JP2013501508A5 - - Google Patents
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- JP2013501508A5 JP2013501508A5 JP2012524151A JP2012524151A JP2013501508A5 JP 2013501508 A5 JP2013501508 A5 JP 2013501508A5 JP 2012524151 A JP2012524151 A JP 2012524151A JP 2012524151 A JP2012524151 A JP 2012524151A JP 2013501508 A5 JP2013501508 A5 JP 2013501508A5
- Authority
- JP
- Japan
- Prior art keywords
- domain
- anchor
- reporter
- nucleic acid
- nucleotides
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US23418909P | 2009-08-14 | 2009-08-14 | |
| US61/234,189 | 2009-08-14 | ||
| PCT/EP2010/004963 WO2011018232A1 (en) | 2009-08-14 | 2010-08-13 | Format of probes to detect nucleic acid differences |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013501508A JP2013501508A (ja) | 2013-01-17 |
| JP2013501508A5 true JP2013501508A5 (enExample) | 2013-07-04 |
| JP5632476B2 JP5632476B2 (ja) | 2014-11-26 |
Family
ID=43027741
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012524151A Active JP5632476B2 (ja) | 2009-08-14 | 2010-08-13 | 核酸の違いを検出するためのプローブの形式 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US8409802B2 (enExample) |
| EP (1) | EP2464745B1 (enExample) |
| JP (1) | JP5632476B2 (enExample) |
| CN (2) | CN102471805A (enExample) |
| CA (1) | CA2770241C (enExample) |
| ES (1) | ES2608455T3 (enExample) |
| WO (1) | WO2011018232A1 (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8409802B2 (en) | 2009-08-14 | 2013-04-02 | Roche Molecular Systems, Inc. | Format of probes to detect nucleic acid differences |
| EP3246416B1 (en) | 2011-04-15 | 2024-06-05 | The Johns Hopkins University | Safe sequencing system |
| KR20210056458A (ko) | 2011-05-04 | 2021-05-18 | 바이오셉트 인코포레이티드 | 핵산 서열 변이체를 검출하는 방법 |
| JP5503021B2 (ja) * | 2011-09-14 | 2014-05-28 | 日本碍子株式会社 | 標的核酸の検出方法 |
| GB201116131D0 (en) * | 2011-09-19 | 2011-11-02 | Epistem Ltd | Probe |
| US20140302501A1 (en) * | 2011-11-16 | 2014-10-09 | Canon U.S. Life Sciences, Inc. | Mutation detection in highly homologous genomic regions |
| EP2824180B1 (en) * | 2012-03-05 | 2019-04-03 | NGK Insulators, Ltd. | Method for detecting target nucleic acid |
| WO2014070462A1 (en) | 2012-10-29 | 2014-05-08 | The Johns Hopkins University | Papanicolaou test for ovarian and endometrial cancers |
| US9637791B2 (en) * | 2013-12-20 | 2017-05-02 | Roche Molecular Systems, Inc. | Multiplexed nucleic acid target identification by strucutre based probe cleavage |
| WO2016098595A1 (ja) * | 2014-12-19 | 2016-06-23 | 栄研化学株式会社 | 一塩基多型検出用オリゴヌクレオチドプローブ及び一塩基多型検出方法 |
| CN114350752B (zh) | 2015-07-17 | 2025-02-25 | 布鲁克空间生物学公司 | 在横切面组织的用户定义区域中的基因表达的同时定量 |
| US11286531B2 (en) | 2015-08-11 | 2022-03-29 | The Johns Hopkins University | Assaying ovarian cyst fluid |
| CA2997120A1 (en) * | 2015-09-03 | 2017-03-09 | Nanostring Technologies, Inc. | Multivalent probes having single nucleotide resolution |
| US20190211377A1 (en) | 2016-12-22 | 2019-07-11 | Roche Molecular Systems, Inc. | Cobra probes to detect a marker for epidemic ribotypes of clostridium difficile |
