JP2017536335A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2017536335A5 JP2017536335A5 JP2017518100A JP2017518100A JP2017536335A5 JP 2017536335 A5 JP2017536335 A5 JP 2017536335A5 JP 2017518100 A JP2017518100 A JP 2017518100A JP 2017518100 A JP2017518100 A JP 2017518100A JP 2017536335 A5 JP2017536335 A5 JP 2017536335A5
- Authority
- JP
- Japan
- Prior art keywords
- hal
- independently
- substituted
- sor
- cor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000000623 heterocyclic group Chemical group 0.000 claims description 9
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims description 6
- 125000003118 aryl group Chemical group 0.000 claims description 5
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 5
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims description 4
- 125000004434 sulfur atom Chemical group 0.000 claims description 4
- 125000004433 nitrogen atom Chemical group N* 0.000 claims description 3
- 125000004430 oxygen atom Chemical group O* 0.000 claims description 3
- 229920006395 saturated elastomer Polymers 0.000 claims description 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 3
- 125000002619 bicyclic group Chemical group 0.000 claims 2
- ZUOUZKKEUPVFJK-UHFFFAOYSA-N diphenyl Chemical compound C1=CC=CC=C1C1=CC=CC=C1 ZUOUZKKEUPVFJK-UHFFFAOYSA-N 0.000 claims 2
- 150000002430 hydrocarbons Chemical group 0.000 claims 2
- 101100118680 Caenorhabditis elegans sec-61.G gene Proteins 0.000 claims 1
- 239000004215 Carbon black (E152) Substances 0.000 claims 1
- 102100030978 Cytochrome c oxidase assembly factor 1 homolog Human genes 0.000 claims 1
- 101000919635 Homo sapiens Cytochrome c oxidase assembly factor 1 homolog Proteins 0.000 claims 1
- 235000010290 biphenyl Nutrition 0.000 claims 1
- 239000004305 biphenyl Substances 0.000 claims 1
- 229930195733 hydrocarbon Natural products 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 125000002950 monocyclic group Chemical group 0.000 claims 1
- -1 monocyclic hydrocarbon Chemical class 0.000 claims 1
- 125000001624 naphthyl group Chemical group 0.000 claims 1
- 229940002612 prodrug Drugs 0.000 claims 1
- 239000000651 prodrug Substances 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000012453 solvate Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14003392.9 | 2014-10-01 | ||
| EP14003392 | 2014-10-01 | ||
| PCT/EP2015/002008 WO2016050359A1 (en) | 2014-10-01 | 2015-10-01 | Boronic acid derivatives |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017536335A JP2017536335A (ja) | 2017-12-07 |
| JP2017536335A5 true JP2017536335A5 (enExample) | 2019-10-17 |
| JP6835711B2 JP6835711B2 (ja) | 2021-02-24 |
Family
ID=51690789
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017518100A Expired - Fee Related JP6835711B2 (ja) | 2014-10-01 | 2015-10-01 | ボロン酸誘導体 |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US10294246B2 (enExample) |
| EP (1) | EP3201207B1 (enExample) |
| JP (1) | JP6835711B2 (enExample) |
| KR (1) | KR102450583B1 (enExample) |
| CN (1) | CN107001390B (enExample) |
| AU (1) | AU2015327346B2 (enExample) |
| BR (1) | BR112017006420A2 (enExample) |
| CA (1) | CA2963205A1 (enExample) |
| ES (1) | ES2873000T3 (enExample) |
| IL (1) | IL251301B (enExample) |
| MX (1) | MX370336B (enExample) |
| RU (1) | RU2017115188A (enExample) |
| SG (1) | SG11201702623TA (enExample) |
| WO (1) | WO2016050359A1 (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2015327411B2 (en) | 2014-10-01 | 2020-01-02 | Merck Patent Gmbh | Boronic acid derivatives |
| CA2963198A1 (en) | 2014-10-01 | 2016-04-07 | Merck Patent Gmbh | Boronic acid derivatives |
| JP6662865B2 (ja) | 2014-10-01 | 2020-03-11 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ | ボロン酸誘導体 |
| WO2019038250A1 (en) | 2017-08-24 | 2019-02-28 | Merck Patent Gmbh | Boronic acid derivatives |
| CN112469480A (zh) * | 2018-07-26 | 2021-03-09 | 默克专利股份公司 | 硼酸衍生物 |
| CN113135943A (zh) * | 2020-01-19 | 2021-07-20 | 首药控股(北京)有限公司 | 硼酸衍生物 |
| CN113135944A (zh) * | 2020-01-19 | 2021-07-20 | 首药控股(北京)有限公司 | 硼酸衍生物 |
| US20250340577A1 (en) * | 2021-03-02 | 2025-11-06 | Case Western Reserve University | Beta-lactomase inhibitors and uses thereof |
| WO2022243155A1 (en) * | 2021-05-19 | 2022-11-24 | Syngenta Crop Protection Ag | Weed control method |
| IL310390A (en) | 2021-07-29 | 2024-03-01 | Merck Patent Gmbh | Crystalline forms of [(1r)-2-(1-benzofuran-3-yl)-1-{[(1s,2r,4r)-7- oxabicyclo[2.2.1]heptan-2-yl]formamido}ethyl]boronic acid, adducts thereof, and processes to obtain |
| KR20240090392A (ko) * | 2021-10-14 | 2024-06-21 | 쇼우야오 홀딩스 (베이징) 코., 엘티디. | 보론산 유도체 |
