JP2014513534A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2014513534A5 JP2014513534A5 JP2014506607A JP2014506607A JP2014513534A5 JP 2014513534 A5 JP2014513534 A5 JP 2014513534A5 JP 2014506607 A JP2014506607 A JP 2014506607A JP 2014506607 A JP2014506607 A JP 2014506607A JP 2014513534 A5 JP2014513534 A5 JP 2014513534A5
- Authority
- JP
- Japan
- Prior art keywords
- temperature
- dna polymerase
- nucleic acid
- template
- target sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims 51
- 108010014303 DNA-directed DNA polymerase Proteins 0.000 claims 18
- 102000016928 DNA-directed DNA polymerase Human genes 0.000 claims 18
- 108020004707 nucleic acids Proteins 0.000 claims 17
- 102000039446 nucleic acids Human genes 0.000 claims 17
- 150000007523 nucleic acids Chemical class 0.000 claims 17
- 230000003321 amplification Effects 0.000 claims 10
- 238000003199 nucleic acid amplification method Methods 0.000 claims 10
- 239000011541 reaction mixture Substances 0.000 claims 9
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims 8
- 150000001768 cations Chemical class 0.000 claims 8
- 102100034343 Integrase Human genes 0.000 claims 6
- 108010092799 RNA-directed DNA polymerase Proteins 0.000 claims 6
- 102000023732 binding proteins Human genes 0.000 claims 6
- 108091008324 binding proteins Proteins 0.000 claims 6
- 238000006243 chemical reaction Methods 0.000 claims 5
- 230000000694 effects Effects 0.000 claims 5
- 150000003839 salts Chemical class 0.000 claims 5
- ZHNUHDYFZUAESO-UHFFFAOYSA-N Formamide Chemical compound NC=O ZHNUHDYFZUAESO-UHFFFAOYSA-N 0.000 claims 4
- 239000003795 chemical substances by application Substances 0.000 claims 4
- 230000000368 destabilizing effect Effects 0.000 claims 4
- 238000002844 melting Methods 0.000 claims 4
- 230000008018 melting Effects 0.000 claims 4
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 3
- 108020004414 DNA Proteins 0.000 claims 3
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 claims 2
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 claims 2
- 102000053602 DNA Human genes 0.000 claims 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims 2
- WHXSMMKQMYFTQS-UHFFFAOYSA-N Lithium Chemical compound [Li] WHXSMMKQMYFTQS-UHFFFAOYSA-N 0.000 claims 2
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 claims 2
- 108010010677 Phosphodiesterase I Proteins 0.000 claims 2
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 claims 2
- 108010006785 Taq Polymerase Proteins 0.000 claims 2
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims 2
- 229910052792 caesium Inorganic materials 0.000 claims 2
- TVFDJXOCXUVLDH-UHFFFAOYSA-N caesium atom Chemical compound [Cs] TVFDJXOCXUVLDH-UHFFFAOYSA-N 0.000 claims 2
- 230000000295 complement effect Effects 0.000 claims 2
- 229910052802 copper Inorganic materials 0.000 claims 2
- 239000010949 copper Substances 0.000 claims 2
- 238000006073 displacement reaction Methods 0.000 claims 2
- 229910052744 lithium Inorganic materials 0.000 claims 2
- 239000011777 magnesium Substances 0.000 claims 2
- 229910052749 magnesium Inorganic materials 0.000 claims 2
- WPBNNNQJVZRUHP-UHFFFAOYSA-L manganese(2+);methyl n-[[2-(methoxycarbonylcarbamothioylamino)phenyl]carbamothioyl]carbamate;n-[2-(sulfidocarbothioylamino)ethyl]carbamodithioate Chemical compound [Mn+2].[S-]C(=S)NCCNC([S-])=S.COC(=O)NC(=S)NC1=CC=CC=C1NC(=S)NC(=O)OC WPBNNNQJVZRUHP-UHFFFAOYSA-L 0.000 claims 2
- 229910052700 potassium Inorganic materials 0.000 claims 2
- 239000011591 potassium Substances 0.000 claims 2
- 229910052701 rubidium Inorganic materials 0.000 claims 2
- IGLNJRXAVVLDKE-UHFFFAOYSA-N rubidium atom Chemical compound [Rb] IGLNJRXAVVLDKE-UHFFFAOYSA-N 0.000 claims 2
- 229910052708 sodium Inorganic materials 0.000 claims 2
- 239000011734 sodium Substances 0.000 claims 2
- 239000011701 zinc Substances 0.000 claims 2
- 229910052725 zinc Inorganic materials 0.000 claims 2
- 102000040650 (ribonucleotides)n+m Human genes 0.000 claims 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 1
- 108020004682 Single-Stranded DNA Proteins 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161477437P | 2011-04-20 | 2011-04-20 | |
| US201161477357P | 2011-04-20 | 2011-04-20 | |
| US61/477,437 | 2011-04-20 | ||
| US61/477,357 | 2011-04-20 | ||
| PCT/US2012/034589 WO2012145725A2 (en) | 2011-04-20 | 2012-04-20 | Oscillating amplification reaction for nucleic acids |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014513534A JP2014513534A (ja) | 2014-06-05 |
| JP2014513534A5 true JP2014513534A5 (enExample) | 2014-12-04 |
| JP5731066B2 JP5731066B2 (ja) | 2015-06-10 |
