AU2015327412B2 - Boronic acid derivatives - Google Patents
Boronic acid derivatives Download PDFInfo
- Publication number
- AU2015327412B2 AU2015327412B2 AU2015327412A AU2015327412A AU2015327412B2 AU 2015327412 B2 AU2015327412 B2 AU 2015327412B2 AU 2015327412 A AU2015327412 A AU 2015327412A AU 2015327412 A AU2015327412 A AU 2015327412A AU 2015327412 B2 AU2015327412 B2 AU 2015327412B2
- Authority
- AU
- Australia
- Prior art keywords
- ethyl
- amino
- boronic acid
- denotes
- phenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 0 *CCC*CC(NC(B(O*)O*)**)=O Chemical compound *CCC*CC(NC(B(O*)O*)**)=O 0.000 description 5
- PYKFJTXFNSEJKN-FQEVSTJZSA-N CCN(CC(N[C@H](B(O)O)Cc1c(C)cc(C)cc1)=O)S(c1cccc(C)c1)(=O)=O Chemical compound CCN(CC(N[C@H](B(O)O)Cc1c(C)cc(C)cc1)=O)S(c1cccc(C)c1)(=O)=O PYKFJTXFNSEJKN-FQEVSTJZSA-N 0.000 description 2
- VSDKORBABKJQQS-UHFFFAOYSA-N C=C(CCS(c1ccccc1)(=O)=O)N Chemical compound C=C(CCS(c1ccccc1)(=O)=O)N VSDKORBABKJQQS-UHFFFAOYSA-N 0.000 description 1
- GVJFAUOIGORIIP-HNNXBMFYSA-N CCC(N(CC)CC(N[C@H](B(O)O)Cc1c(C)cc(C)cc1)=O)=O Chemical compound CCC(N(CC)CC(N[C@H](B(O)O)Cc1c(C)cc(C)cc1)=O)=O GVJFAUOIGORIIP-HNNXBMFYSA-N 0.000 description 1
- DDSGFMLMXIZLAP-OQLLNIDSSA-N CCN(CC(N/C(/B(O)O)=C/c1c[o]c2c(C)cccc12)=O)S(CC)(=O)=O Chemical compound CCN(CC(N/C(/B(O)O)=C/c1c[o]c2c(C)cccc12)=O)S(CC)(=O)=O DDSGFMLMXIZLAP-OQLLNIDSSA-N 0.000 description 1
- CXFGOGSYWFKMJT-UHFFFAOYSA-N CCN(CC(NC(B(O)O)Cc1c(C)cc(C)cc1)=O)S(c1c(C)cccc1)(=O)=O Chemical compound CCN(CC(NC(B(O)O)Cc1c(C)cc(C)cc1)=O)S(c1c(C)cccc1)(=O)=O CXFGOGSYWFKMJT-UHFFFAOYSA-N 0.000 description 1
- ORXZZQLTYXOLKA-UHFFFAOYSA-N CCN(CC(NC(B(O)O)Cc1c(C)cc(C)cc1)=O)S(c1ccc(C)cc1)(=O)=O Chemical compound CCN(CC(NC(B(O)O)Cc1c(C)cc(C)cc1)=O)S(c1ccc(C)cc1)(=O)=O ORXZZQLTYXOLKA-UHFFFAOYSA-N 0.000 description 1
- SJHCWXHQYVNCFJ-FQEVSTJZSA-N CCN(CC(N[C@H](B(O)O)Cc1c[o]c2c(C)cccc12)=O)S(c1ccc(C)cc1)(=O)=O Chemical compound CCN(CC(N[C@H](B(O)O)Cc1c[o]c2c(C)cccc12)=O)S(c1ccc(C)cc1)(=O)=O SJHCWXHQYVNCFJ-FQEVSTJZSA-N 0.000 description 1
- LSUOWQKQCOKYHB-UHFFFAOYSA-N CCOC(CCCC[NH+](C)[O-])=O Chemical compound CCOC(CCCC[NH+](C)[O-])=O LSUOWQKQCOKYHB-UHFFFAOYSA-N 0.000 description 1
- AIQWWVDEOPVPNJ-AWEZNQCLSA-N CCc1cccc(C[C@@H](B(O)O)NC(CCCS(C)(=O)=O)=O)c1 Chemical compound CCc1cccc(C[C@@H](B(O)O)NC(CCCS(C)(=O)=O)=O)c1 AIQWWVDEOPVPNJ-AWEZNQCLSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/025—Boronic and borinic acid compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/69—Boron compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Hematology (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14003391 | 2014-10-01 | ||
| EP14003391.1 | 2014-10-01 | ||
| PCT/EP2015/001931 WO2016050356A1 (en) | 2014-10-01 | 2015-10-01 | Boronic acid derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2015327412A1 AU2015327412A1 (en) | 2017-05-18 |
| AU2015327412B2 true AU2015327412B2 (en) | 2020-01-16 |
Family
ID=51690788
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2015327412A Ceased AU2015327412B2 (en) | 2014-10-01 | 2015-10-01 | Boronic acid derivatives |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US10253049B2 (enExample) |
