JP2014500729A5 - - Google Patents
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- Publication number
- JP2014500729A5 JP2014500729A5 JP2013543299A JP2013543299A JP2014500729A5 JP 2014500729 A5 JP2014500729 A5 JP 2014500729A5 JP 2013543299 A JP2013543299 A JP 2013543299A JP 2013543299 A JP2013543299 A JP 2013543299A JP 2014500729 A5 JP2014500729 A5 JP 2014500729A5
- Authority
- JP
- Japan
- Prior art keywords
- nucleic acid
- target nucleic
- inhibitor
- detected
- conjugated
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US42074710P | 2010-12-07 | 2010-12-07 | |
| US61/420,747 | 2010-12-07 | ||
| PCT/US2011/063654 WO2012078710A1 (en) | 2010-12-07 | 2011-12-07 | Nucleic acid target detection using a detector, a probe and an inhibitor |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014500729A JP2014500729A (ja) | 2014-01-16 |
| JP2014500729A5 true JP2014500729A5 (enExample) | 2015-01-29 |
| JP6096672B2 JP6096672B2 (ja) | 2017-03-15 |
Family
ID=46207491
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013543299A Expired - Fee Related JP6096672B2 (ja) | 2010-12-07 | 2011-12-07 | 検出体、プローブ、および阻害剤を用いた核酸標的検出 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US9581549B2 (enExample) |
| EP (1) | EP2649202B1 (enExample) |
| JP (1) | JP6096672B2 (enExample) |
| CN (2) | CN105603071B (enExample) |
| AU (1) | AU2011338502B2 (enExample) |
| CA (1) | CA2820094C (enExample) |
| SG (1) | SG191725A1 (enExample) |
| WO (1) | WO2012078710A1 (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6096672B2 (ja) | 2010-12-07 | 2017-03-15 | ヌビオ，インコーポレイテッド | 検出体、プローブ、および阻害剤を用いた核酸標的検出 |
| WO2012135259A1 (en) | 2011-03-30 | 2012-10-04 | Gnubio, Inc. | Injection of multiple volumes into or out of droplets |
| US9228898B2 (en) | 2011-03-31 | 2016-01-05 | Gnubio, Inc. | Scalable spectroscopic detection and measurement |
| WO2012135327A1 (en) | 2011-03-31 | 2012-10-04 | Gnubio Inc. | Managing variation in spectroscopic intensity measurements through the use of a reference component |
| WO2014043388A1 (en) | 2012-09-12 | 2014-03-20 | Gnubio, Inc. | Integrated microfluidic system, method and kit for performing assays |
| HK1218151A1 (zh) | 2013-01-25 | 2017-02-03 | Bio-Rad Laboratories, Inc. | 实施液滴膨胀的系统和方法 |
| US20160076082A1 (en) | 2013-04-26 | 2016-03-17 | Gnubio, Inc. | A method for blocking polymerase extension of 3 prime dna ends by stem-loop structure |
| US9766261B2 (en) | 2013-05-29 | 2017-09-19 | Bio-Rad Laboratories, Inc. | Low cost optical high speed discrete measurement system |
| CN105431553B (zh) * | 2013-05-29 | 2020-02-07 | 生物辐射实验室股份有限公司 | 用于在基于乳液的微流体中测序的系统和方法 |
| EP3039119A4 (en) | 2013-08-27 | 2017-04-05 | GnuBIO, Inc. | Microfluidic devices and methods of their use |
| US9555411B2 (en) | 2013-09-30 | 2017-01-31 | Gnubio, Inc. | Microfluidic cartridge devices and methods of use and assembly |
| EP3074122A4 (en) | 2013-11-27 | 2017-11-29 | Bio-Rad Laboratories, Inc. | Microfluidic droplet packing |
| CN106573245B (zh) | 2014-06-30 | 2019-06-18 | 生物辐射实验室股份有限公司 | 实现pcr的浮动热接触 |
