapeutics Inc Bicyclic inhibitors of histone deacetylase
US11458122B2 (en) 2017-08-09 2022-10-04 Children's Hospital Medical Center Methods for treating diseases and nerve injuries
EA037772B1 (ru) * 2017-09-07 2021-05-20 Родин Терапеутикс, Инк. Бициклические ингибиторы деацетилазы гистонов
KR20190043437A (ko) 2017-10-18 2019-04-26 씨제이헬스케어 주식회사 단백질 키나제 억제제로서의 헤테로고리 화합물
JP2021510733A (ja) * 2018-01-12 2021-04-30 ケーディーエーシー セラピューティクス,インコーポレーテッドKdac Therapeutics, Inc. がんの処置のための選択的ヒストンデアセチラーゼ3(hdac3)インヒビターと免疫治療剤との組み合わせ
WO2019235501A1 (ja) * 2018-06-06 2019-12-12 塩野義製薬株式会社 ヒストン脱アセチル化酵素阻害剤
MA53129A (fr) * 2018-07-13 2021-05-19 Alkermes Inc Inhibiteurs de l'histone désacétylase
MX2021000469A (es) * 2018-07-13 2021-06-23 Alkermes Inc Inhibidores biciclicos de las histona desacetilasas.
KR102195348B1 (ko) 2018-11-15 2020-12-24 에이치케이이노엔 주식회사 단백질 키나제 억제제로서의 신규 화합물 및 이를 포함하는 약제학적 조성물
WO2020168241A1 (en) * 2019-02-15 2020-08-20 Flagship Pioneering Inc. X-reactivation modulators and uses thereof
EP3930746A4 (en) 2019-02-25 2023-03-15 Emory University CHIMERA COMPOUNDS AND METHODS FOR MANAGEMENT OF NEUROLOGICAL DISORDERS OR CONDITIONS
US20220227700A1 (en) * 2019-06-13 2022-07-21 Dana-Farber Cancer Institute, Inc. Hdac3 catalytic inhibitor development and uses thereof
WO2021016413A1 (en) * 2019-07-23 2021-01-28 Alkermes, Inc. Synthesis of bicyclic inhibitors of histone deacetylase
AU2020353984B2 (en) 2019-09-27 2025-09-25 Takeda Pharmaceutical Company Limited 2-isoindol-1,3,4-oxadiazole derivatives useful as HDAC6 inhibitors
EP4074700A4 (en) * 2019-12-10 2024-02-07 Shionogi & Co., Ltd HISTONE DEACETYLASE INHIBITOR COMPRISING AROMATIC HETEROCYCLIC GROUP CONTAINING NITROGEN
JP7696997B2 (ja) 2020-08-14 2025-06-23 ミネルヴァ ニューロサイエンシズ,インコーポレーテッド シグマリガンド化合物としての縮合アザ環およびその使用
IL301496A (en) * 2020-09-24 2023-05-01 Nflection Therapeutics Inc Treatment of cognitive dysfunction with pyrrolopyridine-aniline compounds
US12227522B2 (en) 2020-12-21 2025-02-18 Colorado State University Research Foundation Synthesis of structural analogs of largazole and associated compounds
CN114957132A (zh) * 2021-02-20 2022-08-30 中国科学院上海药物研究所 含s构型的氨基苯甲酰胺基哒嗪酮类化合物、其制备方法、药物组合物及应用
JP2025539696A (ja) * 2022-11-07 2025-12-09 ヒューマンウェル ファーマシューティカル ユーエス,インコーポレイテッド ソマトスタチン受容体サブタイプ4(sstr4)アゴニスト及びその応用
CN121219285A (zh) * 2023-05-11 2025-12-26 中国药科大学 氮杂环丁烷衍生物、其制备方法及其医药用途

Family Cites Families (121)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE670584C (de) * 1936-07-09 1939-01-20 I G Farbenindustrie Akt Ges Verfahren zur Herstellung von o-Aminophenolen
DE1108213B (de) 1959-02-28 1961-06-08 Frantisek Sorm Dr Ing Verfahren zur Herstellung von 2, 2-Dimethyl-3-phenylcyclopropan-carbonsaeuren
SE370866B (enExample) * 1968-03-21 1974-11-04 Ciba Geigy Ag
JPS4825500B1 (enExample) * 1970-12-29 1973-07-30
US3850931A (en) 1971-06-25 1974-11-26 American Home Prod 4-(substituted anilino)-2-phenyl-5-pyrimidinecarboxylic acid esters
GB2079480B (en) 1980-07-08 1984-05-16 Kodak Ltd Heat-activated photographic and thermal recording processes employing precursor compounds
NO156828C (no) * 1980-11-10 1987-12-02 Otsuka Pharma Co Ltd Analogifremgangsm te for fremstilling av antibakterielt virksomme benzoheterocykliske forbindelser.
