|
DE670584C
(de)
*
|
1936-07-09 |
1939-01-20 |
I G Farbenindustrie Akt Ges |
Verfahren zur Herstellung von o-Aminophenolen
|
|
DE1108213B
(de)
|
1959-02-28 |
1961-06-08 |
Frantisek Sorm Dr Ing |
Verfahren zur Herstellung von 2, 2-Dimethyl-3-phenylcyclopropan-carbonsaeuren
|
|
SE370866B
(enExample)
*
|
1968-03-21 |
1974-11-04 |
Ciba Geigy Ag |
|
|
JPS4825500B1
(enExample)
*
|
1970-12-29 |
1973-07-30 |
|
|
|
US3850931A
(en)
|
1971-06-25 |
1974-11-26 |
American Home Prod |
4-(substituted anilino)-2-phenyl-5-pyrimidinecarboxylic acid esters
|
|
GB2079480B
(en)
|
1980-07-08 |
1984-05-16 |
Kodak Ltd |
Heat-activated photographic and thermal recording processes employing precursor compounds
|
|
NO156828C
(no)
*
|
1980-11-10 |
1987-12-02 |
Otsuka Pharma Co Ltd |
Analogifremgangsm te for fremstilling av antibakterielt virksomme benzoheterocykliske forbindelser.
|
|
JPS57102887A
(en)
|
1980-12-18 |
1982-06-26 |
Otsuka Pharmaceut Co Ltd |
Preparation of benzo(ij)quinolizine-2-carboxylic acid derivative
|
|
US4404356A
(en)
|
1981-09-09 |
1983-09-13 |
Ciba-Geigy Corporation |
Heat-curable epoxide resin compositions
|
|
JPS5853916A
(ja)
|
1981-09-09 |
1983-03-30 |
チバ−ガイギ−・アクチエンゲゼルシヤフト |
熱硬化性エポキシド樹脂組成物
|
|
US5525727A
(en)
|
1982-05-18 |
1996-06-11 |
University Of Florida |
Brain-specific drug delivery
|
|
DE3511110A1
(de)
*
|
1985-03-27 |
1986-10-02 |
Dr. Karl Thomae Gmbh, 7950 Biberach |
Neue pyridazinone, ihre herstellung und diese verbindungen enthaltende arzneimittel
|
|
GB8508588D0
(en)
|
1985-04-02 |
1985-05-09 |
Akzo Nv |
Indene & napthalene derivatives
|
|
NZ219974A
(en)
|
1986-04-22 |
1989-08-29 |
Goedecke Ag |
N-(2'-aminophenyl)-benzamide derivatives, process for their preparation and their use in the control of neoplastic diseases
|
|
IT1231413B
(it)
*
|
1987-09-23 |
1991-12-04 |
Angeli Inst Spa |
Derivati dell'acido benzimidazolin-2-osso-1-carbossilico utili come antagonisti dei recettori 5-ht
|
|
US5994392A
(en)
|
1988-02-26 |
1999-11-30 |
Neuromedica, Inc. |
Antipsychotic prodrugs comprising an antipsychotic agent coupled to an unsaturated fatty acid
|
|
DE3830054A1
(de)
|
1988-09-03 |
1990-03-15 |
Boehringer Mannheim Gmbh |
Phenylamide - verfahren zu ihrer herstellung sowie diese verbindungen enthaltende arzneimittel
|
|
JPH03232868A
(ja)
*
|
1990-02-05 |
1991-10-16 |
Nippon Telegr & Teleph Corp <Ntt> |
新規光学活性化合物及び液晶組成物
|
|
US5177064A
(en)
|
1990-07-13 |
1993-01-05 |
University Of Florida |
Targeted drug delivery via phosphonate derivatives
|
|
AU643141B2
(en)
|
1991-03-15 |
1993-11-04 |
Amgen, Inc. |
Pulmonary administration of granulocyte colony stimulating factor
|
|
JPH06122669A
(ja)
|
