JP2014500729A5 - - Google Patents
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- Publication number
- JP2014500729A5 JP2014500729A5 JP2013543299A JP2013543299A JP2014500729A5 JP 2014500729 A5 JP2014500729 A5 JP 2014500729A5 JP 2013543299 A JP2013543299 A JP 2013543299A JP 2013543299 A JP2013543299 A JP 2013543299A JP 2014500729 A5 JP2014500729 A5 JP 2014500729A5
- Authority
- JP
- Japan
- Prior art keywords
- nucleic acid
- target nucleic
- inhibitor
- detected
- conjugated
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US42074710P | 2010-12-07 | 2010-12-07 | |
| US61/420,747 | 2010-12-07 | ||
| PCT/US2011/063654 WO2012078710A1 (en) | 2010-12-07 | 2011-12-07 | Nucleic acid target detection using a detector, a probe and an inhibitor |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014500729A JP2014500729A (ja) | 2014-01-16 |
| JP2014500729A5 true JP2014500729A5 (enExample) | 2015-01-29 |
| JP6096672B2 JP6096672B2 (ja) | 2017-03-15 |
Family
ID=46207491
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013543299A Expired - Fee Related JP6096672B2 (ja) | 2010-12-07 | 2011-12-07 | 検出体、プローブ、および阻害剤を用いた核酸標的検出 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US9581549B2 (enExample) |
| EP (1) | EP2649202B1 (enExample) |
| JP (1) | JP6096672B2 (enExample) |
| CN (2) | CN105603071B (enExample) |
| AU (1) | AU2011338502B2 (enExample) |
| CA (1) | CA2820094C (enExample) |
| SG (1) | SG191725A1 (enExample) |
| WO (1) | WO2012078710A1 (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105603071B (zh) | 2010-12-07 | 2019-06-21 | 伯乐实验有限公司 | 使用检测剂、探针和抑制剂检测核酸靶标 |
| WO2012135259A1 (en) | 2011-03-30 | 2012-10-04 | Gnubio, Inc. | Injection of multiple volumes into or out of droplets |
| WO2012135201A1 (en) | 2011-03-31 | 2012-10-04 | Gnubio, Inc. | Scalable spectroscopic detection and measurement |
| US9816931B2 (en) | 2011-03-31 | 2017-11-14 | Bio-Rad Laboratories, Inc. | Managing variation in spectroscopic intensity measurements through the use of a reference component |
| EP2895591A4 (en) | 2012-09-12 | 2016-10-12 | Gnubio Inc | INTEGRATED MICROFLUIDIC SYSTEM, METHOD AND KIT FOR PERFORMING TESTS |
| CN105074303B (zh) | 2013-01-25 | 2018-04-10 | 基纽拜奥股份有限公司 | 实施液滴膨胀的系统和方法 |
| US20160076082A1 (en) | 2013-04-26 | 2016-03-17 | Gnubio, Inc. | A method for blocking polymerase extension of 3 prime dna ends by stem-loop structure |
| CN105393094B (zh) | 2013-05-29 | 2019-07-23 | 生物辐射实验室股份有限公司 | 低成本光学高速离散测量系统 |
| EP3004391B1 (en) | 2013-05-29 | 2019-03-27 | Bio-Rad Laboratories, Inc. | Methods for sequencing in emulsion based microfluidics |
| WO2015031528A1 (en) | 2013-08-27 | 2015-03-05 | Gnubio, Inc. | Microfluidic devices and methods of their use |
| US9555411B2 (en) | 2013-09-30 | 2017-01-31 | Gnubio, Inc. | Microfluidic cartridge devices and methods of use and assembly |
| US10130950B2 (en) | 2013-11-27 | 2018-11-20 | Bio-Rad Laboratories, Inc. | Microfluidic droplet packing |
| US9683792B2 (en) | 2014-06-30 | 2017-06-20 | Bio-Rad Laboratories, Inc. | Floating thermal contact enabled PCR |