| KR20250047324A (ko) | 2017-08-07 | 2025-04-03 | 더 존스 홉킨스 유니버시티 | 암을 평가하고 치료하기 위한 방법 및 재료 |
| WO2021163546A1 (en) | 2020-02-14 | 2021-08-19 | The Johns Hopkins University | Methods and materials for assessing nucleic acids |
| CN117778575A (zh) * | 2023-12-25 | 2024-03-29 | 深圳海普洛斯医学检验实验室 | 一种用于检测SNV位点的TaqMan探针及其应用 |
Family Cites Families (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4469863A (en) | 1980-11-12 | 1984-09-04 | Ts O Paul O P | Nonionic nucleic acid alkyl and aryl phosphonates and processes for manufacture and use thereof |
| US5034506A (en) | 1985-03-15 | 1991-07-23 | Anti-Gene Development Group | Uncharged morpholino-based polymers having achiral intersubunit linkages |
| US5235033A (en) | 1985-03-15 | 1993-08-10 | Anti-Gene Development Group | Alpha-morpholino ribonucleoside derivatives and polymers thereof |
| DE3529478A1 (de) | 1985-08-16 | 1987-02-19 | Boehringer Mannheim Gmbh | 7-desaza-2'desoxyguanosin-nukleotide, verfahren zu deren herstellung und deren verwendung zur nukleinsaeure-sequenzierung |
| US5216141A (en) | 1988-06-06 | 1993-06-01 | Benner Steven A | Oligonucleotide analogs containing sulfur linkages |
| US5602240A (en) | 1990-07-27 | 1997-02-11 | Ciba Geigy Ag. | Backbone modified oligonucleotide analogs |
| US5386023A (en) | 1990-07-27 | 1995-01-31 | Isis Pharmaceuticals | Backbone modified oligonucleotide analogs and preparation thereof through reductive coupling |
| US5994069A (en) * | 1996-01-24 | 1999-11-30 | Third Wave Technologies, Inc. | Detection of nucleic acids by multiple sequential invasive cleavages |
| TW393513B (en) | 1991-11-26 | 2000-06-11 | Isis Pharmaceuticals Inc | Enhanced triple-helix and double-helix formation with oligomers containing modified pyrimidines |
| EP0637965B1 (en) | 1991-11-26 | 2002-10-16 | Isis Pharmaceuticals, Inc. | Enhanced triple-helix and double-helix formation with oligomers containing modified pyrimidines |
| US5484908A (en) | 1991-11-26 | 1996-01-16 | Gilead Sciences, Inc. | Oligonucleotides containing 5-propynyl pyrimidines |
| US5644048A (en) | 1992-01-10 | 1997-07-01 | Isis Pharmaceuticals, Inc. | Process for preparing phosphorothioate oligonucleotides |
| US5925517A (en) | 1993-11-12 | 1999-07-20 | The Public Health Research Institute Of The City Of New York, Inc. | Detectably labeled dual conformation oligonucleotide probes, assays and kits |
| US5637684A (en) | 1994-02-23 | 1997-06-10 | Isis Pharmaceuticals, Inc. | Phosphoramidate and phosphorothioamidate oligomeric compounds |
| DK0866071T3 (da) | 1997-03-20 | 2005-01-17 | Hoffmann La Roche | Modificerede primere |
| WO1999037806A2 (en) * | 1998-01-27 | 1999-07-29 | Cytocell Limited | Modified nucleic acid probes and uses thereof |
| EP1092047B1 (en) | 1998-07-02 | 2009-08-26 | Gen-Probe Incorporated | Molecular torches |
| US6207379B1 (en) | 1998-09-11 | 2001-03-27 | One Lambda | Method for amplification of DNA |
| AU3274600A (en) | 1999-03-18 | 2000-10-09 | Exiqon A/S | One step sample preparation and detection of nucleic acids in complex biologicalsamples |