1991-12-28 |
1994-05-06 |
Ishihara Sangyo Kaisha Ltd |
ジアミノベンゼン誘導体を含有するホスホリパーゼa2阻害剤
|
|
DE4323916A1
(de)
*
|
1993-07-16 |
1995-01-19 |
Basf Ag |
Substituierte 2-Phenylpyridine
|
|
US5451569A
(en)
|
1994-04-19 |
1995-09-19 |
Hong Kong University Of Science And Technology R & D Corporation Limited |
Pulmonary drug delivery system
|
|
EP0809492A4
(en)
*
|
1995-02-17 |
2007-01-24 |
Smithkline Beecham Corp |
IL-8 RECEPTOR ANTAGONISTS
|
|
US5635503A
(en)
*
|
1995-06-07 |
1997-06-03 |
Bristol-Myers Squibb Company |
Dihydropyridine npy antagonists: piperazine derivatives
|
|
US5855887A
(en)
|
1995-07-25 |
1999-01-05 |
The Regents Of The University Of California |
Blockade of lymphocyte down-regulation associated with CTLA-4 signaling
|
|
US5811097A
(en)
|
1995-07-25 |
1998-09-22 |
The Regents Of The University Of California |
Blockade of T lymphocyte down-regulation associated with CTLA-4 signaling
|
|
US6051227A
(en)
|
1995-07-25 |
2000-04-18 |
The Regents Of The University Of California, Office Of Technology Transfer |
Blockade of T lymphocyte down-regulation associated with CTLA-4 signaling
|
|
JPH09227495A
(ja)
*
|
1996-02-16 |
1997-09-02 |
Tanabe Seiyaku Co Ltd |
フェノール誘導体及びその製法
|
|
WO1999000121A1
(en)
|
1997-06-26 |
1999-01-07 |
Eli Lilly And Company |
Antithrombotic agents
|
|
EE05627B1
(et)
|
1998-12-23 |
2013-02-15 |
Pfizer Inc. |
CTLA-4 vastased inimese monoklonaalsed antikehad
|
|
JP4390024B2
(ja)
|
1999-04-23 |
2009-12-24 |
アステラス製薬株式会社 |
新規なジアゼパン誘導体又はその塩
|
|
US6653309B1
(en)
|
1999-04-26 |
2003-11-25 |
Vertex Pharmaceuticals Incorporated |
Inhibitors of IMPDH enzyme technical field of the invention
|
|
NZ517202A
(en)
|
1999-08-24 |
2004-05-28 |
Medarex Inc |
Human CTLA-4 antibodies and their uses
|
|
US7605238B2
(en)
|
1999-08-24 |
2009-10-20 |
Medarex, Inc. |
Human CTLA-4 antibodies and their uses
|
|
US6713454B1
(en)
|
1999-09-13 |
2004-03-30 |
Nobex Corporation |
Prodrugs of etoposide and etoposide analogs
|
|
EP1261376A1
(en)
|
2000-01-27 |
2002-12-04 |
Genetics Institute, LLC |
Antibodies against ctla4(cd152), conjugates comprising same, and uses thereof
|
|
FR2805741B1
(fr)
*
|
2000-03-06 |
2003-06-20 |
Oreal |
Composition de teinture d'oxydation des fibres keratiniques avec un derive particulier de la paraphenylenediamine et un colorant direct particulier
|
|
EP1280764B1
(en)
*
|
2000-03-24 |
2010-11-24 |
Methylgene, Inc. |
Inhibitors of histone deacetylase
|
|
DE10038007A1
(de)
*
|
2000-08-04 |
2002-02-14 |
Bayer Ag |
Neue Amino-und Amido-Diphenylether für Arzneimittel
|
|
US20020173507A1
(en)
|
2000-08-15 |
2002-11-21 |
Vincent Santora |
Urea compounds and methods of uses
|
|
US6645990B2