Family
ID=47042196
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014506611A Active JP5879667B2 (ja) | 2011-04-20 | 2012-04-20 | 核酸の検出および同定のための一体型デバイス |
| JP2014506607A Active JP5731066B2 (ja) | 2011-04-20 | 2012-04-20 | 核酸のための周期変動性増幅反応 |
| JP2015185214A Active JP6014227B2 (ja) | 2011-04-20 | 2015-09-18 | 核酸の検出および同定のための一体型デバイス |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014506611A Active JP5879667B2 (ja) | 2011-04-20 | 2012-04-20 | 核酸の検出および同定のための一体型デバイス |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015185214A Active JP6014227B2 (ja) | 2011-04-20 | 2015-09-18 | 核酸の検出および同定のための一体型デバイス |
Country Status (10)
| Country | Link |
|---|---|
| US (9) | US10519492B2 (enExample) |
| EP (2) | EP2699700B8 (enExample) |
| JP (3) | JP5879667B2 (enExample) |
| KR (3) | KR101508670B1 (enExample) |
| CN (2) | CN103649333B (enExample) |
| CA (2) | CA2853615C (enExample) |
| DK (2) | DK2699698T4 (enExample) |
| ES (2) | ES2583135T3 (enExample) |
| PT (1) | PT2699698T (enExample) |
| WO (2) | WO2012145725A2 (enExample) |
Families Citing this family (75)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008105814A2 (en) | 2006-08-22 | 2008-09-04 | Los Alamos National Security, Llc | Miniturized lateral flow device for rapid and sensitive detection of proteins or nucleic acids |
| CN101903535A (zh) | 2007-03-28 | 2010-12-01 | 信号诊断公司 | 高解析度分析核酸以检测序列变异的系统和方法 |
| US10669574B2 (en) | 2008-11-18 | 2020-06-02 | XCR Diagnostics, Inc. | DNA amplification technology |
| US8837159B1 (en) * | 2009-10-28 | 2014-09-16 | Amazon Technologies, Inc. | Low-profile circuit board assembly |
| ES2583135T3 (es) * | 2011-04-20 | 2016-09-19 | Mesa Biotech, Inc. | Dispositivo integrado para la detección e identificación de ácidos nucleicos |
| US9758837B2 (en) * | 2011-08-02 | 2017-09-12 | The United States Of America, As Represented By The Secretary Of Agriculture | Sensitive and rapid method for Candidatus Liberibacter species detection |
| US9121046B2 (en) * | 2011-11-16 | 2015-09-01 | New England Biolabs, Inc. | Reducing template independent primer extension and threshold time for loop mediated isothermal amplification |
| EP3027729A4 (en) * | 2013-07-29 | 2017-04-05 | MBIO Diagnostics Inc. | Assay cartridge processing systems and methods and associated assay cartridges |
| ES2925313T3 (es) | 2013-10-09 | 2022-10-14 | Fluoresentric Inc | Método para la detección de secuencias de ácido nucleico diana |
| US10195610B2 (en) | 2014-03-10 | 2019-02-05 | Click Diagnostics, Inc. | Cartridge-based thermocycler |
| KR101809645B1 (ko) | 2014-05-30 | 2017-12-15 | 주식회사 이지다이아텍 | 자동 면역분석 수행장치 |
| KR102466599B1 (ko) * | 2014-06-18 | 2022-11-16 | 조에티스 덴마크 에이피에스 | 미세유체 검출 시스템 및 미세유체 카트리지 |
| CN106536704B (zh) * | 2014-07-08 | 2020-03-06 | 国立研究开发法人产业技术综合研究所 | 核酸扩增装置、核酸扩增方法以及核酸扩增用芯片 |
| DE102014015586B3 (de) * | 2014-10-21 | 2016-03-31 | Webasto SE | Heizgerät |
| JP6778194B2 (ja) | 2014-12-31 | 2020-10-28 | ビスビュー メディカル，インコーポレイテッド | 分子診断試験のためのデバイス及び方法 |
| US9671303B2 (en) * | 2015-03-10 | 2017-06-06 | Ford Global Technologies, Llc | Method and system for laser pressure transducer |
| WO2016172724A1 (en) * | 2015-04-24 | 2016-10-27 | Mesa Biotech, Inc. | Fluidic test cassette |
| DE102015110092B4 (de) * | 2015-06-23 | 2017-08-10 | Endress + Hauser Gmbh + Co. Kg | Feldgerät zum Einsatz in hygienischen Anwendungen in der Prozess- und Automatisierungstechnik und Verfahren zu dessen Herstellung |
| US10775370B2 (en) * | 2015-07-17 | 2020-09-15 | Stat-Diagnostica & Innovation, S.L. | Fluidic system for performing assays |
| US10040069B2 (en) | 2015-07-23 | 2018-08-07 | General Electric Company | Amplification and detection of nucleic acids |
| DK3430378T3 (da) * | 2016-03-14 | 2022-10-24 | Lucira Health Inc | Indretninger og fremgangsmåder til modifikation af optiske egenskaber |
| US10987674B2 (en) | 2016-04-22 | 2021-04-27 | Visby Medical, Inc. | Printed circuit board heater for an amplification module |
| WO2017197040A1 (en) | 2016-05-11 | 2017-11-16 | Click Diagnostics, Inc. | Devices and methods for nucleic acid extraction |
| USD800331S1 (en) | 2016-06-29 | 2017-10-17 | Click Diagnostics, Inc. | Molecular diagnostic device |
| CN110325652A (zh) | 2016-06-29 | 2019-10-11 | 易捷仪器诊断股份有限公司 | 使用流动池检测分子的装置和方法 |
| GB201611469D0 (en) | 2016-06-30 | 2016-08-17 | Lumiradx Tech Ltd | Improvements in or relating to nucleic acid amplification processes |
| USD800914S1 (en) | 2016-06-30 | 2017-10-24 | Click Diagnostics, Inc. | Status indicator for molecular diagnostic device |
| CA3029682A1 (en) * | 2016-06-30 | 2018-01-04 | Click Diagnostics, Inc. | Devices and methods for nucleic acid extraction |