JPS57102887A (en) 1980-12-18 1982-06-26 Otsuka Pharmaceut Co Ltd Preparation of benzo(ij)quinolizine-2-carboxylic acid derivative
US4404356A (en) * 1981-09-09 1983-09-13 Ciba-Geigy Corporation Heat-curable epoxide resin compositions
JPS5853916A (ja) 1981-09-09 1983-03-30 チバ−ガイギ−・アクチエンゲゼルシヤフト 熱硬化性エポキシド樹脂組成物
US5525727A (en) 1982-05-18 1996-06-11 University Of Florida Brain-specific drug delivery
DE3511110A1 (de) * 1985-03-27 1986-10-02 Dr. Karl Thomae Gmbh, 7950 Biberach Neue pyridazinone, ihre herstellung und diese verbindungen enthaltende arzneimittel
GB8508588D0 (en) 1985-04-02 1985-05-09 Akzo Nv Indene & napthalene derivatives
NZ219974A (en) 1986-04-22 1989-08-29 Goedecke Ag N-(2'-aminophenyl)-benzamide derivatives, process for their preparation and their use in the control of neoplastic diseases
IT1231413B (it) * 1987-09-23 1991-12-04 Angeli Inst Spa Derivati dell'acido benzimidazolin-2-osso-1-carbossilico utili come antagonisti dei recettori 5-ht
US5994392A (en) 1988-02-26 1999-11-30 Neuromedica, Inc. Antipsychotic prodrugs comprising an antipsychotic agent coupled to an unsaturated fatty acid
DE3830054A1 (de) 1988-09-03 1990-03-15 Boehringer Mannheim Gmbh Phenylamide - verfahren zu ihrer herstellung sowie diese verbindungen enthaltende arzneimittel
JPH03232868A (ja) * 1990-02-05 1991-10-16 Nippon Telegr & Teleph Corp <Ntt> 新規光学活性化合物及び液晶組成物
US5177064A (en) 1990-07-13 1993-01-05 University Of Florida Targeted drug delivery via phosphonate derivatives
NZ241954A (en) 1991-03-15 1994-01-26 Amgen Inc Compositions of g-csf for pulmonary administration.
