JP2010142229A5 - - Google Patents
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- Publication number
- JP2010142229A5 JP2010142229A5 JP2009286615A JP2009286615A JP2010142229A5 JP 2010142229 A5 JP2010142229 A5 JP 2010142229A5 JP 2009286615 A JP2009286615 A JP 2009286615A JP 2009286615 A JP2009286615 A JP 2009286615A JP 2010142229 A5 JP2010142229 A5 JP 2010142229A5
- Authority
- JP
- Japan
- Prior art keywords
- dry composition
- liquid mixture
- aptamer
- stabilizing molecule
- reaction compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims 18
- 238000000034 method Methods 0.000 claims 16
- 150000001875 compounds Chemical class 0.000 claims 15
- 239000007788 liquid Substances 0.000 claims 8
- 230000000087 stabilizing effect Effects 0.000 claims 8
- 108091023037 Aptamer Proteins 0.000 claims 6
- 239000007864 aqueous solution Substances 0.000 claims 5
- 239000000523 sample Substances 0.000 claims 4
- 238000001514 detection method Methods 0.000 claims 3
- 108010006785 Taq Polymerase Proteins 0.000 claims 2
- 239000005018 casein Substances 0.000 claims 2
- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical group NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 claims 2
- 235000021240 caseins Nutrition 0.000 claims 2
- 238000001035 drying Methods 0.000 claims 2
- 239000002773 nucleotide Substances 0.000 claims 2
- 125000003729 nucleotide group Chemical group 0.000 claims 2
- 235000018102 proteins Nutrition 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 238000012408 PCR amplification Methods 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 159000000003 magnesium salts Chemical class 0.000 claims 1
- 108020004707 nucleic acids Proteins 0.000 claims 1
- 102000039446 nucleic acids Human genes 0.000 claims 1
- 150000007523 nucleic acids Chemical class 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP08022082.5 | 2008-12-19 | ||
| EP08022082 | 2008-12-19 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015003548A Division JP2015091261A (ja) | 2008-12-19 | 2015-01-09 | 反応化合物と安定化ポリメラーゼの乾燥組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010142229A JP2010142229A (ja) | 2010-07-01 |
| JP2010142229A5 true JP2010142229A5 (enExample) | 2012-01-26 |
| JP5731113B2 JP5731113B2 (ja) | 2015-06-10 |
Family
ID=40510578
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009286615A Active JP5731113B2 (ja) | 2008-12-19 | 2009-12-17 | 反応化合物と安定化ポリメラーゼの乾燥組成物 |
| JP2015003548A Pending JP2015091261A (ja) | 2008-12-19 | 2015-01-09 | 反応化合物と安定化ポリメラーゼの乾燥組成物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015003548A Pending JP2015091261A (ja) | 2008-12-19 | 2015-01-09 | 反応化合物と安定化ポリメラーゼの乾燥組成物 |
Country Status (6)
| Country | Link |
|---|---|
| US (3) | US8652811B2 (enExample) |
| EP (1) | EP2202302B1 (enExample) |
| JP (2) | JP5731113B2 (enExample) |
| CN (1) | CN101768616B (enExample) |
| CA (1) | CA2688174C (enExample) |
| ES (1) | ES2394754T3 (enExample) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2013527769A (ja) * | 2010-05-06 | 2013-07-04 | アイビス バイオサイエンシズ インコーポレイティッド | 統合された試料調製システムおよび安定化酵素混合物 |