| USD800913S1 (en) | 2016-06-30 | 2017-10-24 | Click Diagnostics, Inc. | Detection window for molecular diagnostic device |
| JP2018023360A (ja) * | 2016-07-29 | 2018-02-15 | セイコーエプソン株式会社 | 核酸増幅反応方法、試薬、および試薬の使用方法 |
| WO2018125271A1 (en) | 2016-12-28 | 2018-07-05 | Neogen Corporation | Fluid retainer cartridge assembly and method for utilizing the same |
| KR101997097B1 (ko) | 2016-12-30 | 2019-07-05 | 주식회사 이지다이아텍 | 거대 자성입자 복합체를 이용한 자동 면역분석장치 및 방법 |
| USD834721S1 (en) | 2017-03-03 | 2018-11-27 | Neogen Corporation | Assay cartridge |
| CN110678556A (zh) | 2017-06-07 | 2020-01-10 | 宝生物工程株式会社 | 寡核苷酸保存方法 |
| KR20190032810A (ko) | 2017-09-20 | 2019-03-28 | 주식회사 이지다이아텍 | 자성 면역분석장치 및 방법 |
| EP3459632A1 (en) * | 2017-09-26 | 2019-03-27 | Lunaphore Technologies SA | Microfluidic cartrige with built-in sampling device |
| JP7239568B2 (ja) | 2017-11-09 | 2023-03-14 | ビスビュー メディカル，インコーポレイテッド | 携帯型分子診断デバイスおよび標的ウイルスの検出方法 |
| GB2569965A (en) * | 2018-01-04 | 2019-07-10 | Lumiradx Uk Ltd | Improvements in or relating to amplification of nucleic acids |
| CN110240999B (zh) * | 2018-03-09 | 2022-09-06 | 浙江品级基因科技有限公司 | 一种提高循环肿瘤dna检出率的检测装置及方法 |
| GB201812192D0 (en) | 2018-07-26 | 2018-09-12 | Ttp Plc | Variable temperature reactor, heater and control circuit for the same |
| GB201813429D0 (en) * | 2018-08-17 | 2018-10-03 | Touchlight Ip Ltd | Synthesis of DNA with improved yield |
| MX2021002533A (es) | 2018-09-03 | 2021-05-27 | Visby Medical Inc | Dispositivos y metodos para pruebas de susceptibilidad a antibioticos. |
| CN113227349A (zh) * | 2018-10-19 | 2021-08-06 | 尤尼沃尔塞尔斯技术股份公司 | 净化生物分子生产系统的方法及适用于净化的系统 |
| KR20210104835A (ko) | 2018-12-19 | 2021-08-25 | 누클레인, 엘엘씨 | 분자 진단을 위한 장치 및 방법 |
| AU2020265586A1 (en) | 2019-04-28 | 2021-10-14 | Visby Medical, Inc. | Molecular diagnostic devices with digital detection capability and wireless connectivity |
| EP4085149A4 (en) | 2020-01-03 | 2024-03-06 | Visby Medical, Inc. | Devices and methods for antibiotic susceptibility testing |
| CN113528624B (zh) * | 2020-04-17 | 2025-12-02 | 青岛简码基因科技有限公司 | 扩增和检测核酸的方法及试剂盒 |
| CN113215224A (zh) * | 2020-01-21 | 2021-08-06 | 青岛大学 | 扩增和检测核酸的方法及试剂盒 |
| WO2021147910A1 (en) * | 2020-01-21 | 2021-07-29 | Qingdao Navid Biotechnology Co., Ltd. | Methods and kits for amplification and detection of nucleic acids |
| WO2021257576A1 (en) * | 2020-06-15 | 2021-12-23 | Arizona Board Of Regents On Behalf Of Arizona State University | Point of need diagnostic with thermal control |
| CA3189716A1 (en) * | 2020-08-26 | 2022-03-03 | Ralph LAMBLE | Devices |
| USD1064314S1 (en) | 2021-08-13 | 2025-02-25 | Visby Medical, Inc. | Molecular diagnostic device |
| WO2023023638A1 (en) | 2021-08-20 | 2023-02-23 | Singular Genomics Systems, Inc. | Chemical and thermal assisted nucleic acid amplification methods |
| WO2023095018A1 (en) * | 2021-11-24 | 2023-06-01 | D-Nome Private Limited | Rapid method for room temperature reverse transcription loop-mediated isothermal amplification (rt-lamp) and reagent kit |
| AU2023222749A1 (en) * | 2022-02-15 | 2024-08-29 | Cepheid | Exponential base-greater-than-base 2 nucleic acid amplification using high- and low-tm primers |
| EP4479550A1 (en) * | 2022-02-17 | 2024-12-25 | One Lambda, Inc. | Systems and methods for protein detection |
| WO2023196973A1 (en) * | 2022-04-08 | 2023-10-12 | The Broad Institute, Inc. | Amplification assays using crispr-cas based detection |
| EP4514994A1 (en) | 2022-04-29 | 2025-03-05 | Cepheid | Nucleic acid extraction and isolation with heat labile silanes and chemically modified solid supports |
| KR20250017227A (ko) | 2022-05-19 | 2025-02-04 | 세페이드 | Mvp 카트리지 및 사용 및 제조 방법 |
| CN114934044B (zh) * | 2022-05-27 | 2023-11-10 | 国网电力科学研究院武汉南瑞有限责任公司 | 一种重组大肠杆菌在养护铅酸蓄电池中的应用 |
| CN115290606A (zh) * | 2022-08-22 | 2022-11-04 | 凤凰医学诊断科技有限公司 | 一种检测装置 |
| DE102022211087A1 (de) * | 2022-10-19 | 2024-04-25 | Robert Bosch Gesellschaft mit beschränkter Haftung | Verfahren und Vorrichtung zur Voramplifikation eines Nukleinsäuregemisches |
| CN115678764B (zh) * | 2022-11-07 | 2023-09-08 | 苏州思迈德生物科技有限公司 | 一种快速分子诊断的微流控芯片 |
| CN120641576A (zh) | 2022-12-16 | 2025-09-12 | 塞弗德公司 | Mpox演化支ii生物标志物组 |
| CN116121349B (zh) * | 2022-12-20 | 2024-04-09 | 南京诺唯赞生物科技股份有限公司 | 一种扩增含乙醇的核酸样本的方法 |
| EP4658408A2 (en) | 2023-01-30 | 2025-12-10 | Cepheid | Respiratory biomarker panel |
| WO2024216275A2 (en) * | 2023-04-13 | 2024-10-17 | 5Prime Biosciences, Inc. | Compositions and methods for upregulation of reverse transcription and reduction of sequence bias in rna sequencing |