JPH06122669A (ja) 1991-12-28 1994-05-06 Ishihara Sangyo Kaisha Ltd ジアミノベンゼン誘導体を含有するホスホリパーゼa2阻害剤
DE4323916A1 (de) * 1993-07-16 1995-01-19 Basf Ag Substituierte 2-Phenylpyridine
US5451569A (en) 1994-04-19 1995-09-19 Hong Kong University Of Science And Technology R & D Corporation Limited Pulmonary drug delivery system
EP0809492A4 (en) * 1995-02-17 2007-01-24 Smithkline Beecham Corp IL-8 RECEPTOR ANTAGONISTS
US5635503A (en) * 1995-06-07 1997-06-03 Bristol-Myers Squibb Company Dihydropyridine npy antagonists: piperazine derivatives
US5855887A (en) 1995-07-25 1999-01-05 The Regents Of The University Of California Blockade of lymphocyte down-regulation associated with CTLA-4 signaling
US5811097A (en) 1995-07-25 1998-09-22 The Regents Of The University Of California Blockade of T lymphocyte down-regulation associated with CTLA-4 signaling
US6051227A (en) 1995-07-25 2000-04-18 The Regents Of The University Of California, Office Of Technology Transfer Blockade of T lymphocyte down-regulation associated with CTLA-4 signaling
JPH09227495A (ja) * 1996-02-16 1997-09-02 Tanabe Seiyaku Co Ltd フェノール誘導体及びその製法
AU8270898A (en) 1997-06-26 1999-01-19 Eli Lilly And Company Antithrombotic agents
EE05627B1 (et) 1998-12-23 2013-02-15 Pfizer Inc. CTLA-4 vastased inimese monoklonaalsed antikehad
JP4390024B2 (ja) 1999-04-23 2009-12-24 アステラス製薬株式会社 新規なジアゼパン誘導体又はその塩
US6653309B1 (en) 1999-04-26 2003-11-25 Vertex Pharmaceuticals Incorporated Inhibitors of IMPDH enzyme technical field of the invention
CN102766210B (zh) 1999-08-24 2015-07-08 E.R.施贵宝&圣斯有限责任公司 人ctla-4抗体及其应用
US7605238B2 (en) 1999-08-24 2009-10-20 Medarex, Inc. Human CTLA-4 antibodies and their uses
US6713454B1 (en) 1999-09-13 2004-03-30 Nobex Corporation Prodrugs of etoposide and etoposide analogs
EP1261376A1 (en) 2000-01-27 2002-12-04 Genetics Institute, LLC Antibodies against ctla4(cd152), conjugates comprising same, and uses thereof
FR2805741B1 (fr) * 2000-03-06 2003-06-20 Oreal Composition de teinture d'oxydation des fibres keratiniques avec un derive particulier de la paraphenylenediamine et un colorant direct particulier
AU2001248701A1 (en) * 2000-03-24 2001-10-03 Methylgene, Inc. Inhibitors of histone deacetylase
DE10038007A1 (de) * 2000-08-04 2002-02-14 Bayer Ag Neue Amino-und Amido-Diphenylether für Arzneimittel
US6645990B2 (en) * 2000-08-15 2003-11-11 Amgen Inc. Thiazolyl urea compounds and methods of uses
US20020173507A1 (en) 2000-08-15 2002-11-21 Vincent Santora Urea compounds and methods of uses
CA2417432C (en) 2000-09-01 2010-11-02 The Center For Blood Research, Inc. Modified polypeptides stabilized in a desired conformation and methods for producing same
MXPA03005120A (es) 2000-12-07 2004-03-10 Cv Therapeutics Inc Compuestos para el incremento de abca-1.
JP4183923B2 (ja) 2001-03-29 2008-11-19 富士フイルム株式会社 熱現像感光材料
IL157873A0 (en) * 2001-04-12 2004-03-28 Hoffmann La Roche DIHYDRO-BENZO [b] [1,4] DIAZEPIN-2-ONE DERIVATIVES AS MGLUR2 ANTAGONISTS II
AR034897A1 (es) * 2001-08-07 2004-03-24 Hoffmann La Roche Derivados n-monoacilados de o-fenilendiaminas, sus analogos heterociclicos de seis miembros y su uso como agentes farmaceuticos
US6949542B2 (en) 2002-02-06 2005-09-27 Hoffman-La Roche Inc. Dihydro-benzo[b][1,4]diazepin-2-one derivatives
TWI319387B (en) 2002-04-05 2010-01-11 Astrazeneca Ab Benzamide derivatives
ES2384168T3 (es) 2002-04-12 2012-07-02 Medarex, Inc. Procedimientos de tratamiento usando anticuerpos CTLA-4
EP1402888A1 (en) * 2002-09-18 2004-03-31 Jerini AG The use of substituted carbocyclic compounds as rotamases inhibitors
US7244751B2 (en) 2003-02-14 2007-07-17 Shenzhen Chipscreen Biosciences Ltd. Histone deacetylase inhibitors of novel benzamide derivatives with potent differentiation and anti-proliferation activity
MXPA05008106A (es) 2003-02-18 2005-09-21 Pfizer Inhibidores del virus de la hepatitis c, composiciones y tratamientos que los emplean.