| CN110234696B (zh) | 2017-01-30 | 2022-05-31 | 生物辐射实验室股份有限公司 | 乳液组合物及其使用方法 |
| US10941445B2 (en) | 2017-03-24 | 2021-03-09 | Bio-Rad Laboratories, Inc. | Universal hairpin primers |
Family Cites Families (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5538848A (en) * | 1994-11-16 | 1996-07-23 | Applied Biosystems Division, Perkin-Elmer Corp. | Method for detecting nucleic acid amplification using self-quenching fluorescence probe |
| US6007994A (en) * | 1995-12-22 | 1999-12-28 | Yale University | Multiparametric fluorescence in situ hybridization |
| US6235502B1 (en) * | 1998-09-18 | 2001-05-22 | Molecular Staging Inc. | Methods for selectively isolating DNA using rolling circle amplification |
| US20030148303A1 (en) * | 2000-09-19 | 2003-08-07 | Nadeau James G. | Universal probes and methods for detection of nucleic acids |
| WO2003000933A1 (en) * | 2001-06-25 | 2003-01-03 | Georgia Tech Research Corporation | Dual resonance energy transfer nucleic acid probes |
| EP1658133A1 (en) | 2003-08-27 | 2006-05-24 | President And Fellows Of Harvard College | Electronic control of fluidic species |
| AU2006335290A1 (en) | 2006-01-11 | 2007-07-19 | Raindance Technologies, Inc. | Microfluidic devices and methods of use in the formation and control of nanoreactors |
| EP3335782B1 (en) | 2006-05-11 | 2020-09-09 | Bio-Rad Laboratories, Inc. | Microfluidic devices |
| EP2059614A4 (en) * | 2006-08-15 | 2010-06-30 | Zygene Biotech Llc | ANTISONDON PROBE COMPOSITIONS AND METHODS OF DETECTION OF DNA OR RNA |
| EP2076609A1 (en) * | 2006-10-10 | 2009-07-08 | Illumina Inc. | Compositions and methods for representational selection of nucleic acids fro complex mixtures using hybridization |
| US20100129792A1 (en) * | 2007-02-06 | 2010-05-27 | Gerassimos Makrigiorgos | Direct monitoring and pcr amplification of the dosage and dosage difference between target genetic regions |
| US20100273156A1 (en) * | 2007-05-31 | 2010-10-28 | Becton, Dickinson And Company | Sequences and methods for detecting influenza a and influenza b virus |
| JP5738597B2 (ja) | 2007-12-21 | 2015-06-24 | プレジデント アンド フェローズ オブ ハーバード カレッジ | 核酸の配列決定のためのシステムおよび方法 |
| CN105344389B (zh) | 2008-05-16 | 2018-01-02 | 哈佛大学 | 微流体系统、方法和装置 |
| US20110218123A1 (en) | 2008-09-19 | 2011-09-08 | President And Fellows Of Harvard College | Creation of libraries of droplets and related species |
| WO2010080134A1 (en) | 2008-12-19 | 2010-07-15 | President And Fellows Of Harvard College | Particle-assisted nucleic acid sequencing |
| EP3415235B1 (en) | 2009-03-23 | 2025-11-12 | Bio-Rad Laboratories, Inc. | Manipulation of microfluidic droplets |
| JP5687414B2 (ja) * | 2009-04-20 | 2015-03-18 | オリンパス株式会社 | 多型の識別方法 |
| CN102483424B (zh) | 2009-06-26 | 2014-11-05 | 哈佛学院院长等 | 用于流体操作的方法以及微流体装置 |
| CN102648053B (zh) | 2009-10-27 | 2016-04-27 | 哈佛学院院长等 | 液滴生成技术 |
| EP4484577A3 (en) | 2010-02-12 | 2025-03-26 | Bio-Rad Laboratories, Inc. | Digital analyte analysis |
| CN105603071B (zh) | 2010-12-07 | 2019-06-21 | 伯乐实验有限公司 | 使用检测剂、探针和抑制剂检测核酸靶标 |