| WO2025006633A1 (en) | 2023-06-27 | 2025-01-02 | Cepheid | Pancoronavirus biomarker panel |
| WO2025049642A1 (en) | 2023-08-29 | 2025-03-06 | Cepheid | Integrated valve body and syringe tube component for assay cartridges |
| US20250171840A1 (en) | 2023-09-18 | 2025-05-29 | Cepheid | Three-phase nested amplification and multi-phasic detection |
| WO2025165828A1 (en) | 2024-01-29 | 2025-08-07 | Cepheid | Universal assay cartridge with integrated valve body and syringe tube use |
| WO2025175133A1 (en) | 2024-02-14 | 2025-08-21 | Cepheid | Melt shape genotyping |
| WO2025179142A1 (en) | 2024-02-22 | 2025-08-28 | Cepheid | Maximizing optical channel capabilities for target detection |
| US20250297303A1 (en) | 2024-03-21 | 2025-09-25 | Cepheid | Compositions and methods for selective extraction of oligonucleotides from complex matrices |
| WO2025207561A1 (en) | 2024-03-27 | 2025-10-02 | Cepheid | Isothermal amplification using novel synthetic oligonucleotides |
Family Cites Families (145)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3667607A (en) | 1970-11-27 | 1972-06-06 | Baker Chem Co J T | Chromatographic material |
| US4235601A (en) | 1979-01-12 | 1980-11-25 | Thyroid Diagnostics, Inc. | Test device and method for its use |
| US4663277A (en) | 1983-05-20 | 1987-05-05 | Profile Diagnostic Sciences Inc. | Virus detection method and materials |
| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
| US4683105A (en) | 1985-10-31 | 1987-07-28 | Westinghouse Electric Corp. | Testable, fault-tolerant power interface circuit for normally de-energized loads |
| US4800159A (en) | 1986-02-07 | 1989-01-24 | Cetus Corporation | Process for amplifying, detecting, and/or cloning nucleic acid sequences |
| US4960691A (en) | 1986-09-29 | 1990-10-02 | Abbott Laboratories | Chromatographic test strip for determining ligands or receptors |
| IE69047B1 (en) | 1989-03-23 | 1996-08-07 | Gary Harold Gregory Hen Thorpe | Liquid transfer devices |
| US5541099A (en) | 1989-08-10 | 1996-07-30 | Life Technologies, Inc. | Cloning and expression of T5 DNA polymerase reduced in 3'-to-5' exonuclease activity |
| US5225163A (en) | 1989-08-18 | 1993-07-06 | Angenics, Inc. | Reaction apparatus employing gravitational flow |
| DK0455905T3 (da) | 1990-05-11 | 1998-12-07 | Microprobe Corp | Dipsticks til nukleinsyrehybridiseringsassays og fremgangsmåde til kovalent immobilisering af oligonukleotider |
| US6007999A (en) | 1991-07-31 | 1999-12-28 | Idexx Laboratories, Inc. | Reversible flow chromatographic binding assay |
| GB9123922D0 (en) | 1991-11-11 | 1992-01-02 | Bunce Roger A | Liquid transfer devices |
| JP2832117B2 (ja) | 1991-11-29 | 1998-12-02 | キヤノン株式会社 | サンプル測定デバイス及びサンプル測定システム |
| WO1993014217A1 (en) | 1992-01-10 | 1993-07-22 | Life Technologies, Inc. | Use of predetermined nucleotides having altered base pairing characteristics in the amplification of nucleic acid molecules |
| US6555349B1 (en) | 1993-01-22 | 2003-04-29 | Cornell Research Foundation, Inc. | Methods for amplifying and sequencing nucleic acid molecules using a three component polymerase |
| US5516664A (en) | 1992-12-23 | 1996-05-14 | Hyman; Edward D. | Enzymatic synthesis of repeat regions of oligonucleotides |
| US5432065A (en) * | 1993-03-30 | 1995-07-11 | United States Biochemical Corporation | Cycle sequencing with non-thermostable DNA polymerases |
| GB9307319D0 (en) | 1993-04-07 | 1993-06-02 | British Tech Group | Liquid transfer devices |
| CA2185239C (en) | 1994-03-16 | 2002-12-17 | Nanibhushan Dattagupta | Isothermal strand displacement nucleic acid amplification |
| US6037127A (en) | 1994-03-31 | 2000-03-14 | E. I. Du Pont De Nemours And Company | Method for detection of non-denatured nucleic acid fragments |
| GB9416002D0 (en) | 1994-08-08 | 1994-09-28 | Univ Cranfield | Fluid transport device |
| GB9502112D0 (en) | 1995-02-03 | 1995-03-22 | British Biocell Int | Assay device and method |
| US20040110167A1 (en) | 1995-07-13 | 2004-06-10 | Gerdes John C. | Lateral flow system for nucleic acid detection |
| US5989813A (en) | 1995-07-13 | 1999-11-23 | Molecular Innovations, Inc. | Detection of amplified nucleic acid sequences using bifunctional haptenization and dyed microparticles |
| US6130098A (en) | 1995-09-15 | 2000-10-10 | The Regents Of The University Of Michigan | Moving microdroplets |
| AU703769B2 (en) | 1996-01-05 | 1999-04-01 | Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The | Mesothelium antigen and methods and kits for targeting it |
| US6750031B1 (en) | 1996-01-11 | 2004-06-15 | The United States Of America As Represented By The Secretary Of The Navy | Displacement assay on a porous membrane |