WO2005025557A1 (en) 2003-09-16 2005-03-24 Monash University An agent for plasminogen-activation and matrix metalloproteinase associated conditions and methods of use
CA2539117A1 (en) * 2003-09-24 2005-04-07 Methylgene Inc. Inhibitors of histone deacetylase
EP1687513B1 (en) 2003-10-02 2010-12-22 Jesel, Inc. Double roller cam follower
US7935724B2 (en) 2003-10-09 2011-05-03 Merck Hdac Research, Llc Thiophene and benzothiophene hydroxamic acid derivatives
US20080070954A1 (en) 2003-10-27 2008-03-20 S*Bio Pte Ltd. Acylurea Connected And Sulfonylurea Connected Hydroxamates
WO2005066151A2 (en) 2003-12-19 2005-07-21 Takeda San Diego, Inc. Histone deacetylase inhibitors
US20100234409A1 (en) 2004-05-21 2010-09-16 Lihu Yang Amino cyclopentyl heterocyclic and carbocyclic modulators of chemokine receptor activity
US20060008517A1 (en) 2004-07-09 2006-01-12 Lynch Marina A Treatment of age-related memory impairment
JP4946861B2 (ja) * 2004-08-09 2012-06-06 アステラス製薬株式会社 ヒストンデアセチラーゼ(hdac)の阻害活性を有するヒドロキシアミド化合物
WO2006028161A1 (ja) * 2004-09-09 2006-03-16 Research Foundation Itsuu Laboratory セロトニン5-ht3受容体作動薬
JP2008546793A (ja) 2005-06-24 2008-12-25 メルク エンド カムパニー インコーポレーテッド 修飾マロン酸誘導体
CA2612241C (en) 2005-07-01 2018-11-06 Medarex, Inc. Human monoclonal antibodies to programmed death ligand 1 (pd-l1)
CA2635210A1 (en) 2006-01-12 2007-08-02 Merck & Co., Inc. Hydroxyalkylarylamide derivatives
ES2452820T3 (es) * 2006-04-07 2014-04-02 Methylgene, Inc. Derivados de benzamida como inhibidores de histona desacetilasa
US20100029615A1 (en) 2006-12-15 2010-02-04 Michael John Munchhof Benzimidazole derivatives
AU2007337088A1 (en) 2006-12-19 2008-07-03 Genentech, Inc. Pyrimidine kinase inhibitors
CA2947292C (en) 2006-12-27 2019-07-23 Emory University Compositions and methods for the treatment of infections and tumors
CN103087043A (zh) 2007-03-16 2013-05-08 中国人民解放军军事医学科学院放射与辐射医学研究所 具有抗增殖活性的苯甲酰胺类衍生物及其药用制剂
KR101586617B1 (ko) 2007-06-18 2016-01-20 머크 샤프 앤 도메 비.브이. 사람 프로그램된 사멸 수용체 pd-1에 대한 항체
EP2170882A1 (en) 2007-06-26 2010-04-07 Gilead Colorado, Inc. Imidazopyridinyl thiazolyl histone deacetylase inhibitors
AU2008269154B2 (en) * 2007-06-27 2014-06-12 Merck Sharp & Dohme Llc 4-carboxybenzylamino derivatives as histone deacetylase inhibitors
US8138168B1 (en) 2007-09-26 2012-03-20 Takeda Pharmaceutical Company Limited Renin inhibitors
KR20100074288A (ko) 2007-10-22 2010-07-01 오키드 리서치 레버라토리즈 리미티드 히스톤 디아세틸라제 억제제
BRPI0817897A2 (pt) 2007-11-02 2019-09-24 Methylgene Inc composto, composição, e, métodos de inibição da atividade hdac, e de tratamento de uma doença responsiva a um inibidor de atividade hdac