(en)
*
|
2000-08-15 |
2003-11-11 |
Amgen Inc. |
Thiazolyl urea compounds and methods of uses
|
|
ATE448306T1
(de)
|
2000-09-01 |
2009-11-15 |
Blood Res Center |
Veränderte, in gewünschter konformation stabilisierte polypeptide und verfahren zu deren herstellung
|
|
WO2002046172A2
(en)
|
2000-12-07 |
2002-06-13 |
Cv Therapeutics, Inc. |
Substituted 1, 3, 5-triazines and pyrimidines as abca-1 elevating compounds against coronary artery disease or atherosclerosis
|
|
JP4183923B2
(ja)
|
2001-03-29 |
2008-11-19 |
富士フイルム株式会社 |
熱現像感光材料
|
|
CA2442557C
(en)
*
|
2001-04-12 |
2008-12-23 |
F. Hoffmann-La Roche Ag |
Dihydro-benzo¬b|¬1,4|diazepin-2-one derivatives as mglur2 antagonists ii
|
|
AR034897A1
(es)
*
|
2001-08-07 |
2004-03-24 |
Hoffmann La Roche |
Derivados n-monoacilados de o-fenilendiaminas, sus analogos heterociclicos de seis miembros y su uso como agentes farmaceuticos
|
|
US6949542B2
(en)
|
2002-02-06 |
2005-09-27 |
Hoffman-La Roche Inc. |
Dihydro-benzo[b][1,4]diazepin-2-one derivatives
|
|
TWI319387B
(en)
|
2002-04-05 |
2010-01-11 |
Astrazeneca Ab |
Benzamide derivatives
|
|
IL164287A0
(en)
|
2002-04-12 |
2005-12-18 |
Medarex Inc |
Methods of treatment using ctla-4 antibodies
|
|
EP1402888A1
(en)
*
|
2002-09-18 |
2004-03-31 |
Jerini AG |
The use of substituted carbocyclic compounds as rotamases inhibitors
|
|
US7244751B2
(en)
|
2003-02-14 |
2007-07-17 |
Shenzhen Chipscreen Biosciences Ltd. |
Histone deacetylase inhibitors of novel benzamide derivatives with potent differentiation and anti-proliferation activity
|
|
BRPI0407587A
(pt)
|
2003-02-18 |
2006-02-14 |
Pfizer |
inibidores do vìrus da hepatite c, composições e tratamentos que os utilizam
|
|
WO2005025557A1
(en)
|
2003-09-16 |
2005-03-24 |
Monash University |
An agent for plasminogen-activation and matrix metalloproteinase associated conditions and methods of use
|
|
WO2005030704A1
(en)
|
2003-09-24 |
2005-04-07 |
Methylgene, Inc. |
Inhibitors of histone deacetylase
|
|
EP1687513B1
(en)
|
2003-10-02 |
2010-12-22 |
Jesel, Inc. |
Double roller cam follower
|
|
WO2005034880A2
(en)
|
2003-10-09 |
2005-04-21 |
Aton Pharma, Inc. |
Thiophene and benzothiophene hydroxamic acid derivatives
|
|
US20080070954A1
(en)
|
2003-10-27 |
2008-03-20 |
S*Bio Pte Ltd. |
Acylurea Connected And Sulfonylurea Connected Hydroxamates
|
|
WO2005066151A2
(en)
|
2003-12-19 |
2005-07-21 |
Takeda San Diego, Inc. |
Histone deacetylase inhibitors
|
|
WO2006001958A2
(en)
|
2004-05-21 |
2006-01-05 |
Merck & Co., Inc. |
Amino cyclopentyl heterocyclic and carbocyclic modulators of chemokine receptor activity
|
|
US20060008517A1
(en)
|
2004-07-09 |
2006-01-12 |