| EP0880598A4 (en) | 1996-01-23 | 2005-02-23 | Affymetrix Inc | RAPID EVALUATION OF NUCLEIC ACID ABUNDANCE DIFFERENCE, WITH A HIGH-DENSITY OLIGONUCLEOTIDE SYSTEM |
| US5741647A (en) | 1996-02-16 | 1998-04-21 | Tam; Joseph Wing On | Flow through nucleic acid hybridisation uses thereof and a device thereof |
| DE19609838A1 (de) | 1996-03-13 | 1997-09-18 | Boehringer Mannheim Gmbh | Verfahren und Teststreifen zur Bestimmung eines Analyten |
| US5824478A (en) | 1996-04-30 | 1998-10-20 | Vysis, Inc. | Diagnostic methods and probes |
| US6582921B2 (en) | 1996-07-29 | 2003-06-24 | Nanosphere, Inc. | Nanoparticles having oligonucleotides attached thereto and uses thereof |
| AU746549B2 (en) * | 1996-11-20 | 2002-05-02 | Becton Dickinson & Company | Microfabricated isothermal nucleic acid amplification devices and methods |
| US5922617A (en) | 1997-11-12 | 1999-07-13 | Functional Genetics, Inc. | Rapid screening assay methods and devices |
| US6190612B1 (en) | 1998-01-21 | 2001-02-20 | Bayer Corporation | Oxygen sensing membranes and methods of making same |
| CA2326392A1 (en) | 1998-03-30 | 1999-10-07 | Epitope, Inc. | Collection device for single step assay of oral fluids |
| US7640083B2 (en) | 2002-11-22 | 2009-12-29 | Monroe David A | Record and playback system for aircraft |
| US6207379B1 (en) * | 1998-09-11 | 2001-03-27 | One Lambda | Method for amplification of DNA |
| US6261779B1 (en) | 1998-11-10 | 2001-07-17 | Bio-Pixels Ltd. | Nanocrystals having polynucleotide strands and their use to form dendrimers in a signal amplification system |
| WO2000029112A1 (en) | 1998-11-18 | 2000-05-25 | Orchid Biosciences, Inc. | One-step nucleic acid dipstick device with movable membrane |
| WO2000031538A1 (en) | 1998-11-23 | 2000-06-02 | Praxsys Biosystems, Inc. | Improved lateral flow assays |
| US6416642B1 (en) | 1999-01-21 | 2002-07-09 | Caliper Technologies Corp. | Method and apparatus for continuous liquid flow in microscale channels using pressure injection, wicking, and electrokinetic injection |
| US20020177135A1 (en) | 1999-07-27 | 2002-11-28 | Doung Hau H. | Devices and methods for biochip multiplexing |
| US6300069B1 (en) * | 1999-05-03 | 2001-10-09 | Qiagen Gmbh | Generation and amplification of nucleic acids from ribonucleic acids |
| WO2001026813A2 (en) | 1999-10-08 | 2001-04-19 | Micronics, Inc. | Microfluidics without electrically of mechanically operated pumps |
| US6471916B1 (en) | 1999-11-09 | 2002-10-29 | Packard Instrument Company | Apparatus and method for calibration of a microarray scanning system |
| US6875619B2 (en) | 1999-11-12 | 2005-04-05 | Motorola, Inc. | Microfluidic devices comprising biochannels |
| AU1812801A (en) | 1999-12-06 | 2001-06-12 | Pioneer Hi-Bred International, Inc. | Short shared nucleotide sequences |
| US6468749B1 (en) | 2000-03-30 | 2002-10-22 | Quark Biotech, Inc. | Sequence-dependent gene sorting techniques |
| GB0016813D0 (en) | 2000-07-07 | 2000-08-30 | Lee Helen | Improved dipstick assays (4) |
| GB0016814D0 (en) | 2000-07-07 | 2000-08-30 | Lee Helen | Improved dipstick assays (3) |
| US20050079492A1 (en) | 2000-09-12 | 2005-04-14 | Burgess Jr. Robert M. | Micro-arrayed organization of transcription factor target genes |
| AU2001297014A1 (en) | 2000-10-10 | 2002-04-22 | Aviva Biosciences Corporation | An integrated biochip system for sample preparation and analysis |
| EP1347299B1 (en) | 2000-12-26 | 2006-03-08 | Matsushita Electric Industrial Co., Ltd. | Specific bonding analysis method and specific bonding analysis device using it |
| EP1390537B1 (en) | 2001-03-09 | 2013-11-13 | Nugen Technologies, Inc. | Methods and compositions for amplification of rna sequences |
| NZ523167A (en) | 2001-03-09 | 2006-08-31 | Nugen Technologies Inc | Methods, compositions and kits for amplifying RNA sequences of interest which employ an RNA/DNA composite primer |
| US6960437B2 (en) | 2001-04-06 | 2005-11-01 | California Institute Of Technology | Nucleic acid amplification utilizing microfluidic devices |
| US7105311B2 (en) | 2001-05-03 | 2006-09-12 | Immunetics, Inc. | Systems and methods for detection of analytes in biological fluids |
| PT1857122E (pt) | 2001-06-05 | 2011-03-07 | Curevac Gmbh | Arnm estabilizado com teor de g/c aumentado, codificando para um antigénio viral |
| US20030044862A1 (en) | 2001-06-22 | 2003-03-06 | The Board Of Trustees Of The Leland Stanford Jr. University | Diagnostic marker for tumor hypoxia and prognosis |
| US7790439B2 (en) | 2001-08-09 | 2010-09-07 | Panasonic Corporation | Biosensor and measurement method |
