JP2018502048A5 - - Google Patents
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- Publication number
- JP2018502048A5 JP2018502048A5 JP2017518064A JP2017518064A JP2018502048A5 JP 2018502048 A5 JP2018502048 A5 JP 2018502048A5 JP 2017518064 A JP2017518064 A JP 2017518064A JP 2017518064 A JP2017518064 A JP 2017518064A JP 2018502048 A5 JP2018502048 A5 JP 2018502048A5
- Authority
- JP
- Japan
- Prior art keywords
- hal
- cor
- nhr
- unsubstituted
- conhr
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14003391.1 | 2014-10-01 | ||
| EP14003391 | 2014-10-01 | ||
| PCT/EP2015/001931 WO2016050356A1 (en) | 2014-10-01 | 2015-10-01 | Boronic acid derivatives |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018502048A JP2018502048A (ja) | 2018-01-25 |
| JP2018502048A5 true JP2018502048A5 (enExample) | 2019-10-17 |
| JP6896618B2 JP6896618B2 (ja) | 2021-06-30 |
Family
ID=51690788
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017518064A Expired - Fee Related JP6896618B2 (ja) | 2014-10-01 | 2015-10-01 | ボロン酸誘導体 |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US10253049B2 (enExample) |
| EP (1) | EP3201208B1 (enExample) |
| JP (1) | JP6896618B2 (enExample) |
| KR (1) | KR20170062518A (enExample) |
| CN (1) | CN107074885B (enExample) |
| AU (1) | AU2015327412B2 (enExample) |
| BR (1) | BR112017006349A2 (enExample) |
| CA (1) | CA2963198A1 (enExample) |
| ES (1) | ES2876287T3 (enExample) |
| IL (1) | IL251299A0 (enExample) |
| MX (1) | MX2017004043A (enExample) |
| RU (1) | RU2017115191A (enExample) |
| SG (1) | SG11201702620SA (enExample) |
| WO (1) | WO2016050356A1 (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG11201702623TA (en) | 2014-10-01 | 2017-04-27 | Merck Patent Gmbh | Boronic acid derivatives |
| AU2015327411B2 (en) | 2014-10-01 | 2020-01-02 | Merck Patent Gmbh | Boronic acid derivatives |
| JP6662865B2 (ja) | 2014-10-01 | 2020-03-11 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ | ボロン酸誘導体 |
| SI3571208T1 (sl) * | 2017-01-18 | 2021-06-30 | Principia Biopharma Inc. | Zaviralci imunoproteasomov |
| WO2019038250A1 (en) | 2017-08-24 | 2019-02-28 | Merck Patent Gmbh | Boronic acid derivatives |
| WO2019060651A1 (en) | 2017-09-21 | 2019-03-28 | Kezar Life Sciences | POLY THERAPY FOR IMMUNOLOGICAL DISEASES |
| CN112469480A (zh) | 2018-07-26 | 2021-03-09 | 默克专利股份公司 | 硼酸衍生物 |
| CN113135943A (zh) * | 2020-01-19 | 2021-07-20 | 首药控股(北京)有限公司 | 硼酸衍生物 |
| CN113135944A (zh) * | 2020-01-19 | 2021-07-20 | 首药控股(北京)有限公司 | 硼酸衍生物 |
| IL310390A (en) | 2021-07-29 | 2024-03-01 | Merck Patent Gmbh | Crystalline forms of [(1r)-2-(1-benzofuran-3-yl)-1-{[(1s,2r,4r)-7- oxabicyclo[2.2.1]heptan-2-yl]formamido}ethyl]boronic acid, adducts thereof, and processes to obtain |
| KR20240090392A (ko) * | 2021-10-14 | 2024-06-21 | 쇼우야오 홀딩스 (베이징) 코., 엘티디. | 보론산 유도체 |
| CN117003776A (zh) * | 2022-04-29 | 2023-11-07 | 科辉智药生物科技(深圳)有限公司 | 一种硼酸类蛋白酶体抑制剂及其用途 |
| WO2023232830A1 (en) | 2022-06-02 | 2023-12-07 | Merck Patent Gmbh | Boronic acid adducts |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL111175A0 (en) * | 1993-10-07 | 1994-12-29 | Du Pont Merck Pharma | Electrophilic peptide analogs as inhibitors of trypsin-like serine proteases and pharmaceutical compositions containing them |
| US6083903A (en) * | 1994-10-28 | 2000-07-04 | Leukosite, Inc. | Boronic ester and acid compounds, synthesis and uses |
| EP1196436A2 (en) * | 1999-07-07 | 2002-04-17 | Bristol-Myers Squibb Pharma Company | Peptide boronic acid inhibitors of hepatitis c virus protease |
| EP1863513A2 (en) * | 2005-03-11 | 2007-12-12 | The University of North Carolina at Chapel Hill | Potent and specific immunoproteasome inhibitors |
| EA201000774A1 (ru) * | 2007-11-13 | 2010-12-30 | Новартис Интернэшнл Фармасьютикл Лтд. | Ингибиторы бета-лактамазы |
| AR075090A1 (es) * | 2008-09-29 | 2011-03-09 | Millennium Pharm Inc | Derivados de acido 1-amino-2-ciclobutiletilboronico inhibidores de proteosoma,utiles como agentes anticancerigenos, y composiciones farmaceuticas que los comprenden. |
| US9359398B2 (en) * | 2010-03-01 | 2016-06-07 | Onyx Therapeutics, Inc. | Compounds for immunoproteasome inhibition |
| SG10201605152SA (en) * | 2011-12-22 | 2016-08-30 | Ares Trading Sa | Alpha-amino boronic acid derivatives, selective immunoproteasome inhibitors |
| JP6018319B2 (ja) * | 2012-12-03 | 2016-11-02 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | 置換トリアゾールボロン酸化合物 |
| AU2015327411B2 (en) | 2014-10-01 | 2020-01-02 | Merck Patent Gmbh | Boronic acid derivatives |
| JP6662865B2 (ja) | 2014-10-01 | 2020-03-11 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ | ボロン酸誘導体 |
| SG11201702623TA (en) | 2014-10-01 | 2017-04-27 | Merck Patent Gmbh | Boronic acid derivatives |
-
2015
- 2015-10-01 CA CA2963198A patent/CA2963198A1/en active Pending
- 2015-10-01 RU RU2017115191A patent/RU2017115191A/ru not_active Application Discontinuation
- 2015-10-01 CN CN201580053454.8A patent/CN107074885B/zh not_active Expired - Fee Related
- 2015-10-01 MX MX2017004043A patent/MX2017004043A/es unknown
- 2015-10-01 US US15/516,422 patent/US10253049B2/en active Active
- 2015-10-01 JP JP2017518064A patent/JP6896618B2/ja not_active Expired - Fee Related
- 2015-10-01 SG SG11201702620SA patent/SG11201702620SA/en unknown
- 2015-10-01 EP EP15800714.6A patent/EP3201208B1/en active Active
- 2015-10-01 BR BR112017006349A patent/BR112017006349A2/pt not_active IP Right Cessation
- 2015-10-01 ES ES15800714T patent/ES2876287T3/es active Active
- 2015-10-01 AU AU2015327412A patent/AU2015327412B2/en not_active Ceased
- 2015-10-01 WO PCT/EP2015/001931 patent/WO2016050356A1/en not_active Ceased
- 2015-10-01 KR KR1020177011646A patent/KR20170062518A/ko not_active Withdrawn
-
2017
- 2017-03-21 IL IL251299A patent/IL251299A0/en unknown
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