| IL145496A0 (en) | 1999-03-24 | 2002-06-30 | Exiqon As | Improved synthesis of [2.2.1] bicyclo nucleosides |
| US6734291B2 (en) | 1999-03-24 | 2004-05-11 | Exiqon A/S | Synthesis of [2.2.1]bicyclo nucleosides |
| US6383752B1 (en) * | 1999-03-31 | 2002-05-07 | Hybridon, Inc. | Pseudo-cyclic oligonucleobases |
| EP1242626B1 (en) * | 1999-12-21 | 2009-06-10 | Ortho-Clinical Diagnostics, Inc. | Detection of nucleic acids |
| US6451588B1 (en) | 2000-06-30 | 2002-09-17 | Pe Corporation (Ny) | Multipartite high-affinity nucleic acid probes |
| BR0212773A (pt) | 2001-09-24 | 2004-10-13 | One Lambda | Métodos para detecção de sequências-alvo de ácido nucléico com marcadores diagnósticos |
| GB2395557A (en) | 2002-11-22 | 2004-05-26 | Dynal Biotech Ltd | Nucleic acid probes |
| CN1515692A (zh) * | 2003-01-02 | 2004-07-28 | 缪金明 | “锚定点灯”式寡核苷酸芯片的检测技术 |
| AU2004235747B2 (en) | 2003-05-01 | 2009-05-28 | Gen-Probe Incorporated | Oligonucleotides comprising a molecular switch |
| DE10356837A1 (de) * | 2003-12-05 | 2005-06-30 | Dmitry Cherkasov | Modifizierte Nukleotide und Nukleoside |
| US7745125B2 (en) * | 2004-06-28 | 2010-06-29 | Roche Molecular Systems, Inc. | 2′-terminator related pyrophosphorolysis activated polymerization |
| CA2588865A1 (en) * | 2004-11-23 | 2006-06-01 | Xiao Bing Wang | Detection of nucleic acid variation by cleavage-amplification method |
| JP2008541698A (ja) * | 2005-05-03 | 2008-11-27 | アンサンブル ディスカバリー コーポレイション | 核酸検出のためのターンオーバープローブおよびその使用 |
| US20080076131A1 (en) * | 2005-12-02 | 2008-03-27 | Chagovetz Alexander M | Methods and devices for nucleic acid amplification on a surface |
| JP2009519041A (ja) | 2005-12-12 | 2009-05-14 | アメリカ合衆国 | 核酸配列決定のためのプローブおよび使用方法 |
| CA2648702A1 (en) | 2006-04-04 | 2007-10-11 | Arcxis Biotechnologies, Inc. | Cooperative probes and methods of using them |
| CN100564542C (zh) * | 2006-11-03 | 2009-12-02 | 罗光华 | 检测脱氧核糖核酸的单核苷酸多态性的方法 |
| US20080131880A1 (en) | 2006-11-22 | 2008-06-05 | Bortolin Laura T | PNA-DNA oligomers and methods of use thereof |
| CN102056660B (zh) | 2008-07-11 | 2013-10-02 | 三井金属矿业株式会社 | 脱氧剂 |
| US20100159452A1 (en) * | 2008-12-22 | 2010-06-24 | Roche Molecular Systems, Inc. | Method For Detecting a Target Nucleic Acid in a Sample |
| US8409802B2 (en) | 2009-08-14 | 2013-04-02 | Roche Molecular Systems, Inc. | Format of probes to detect nucleic acid differences |
-
2010
- 2010-08-09 US US12/852,936 patent/US8409802B2/en active Active
- 2010-08-13 CN CN2010800360045A patent/CN102471805A/zh active Pending
- 2010-08-13 CN CN201710655783.0A patent/CN107254540B/zh active Active
- 2010-08-13 ES ES10745171.8T patent/ES2608455T3/es active Active
- 2010-08-13 CA CA2770241A patent/CA2770241C/en active Active
- 2010-08-13 WO PCT/EP2010/004963 patent/WO2011018232A1/en not_active Ceased
- 2010-08-13 EP EP10745171.8A patent/EP2464745B1/en active Active
- 2010-08-13 JP JP2012524151A patent/JP5632476B2/ja active Active
-
2013
- 2013-03-06 US US13/786,749 patent/US9068225B2/en active Active
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