| US6916541B2 (en) | 2001-09-07 | 2005-07-12 | Penn State Research Foundation | Modified substrates for the attachment of biomolecules |
| KR100488281B1 (ko) | 2001-09-15 | 2005-05-10 | 아람 바이오시스템 주식회사 | 열 대류를 이용한 염기서열 증폭 방법 및 장치 |
| ATE509272T1 (de) | 2001-11-09 | 2011-05-15 | 3Dbiosurfaces Technologies Llc | Substrate mit hochliegendem oberflächenbereich für mikroarrays sowie verfahren zur herstellung davon |
| JP2005511066A (ja) | 2001-12-07 | 2005-04-28 | ダイアックス、コープ | 磁気応答性粒子を洗浄する方法及び装置 |
| US7772383B2 (en) | 2002-01-25 | 2010-08-10 | The Trustees Of Princeton University | Chemical PCR: Compositions for enhancing polynucleotide amplification reactions |
| US20030211488A1 (en) | 2002-05-07 | 2003-11-13 | Northwestern University | Nanoparticle probs with Raman spectrocopic fingerprints for analyte detection |
| JP2005532827A (ja) | 2002-07-12 | 2005-11-04 | ブリティッシュ・バイオセル・インターナショナル・リミテッド | 側方フローアッセイ用のデバイスおよびその方法 |
| US20050239358A1 (en) | 2002-07-23 | 2005-10-27 | Microban Products Company | Antimicrobial melamine resin and products made therefrom |
| US20040064435A1 (en) | 2002-07-26 | 2004-04-01 | Ahmad-Maher Moubayed | Clinical assessment and diagnostic tool for use with peristaltic pump |
| US20040018577A1 (en) | 2002-07-29 | 2004-01-29 | Emerson Campbell John Lewis | Multiple hybrid immunoassay |
| CA2498764C (en) | 2002-09-20 | 2015-11-10 | New England Biolabs, Inc. | Helicase dependent amplification of nucleic acids |
| US7662594B2 (en) | 2002-09-20 | 2010-02-16 | New England Biolabs, Inc. | Helicase-dependent amplification of RNA |
| KR100463203B1 (ko) | 2002-12-10 | 2004-12-23 | 삼성전자주식회사 | 활성 영역을 구비하는 반도체 소자 |
| US7132233B2 (en) | 2002-12-12 | 2006-11-07 | Novartis Vaccines And Diagnostics, Inc. | Identification of oligonucleotides for the capture, detection and quantitation of West Nile virus |
| US20050221281A1 (en) * | 2003-01-08 | 2005-10-06 | Ho Winston Z | Self-contained microfluidic biochip and apparatus |
| JP2004263708A (ja) | 2003-01-14 | 2004-09-24 | Kyowa Metal Work Co Ltd | ツインクラッチ式変速機 |
| EP1592505A2 (en) | 2003-01-21 | 2005-11-09 | Micronics, Inc. | Method and system for microfluidic manipulation, amplification and analysis of fluids, for example, bacteria assays and antiglobulin testing |
| WO2004076684A2 (en) | 2003-02-27 | 2004-09-10 | Strategic Diagnostics Inc. | Compositions and methods for the detection of mammalian muscle troponin i |
| TWI333545B (en) | 2003-04-02 | 2010-11-21 | Cholestech Corp | Adhered membranes retaining porosity and biological activity |
| FR2856046B1 (fr) | 2003-06-16 | 2005-07-29 | Biomerieux Sa | Microvanne fluidique a ouverture par commande electrique |
| US7722817B2 (en) | 2003-08-28 | 2010-05-25 | Epocal Inc. | Lateral flow diagnostic devices with instrument controlled fluidics |
| SG146630A1 (en) | 2003-09-03 | 2008-10-30 | Life Patch International Inc | Personal diagnostic devices and related methods |
| US7354706B2 (en) | 2003-09-09 | 2008-04-08 | The Regents Of The University Of Colorado, A Body Corporate | Use of photopolymerization for amplification and detection of a molecular recognition event |
| US20070039835A1 (en) | 2003-09-15 | 2007-02-22 | Diagno Swiss S.A. | Microfluidic flow monitoring device |
| JP2005110621A (ja) * | 2003-10-10 | 2005-04-28 | Aisin Seiki Co Ltd | 核酸増幅方法及び核酸増幅用試薬キット |
| CN100540313C (zh) | 2003-10-24 | 2009-09-16 | 索尼株式会社 | 头模块和液体喷射装置以及它们的制造方法 |
| CA2545653C (en) | 2003-11-21 | 2014-07-08 | Anp Technologies, Inc. | Asymmetrically branched polymer conjugates and microarray assays |
| JP4250523B2 (ja) | 2003-12-25 | 2009-04-08 | 株式会社東芝 | マイクロリアクタ、分析システム、分析方法、反応システム、反応方法、分離システム、分離方法 |
| JP4980884B2 (ja) | 2004-03-30 | 2012-07-18 | ジーイー・ヘルスケア・バイオサイエンス・コーポレイション | 側方流動方式、材料、及び方法 |
| WO2006071247A2 (en) | 2004-03-30 | 2006-07-06 | California Institute Of Technology | Diagnostic assays including multiplexed lateral flow immunoassays with quantum dots |
| CN105087777A (zh) | 2004-04-07 | 2015-11-25 | 安克塞斯生物公司 | 核酸检测系统 |
| US8173078B2 (en) | 2004-04-28 | 2012-05-08 | Industrial Technology Research Institute | Gravity-driven micropump |
| US7273590B2 (en) | 2004-04-29 | 2007-09-25 | Industrial Technology Research Institute | gravity-driven apparatus and method for control of microfluidic devices |
| US7796266B2 (en) | 2004-04-30 | 2010-09-14 | Kimberly-Clark Worldwide, Inc. | Optical detection system using electromagnetic radiation to detect presence or quantity of analyte |
| CA2566962A1 (en) | 2004-05-21 | 2005-12-01 | Atonomics A/S | Surface acoustic wave sensor comprising a hydrogel |
