JP2017536335A5 - - Google Patents
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- Publication number
- JP2017536335A5 JP2017536335A5 JP2017518100A JP2017518100A JP2017536335A5 JP 2017536335 A5 JP2017536335 A5 JP 2017536335A5 JP 2017518100 A JP2017518100 A JP 2017518100A JP 2017518100 A JP2017518100 A JP 2017518100A JP 2017536335 A5 JP2017536335 A5 JP 2017536335A5
- Authority
- JP
- Japan
- Prior art keywords
- hal
- independently
- substituted
- sor
- cor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000000623 heterocyclic group Chemical group 0.000 claims description 9
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims description 6
- 125000003118 aryl group Chemical group 0.000 claims description 5
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 5
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims description 4
- 125000004434 sulfur atom Chemical group 0.000 claims description 4
- 125000004433 nitrogen atom Chemical group N* 0.000 claims description 3
- 125000004430 oxygen atom Chemical group O* 0.000 claims description 3
- 229920006395 saturated elastomer Polymers 0.000 claims description 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 3
- 125000002619 bicyclic group Chemical group 0.000 claims 2
- ZUOUZKKEUPVFJK-UHFFFAOYSA-N diphenyl Chemical compound C1=CC=CC=C1C1=CC=CC=C1 ZUOUZKKEUPVFJK-UHFFFAOYSA-N 0.000 claims 2
- 150000002430 hydrocarbons Chemical group 0.000 claims 2
- 101100118680 Caenorhabditis elegans sec-61.G gene Proteins 0.000 claims 1
- 239000004215 Carbon black (E152) Substances 0.000 claims 1
- 102100030978 Cytochrome c oxidase assembly factor 1 homolog Human genes 0.000 claims 1
- 101000919635 Homo sapiens Cytochrome c oxidase assembly factor 1 homolog Proteins 0.000 claims 1
- 235000010290 biphenyl Nutrition 0.000 claims 1
- 239000004305 biphenyl Substances 0.000 claims 1
- 229930195733 hydrocarbon Natural products 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 125000002950 monocyclic group Chemical group 0.000 claims 1
- -1 monocyclic hydrocarbon Chemical class 0.000 claims 1
- 125000001624 naphthyl group Chemical group 0.000 claims 1
- 229940002612 prodrug Drugs 0.000 claims 1
- 239000000651 prodrug Substances 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000012453 solvate Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14003392.9 | 2014-10-01 | ||
| EP14003392 | 2014-10-01 | ||
| PCT/EP2015/002008 WO2016050359A1 (en) | 2014-10-01 | 2015-10-01 | Boronic acid derivatives |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017536335A JP2017536335A (ja) | 2017-12-07 |
| JP2017536335A5 true JP2017536335A5 (enExample) | 2019-10-17 |
| JP6835711B2 JP6835711B2 (ja) | 2021-02-24 |
Family
ID=51690789
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017518100A Expired - Fee Related JP6835711B2 (ja) | 2014-10-01 | 2015-10-01 | ボロン酸誘導体 |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US10294246B2 (enExample) |
| EP (1) | EP3201207B1 (enExample) |
| JP (1) | JP6835711B2 (enExample) |
| KR (1) | KR102450583B1 (enExample) |
| CN (1) | CN107001390B (enExample) |
| AU (1) | AU2015327346B2 (enExample) |
| BR (1) | BR112017006420A2 (enExample) |
| CA (1) | CA2963205A1 (enExample) |
| ES (1) | ES2873000T3 (enExample) |
| IL (1) | IL251301B (enExample) |
| MX (1) | MX370336B (enExample) |
| RU (1) | RU2017115188A (enExample) |
| SG (1) | SG11201702623TA (enExample) |
| WO (1) | WO2016050359A1 (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3201208B1 (en) | 2014-10-01 | 2021-03-24 | Merck Patent GmbH | Boronic acid derivatives |