WO2009076234A2 (en) 2007-12-07 2009-06-18 University Of Maryland, Baltimore Synthesis methods of histone deacetylase inhibitors (hdacis)
US8138138B2 (en) 2008-01-04 2012-03-20 Ecolab Usa Inc. Solidification matrix using a polycarboxylic acid polymer
MY156226A (en) 2008-02-22 2016-01-29 Otsuka Pharma Co Ltd Benzodiazepine compound and pharmaceutical composition
US8093000B2 (en) 2008-05-09 2012-01-10 The Regents Of The University Of California Methods for predicting and treating tumors resistant to drug, immunotherapy, and radiation
AU2009271003A1 (en) 2008-07-14 2010-01-21 Gilead Sciences, Inc. Imidazolylpyrimidine compounds as HDAC and/or CDK inhibitors
US20110178138A1 (en) 2008-07-28 2011-07-21 The Regents Of The University Of California Inhibitors of protein prenyltransferases
WO2010014784A2 (en) 2008-08-01 2010-02-04 Bristol-Myers Squibb Company Combination of anti-ctla4 antibody with diverse therapeutic regimens for the synergistic treatment of proliferative diseases
ES2545609T3 (es) 2008-08-25 2015-09-14 Amplimmune, Inc. Composiciones de antagonistas de PD-1 y métodos de uso
AU2009289649B2 (en) 2008-09-03 2016-05-05 Biomarin Pharmaceutical Inc. Compositions including 6-aminohexanoic acid derivatives as HDAC inhibitors
PL2342226T3 (pl) 2008-09-26 2017-01-31 Dana-Farber Cancer Institute, Inc. Ludzkie przeciwciała anty-PD-1, PD-L1 i PD-L2 oraz ich zastosowania
WO2010042433A1 (en) 2008-10-06 2010-04-15 Bristol-Myers Squibb Company Combination of cd137 antibody and ctla-4 antibody for the treatment of proliferative diseases
US8232409B2 (en) * 2008-10-15 2012-07-31 Janssen Pharmaceutica N.V. Heterocyclic benzimidazoles as TRPM8 modulators
EP2367599A4 (en) 2008-12-03 2012-08-08 Massachusetts Inst Technology HDAC2-INHIBITION FOR MEMORY STRENGTH
EP4209510B1 (en) 2008-12-09 2024-01-31 F. Hoffmann-La Roche AG Anti-pd-l1 antibodies and their use to enhance t-cell function
EP3192811A1 (en) 2009-02-09 2017-07-19 Université d'Aix-Marseille Pd-1 antibodies and pd-l1 antibodies and uses thereof
KR20110117194A (ko) 2009-02-23 2011-10-26 에프. 호프만-라 로슈 아게 암 치료를 위한 신규한 오르토-아미노아미드
EP2432779A1 (en) * 2009-05-22 2012-03-28 Exelixis, Inc. Benzoxazepines based p13k/mt0r inhibitors against proliferative diseases
US8211901B2 (en) 2009-05-22 2012-07-03 Shenzhen Chipscreen Biosciences Ltd. Naphthamide derivatives as multi-target protein kinase inhibitors and histone deacetylase inhibitors
MX2011013294A (es) 2009-06-11 2012-01-12 Siena Biotech Spa Antagonistas de la trayectoria de hedgehog y aplicaciones terapeuticas de los mismos.