Lynch Marina A |
Treatment of age-related memory impairment
|
|
CN101001851B
(zh)
|
2004-08-09 |
2011-04-20 |
安斯泰来制药有限公司 |
具有作为组蛋白脱乙酰酶(hdac)抑制剂的活性的羟基酰胺化合物
|
|
JPWO2006028161A1
(ja)
*
|
2004-09-09 |
2008-05-08 |
財団法人乙卯研究所 |
セロトニン5−ht3受容体作動薬
|
|
EP1896395B1
(en)
|
2005-06-24 |
2015-07-15 |
Merck Sharp & Dohme Corp. |
Modified malonate derivatives
|
|
EA019344B1
(ru)
|
2005-07-01 |
2014-03-31 |
МЕДАРЕКС, Эл.Эл.Си. |
Человеческие моноклональные антитела против лиганда-1 запрограммированной гибели клеток (pd-l1) и их применения
|
|
AU2007208495A1
(en)
|
2006-01-12 |
2007-08-02 |
Merck Sharp & Dohme Corp. |
Hydroxyalkylarylamide derivatives
|
|
WO2007118137A1
(en)
*
|
2006-04-07 |
2007-10-18 |
Methylgene Inc. |
Benzamide derivatives as inhibitors of histone deacetylase
|
|
EP2121626A1
(en)
|
2006-12-15 |
2009-11-25 |
Pfizer Products Inc. |
Benzimidazole derivatives
|
|
EP2099771A1
(en)
|
2006-12-19 |
2009-09-16 |
Genentech, Inc. |
Pyrimidine kinase inhibitors
|
|
CA2673870A1
(en)
|
2006-12-27 |
2008-07-10 |
Emory University |
Compositions and methods for the treatment of infections and tumors
|
|
CN101730703B
(zh)
|
2007-03-16 |
2012-12-26 |
中国人民解放军军事医学科学院放射与辐射医学研究所 |
具有抗增殖活性的苯甲酰胺类衍生物及其药用制剂
|
|
JP5191537B2
(ja)
|
2007-06-18 |
2013-05-08 |
エム・エス・ディー・オス・ベー・フェー |
ヒトのプログラムされたデスレセプターpd−1に対する抗体
|
|
WO2009002534A1
(en)
|
2007-06-26 |
2008-12-31 |
Gilead Colorado, Inc. |
Imidazopyridinyl thiazolyl histone deacetylase inhibitors
|
|
US8389553B2
(en)
*
|
2007-06-27 |
2013-03-05 |
Merck Sharp & Dohme Corp. |
4-carboxybenzylamino derivatives as histone deacetylase inhibitors
|
|
US8138168B1
(en)
*
|
2007-09-26 |
2012-03-20 |
Takeda Pharmaceutical Company Limited |
Renin inhibitors
|
|
MX2010004402A
(es)
|
2007-10-22 |
2010-10-15 |
Orchid Res Lab Ltd |
Inhibidores de histona deacetilasa.
|
|
EP2217588A4
(en)
|
2007-11-02 |
2013-12-04 |
Methylgene Inc |
INHIBITORS OF HISTONE DEACETYLASE
|
|
WO2009076234A2
(en)
|
2007-12-07 |
2009-06-18 |
University Of Maryland, Baltimore |
Synthesis methods of histone deacetylase inhibitors (hdacis)
|
|
US8138138B2
(en)
|
2008-01-04 |
2012-03-20 |
Ecolab Usa Inc. |
Solidification matrix using a polycarboxylic acid polymer
|
|
UA103018C2
(uk)
|
2008-02-22 |
2013-09-10 |
Оцука Фармасьютікал Ко., Лтд. |
Сполуки бензодіазепіну і фармацевтична композиція
|
|
US8093000B2
(en)
|
2008-05-09 |
2012-01-10 |
The Regents Of The University Of California |
Methods for predicting and treating tumors resistant to drug, immunotherapy, and radiation
|
|
WO2010009139A2
(en)
|
2008-07-14 |
2010-01-21 |
Gilead Colorado, Inc. |
Imidazolyl pyrimidine inhibitor compounds
|
|
US20110178138A1
(en)
|
2008-07-28 |
