JP2009504192A5 - - Google Patents
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- Publication number
- JP2009504192A5 JP2009504192A5 JP2008527196A JP2008527196A JP2009504192A5 JP 2009504192 A5 JP2009504192 A5 JP 2009504192A5 JP 2008527196 A JP2008527196 A JP 2008527196A JP 2008527196 A JP2008527196 A JP 2008527196A JP 2009504192 A5 JP2009504192 A5 JP 2009504192A5
- Authority
- JP
- Japan
- Prior art keywords
- nucleic acid
- nucleotide sequence
- test molecule
- molecule
- seq
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 239000002773 nucleotide Substances 0.000 claims 28
- 125000003729 nucleotide group Chemical group 0.000 claims 27
- 108020004707 nucleic acids Proteins 0.000 claims 25
- 102000039446 nucleic acids Human genes 0.000 claims 25
- 150000007523 nucleic acids Chemical class 0.000 claims 24
- 108020004418 ribosomal RNA Proteins 0.000 claims 9
- OPTASPLRGRRNAP-UHFFFAOYSA-N cytosine Chemical compound NC=1C=CNC(=O)N=1 OPTASPLRGRRNAP-UHFFFAOYSA-N 0.000 claims 8
- UYTPUPDQBNUYGX-UHFFFAOYSA-N guanine Chemical compound O=C1NC(N)=NC2=C1N=CN2 UYTPUPDQBNUYGX-UHFFFAOYSA-N 0.000 claims 8
- 238000000034 method Methods 0.000 claims 8
- 210000003705 ribosome Anatomy 0.000 claims 6
- 102000004169 proteins and genes Human genes 0.000 claims 5
- 108091034117 Oligonucleotide Proteins 0.000 claims 4
- 229940104302 cytosine Drugs 0.000 claims 4
- 108090000623 proteins and genes Proteins 0.000 claims 4
- 239000000523 sample Substances 0.000 claims 4
- 230000003321 amplification Effects 0.000 claims 3
- 150000001875 compounds Chemical class 0.000 claims 3
- 238000003199 nucleic acid amplification method Methods 0.000 claims 3
- 230000015572 biosynthetic process Effects 0.000 claims 2
- 230000000295 complement effect Effects 0.000 claims 2
- 230000003993 interaction Effects 0.000 claims 2
- 238000001668 nucleic acid synthesis Methods 0.000 claims 2
- 238000003786 synthesis reaction Methods 0.000 claims 2
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 1
- 108091005461 Nucleic proteins Proteins 0.000 claims 1
- 108020001027 Ribosomal DNA Proteins 0.000 claims 1
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 238000009396 hybridization Methods 0.000 claims 1
Applications Claiming Priority (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US70959805P | 2005-08-19 | 2005-08-19 | |
| US73246005P | 2005-11-01 | 2005-11-01 | |
| US75159305P | 2005-12-19 | 2005-12-19 | |
| US77592406P | 2006-02-22 | 2006-02-22 | |
| US77932706P | 2006-03-02 | 2006-03-02 | |
| US78380106P | 2006-03-16 | 2006-03-16 | |
| US78910906P | 2006-04-03 | 2006-04-03 | |
| PCT/US2006/032508 WO2007022474A2 (en) | 2005-08-19 | 2006-08-18 | HUMAN RIBOSOMAL DNA(rDNA) AND RIBOSOMAL RNA (rRNA) NUCLEIC ACIDS AND USES THEREOF |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009504192A JP2009504192A (ja) | 2009-02-05 |
| JP2009504192A5 true JP2009504192A5 (enExample) | 2009-10-01 |
Family
ID=37758472
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008527196A Pending JP2009504192A (ja) | 2005-08-19 | 2006-08-18 | ヒトリボソームＤＮＡ（ｒＤＮＡ）およびリボソームＲＮＡ（ｒＲＮＡ）核酸ならびにそれらの使用 |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US20070117770A1 (enExample) |
| EP (1) | EP1926372A2 (enExample) |
| JP (1) | JP2009504192A (enExample) |
| CA (1) | CA2619663A1 (enExample) |
| WO (1) | WO2007022474A2 (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20100063046A1 (en) * | 2006-05-17 | 2010-03-11 | Whitten Jeffrey P | Tetracyclic imidazole analogs |
| US8278057B2 (en) * | 2007-09-14 | 2012-10-02 | Nestec S.A. | Addressable antibody arrays and methods of use |
| DK3092901T3 (da) | 2007-10-05 | 2020-05-18 | Senhwa Biosciences Inc | Quinolonanaloger og fremgangsmåder relateret dertil |
| US20110059859A1 (en) * | 2008-05-09 | 2011-03-10 | Zhiping Liu | Molecule Detecting System |
| US9115407B2 (en) | 2008-12-10 | 2015-08-25 | University Of Washington | Ratiometric pre-rRNA analysis |
| CN102414320A (zh) * | 2009-05-15 | 2012-04-11 | 贝林格尔.英格海姆国际有限公司 | 具有降低的nocr表达的改良细胞系及其用途 |
| KR100998365B1 (ko) * | 2009-06-29 | 2010-12-06 | 압타바이오 주식회사 | 치료 효능이 있는 변형핵산 및 구아노신을 함유하는 올리고뉴클레오티드 변형체 |
| CN103533934B (zh) * | 2011-03-17 | 2016-03-30 | 特尔汗什莫尔医学基础设施研究和服务公司 | 用于治疗自身免疫性疾病的喹诺酮类似物 |
| WO2015079411A1 (en) | 2013-11-28 | 2015-06-04 | Tel Hashomer Medical Research Infrastructure And Services Ltd. | Rna polymerase i inhibitors and uses thereof |
| WO2017087235A1 (en) | 2015-11-20 | 2017-05-26 | Senhwa Biosciences, Inc. | Combination therapy of tetracyclic quinolone analogs for treating cancer |
