CN107254540B - 检测核酸差异的探针形式 - Google Patents

检测核酸差异的探针形式 Download PDF

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Publication number
CN107254540B
CN107254540B CN201710655783.0A CN201710655783A CN107254540B CN 107254540 B CN107254540 B CN 107254540B CN 201710655783 A CN201710655783 A CN 201710655783A CN 107254540 B CN107254540 B CN 107254540B
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nucleic acid
reporter
anchor
probe
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CN107254540A (zh
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S.G.威尔
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F Hoffmann La Roche AG
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
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  • Molecular Biology (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
CN201710655783.0A 2009-08-14 2010-08-13 检测核酸差异的探针形式 Active CN107254540B (zh)

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US23418909P 2009-08-14 2009-08-14
US61/234189 2009-08-14
CN2010800360045A CN102471805A (zh) 2009-08-14 2010-08-13 检测核酸差异的探针形式

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CN107254540A CN107254540A (zh) 2017-10-17
CN107254540B true CN107254540B (zh) 2021-11-16

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CN2010800360045A Pending CN102471805A (zh) 2009-08-14 2010-08-13 检测核酸差异的探针形式

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EP (1) EP2464745B1 (enExample)
JP (1) JP5632476B2 (enExample)
CN (2) CN107254540B (enExample)
CA (1) CA2770241C (enExample)
ES (1) ES2608455T3 (enExample)
WO (1) WO2011018232A1 (enExample)

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WO2012151560A2 (en) 2011-05-04 2012-11-08 Biocept, Inc. Methods for detecting nucleic acid sequence variants
ES2736977T3 (es) * 2011-09-14 2020-01-09 Ngk Insulators Ltd Método para detectar ácido nucleico diana
GB201116131D0 (en) * 2011-09-19 2011-11-02 Epistem Ltd Probe
US20140302501A1 (en) * 2011-11-16 2014-10-09 Canon U.S. Life Sciences, Inc. Mutation detection in highly homologous genomic regions
EP2824180B1 (en) * 2012-03-05 2019-04-03 NGK Insulators, Ltd. Method for detecting target nucleic acid
ES2886507T5 (es) 2012-10-29 2024-11-15 Univ Johns Hopkins Prueba de Papanicolaou para cánceres de ovario y de endometrio
US9637791B2 (en) * 2013-12-20 2017-05-02 Roche Molecular Systems, Inc. Multiplexed nucleic acid target identification by strucutre based probe cleavage
JP6495333B2 (ja) * 2014-12-19 2019-04-03 栄研化学株式会社 一塩基多型検出用オリゴヌクレオチドプローブ及び一塩基多型検出方法
WO2017027653A1 (en) 2015-08-11 2017-02-16 The Johns Hopkins University Assaying ovarian cyst fluid
US20170081713A1 (en) * 2015-09-03 2017-03-23 Nanostring Technologies, Inc. Multivalent probes having single nucleotide resolution
US20190211377A1 (en) * 2016-12-22 2019-07-11 Roche Molecular Systems, Inc. Cobra probes to detect a marker for epidemic ribotypes of clostridium difficile
CN111868260B (zh) 2017-08-07 2025-02-21 约翰斯霍普金斯大学 用于评估和治疗癌症的方法和材料
CN115516108A (zh) 2020-02-14 2022-12-23 约翰斯霍普金斯大学 评估核酸的方法和材料
CN117778575A (zh) * 2023-12-25 2024-03-29 深圳海普洛斯医学检验实验室 一种用于检测SNV位点的TaqMan探针及其应用

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CN1515692A (zh) * 2003-01-02 2004-07-28 缪金明 “锚定点灯”式寡核苷酸芯片的检测技术
WO2004098386A2 (en) * 2003-05-01 2004-11-18 Gen-Probe Incorporated Oligonucleotides comprising a molecular switch
WO2008066730A2 (en) * 2006-11-22 2008-06-05 Massachusetts Institute Of Technology Pna-dna oligomers and methods of use thereof

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Publication number Priority date Publication date Assignee Title
CN1434874A (zh) * 1999-12-21 2003-08-06 奥索临床诊断有限公司 核酸的检测
CN1515692A (zh) * 2003-01-02 2004-07-28 缪金明 “锚定点灯”式寡核苷酸芯片的检测技术
WO2004098386A2 (en) * 2003-05-01 2004-11-18 Gen-Probe Incorporated Oligonucleotides comprising a molecular switch
WO2008066730A2 (en) * 2006-11-22 2008-06-05 Massachusetts Institute Of Technology Pna-dna oligomers and methods of use thereof

Also Published As

Publication number Publication date
WO2011018232A1 (en) 2011-02-17
EP2464745A1 (en) 2012-06-20
US9068225B2 (en) 2015-06-30
US20130266938A1 (en) 2013-10-10
CA2770241C (en) 2016-03-29
US8409802B2 (en) 2013-04-02
JP2013501508A (ja) 2013-01-17
JP5632476B2 (ja) 2014-11-26
ES2608455T3 (es) 2017-04-11
EP2464745B1 (en) 2016-11-09
CA2770241A1 (en) 2011-02-17
US20110039264A1 (en) 2011-02-17
CN102471805A (zh) 2012-05-23
CN107254540A (zh) 2017-10-17

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