CA2770241C - Method and probes to detect nucleic acid differences - Google Patents

Method and probes to detect nucleic acid differences Download PDF

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Publication number
CA2770241C
CA2770241C CA2770241A CA2770241A CA2770241C CA 2770241 C CA2770241 C CA 2770241C CA 2770241 A CA2770241 A CA 2770241A CA 2770241 A CA2770241 A CA 2770241A CA 2770241 C CA2770241 C CA 2770241C
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nucleic acid
reporter
anchor
probe
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CA2770241A
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English (en)
French (fr)
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CA2770241A1 (en
Inventor
Stephen Gordon Will
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F Hoffmann La Roche AG
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F Hoffmann La Roche AG
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
CA2770241A 2009-08-14 2010-08-13 Method and probes to detect nucleic acid differences Active CA2770241C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US23418909P 2009-08-14 2009-08-14
US61/234,189 2009-08-14
PCT/EP2010/004963 WO2011018232A1 (en) 2009-08-14 2010-08-13 Format of probes to detect nucleic acid differences

Publications (2)

Publication Number Publication Date
CA2770241A1 CA2770241A1 (en) 2011-02-17
CA2770241C true CA2770241C (en) 2016-03-29

Family

ID=43027741

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2770241A Active CA2770241C (en) 2009-08-14 2010-08-13 Method and probes to detect nucleic acid differences

Country Status (7)

Country Link
US (2) US8409802B2 (enExample)
EP (1) EP2464745B1 (enExample)
JP (1) JP5632476B2 (enExample)
CN (2) CN102471805A (enExample)
CA (1) CA2770241C (enExample)
ES (1) ES2608455T3 (enExample)
WO (1) WO2011018232A1 (enExample)

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US8409802B2 (en) 2009-08-14 2013-04-02 Roche Molecular Systems, Inc. Format of probes to detect nucleic acid differences
PL3246416T3 (pl) 2011-04-15 2024-09-30 The Johns Hopkins University Bezpieczny system sekwencjonowania
EP3382039B1 (en) * 2011-05-04 2023-09-13 Biocept, Inc. Methods for detecting nucleic acid sequence variants
EP2762562B1 (en) * 2011-09-14 2019-05-22 NGK Insulators, Ltd. Method for detecting target nucleic acid
GB201116131D0 (en) * 2011-09-19 2011-11-02 Epistem Ltd Probe
JP2014533506A (ja) * 2011-11-16 2014-12-15 キヤノン ユー．エス． ライフ サイエンシズ， インコーポレイテッドＣａｎｏｎ Ｕ．Ｓ． Ｌｉｆｅ Ｓｃｉｅｎｃｅｓ， Ｉｎｃ． 高度に相同的なゲノム領域での突然変異の検出
CN109457030B (zh) 2012-10-29 2022-02-18 约翰·霍普金斯大学 卵巢和子宫内膜癌的帕帕尼科拉乌测试
US9637791B2 (en) * 2013-12-20 2017-05-02 Roche Molecular Systems, Inc. Multiplexed nucleic acid target identification by strucutre based probe cleavage
EP3241900B1 (en) * 2014-12-19 2020-07-08 Eiken Kagaku Kabushiki Kaisha Oligonucleotide probe for detecting single nucleotide polymorphism, and method for detecting single nucleotide polymorphism
US11286531B2 (en) 2015-08-11 2022-03-29 The Johns Hopkins University Assaying ovarian cyst fluid
CA2997120A1 (en) * 2015-09-03 2017-03-09 Nanostring Technologies, Inc. Multivalent probes having single nucleotide resolution
US20190211377A1 (en) * 2016-12-22 2019-07-11 Roche Molecular Systems, Inc. Cobra probes to detect a marker for epidemic ribotypes of clostridium difficile
EP3665308A1 (en) 2017-08-07 2020-06-17 The Johns Hopkins University Methods and materials for assessing and treating cancer
BR112022015909A2 (pt) 2020-02-14 2022-10-04 Univ Johns Hopkins Métodos e materiais para avaliação de ácidos nucleicos
CN117778575A (zh) * 2023-12-25 2024-03-29 深圳海普洛斯医学检验实验室 一种用于检测SNV位点的TaqMan探针及其应用