| US11118217B2 (en) | 2017-01-30 | 2021-09-14 | Bio-Rad Laboratories, Inc. | Emulsion compositions and methods of their use |
| US10941445B2 (en) | 2017-03-24 | 2021-03-09 | Bio-Rad Laboratories, Inc. | Universal hairpin primers |
Family Cites Families (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5538848A (en) * | 1994-11-16 | 1996-07-23 | Applied Biosystems Division, Perkin-Elmer Corp. | Method for detecting nucleic acid amplification using self-quenching fluorescence probe |
| US6007994A (en) * | 1995-12-22 | 1999-12-28 | Yale University | Multiparametric fluorescence in situ hybridization |
| US6235502B1 (en) * | 1998-09-18 | 2001-05-22 | Molecular Staging Inc. | Methods for selectively isolating DNA using rolling circle amplification |
| US20030148303A1 (en) * | 2000-09-19 | 2003-08-07 | Nadeau James G. | Universal probes and methods for detection of nucleic acids |
| CA2451614C (en) * | 2001-06-25 | 2011-01-04 | Georgia Tech Research Corporation | Dual resonance energy transfer nucleic acid probes |
| CN104069784B (zh) | 2003-08-27 | 2017-01-11 | 哈佛大学 | 流体物种的电子控制 |
| WO2007081387A1 (en) | 2006-01-11 | 2007-07-19 | Raindance Technologies, Inc. | Microfluidic devices, methods of use, and kits for performing diagnostics |
| EP2481815B1 (en) * | 2006-05-11 | 2016-01-27 | Raindance Technologies, Inc. | Microfluidic devices |
| US8076067B2 (en) * | 2006-08-15 | 2011-12-13 | Genetag Technology, Inc. | Probe-antiprobe compositions and methods for DNA or RNA detection |
| US8568979B2 (en) * | 2006-10-10 | 2013-10-29 | Illumina, Inc. | Compositions and methods for representational selection of nucleic acids from complex mixtures using hybridization |
| US20100129792A1 (en) * | 2007-02-06 | 2010-05-27 | Gerassimos Makrigiorgos | Direct monitoring and pcr amplification of the dosage and dosage difference between target genetic regions |
| WO2008150998A1 (en) * | 2007-05-31 | 2008-12-11 | Becton, Dickinson And Company | Sequences and methods for detecting influenza a and influenza b virus |
| CN101946010B (zh) | 2007-12-21 | 2014-08-20 | 哈佛大学 | 用于核酸测序的系统和方法 |
| US9358539B2 (en) | 2008-05-16 | 2016-06-07 | President And Fellows Of Harvard College | Valves and other flow control in fluidic systems including microfluidic systems |
| WO2010033200A2 (en) | 2008-09-19 | 2010-03-25 | President And Fellows Of Harvard College | Creation of libraries of droplets and related species |
| EP3587594B1 (en) | 2008-12-19 | 2022-04-13 | President and Fellows of Harvard College | Particle-assisted nucleic acid sequencing |
| US8528589B2 (en) | 2009-03-23 | 2013-09-10 | Raindance Technologies, Inc. | Manipulation of microfluidic droplets |
| JP5687414B2 (ja) * | 2009-04-20 | 2015-03-18 | オリンパス株式会社 | 多型の識別方法 |
| JP5841937B2 (ja) | 2009-06-26 | 2016-01-13 | プレジデント アンド フェローズ オブ ハーバード カレッジ | 流体注入 |
| CN102648053B (zh) | 2009-10-27 | 2016-04-27 | 哈佛学院院长等 | 液滴生成技术 |
| EP4435111A1 (en) | 2010-02-12 | 2024-09-25 | Bio-Rad Laboratories, Inc. | Digital analyte analysis |
| JP6096672B2 (ja) | 2010-12-07 | 2017-03-15 | ヌビオ，インコーポレイテッド | 検出体、プローブ、および阻害剤を用いた核酸標的検出 |