| SE527036C2 (sv) | 2004-06-02 | 2005-12-13 | Aamic Ab | Analysanordning med reglerat flöde och motsvarande förfarande |
| JP2008521432A (ja) * | 2004-11-30 | 2008-06-26 | グローバル テクノロジーズ （エヌゼット） リミテッド | サンプル分析方法及びそのための装置 |
| US20060127886A1 (en) | 2004-12-15 | 2006-06-15 | Kaylor Rosann M | Sample-efficient lateral flow immunoassay |
| JP2006185972A (ja) | 2004-12-27 | 2006-07-13 | Nikon Corp | マスク及び露光方法 |
| US9101927B2 (en) | 2005-01-31 | 2015-08-11 | Realbio Technologies Ltd. | Multistep reaction lateral flow capillary device |
| US7396689B2 (en) | 2005-02-04 | 2008-07-08 | Decision Biomarkers Incorporated | Method of adjusting the working range of a multi-analyte assay |
| WO2006098804A2 (en) | 2005-03-11 | 2006-09-21 | Chembio Diagnostic Systems, Inc. | Dual path immunoassay device |
| KR20070117665A (ko) | 2005-03-31 | 2007-12-12 | 후지필름 가부시키가이샤 | 표면 그래프트 재료와 그 제조방법, 도전성 재료와 그제조방법, 및 도전성 패턴 재료 |
| US7439079B2 (en) | 2005-04-29 | 2008-10-21 | Kimberly-Clark Worldwide, Inc. | Assay devices having detection capabilities within the hook effect region |
| WO2006122311A2 (en) | 2005-05-11 | 2006-11-16 | The Trustees Of The University Of Pennsylvania | Microfluidic chip |
| ATE515703T1 (de) | 2005-05-23 | 2011-07-15 | Phadia Ab | Verfahren und vorrichtungen für lateralfluss- tests mit zwei schritten |
| US20070015166A1 (en) | 2005-07-14 | 2007-01-18 | Nilsen Thor W | Lateral flow methods and devices for detection of nucleic acid binding proteins |
| CA2621146A1 (en) | 2005-09-06 | 2007-03-15 | Gen-Probe Incorporated | Methods, compositions and kits for isothermal amplification of nucleic acids |
| CN101400993A (zh) * | 2005-11-10 | 2009-04-01 | 阿普尔拉股份有限公司 | 包括多孔聚合物电极的微流体系统 |
| WO2008002462A2 (en) | 2006-06-23 | 2008-01-03 | Micronics, Inc. | Methods and devices for microfluidic point-of-care immunoassays |
| CN101360819A (zh) * | 2006-01-20 | 2009-02-04 | 凸版印刷株式会社 | 反应容器及dna的扩增反应方法 |
| US7537917B2 (en) * | 2006-03-31 | 2009-05-26 | Collins Michael J | Microwave assisted PCR amplification of DNA |
| US8980561B1 (en) | 2006-08-22 | 2015-03-17 | Los Alamos National Security, Llc. | Nucleic acid detection system and method for detecting influenza |
| WO2008105814A2 (en) | 2006-08-22 | 2008-09-04 | Los Alamos National Security, Llc | Miniturized lateral flow device for rapid and sensitive detection of proteins or nucleic acids |
| JP2008148690A (ja) * | 2006-11-22 | 2008-07-03 | Fujifilm Corp | マイクロチップを用いた核酸増幅方法およびマイクロチップ、それを用いた核酸増幅システム |
| EP1972938B1 (de) | 2007-03-19 | 2014-05-14 | Ivoclar Vivadent | Teststreifen für die Bestimmung des Kariesrisikos |
| US8105783B2 (en) | 2007-07-13 | 2012-01-31 | Handylab, Inc. | Microfluidic cartridge |
| KR101376359B1 (ko) | 2007-08-01 | 2014-03-27 | 다나-파버 캔서 인스티튜트 인크. | 표적 서열 강화 |
| TW200909338A (en) | 2007-08-23 | 2009-03-01 | Ind Tech Res Inst | Autonomous microfluidic apparatus |
| US20090086357A1 (en) | 2007-09-28 | 2009-04-02 | Toshiba America Information Systems, Inc. | In drive written spirals for self servo writing |
| CN101409933B (zh) | 2007-10-11 | 2010-08-04 | 华为技术有限公司 | 一种释放资源的方法和设备 |
| US9409166B2 (en) | 2007-12-10 | 2016-08-09 | The Trustees Of The University Of Pennsylvania | Integrated PCR reactor for cell lysis, nucleic acid isolation and purification, and nucleic acid amplication related applications |
| DE102007062441A1 (de) | 2007-12-20 | 2009-06-25 | Aj Innuscreen Gmbh | Mobiles Schnelltestsystem für die Nukleinsäureanalytik |
| EP2252890B1 (en) | 2008-02-22 | 2014-07-02 | Orion Diagnostica Oy | Method and device for detection of carbohydrates |
| JP5390540B2 (ja) * | 2008-02-29 | 2014-01-15 | ノースウエスタン ユニバーシティ | 生物反応促進用バリア |
| EP2279403B1 (en) | 2008-05-05 | 2016-03-16 | Los Alamos National Security, LLC | Highly simplified lateral flow-based nucleic acid sample preparation and passive fluid flow control |
| WO2009137055A1 (en) | 2008-05-05 | 2009-11-12 | Los Alamos National Security, Llc | Nanocrystal-based lateral flow microarrays and low-voltage signal detection systems |
| US7910309B2 (en) * | 2008-07-31 | 2011-03-22 | Los Alamos National Security, Llc | Multiplexed lateral flow microarray assay for detection of citrus pathogens Xylella fastidiosa and Xanthomonas axonopodis pv citri |
| EP2172260A1 (en) | 2008-09-29 | 2010-04-07 | Corning Incorporated | Multiple flow path microfluidic devices |
| EP2406394B1 (en) * | 2009-03-12 | 2014-01-08 | Brandeis University | Reagents and methods for pcr |
| US8084272B2 (en) | 2009-03-25 | 2011-12-27 | Abbott Point Of Care Inc. | Amelioration of heterophile antibody immunosensor interference |