| US9957282B2 (en) | 2015-12-14 | 2018-05-01 | Senhwa Biosciences, Inc. | Crystalline forms of quinolone analogs and their salts |
| EP4249072A3 (en) * | 2015-12-14 | 2023-10-25 | Senhwa Biosciences, Inc. | Crystalline forms of quinolone analogs and their salts |
| CA3021645A1 (en) | 2016-04-29 | 2017-11-02 | Icahn School Of Medicine At Mount Sinai | Targeting the innate immune system to induce long-term tolerance and to resolve macrophage accumulation in atherosclerosis |
| CN112334133A (zh) | 2018-02-15 | 2021-02-05 | 生华生物科技股份有限公司 | 喹诺酮类似物及其盐、组合物及其使用方法 |
| AU2022239614A1 (en) | 2021-03-19 | 2023-10-12 | Icahn School Of Medicine At Mount Sinai | Compounds for regulating trained immunity, and their methods of use |
| CN116472066B (zh) * | 2021-08-23 | 2024-05-31 | 北京嘉树佳业科技有限公司 | 来源于药用植物的sRNA及其应用 |
| WO2025114459A1 (en) * | 2023-11-28 | 2025-06-05 | Genome Therapeutics Ltd | Tetracyclic compounds for use in antibody-drug conjugates for the treatment of cancer |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5601984A (en) * | 1983-01-10 | 1997-02-11 | Gen-Probe Incorporated | Method for detecting, the presense or amount of a taxonomic group of organisms using specific R-RNA subsequences as probes |
| US5723597A (en) * | 1983-01-10 | 1998-03-03 | Gen-Probe Incorporated | Ribosomal nucleic acid probes for detecting organisms or groups of organisms |
| US5681698A (en) * | 1991-04-25 | 1997-10-28 | Gen-Probe Incorporated | 23S rRNA nucleic acid probes to mycobacterium kansasii |
| SI0787726T1 (en) * | 1994-06-14 | 2002-04-30 | Dainippon Pharmaceutical Co., Ltd. | Novel compound, process for producing the same, and antitumor agent |
| US20050191661A1 (en) * | 1996-11-06 | 2005-09-01 | Tetsuya Gatanaga | Treatment of inflammatory disease by cleaving TNF receptors |
| US6593456B1 (en) * | 1996-11-06 | 2003-07-15 | The Regents Of The University Of California | Tumor necrosis factor receptor releasing enzyme |
| CA2270898A1 (en) * | 1996-11-06 | 1998-05-14 | The Regents Of The University Of California | Isolated tumor necrosis factor receptor releasing enzyme, compositions comprising the enzyme and methods of the use thereof |
| US6930084B1 (en) * | 1996-11-06 | 2005-08-16 | The Regents Of The University Of California | Treating arthritis with TNF receptor releasing enzyme |
| US7138384B1 (en) * | 1997-08-29 | 2006-11-21 | The Regents Of The University Of California | Modulators of DNA cytosine-5 methyltransferase and methods for use thereof |
| US6528517B1 (en) * | 1998-02-04 | 2003-03-04 | Board Of Regents, The University Of Texas System | Synthesis of quinobenzoxazine analogues with topoisomerase II and quadruplex interactions for use as antineoplastic agents |
| US6911314B2 (en) * | 1999-05-14 | 2005-06-28 | The Regents Of The University Of California | Screening for drugs that affect TNF receptor releasing enzyme |
| US20030204075A9 (en) * | 1999-08-09 | 2003-10-30 | The Snp Consortium | Identification and mapping of single nucleotide polymorphisms in the human genome |
| WO2002012331A2 (en) * | 2000-08-07 | 2002-02-14 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of pancreatic cancer |
| US20030166213A1 (en) * | 2000-12-15 | 2003-09-04 | Greenspan Ralph J. | Methods for identifying compounds that modulate disorders related to nitric oxide/ cGMP-dependent protein kinase signaling |
| US6645749B2 (en) * | 2001-05-25 | 2003-11-11 | Novozymes A/S | Lipolytic enzyme |
| AU2003226304A1 (en) * | 2002-04-05 | 2003-10-27 | Cylene Pharmaceuticals, Inc. | Methods for targeting quadruplex dna |
| US7001588B2 (en) * | 2002-09-12 | 2006-02-21 | Cylene Pharmaceuticals | Expanded porphyrin compositions for tumor inhibition |
| US7354916B2 (en) * | 2003-04-07 | 2008-04-08 | Cylene Pharmaceuticals | Substituted quinobenzoxazine analogs |
| US20040115706A1 (en) * | 2003-09-11 | 2004-06-17 | Jin Cheng He | High-throughput methods for identifying quadruplex forming nucleic acids and modulators thereof |
| SI1729770T1 (sl) * | 2004-03-15 | 2010-02-26 | Sunesis Pharmaceuticals Inc | SNS-595 in postopki za uporabo le-tega |
-
2006
- 2006-08-18 US US11/506,588 patent/US20070117770A1/en not_active Abandoned
- 2006-08-18 WO PCT/US2006/032508 patent/WO2007022474A2/en not_active Ceased
- 2006-08-18 CA CA002619663A patent/CA2619663A1/en not_active Abandoned
- 2006-08-18 JP JP2008527196A patent/JP2009504192A/ja active Pending
- 2006-08-18 EP EP06801941A patent/EP1926372A2/en not_active Withdrawn
-
2008
- 2008-02-04 US US12/025,705 patent/US20090181377A1/en not_active Abandoned
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