| US9364803B2 (en) | 2011-02-11 | 2016-06-14 | Raindance Technologies, Inc. | Methods for forming mixed droplets |
| US9150852B2 (en) | 2011-02-18 | 2015-10-06 | Raindance Technologies, Inc. | Compositions and methods for molecular labeling |
| WO2012135259A1 (en) | 2011-03-30 | 2012-10-04 | Gnubio, Inc. | Injection of multiple volumes into or out of droplets |
| WO2012135327A1 (en) | 2011-03-31 | 2012-10-04 | Gnubio Inc. | Managing variation in spectroscopic intensity measurements through the use of a reference component |
| US9228898B2 (en) | 2011-03-31 | 2016-01-05 | Gnubio, Inc. | Scalable spectroscopic detection and measurement |
| US8841071B2 (en) | 2011-06-02 | 2014-09-23 | Raindance Technologies, Inc. | Sample multiplexing |
| WO2013095737A2 (en) | 2011-09-28 | 2013-06-27 | President And Fellows Of Harvard College | Systems and methods for droplet production and/or fluidic manipulation |
| WO2013122826A1 (en) | 2012-02-14 | 2013-08-22 | Gnubio, Inc. | Cascaded addition of target specific universal adapters to nucleic acids |
| WO2013165748A1 (en) | 2012-04-30 | 2013-11-07 | Raindance Technologies, Inc | Digital analyte analysis |
| WO2014043388A1 (en) | 2012-09-12 | 2014-03-20 | Gnubio, Inc. | Integrated microfluidic system, method and kit for performing assays |
| EP2931259A4 (en) | 2012-12-14 | 2016-07-13 | Gnubio Inc | METHOD FOR MAINTAINING HETEROGENIC CONCENTRATION OF MOLECULES IN EMULSION STUFFS |
| HK1218151A1 (zh) | 2013-01-25 | 2017-02-03 | Bio-Rad Laboratories, Inc. | 实施液滴膨胀的系统和方法 |
| US20160076082A1 (en) | 2013-04-26 | 2016-03-17 | Gnubio, Inc. | A method for blocking polymerase extension of 3 prime dna ends by stem-loop structure |
| US9766261B2 (en) | 2013-05-29 | 2017-09-19 | Bio-Rad Laboratories, Inc. | Low cost optical high speed discrete measurement system |
| CN105431553B (zh) | 2013-05-29 | 2020-02-07 | 生物辐射实验室股份有限公司 | 用于在基于乳液的微流体中测序的系统和方法 |
| EP3039119A4 (en) | 2013-08-27 | 2017-04-05 | GnuBIO, Inc. | Microfluidic devices and methods of their use |
| US9555411B2 (en) | 2013-09-30 | 2017-01-31 | Gnubio, Inc. | Microfluidic cartridge devices and methods of use and assembly |
| CN106573245B (zh) | 2014-06-30 | 2019-06-18 | 生物辐射实验室股份有限公司 | 实现pcr的浮动热接触 |
-
2011
- 2011-12-07 JP JP2013543299A patent/JP6096672B2/ja not_active Expired - Fee Related
- 2011-12-07 CN CN201610045852.1A patent/CN105603071B/zh not_active Expired - Fee Related
- 2011-12-07 WO PCT/US2011/063654 patent/WO2012078710A1/en not_active Ceased
- 2011-12-07 CN CN201180058333.4A patent/CN103348017B/zh not_active Expired - Fee Related
- 2011-12-07 SG SG2013043880A patent/SG191725A1/en unknown
- 2011-12-07 AU AU2011338502A patent/AU2011338502B2/en not_active Ceased
- 2011-12-07 US US13/992,187 patent/US9581549B2/en not_active Expired - Fee Related
- 2011-12-07 CA CA2820094A patent/CA2820094C/en active Active
- 2011-12-07 EP EP11846231.6A patent/EP2649202B1/en not_active Not-in-force
-
2017
- 2017-01-17 US US15/408,191 patent/US10533212B2/en active Active
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