| EP (1) | EP3201208B1 (enExample) |
| JP (1) | JP6896618B2 (enExample) |
| KR (1) | KR20170062518A (enExample) |
| CN (1) | CN107074885B (enExample) |
| AU (1) | AU2015327412B2 (enExample) |
| BR (1) | BR112017006349A2 (enExample) |
| CA (1) | CA2963198A1 (enExample) |
| ES (1) | ES2876287T3 (enExample) |
| IL (1) | IL251299A0 (enExample) |
| MX (1) | MX2017004043A (enExample) |
| RU (1) | RU2017115191A (enExample) |
| SG (1) | SG11201702620SA (enExample) |
| WO (1) | WO2016050356A1 (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2963186A1 (en) | 2014-10-01 | 2016-04-07 | Merck Patent Gmbh | Boronic acid derivatives |
| KR102457840B1 (ko) | 2014-10-01 | 2022-10-21 | 메르크 파텐트 게엠베하 | 보론산 유도체 |
| EP3201207B1 (en) | 2014-10-01 | 2021-02-24 | Merck Patent GmbH | Boronic acid derivatives |
| HRP20210663T1 (hr) * | 2017-01-18 | 2021-05-28 | Principia Biopharma Inc. | Inhibitori imunoproteasoma |
| KR20200040295A (ko) | 2017-08-24 | 2020-04-17 | 메르크 파텐트 게엠베하 | 보론산 유도체 |
| WO2019060651A1 (en) | 2017-09-21 | 2019-03-28 | Kezar Life Sciences | POLY THERAPY FOR IMMUNOLOGICAL DISEASES |
| CA3107377A1 (en) * | 2018-07-26 | 2020-01-30 | Merck Patent Gmbh | Boronic acid derivatives |
| CN113135943A (zh) * | 2020-01-19 | 2021-07-20 | 首药控股(北京)有限公司 | 硼酸衍生物 |
| CN113135944A (zh) * | 2020-01-19 | 2021-07-20 | 首药控股(北京)有限公司 | 硼酸衍生物 |
| EP4377324A1 (en) | 2021-07-29 | 2024-06-05 | Merck Patent GmbH | Novel crystalline forms of [(1r)-2-(1-benzofuran-3-yl)-1-{[(1s,2r,4r)-7- oxabicyclo[2.2.1]heptan-2-yl]formamido}ethyl]boronic acid, adducts thereof, and processes to obtain |
| EP4417614A4 (en) * | 2021-10-14 | 2025-05-28 | Shouyao Holdings (Beijing) Co., Ltd. | BORONIC ACID DERIVATIVE |
| CN117003776A (zh) * | 2022-04-29 | 2023-11-07 | 科辉智药生物科技(深圳)有限公司 | 一种硼酸类蛋白酶体抑制剂及其用途 |
| WO2023232830A1 (en) | 2022-06-02 | 2023-12-07 | Merck Patent Gmbh | Boronic acid adducts |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013092979A1 (en) * | 2011-12-22 | 2013-06-27 | Ares Trading S.A. | Alpha-amino boronic acid derivatives, selective immunoproteasome inhibitors |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL111175A0 (en) * | 1993-10-07 | 1994-12-29 | Du Pont Merck Pharma | Electrophilic peptide analogs as inhibitors of trypsin-like serine proteases and pharmaceutical compositions containing them |
| US6083903A (en) * | 1994-10-28 | 2000-07-04 | Leukosite, Inc. | Boronic ester and acid compounds, synthesis and uses |
| AU5920400A (en) * | 1999-07-07 | 2001-01-22 | Du Pont Pharmaceuticals Company | Cell-based assay systems for examining hcv ns3 protease activity |
| WO2006099261A2 (en) * | 2005-03-11 | 2006-09-21 | The University Of North Carolina At Chapel Hill | Potent and specific immunoproteasome inhibitors |
| AR069463A1 (es) * | 2007-11-13 | 2010-01-27 | Protez Pharmaceuticals Inc | Inhibidores de beta-lactamasa |
| AR075090A1 (es) * | 2008-09-29 | 2011-03-09 | Millennium Pharm Inc | Derivados de acido 1-amino-2-ciclobutiletilboronico inhibidores de proteosoma,utiles como agentes anticancerigenos, y composiciones farmaceuticas que los comprenden. |