EP2454254A2 (en) * 2009-07-16 2012-05-23 Vertex Pharmaceuticals Incorporated Benzimidazole analogues for the treatment or prevention of flavivirus infections
IN2012DN03807A (enExample) * 2009-10-30 2015-08-28 Massachusetts Inst Technology
US20130017199A1 (en) 2009-11-24 2013-01-17 AMPLIMMUNE ,Inc. a corporation Simultaneous inhibition of pd-l1/pd-l2
JP2013526537A (ja) * 2010-05-13 2013-06-24 アムジエン・インコーポレーテツド Pde10阻害剤としてのヘテロアリールオキシカルボシクリル化合物
US20140107166A1 (en) 2011-02-14 2014-04-17 Dana-Farber Cancer Institute, Inc. Histone deacetylase inhibitors and methods of use thereof
US8957066B2 (en) 2011-02-28 2015-02-17 Biomarin Pharmaceutical Inc. Histone deacetylase inhibitors
WO2012118750A2 (en) 2011-02-28 2012-09-07 Genentech, Inc. Biological markers and methods for predicting response to b-cell antagonists
JP6250403B2 (ja) 2011-02-28 2017-12-20 バイオマリン ファーマシューティカル インク ヒストン脱アセチル化酵素阻害剤
EP2701699B1 (en) 2011-04-28 2019-10-16 The Broad Institute, Inc. Inhibitors of histone deacetylase
CN102775356B (zh) 2011-05-13 2015-07-22 江苏恒谊药业有限公司 4-氨基喹唑啉衍生物及其应用
US20130071403A1 (en) 2011-09-20 2013-03-21 Vical Incorporated Synergistic anti-tumor efficacy using alloantigen combination immunotherapy
WO2013059582A2 (en) 2011-10-20 2013-04-25 Nupotential, Inc. Small molecule inhibitors of histone deacteylases
WO2013067391A1 (en) 2011-11-02 2013-05-10 The Broad Institute, Inc. Fluorescent substrates for determining lysine modifying enzyme activity
CA2759407A1 (en) 2011-12-02 2013-06-02 Marrett Alexander GREEN Grey water recycling systems and valves
CN104159911A (zh) 2012-03-07 2014-11-19 奥瑞基尼探索技术有限公司 作为免疫调节剂的模拟肽化合物
AU2013263076B2 (en) 2012-05-15 2017-08-31 Bristol-Myers Squibb Company Cancer immunotherapy by disrupting PD-1/PD-L1 signaling
JP6337255B2 (ja) 2012-07-27 2018-06-06 ザ ブロード インスティテュート, インコーポレーテッドThe Broad Institute, Inc. ヒストンデアセチラーゼの阻害剤
US9914717B2 (en) 2012-12-20 2018-03-13 The Broad Institute, Inc. Cycloalkenyl hydroxamic acid derivatives and their use as histone deacetylase inhibitors
USRE49240E1 (en) 2013-11-05 2022-10-11 The General Hospital Corporation Inhibitors of histone deacetylase
JP2017508798A (ja) 2014-03-07 2017-03-30 ザ ジョンズ ホプキンス ユニバーシティ ヒストンリジン特異的デメチラーゼ(lsd1)およびヒストンデアセチラーゼ(hdac)の阻害剤
WO2016061142A1 (en) 2014-10-14 2016-04-21 Novartis Ag Antibody molecules to pd-l1 and uses thereof
ES2710618T3 (es) 2015-08-06 2019-04-26 Agency Science Tech & Res Anticuerpos frente a IL2R-Beta/cadena gamma común
TWI794171B (zh) 2016-05-11 2023-03-01 美商滬亞生物國際有限公司 Hdac抑制劑與pd-l1抑制劑之組合治療
CA3047334A1 (en) 2017-01-10 2018-07-19 Dana-Farber Cancer Institute, Inc. Compositions and methods using an epigenetic inhibitor
JP2021510733A (ja) 2018-01-12 2021-04-30 ケーディーエーシー セラピューティクス,インコーポレーテッドKdac Therapeutics, Inc. がんの処置のための選択的ヒストンデアセチラーゼ3(hdac3)インヒビターと免疫治療剤との組み合わせ

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