| FR2945097B1 (fr) | 2009-04-30 | 2011-06-03 | Commissariat Energie Atomique | Vanne microfluidique a usage unique. |
| JP5577681B2 (ja) | 2009-11-30 | 2014-08-27 | 住友電気工業株式会社 | 半導体装置 |
| WO2011087813A2 (en) | 2009-12-22 | 2011-07-21 | University Of Washington | Capillarity-based devices for performing chemical processes and associated systems and methods |
| EP4124857A1 (en) * | 2010-03-09 | 2023-02-01 | ANDE Corporation | Method of performing automated electrophoresis on unprocessed sample |
| EP2553473A4 (en) * | 2010-03-30 | 2016-08-10 | Advanced Liquid Logic Inc | DROPLET OPERATION PLATFORM |
| CN118086471A (zh) * | 2010-12-17 | 2024-05-28 | 生命技术公司 | 用于核酸扩增的方法、组合物、系统、仪器和试剂盒 |
| JP6087293B2 (ja) | 2011-01-06 | 2017-03-01 | メソ スケール テクノロジーズ エルエルシー | アッセイカートリッジ及びその使用方法 |
| ES2583135T3 (es) | 2011-04-20 | 2016-09-19 | Mesa Biotech, Inc. | Dispositivo integrado para la detección e identificación de ácidos nucleicos |
| BR112015010695B1 (pt) * | 2013-01-11 | 2023-03-07 | Becton, Dickinson And Company | Dispositivo microfluídico e método para realizar um ensaio de uma amostra líquida, método para formar um dispositivo microfluídico, sistema e kit |
| WO2016172724A1 (en) | 2015-04-24 | 2016-10-27 | Mesa Biotech, Inc. | Fluidic test cassette |
| CA3062287A1 (en) | 2017-04-21 | 2018-10-25 | Mesa Biotech, Inc. | Fluidic test cassette |
-
2012
- 2012-04-20 ES ES12774413.4T patent/ES2583135T3/es active Active
- 2012-04-20 EP EP12774413.4A patent/EP2699700B8/en active Active
- 2012-04-20 EP EP12773717.9A patent/EP2699698B9/en active Active
- 2012-04-20 US US14/113,146 patent/US10519492B2/en active Active
- 2012-04-20 WO PCT/US2012/034589 patent/WO2012145725A2/en not_active Ceased
- 2012-04-20 KR KR1020137030852A patent/KR101508670B1/ko active Active
- 2012-04-20 US US14/113,200 patent/US9428781B2/en active Active
- 2012-04-20 ES ES12773717T patent/ES2621390T5/es active Active
- 2012-04-20 CN CN201280030566.8A patent/CN103649333B/zh active Active
- 2012-04-20 PT PT127737179T patent/PT2699698T/pt unknown
- 2012-04-20 DK DK12773717.9T patent/DK2699698T4/da active
- 2012-04-20 WO PCT/US2012/034596 patent/WO2012145730A2/en not_active Ceased
- 2012-04-20 KR KR1020137030853A patent/KR20140044323A/ko not_active Ceased
- 2012-04-20 JP JP2014506611A patent/JP5879667B2/ja active Active
- 2012-04-20 CA CA2853615A patent/CA2853615C/en active Active
- 2012-04-20 JP JP2014506607A patent/JP5731066B2/ja active Active
- 2012-04-20 CN CN201280030581.2A patent/CN103608467B/zh active Active
- 2012-04-20 CA CA2856304A patent/CA2856304C/en active Active
- 2012-04-20 DK DK12774413.4T patent/DK2699700T3/en active
- 2012-04-20 KR KR1020167005417A patent/KR101878889B1/ko active Active
-
2015
- 2015-09-18 JP JP2015185214A patent/JP6014227B2/ja active Active
-
2016
- 2016-08-25 US US15/247,728 patent/US10316358B2/en active Active
-
2019
- 2019-04-08 US US16/377,749 patent/US11293058B2/en active Active
- 2019-11-08 US US16/678,973 patent/US11268142B2/en active Active
-
2022
- 2022-01-21 US US17/581,285 patent/US11999997B2/en active Active
- 2022-03-16 US US17/696,027 patent/US20220205019A1/en active Pending
-
2024
- 2024-05-06 US US18/656,534 patent/US12421543B2/en active Active
- 2024-05-13 US US18/662,895 patent/US20240344121A1/en active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2014513534A5 (enExample) | ||
| JP2009521954A5 (enExample) | ||
| JP2018538007A5 (enExample) | ||
| JP2010535480A5 (enExample) | ||
| WO2007081841A3 (en) | Reaction buffer composition for nucleic acid replication with packed dna polymerases | |
| CN111836903A (zh) | 基于crispr效应系统的多重诊断 | |
| WO2011106724A3 (en) | Fast pcr for str genotyping | |
| CN112020562A (zh) | 基于crispr效应系统的诊断 | |
| JP2010142229A5 (enExample) | ||
| WO2015081229A3 (en) | Selective amplification of nucleic acid sequences | |
| JP2018088924A (ja) | 鋳型切り替え反応を用いるｃＤＮＡ合成および単一細胞トランスクリプトームプロファイリングのための方法および組成物 | |
| WO2009102896A3 (en) | Isothermal nucleic acid amplification methods and compositions | |
| GB2473778A (en) | Chemically modified nucleoside 5'-triphosphates for thermally initiated amplification of nucleic acid | |
| JP7013069B2 (ja) | 低塩条件下での等温増幅 | |
| JP2008506417A5 (enExample) | ||
| JP2016540517A5 (enExample) | ||
| AU2021219095A1 (en) | DNA synthesis yield improvements | |
| JP2013501508A5 (enExample) | ||
| JP2017537658A5 (enExample) | ||
| JP2017508474A5 (enExample) | ||
| RU2018144299A (ru) | Способ амплификации кольцевой днк | |
| JP2016527896A5 (enExample) | ||
| JP2019520815A5 (enExample) | ||
| WO2014118377A3 (en) | Primer technology | |
| TW201239086A (en) | Polymerase chain reaction solution |