| EP3412778A1 (en) | 2011-02-11 | 2018-12-12 | Raindance Technologies, Inc. | Methods for forming mixed droplets |
| EP2675819B1 (en) | 2011-02-18 | 2020-04-08 | Bio-Rad Laboratories, Inc. | Compositions and methods for molecular labeling |
| WO2012135259A1 (en) | 2011-03-30 | 2012-10-04 | Gnubio, Inc. | Injection of multiple volumes into or out of droplets |
| US9816931B2 (en) | 2011-03-31 | 2017-11-14 | Bio-Rad Laboratories, Inc. | Managing variation in spectroscopic intensity measurements through the use of a reference component |
| WO2012135201A1 (en) | 2011-03-31 | 2012-10-04 | Gnubio, Inc. | Scalable spectroscopic detection and measurement |
| US8841071B2 (en) | 2011-06-02 | 2014-09-23 | Raindance Technologies, Inc. | Sample multiplexing |
| US11389800B2 (en) | 2011-09-28 | 2022-07-19 | President And Fellows Of Harvard College | Systems and methods for droplet production and/or fluidic manipulation |
| US20150045258A1 (en) | 2012-02-14 | 2015-02-12 | Gnubio, Inc. | Cascaded addition of target specific universal adapters to nucleic acids |
| EP3524693A1 (en) | 2012-04-30 | 2019-08-14 | Raindance Technologies, Inc. | Digital analyte analysis |
| EP2895591A4 (en) | 2012-09-12 | 2016-10-12 | Gnubio Inc | INTEGRATED MICROFLUIDIC SYSTEM, METHOD AND KIT FOR PERFORMING TESTS |
| CN105050583A (zh) | 2012-12-14 | 2015-11-11 | 基纽拜奥股份有限公司 | 在乳液滴中维持分子的不均匀浓度的方法 |
| CN105074303B (zh) | 2013-01-25 | 2018-04-10 | 基纽拜奥股份有限公司 | 实施液滴膨胀的系统和方法 |
| US20160076082A1 (en) | 2013-04-26 | 2016-03-17 | Gnubio, Inc. | A method for blocking polymerase extension of 3 prime dna ends by stem-loop structure |
| CN105393094B (zh) | 2013-05-29 | 2019-07-23 | 生物辐射实验室股份有限公司 | 低成本光学高速离散测量系统 |
| EP3004391B1 (en) | 2013-05-29 | 2019-03-27 | Bio-Rad Laboratories, Inc. | Methods for sequencing in emulsion based microfluidics |
| WO2015031528A1 (en) | 2013-08-27 | 2015-03-05 | Gnubio, Inc. | Microfluidic devices and methods of their use |
| US9555411B2 (en) | 2013-09-30 | 2017-01-31 | Gnubio, Inc. | Microfluidic cartridge devices and methods of use and assembly |
| US9683792B2 (en) | 2014-06-30 | 2017-06-20 | Bio-Rad Laboratories, Inc. | Floating thermal contact enabled PCR |
-
2011
- 2011-12-07 CN CN201610045852.1A patent/CN105603071B/zh not_active Expired - Fee Related
- 2011-12-07 EP EP11846231.6A patent/EP2649202B1/en not_active Not-in-force
- 2011-12-07 SG SG2013043880A patent/SG191725A1/en unknown
- 2011-12-07 CN CN201180058333.4A patent/CN103348017B/zh not_active Expired - Fee Related
- 2011-12-07 JP JP2013543299A patent/JP6096672B2/ja not_active Expired - Fee Related
- 2011-12-07 AU AU2011338502A patent/AU2011338502B2/en not_active Ceased
- 2011-12-07 WO PCT/US2011/063654 patent/WO2012078710A1/en not_active Ceased
- 2011-12-07 US US13/992,187 patent/US9581549B2/en not_active Expired - Fee Related
- 2011-12-07 CA CA2820094A patent/CA2820094C/en active Active
-
2017
- 2017-01-17 US US15/408,191 patent/US10533212B2/en active Active
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