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US5235033A (en) 1985-03-15 1993-08-10 Anti-Gene Development Group Alpha-morpholino ribonucleoside derivatives and polymers thereof
US5034506A (en) 1985-03-15 1991-07-23 Anti-Gene Development Group Uncharged morpholino-based polymers having achiral intersubunit linkages
DE3529478A1 (de) 1985-08-16 1987-02-19 Boehringer Mannheim Gmbh 7-desaza-2'desoxyguanosin-nukleotide, verfahren zu deren herstellung und deren verwendung zur nukleinsaeure-sequenzierung
US5216141A (en) 1988-06-06 1993-06-01 Benner Steven A Oligonucleotide analogs containing sulfur linkages
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US5386023A (en) 1990-07-27 1995-01-31 Isis Pharmaceuticals Backbone modified oligonucleotide analogs and preparation thereof through reductive coupling
US5994069A (en) * 1996-01-24 1999-11-30 Third Wave Technologies, Inc. Detection of nucleic acids by multiple sequential invasive cleavages
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TW393513B (en) 1991-11-26 2000-06-11 Isis Pharmaceuticals Inc Enhanced triple-helix and double-helix formation with oligomers containing modified pyrimidines
AU3222793A (en) 1991-11-26 1993-06-28 Gilead Sciences, Inc. Enhanced triple-helix and double-helix formation with oligomers containing modified pyrimidines
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AU3418800A (en) 1999-03-24 2000-10-09 Exiqon A/S Improved synthesis of (2.2.1)bicyclo nucleosides
US6383752B1 (en) * 1999-03-31 2002-05-07 Hybridon, Inc. Pseudo-cyclic oligonucleobases
CA2394974A1 (en) * 1999-12-21 2001-06-28 Ortho-Clinical Diagnostics, Inc. Method of nucleic acid detection using target-specific assays
US6451588B1 (en) 2000-06-30 2002-09-17 Pe Corporation (Ny) Multipartite high-affinity nucleic acid probes
US8512953B2 (en) 2001-09-24 2013-08-20 One Lambda Diagnostic probe detection system
GB2395557A (en) 2002-11-22 2004-05-26 Dynal Biotech Ltd Nucleic acid probes
CN1515692A (zh) * 2003-01-02 2004-07-28 缪金明 “锚定点灯”式寡核苷酸芯片的检测技术
JP2006525027A (ja) 2003-05-01 2006-11-09 ジェン−プロウブ インコーポレイテッド 分子スイッチを含むオリゴヌクレオチド
DE10356837A1 (de) * 2003-12-05 2005-06-30 Dmitry Cherkasov Modifizierte Nukleotide und Nukleoside
US7745125B2 (en) * 2004-06-28 2010-06-29 Roche Molecular Systems, Inc. 2′-terminator related pyrophosphorolysis activated polymerization
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US7968289B2 (en) * 2005-05-03 2011-06-28 Ensemble Therapeutics Corporation Turn over probes and use thereof for nucleic acid detection
US20080076131A1 (en) * 2005-12-02 2008-03-27 Chagovetz Alexander M Methods and devices for nucleic acid amplification on a surface
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WO2010004963A1 (ja) 2008-07-11 2010-01-14 三井金属鉱業株式会社 脱酸素剤
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US8409802B2 (en) 2009-08-14 2013-04-02 Roche Molecular Systems, Inc. Format of probes to detect nucleic acid differences

Also Published As

Publication number Publication date
CN107254540B (zh) 2021-11-16
CN102471805A (zh) 2012-05-23
CN107254540A (zh) 2017-10-17
US20130266938A1 (en) 2013-10-10
ES2608455T3 (es) 2017-04-11
US8409802B2 (en) 2013-04-02
EP2464745A1 (en) 2012-06-20
JP2013501508A (ja) 2013-01-17
CA2770241A1 (en) 2011-02-17
US20110039264A1 (en) 2011-02-17
WO2011018232A1 (en) 2011-02-17
EP2464745B1 (en) 2016-11-09
US9068225B2 (en) 2015-06-30
JP5632476B2 (ja) 2014-11-26

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