2011-07-21 |
The Regents Of The University Of California |
Inhibitors of protein prenyltransferases
|
|
US8119129B2
(en)
|
2008-08-01 |
2012-02-21 |
Bristol-Myers Squibb Company |
Combination of anti-CTLA4 antibody with dasatinib for the treatment of proliferative diseases
|
|
RS54233B1
(sr)
|
2008-08-25 |
2015-12-31 |
Amplimmune Inc. |
Kompozicije pd-1 antagonista i postupci za njihovu primenu
|
|
CA2735593C
(en)
|
2008-09-03 |
2017-08-15 |
Repligen Corporation |
Compositions including 6-aminohexanoic acid derivatives as hdac inhibitors
|
|
BRPI0919377A2
(pt)
|
2008-09-26 |
2016-09-27 |
Dana Farber Cancer Inst Inc |
anticorpo isolado ou um fragmento ligante de antígeno do memso, ácido nucleico isolado, vetor, célula hospedeira, composição farmacêutica, método de produzir o referido anticorpo ou fragmento, uso dos mesmos, e composição compreendendo o referido anticorpo ou fragmento
|
|
WO2010042433A1
(en)
|
2008-10-06 |
2010-04-15 |
Bristol-Myers Squibb Company |
Combination of cd137 antibody and ctla-4 antibody for the treatment of proliferative diseases
|
|
US8232409B2
(en)
*
|
2008-10-15 |
2012-07-31 |
Janssen Pharmaceutica N.V. |
Heterocyclic benzimidazoles as TRPM8 modulators
|
|
NZ593447A
(en)
|
2008-12-03 |
2012-12-21 |
Harvard College |
Inhibition of hdac2 to promote memory
|
|
HUE065752T2
(hu)
|
2008-12-09 |
2024-06-28 |
Hoffmann La Roche |
Anti-PD-L1 antitestek és felhasználásuk T-sejt funkció elõsegítésére
|
|
ES2629337T3
(es)
|
2009-02-09 |
2017-08-08 |
Inserm - Institut National De La Santé Et De La Recherche Médicale |
Anticuerpos contra PD-1 y anticuerpos contra PD-L1 y usos de los mismos
|
|
WO2010094678A1
(en)
*
|
2009-02-23 |
2010-08-26 |
F. Hoffmann-La Roche Ag |
Novel ortho-aminoamides for the treatment of cancer
|
|
US8211901B2
(en)
|
2009-05-22 |
2012-07-03 |
Shenzhen Chipscreen Biosciences Ltd. |
Naphthamide derivatives as multi-target protein kinase inhibitors and histone deacetylase inhibitors
|
|
CN102459249A
(zh)
*
|
2009-05-22 |
2012-05-16 |
埃克塞里艾克西斯公司 |
作为PI3K/mTOR抑制剂的苯并氧氮杂环庚三烯以及它们使用与制造方法
|
|
CN102803246A
(zh)
|
2009-06-11 |
2012-11-28 |
锡耶纳生物技术股份公司 |
Hedgehog途径拮抗剂及其治疗应用
|
|
JP2012533569A
(ja)
*
|
2009-07-16 |
2012-12-27 |
ヴァーテックス ファーマシューティカルズ、 インコーポレイテッド |
フラビウイルス感染症を治療又は予防するためのベンゾイミダゾール類似体
|
|
IN2012DN03807A
(enExample)
*
|
2009-10-30 |
2015-08-28 |
Massachusetts Inst Technology |
|
|
EP2504028A4
(en)
|
2009-11-24 |
2014-04-09 |
Amplimmune Inc |
SIMULTANEOUS INHIBITION OF PD-L1 / PD-L2
|
|
US8952037B2
(en)
*
|
2010-05-13 |
2015-02-10 |
Amgen Inc. |
Heteroaryloxycarbocyclyl compounds as PDE10 inhibitors
|
|
US20140107166A1
(en)
|
2011-02-14 |
2014-04-17 |