| WO2023232830A1 (en) | 2022-06-02 | 2023-12-07 | Merck Patent Gmbh | Boronic acid adducts |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL111175A0 (en) * | 1993-10-07 | 1994-12-29 | Du Pont Merck Pharma | Electrophilic peptide analogs as inhibitors of trypsin-like serine proteases and pharmaceutical compositions containing them |
| EP1196436A2 (en) * | 1999-07-07 | 2002-04-17 | Bristol-Myers Squibb Pharma Company | Peptide boronic acid inhibitors of hepatitis c virus protease |
| US7271186B1 (en) | 2002-12-09 | 2007-09-18 | Northwestern University | Nanomolar β-lactamase inhibitors |
| EA201000774A1 (ru) * | 2007-11-13 | 2010-12-30 | Новартис Интернэшнл Фармасьютикл Лтд. | Ингибиторы бета-лактамазы |
| AR075090A1 (es) * | 2008-09-29 | 2011-03-09 | Millennium Pharm Inc | Derivados de acido 1-amino-2-ciclobutiletilboronico inhibidores de proteosoma,utiles como agentes anticancerigenos, y composiciones farmaceuticas que los comprenden. |
| SG10201605152SA (en) * | 2011-12-22 | 2016-08-30 | Ares Trading Sa | Alpha-amino boronic acid derivatives, selective immunoproteasome inhibitors |
| AU2015327411B2 (en) | 2014-10-01 | 2020-01-02 | Merck Patent Gmbh | Boronic acid derivatives |
| CA2963198A1 (en) | 2014-10-01 | 2016-04-07 | Merck Patent Gmbh | Boronic acid derivatives |
| JP6662865B2 (ja) | 2014-10-01 | 2020-03-11 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ | ボロン酸誘導体 |
-
2015
- 2015-10-01 SG SG11201702623TA patent/SG11201702623TA/en unknown
- 2015-10-01 CN CN201580053425.1A patent/CN107001390B/zh not_active Expired - Fee Related
- 2015-10-01 EP EP15780765.2A patent/EP3201207B1/en active Active
- 2015-10-01 JP JP2017518100A patent/JP6835711B2/ja not_active Expired - Fee Related
- 2015-10-01 CA CA2963205A patent/CA2963205A1/en active Pending
- 2015-10-01 WO PCT/EP2015/002008 patent/WO2016050359A1/en not_active Ceased
- 2015-10-01 ES ES15780765T patent/ES2873000T3/es active Active
- 2015-10-01 RU RU2017115188A patent/RU2017115188A/ru not_active Application Discontinuation
- 2015-10-01 MX MX2017004046A patent/MX370336B/es active IP Right Grant
- 2015-10-01 KR KR1020177011643A patent/KR102450583B1/ko active Active
- 2015-10-01 BR BR112017006420A patent/BR112017006420A2/pt active Search and Examination
- 2015-10-01 AU AU2015327346A patent/AU2015327346B2/en not_active Ceased
- 2015-10-01 US US15/516,424 patent/US10294246B2/en active Active
-
2017
- 2017-03-21 IL IL251301A patent/IL251301B/en unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2017536335A5 (enExample) | ||
| JP2018502048A5 (enExample) | ||
| CY1122821T1 (el) | Παραγωγα 1,3-βενζοδιοξολιου ως αναστολεις εζη1 ή/και εζη2 | |
| AR106605A1 (es) | Oxadiazoles sustituidos para combatir hongos fitopatógenos | |
| AR119454A2 (es) | COMPUESTOS ÚTILES COMO MODULADORES DE RORg, SALES FARMACÉUTICAMENTE ACEPTABLES DE LOS MISMOS, COMPOSICIONES FARMACÉUTICAS Y DICHOS COMPUESTOS PARA USO COMO MEDICAMENTO | |
| EA201891191A1 (ru) | 2-замещенные соединения хиназолина, содержащие замещенную гетероциклическую группу, и способы их применения | |
| HRP20191524T1 (hr) | Spojevi n-((het)arilmetil)-heteroaril-karboksamida kao inhibitori kalikreina plazme | |
| PE20190258A1 (es) | Antagonistas del receptor de la apelina (apj) mejorados y usos de los mismos | |
| EA201892710A1 (ru) | Карбамоилоксиметилтриазолциклогексильные кислоты в качестве антагонистов lpa | |
| AR109788A1 (es) | Compuestos de benzo[b]tiofeno como agonistas de sting | |
| UY36275A (es) | Compuestos aminopirimidinilo | |
| EA201692266A1 (ru) | Ингибиторы фосфатидилинозитол-3-киназы | |
| AR106763A1 (es) | Oxadiazoles sustituidos para combatir hongos fitopatógenos | |
| MX379155B (es) | Compuestos que inhiben la proteína mcl-1. | |
| EA202091505A1 (ru) | Триазолазолы циклогексильной кислоты в качестве антагонистов lpa | |
| MX380928B (es) | Inhibidores de kras g12c. | |
| CL2015003298A1 (es) | Novedosas heteroarildihidropirimidinas unidas por puentes en 6 para el tratamiento y la profilaxis de infeccion por el virus de la hepatitis b | |
| AR099111A1 (es) | Derivados de azepano y su uso para tratar infecciones de hepatitis b | |
| EA201791304A1 (ru) | Производные изохинолина для лечения вич | |
| PE20180232A1 (es) | Derivados de indol mono o disustituidos como inhibidores de la replicacion viral del dengue | |
| AR104963A1 (es) | Derivados de 2-(pirazolopiridin-3-il)pirimidina como inhibidores de jak | |
| EA201692265A1 (ru) | Ингибиторы фосфатидилинозитол-3-киназы | |
| AR106138A1 (es) | Compuestos y métodos para inhibir jak | |
| EA201691670A1 (ru) | Тетразолонзамещенные дигидропиридиноновые ингибиторы mgat2 | |
| AR099160A1 (es) | Compuestos y composiciones farmacéuticas de los mismos para el tratamiento de trastornos inflamatorios |