| WO2011109355A1 (en) * | 2010-03-01 | 2011-09-09 | Onyx Therapeutics, Inc. | Compounds for immunoproteasome inhibition |
| WO2014086664A1 (en) * | 2012-12-03 | 2014-06-12 | F. Hoffmann-La Roche Ag | Substituted triazole boronic acid compounds |
| CA2963186A1 (en) | 2014-10-01 | 2016-04-07 | Merck Patent Gmbh | Boronic acid derivatives |
| EP3201207B1 (en) | 2014-10-01 | 2021-02-24 | Merck Patent GmbH | Boronic acid derivatives |
| KR102457840B1 (ko) | 2014-10-01 | 2022-10-21 | 메르크 파텐트 게엠베하 | 보론산 유도체 |
-
2015
- 2015-10-01 CA CA2963198A patent/CA2963198A1/en active Pending
- 2015-10-01 RU RU2017115191A patent/RU2017115191A/ru not_active Application Discontinuation
- 2015-10-01 US US15/516,422 patent/US10253049B2/en active Active
- 2015-10-01 BR BR112017006349A patent/BR112017006349A2/pt not_active IP Right Cessation
- 2015-10-01 WO PCT/EP2015/001931 patent/WO2016050356A1/en not_active Ceased
- 2015-10-01 SG SG11201702620SA patent/SG11201702620SA/en unknown
- 2015-10-01 KR KR1020177011646A patent/KR20170062518A/ko not_active Withdrawn
- 2015-10-01 AU AU2015327412A patent/AU2015327412B2/en not_active Ceased
- 2015-10-01 MX MX2017004043A patent/MX2017004043A/es unknown
- 2015-10-01 EP EP15800714.6A patent/EP3201208B1/en active Active
- 2015-10-01 ES ES15800714T patent/ES2876287T3/es active Active
- 2015-10-01 CN CN201580053454.8A patent/CN107074885B/zh not_active Expired - Fee Related
- 2015-10-01 JP JP2017518064A patent/JP6896618B2/ja not_active Expired - Fee Related
-
2017
- 2017-03-21 IL IL251299A patent/IL251299A0/en unknown
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013092979A1 (en) * | 2011-12-22 | 2013-06-27 | Ares Trading S.A. | Alpha-amino boronic acid derivatives, selective immunoproteasome inhibitors |
Also Published As
| Publication number | Publication date |
|---|---|
| EP3201208B1 (en) | 2021-03-24 |
| IL251299A0 (en) | 2017-05-29 |
| JP2018502048A (ja) | 2018-01-25 |
| AU2015327412A1 (en) | 2017-05-18 |
| US10253049B2 (en) | 2019-04-09 |
| EP3201208A1 (en) | 2017-08-09 |
| MX2017004043A (es) | 2017-07-04 |
| BR112017006349A2 (pt) | 2017-12-12 |
| SG11201702620SA (en) | 2017-04-27 |
| CN107074885B (zh) | 2020-11-27 |
| RU2017115191A (ru) | 2018-11-06 |
| RU2017115191A3 (enExample) | 2019-02-12 |
| US20180105538A1 (en) | 2018-04-19 |
| CN107074885A (zh) | 2017-08-18 |
| ES2876287T3 (es) | 2021-11-12 |
| CA2963198A1 (en) | 2016-04-07 |
| KR20170062518A (ko) | 2017-06-07 |
| WO2016050356A1 (en) | 2016-04-07 |
| JP6896618B2 (ja) | 2021-06-30 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AU2015327412B2 (en) | Boronic acid derivatives | |
| AU2015327411B2 (en) | Boronic acid derivatives | |
| AU2015327346B2 (en) | Boronic acid derivatives | |
| AU2015327345B2 (en) | Boronic acid derivatives | |
| EP2793900A1 (en) | Alpha-amino boronic acid derivatives, selective immunoproteasome inhibitors |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FGA | Letters patent sealed or granted (standard patent) | ||
| MK14 | Patent ceased section 143(a) (annual fees not paid) or expired |