Dana-Farber Cancer Institute, Inc. |
Histone deacetylase inhibitors and methods of use thereof
|
|
RU2013140975A
(ru)
|
2011-02-28 |
2015-04-10 |
Дженентек, Инк. |
Биологические маркеры и способы прогнозирования восприимчивости к антагонистам в-клеток
|
|
EP3524324A1
(en)
|
2011-02-28 |
2019-08-14 |
BioMarin Pharmaceutical Inc. |
Histone deacetylase inhibitors
|
|
US8957066B2
(en)
|
2011-02-28 |
2015-02-17 |
Biomarin Pharmaceutical Inc. |
Histone deacetylase inhibitors
|
|
EP2701699B1
(en)
|
2011-04-28 |
2019-10-16 |
The Broad Institute, Inc. |
Inhibitors of histone deacetylase
|
|
CN102775356B
(zh)
|
2011-05-13 |
2015-07-22 |
江苏恒谊药业有限公司 |
4-氨基喹唑啉衍生物及其应用
|
|
US20130071403A1
(en)
|
2011-09-20 |
2013-03-21 |
Vical Incorporated |
Synergistic anti-tumor efficacy using alloantigen combination immunotherapy
|
|
WO2013059582A2
(en)
|
2011-10-20 |
2013-04-25 |
Nupotential, Inc. |
Small molecule inhibitors of histone deacteylases
|
|
EP2773653A4
(en)
|
2011-11-02 |
2015-08-05 |
Broad Inst Inc |
FLUORESCENT SUBSTRATES FOR DETERMINING THE ACTIVITY OF A LYSIN-MODIFYING ENZYME
|
|
CA2759407A1
(en)
|
2011-12-02 |
2013-06-02 |
Marrett Alexander GREEN |
Grey water recycling systems and valves
|
|
CN104159911A
(zh)
|
2012-03-07 |
2014-11-19 |
奥瑞基尼探索技术有限公司 |
作为免疫调节剂的模拟肽化合物
|
|
US9212224B2
(en)
|
2012-05-15 |
2015-12-15 |
Bristol-Myers Squibb Company |
Antibodies that bind PD-L1 and uses thereof
|
|
JP6337255B2
(ja)
|
2012-07-27 |
2018-06-06 |
ザ ブロード インスティテュート, インコーポレーテッドThe Broad Institute, Inc. |
ヒストンデアセチラーゼの阻害剤
|
|
US9914717B2
(en)
|
2012-12-20 |
2018-03-13 |
The Broad Institute, Inc. |
Cycloalkenyl hydroxamic acid derivatives and their use as histone deacetylase inhibitors
|
|
US9988343B2
(en)
|
2013-11-05 |
2018-06-05 |
Dana-Farber Cancer Institute, Inc. |
Inhibitors of histone deacetylase
|
|
EP3114109A4
(en)
|
2014-03-07 |
2017-10-18 |
The Johns Hopkins University |
Inhibitors of histone lysine specific demethylase (lsd1) and histone deacetylases (hdacs)
|
|
UY36351A
(es)
|
2014-10-14 |
2016-06-01 |
Novartis Ag |
Moléculas de anticuerpo que se unen a pd-l1 y usos de las mismas
|
|
CN115925939A
(zh)
|
2015-08-06 |
2023-04-07 |
新加坡科技研究局 |
IL2Rβ/通用γ链抗体
|
|
TWI794171B
(zh)
|
2016-05-11 |
2023-03-01 |
美商滬亞生物國際有限公司 |
Hdac抑制劑與pd-l1抑制劑之組合治療
|
|
US12440451B2
(en)
|
2017-01-10 |
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Compositions and methods using an epigenetic inhibitor
|
|
US12128018B2
(en)
|
2018-01-12 |
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KDAc Therapeutics, Inc. |
Combination of a selective histone deacetylase 3 (HDAC3) inhibitor and an immunotherapy agent for the treatment of cancer
|