JP2017530959A5 - - Google Patents

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Publication number
JP2017530959A5
JP2017530959A5 JP2017514627A JP2017514627A JP2017530959A5 JP 2017530959 A5 JP2017530959 A5 JP 2017530959A5 JP 2017514627 A JP2017514627 A JP 2017514627A JP 2017514627 A JP2017514627 A JP 2017514627A JP 2017530959 A5 JP2017530959 A5 JP 2017530959A5
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JP
Japan
Prior art keywords
unsubstituted
substituted
alkyl
haloalkyl
hydrogen
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Application number
JP2017514627A
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English (en)
Japanese (ja)
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JP2017530959A (ja
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Priority claimed from PCT/US2015/050712 external-priority patent/WO2016044604A1/en
Publication of JP2017530959A publication Critical patent/JP2017530959A/ja
Publication of JP2017530959A5 publication Critical patent/JP2017530959A5/ja
Withdrawn legal-status Critical Current

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JP2017514627A 2014-09-17 2015-09-17 Carm1阻害剤およびその使用 Withdrawn JP2017530959A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462051872P 2014-09-17 2014-09-17
US62/051,872 2014-09-17
PCT/US2015/050712 WO2016044604A1 (en) 2014-09-17 2015-09-17 Carm1 inhibitors and uses thereof

Publications (2)

Publication Number Publication Date
JP2017530959A JP2017530959A (ja) 2017-10-19
JP2017530959A5 true JP2017530959A5 (enExample) 2018-11-01

Family

ID=55533856

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2017514627A Withdrawn JP2017530959A (ja) 2014-09-17 2015-09-17 Carm1阻害剤およびその使用

Country Status (4)

Country Link
US (1) US20170305922A1 (enExample)
EP (1) EP3193608A4 (enExample)
JP (1) JP2017530959A (enExample)
WO (1) WO2016044604A1 (enExample)

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JP2016505000A (ja) 2012-12-21 2016-02-18 エピザイム,インコーポレイティド Prmt5阻害剤およびその使用
MY199894A (en) 2012-12-21 2023-11-27 Epizyme Inc Prmt5 inhibitors and uses thereof
JP2016505002A (ja) 2012-12-21 2016-02-18 エピザイム,インコーポレイティド ジヒドロイソキノリンまたはテトラヒドロイソキノリンを含有するprmt5阻害剤およびその使用
WO2014144659A1 (en) 2013-03-14 2014-09-18 Epizyme, Inc. Pyrazole derivatives as prmt1 inhibitors and uses thereof
AU2014260433A1 (en) 2013-03-14 2015-09-10 Epizyme, Inc. Pyrazole derivatives as arginine methyltransferase inhibitors and uses thereof
EP2970136A1 (en) 2013-03-14 2016-01-20 Epizyme, Inc. Arginine methyl transferase inhibtors and uses thereof
SG11201506972PA (en) 2013-03-14 2015-10-29 Epizyme Inc Arginine methyltransferase inhibitors and uses thereof
US9120757B2 (en) 2013-03-14 2015-09-01 Epizyme, Inc. Arginine methyltransferase inhibitors and uses thereof
WO2014153208A1 (en) 2013-03-14 2014-09-25 Epizyme, Inc. Arginine methyltransferase inhibitors and uses thereof
KR20160003647A (ko) 2013-03-15 2016-01-11 에피자임, 인코포레이티드 Carm1 억제제 및 이의 용도
EP2970266B1 (en) 2013-03-15 2018-01-31 Epizyme, Inc. 1-phenoxy-3-(alkylamino)-propan-2-ol derivatives as carm1 inhibitors and uses thereof
TWI659021B (zh) 2013-10-10 2019-05-11 亞瑞克西斯製藥公司 Kras g12c之抑制劑
CA2953572A1 (en) 2014-08-04 2016-02-11 Epizyme, Inc. Prmt5 inhibitors and uses thereof
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US20180179201A1 (en) 2016-12-22 2018-06-28 Incyte Corporation Heterocyclic compounds as immunomodulators
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EP3558973B1 (en) 2016-12-22 2021-09-15 Incyte Corporation Pyridine derivatives as immunomodulators
MY197501A (en) 2016-12-22 2023-06-19 Incyte Corp Tetrahydro imidazo[4,5-c]pyridine derivatives as pd-l1 internalization inducers
WO2018140512A1 (en) 2017-01-26 2018-08-02 Araxes Pharma Llc Fused bicyclic benzoheteroaromatic compounds and methods of use thereof
US11279689B2 (en) 2017-01-26 2022-03-22 Araxes Pharma Llc 1-(3-(6-(3-hydroxynaphthalen-1-yl)benzofuran-2-yl)azetidin-1 yl)prop-2-en-1-one derivatives and similar compounds as KRAS G12C modulators for treating cancer
WO2018140514A1 (en) 2017-01-26 2018-08-02 Araxes Pharma Llc 1-(6-(3-hydroxynaphthalen-1-yl)quinazolin-2-yl)azetidin-1-yl)prop-2-en-1-one derivatives and similar compounds as kras g12c inhibitors for the treatment of cancer
US11358959B2 (en) 2017-01-26 2022-06-14 Araxes Pharma Llc Benzothiophene and benzothiazole compounds and methods of use thereof
EP3573967A1 (en) 2017-01-26 2019-12-04 Araxes Pharma LLC Fused hetero-hetero bicyclic compounds and methods of use thereof
KR102007135B1 (ko) 2017-03-20 2019-08-02 포르마 세라퓨틱스 인크. 피루베이트 키나제 (pkr) 활성화제로서의 피롤로피롤 조성물
CN110831933A (zh) 2017-05-25 2020-02-21 亚瑞克西斯制药公司 喹唑啉衍生物作为突变kras、hras或nras的调节剂
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EP4212529B1 (en) 2018-03-30 2025-01-29 Incyte Corporation Heterocyclic compounds as immunomodulators
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EP3829580A1 (en) * 2018-08-01 2021-06-09 Araxes Pharma LLC Heterocyclic spiro compounds and methods of use thereof for the treatment of cancer
EP3852791B1 (en) 2018-09-19 2024-07-03 Novo Nordisk Health Care AG Activating pyruvate kinase r
US20200129485A1 (en) 2018-09-19 2020-04-30 Forma Therapeutics, Inc. Treating sickle cell disease with a pyruvate kinase r activating compound
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CA3150434A1 (en) 2019-08-09 2021-02-18 Incyte Corporation Salts of a pd-1/pd-l1 inhibitor
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KR20160003647A (ko) * 2013-03-15 2016-01-11 에피자임, 인코포레이티드 Carm1 억제제 및 이의 용도
WO2016044641A2 (en) * 2014-09-17 2016-03-24 Epizyme, Inc. Carm1 inhibitors and uses thereof

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