CA2770241C - Method and probes to detect nucleic acid differences - Google Patents

Method and probes to detect nucleic acid differences Download PDF

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Publication number
CA2770241C
CA2770241C CA2770241A CA2770241A CA2770241C CA 2770241 C CA2770241 C CA 2770241C CA 2770241 A CA2770241 A CA 2770241A CA 2770241 A CA2770241 A CA 2770241A CA 2770241 C CA2770241 C CA 2770241C
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domain
nucleic acid
reporter
anchor
probe
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CA2770241A
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English (en)
French (fr)
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CA2770241A1 (en
Inventor
Stephen Gordon Will
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F Hoffmann La Roche AG
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F Hoffmann La Roche AG
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
CA2770241A 2009-08-14 2010-08-13 Method and probes to detect nucleic acid differences Active CA2770241C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US23418909P 2009-08-14 2009-08-14
US61/234,189 2009-08-14
PCT/EP2010/004963 WO2011018232A1 (en) 2009-08-14 2010-08-13 Format of probes to detect nucleic acid differences

Publications (2)

Publication Number Publication Date
CA2770241A1 CA2770241A1 (en) 2011-02-17
CA2770241C true CA2770241C (en) 2016-03-29

Family

ID=43027741

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2770241A Active CA2770241C (en) 2009-08-14 2010-08-13 Method and probes to detect nucleic acid differences

Country Status (7)

Country Link
US (2) US8409802B2 (enExample)
EP (1) EP2464745B1 (enExample)
JP (1) JP5632476B2 (enExample)
CN (2) CN102471805A (enExample)
CA (1) CA2770241C (enExample)
ES (1) ES2608455T3 (enExample)
WO (1) WO2011018232A1 (enExample)

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EP3246416B1 (en) 2011-04-15 2024-06-05 The Johns Hopkins University Safe sequencing system
KR20210056458A (ko) 2011-05-04 2021-05-18 바이오셉트 인코포레이티드 핵산 서열 변이체를 검출하는 방법
JP5503021B2 (ja) * 2011-09-14 2014-05-28 日本碍子株式会社 標的核酸の検出方法
GB201116131D0 (en) * 2011-09-19 2011-11-02 Epistem Ltd Probe
US20140302501A1 (en) * 2011-11-16 2014-10-09 Canon U.S. Life Sciences, Inc. Mutation detection in highly homologous genomic regions
EP2824180B1 (en) * 2012-03-05 2019-04-03 NGK Insulators, Ltd. Method for detecting target nucleic acid
WO2014070462A1 (en) 2012-10-29 2014-05-08 The Johns Hopkins University Papanicolaou test for ovarian and endometrial cancers
US9637791B2 (en) * 2013-12-20 2017-05-02 Roche Molecular Systems, Inc. Multiplexed nucleic acid target identification by strucutre based probe cleavage
WO2016098595A1 (ja) * 2014-12-19 2016-06-23 栄研化学株式会社 一塩基多型検出用オリゴヌクレオチドプローブ及び一塩基多型検出方法
CN114350752B (zh) 2015-07-17 2025-02-25 布鲁克空间生物学公司 在横切面组织的用户定义区域中的基因表达的同时定量
US11286531B2 (en) 2015-08-11 2022-03-29 The Johns Hopkins University Assaying ovarian cyst fluid
CA2997120A1 (en) * 2015-09-03 2017-03-09 Nanostring Technologies, Inc. Multivalent probes having single nucleotide resolution
US20190211377A1 (en) 2016-12-22 2019-07-11 Roche Molecular Systems, Inc. Cobra probes to detect a marker for epidemic ribotypes of clostridium difficile
KR20250047324A (ko) 2017-08-07 2025-04-03 더 존스 홉킨스 유니버시티 암을 평가하고 치료하기 위한 방법 및 재료
WO2021163546A1 (en) 2020-02-14 2021-08-19 The Johns Hopkins University Methods and materials for assessing nucleic acids
CN117778575A (zh) * 2023-12-25 2024-03-29 深圳海普洛斯医学检验实验室 一种用于检测SNV位点的TaqMan探针及其应用

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Also Published As

Publication number Publication date
JP5632476B2 (ja) 2014-11-26
EP2464745A1 (en) 2012-06-20
CN102471805A (zh) 2012-05-23
US9068225B2 (en) 2015-06-30
WO2011018232A1 (en) 2011-02-17
ES2608455T3 (es) 2017-04-11
US20110039264A1 (en) 2011-02-17
CA2770241A1 (en) 2011-02-17
US8409802B2 (en) 2013-04-02
US20130266938A1 (en) 2013-10-10
CN107254540B (zh) 2021-11-16
JP2013501508A (ja) 2013-01-17
EP2464745B1 (en) 2016-11-09
CN107254540A (zh) 2017-10-17

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