| CN107001391B (zh) | 2014-10-01 | 2020-11-27 | 默克专利股份公司 | 硼酸衍生物 |
| EP3201205B1 (en) | 2014-10-01 | 2020-05-13 | Merck Patent GmbH | Boronic acid derivatives |
| US11274109B2 (en) | 2017-08-24 | 2022-03-15 | Merck Patent Gmbh | Boronic acid derivatives |
| IL280376B2 (en) * | 2018-07-26 | 2024-08-01 | Merck Patent Gmbh | Boronic acid derivatives, their preparation and pharmaceutical compositions containing them |
| CN113135944A (zh) * | 2020-01-19 | 2021-07-20 | 首药控股(北京)有限公司 | 硼酸衍生物 |
| CN113135943A (zh) * | 2020-01-19 | 2021-07-20 | 首药控股(北京)有限公司 | 硼酸衍生物 |
| WO2022187362A1 (en) * | 2021-03-02 | 2022-09-09 | Case Western Reserve University | Β-lactamase inhibitors and uses thereof |
| CN117320550A (zh) * | 2021-05-19 | 2023-12-29 | 先正达农作物保护股份公司 | 杂草控制方法 |
| EP4377324A1 (en) | 2021-07-29 | 2024-06-05 | Merck Patent GmbH | Novel crystalline forms of [(1r)-2-(1-benzofuran-3-yl)-1-{[(1s,2r,4r)-7- oxabicyclo[2.2.1]heptan-2-yl]formamido}ethyl]boronic acid, adducts thereof, and processes to obtain |
| US20240425529A1 (en) * | 2021-10-14 | 2024-12-26 | Shouyao Holdings (beijing) Co., Ltd. | Boric acid derivative |
| WO2023232830A1 (en) | 2022-06-02 | 2023-12-07 | Merck Patent Gmbh | Boronic acid adducts |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL111175A0 (en) * | 1993-10-07 | 1994-12-29 | Du Pont Merck Pharma | Electrophilic peptide analogs as inhibitors of trypsin-like serine proteases and pharmaceutical compositions containing them |
| AU5920400A (en) * | 1999-07-07 | 2001-01-22 | Du Pont Pharmaceuticals Company | Cell-based assay systems for examining hcv ns3 protease activity |
| US7271186B1 (en) * | 2002-12-09 | 2007-09-18 | Northwestern University | Nanomolar β-lactamase inhibitors |
| JP2011504468A (ja) * | 2007-11-13 | 2011-02-10 | プロテズ・ファーマシューティカルズ・インコーポレイテッド | β−ラクタマーゼ阻害剤 |
| AR075090A1 (es) * | 2008-09-29 | 2011-03-09 | Millennium Pharm Inc | Derivados de acido 1-amino-2-ciclobutiletilboronico inhibidores de proteosoma,utiles como agentes anticancerigenos, y composiciones farmaceuticas que los comprenden. |
| SG11201403254QA (en) * | 2011-12-22 | 2014-07-30 | Ares Trading Sa | Alpha-amino boronic acid derivatives, selective immunoproteasome inhibitors |
| EP3201208B1 (en) | 2014-10-01 | 2021-03-24 | Merck Patent GmbH | Boronic acid derivatives |
| CN107001391B (zh) | 2014-10-01 | 2020-11-27 | 默克专利股份公司 | 硼酸衍生物 |
| EP3201205B1 (en) | 2014-10-01 | 2020-05-13 | Merck Patent GmbH | Boronic acid derivatives |
-
2015
- 2015-10-01 US US15/516,424 patent/US10294246B2/en active Active
- 2015-10-01 WO PCT/EP2015/002008 patent/WO2016050359A1/en not_active Ceased
- 2015-10-01 CA CA2963205A patent/CA2963205A1/en active Pending
- 2015-10-01 BR BR112017006420A patent/BR112017006420A2/pt active Search and Examination
- 2015-10-01 RU RU2017115188A patent/RU2017115188A/ru not_active Application Discontinuation
- 2015-10-01 SG SG11201702623TA patent/SG11201702623TA/en unknown
- 2015-10-01 MX MX2017004046A patent/MX370336B/es active IP Right Grant
- 2015-10-01 CN CN201580053425.1A patent/CN107001390B/zh not_active Expired - Fee Related
- 2015-10-01 EP EP15780765.2A patent/EP3201207B1/en active Active
- 2015-10-01 AU AU2015327346A patent/AU2015327346B2/en not_active Ceased
- 2015-10-01 ES ES15780765T patent/ES2873000T3/es active Active
- 2015-10-01 JP JP2017518100A patent/JP6835711B2/ja not_active Expired - Fee Related
- 2015-10-01 KR KR1020177011643A patent/KR102450583B1/ko active Active
-
2017
- 2017-03-21 IL IL251301A patent/IL251301B/en unknown
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