| WO2012018638A2 (en) | 2010-07-26 | 2012-02-09 | Biomatrica, Inc. | Compositions for stabilizing dna, rna and proteins in blood and other biological samples during shipping and storage at ambient temperatures |
| EP2598661B1 (en) | 2010-07-26 | 2017-09-27 | Biomatrica, INC. | Compositions for stabilizing dna, rna and proteins in saliva and other biological samples during shipping and storage at ambient temperatures |
| EP2625285B1 (en) | 2010-10-04 | 2020-04-29 | Roche Diagniostics GmbH | Method for cell lysis and pcr within the same reaction vessel |
| EP2625284B1 (en) | 2010-10-04 | 2015-01-28 | Roche Diagniostics GmbH | Method for cell lysis in a rt-pcr reaction buffer |
| JP2013005796A (ja) * | 2011-05-26 | 2013-01-10 | Arkray Inc | 乾燥試薬、乾燥試薬キット、試薬器、乾燥試薬の製造方法 |
| EP2574931B1 (en) | 2011-09-29 | 2017-03-22 | Qiagen GmbH | Dry composition comprising a control dye |
| US9994891B2 (en) * | 2011-10-11 | 2018-06-12 | Qiagen Gmbh | Sample processing method and sample processing cartridge |
| EP2776577B1 (en) | 2011-11-07 | 2017-01-11 | Qiagen GmbH | Lysis method and lysis composition |
| EP2730653A1 (en) | 2012-11-07 | 2014-05-14 | QIAGEN GmbH | Method for lysing a fixed biological sample |
| CN103849548A (zh) | 2012-12-03 | 2014-06-11 | 三星电子株式会社 | 用于扩增核酸的试剂容器及其制备方法、存储试剂的方法和用于核酸分析的微流体系统 |
| EP2934572A4 (en) | 2012-12-20 | 2016-11-23 | Biomatrica Inc | FORMULATIONS AND METHODS FOR STABILIZING PCR REAGENTS |
| JP5904153B2 (ja) * | 2013-03-29 | 2016-04-13 | ソニー株式会社 | 核酸増幅反応用試料の調製方法、核酸増幅方法、固相状核酸増幅反応用試薬及びマイクロチップ |
| CN105431527A (zh) | 2013-06-11 | 2016-03-23 | 比奥卡尔齐斯股份有限公司 | 用于长期储存的生物分子干燥方法 |
| US10036061B2 (en) * | 2013-12-20 | 2018-07-31 | Roche Molecular Systems, Inc. | Oligonucleotide inhibitor of DNA polymerases |
| JP6661554B2 (ja) | 2014-06-10 | 2020-03-11 | バイオマトリカ，インク． | 周囲温度における血小板の安定化 |
| EP3015553A1 (de) * | 2014-10-30 | 2016-05-04 | Biotecon Diagnostics GmbH | Stabilisierte Reaktionsmischung |
| JP6827048B2 (ja) | 2015-12-08 | 2021-02-10 | バイオマトリカ，インク． | 赤血球沈降速度の低下 |
| GB201716963D0 (en) * | 2017-10-16 | 2017-11-29 | Biofortuna Ltd | Compositions and methods for use in stabilising nucleic acid amplification assays |
| CN109486824B (zh) * | 2018-11-20 | 2021-11-16 | 安徽省昂普拓迈生物科技有限责任公司 | 一种特异性结合Taq酶的核酸适配体及其筛选方法、应用 |
| CN111961709A (zh) * | 2020-01-21 | 2020-11-20 | 上海酷乐生物科技有限公司 | 一种用于口腔拭子直接荧光pcr扩增的试剂和试剂盒 |
| JPWO2024106507A1 (enExample) * | 2022-11-18 | 2024-05-23 | ||
| CN115851889B (zh) * | 2022-11-30 | 2025-12-05 | 北京全式金生物技术股份有限公司 | 松三糖和可逆结合因子Oligo在提升荧光定量PCR全预混体系的保存稳定性中的应用 |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3300474A (en) | 1964-02-12 | 1967-01-24 | Pharmacia Ab | Sucrose ether copolymerizates |
| US5118801A (en) | 1988-09-30 | 1992-06-02 | The Public Health Research Institute | Nucleic acid process containing improved molecular switch |
| GB8826429D0 (en) | 1988-11-11 | 1988-12-14 | Univ Leeds Ind Service Ltd | Enzyme stabilisation systems |
| GB8903593D0 (en) | 1989-02-16 | 1989-04-05 | Pafra Ltd | Storage of materials |
| US5270163A (en) | 1990-06-11 | 1993-12-14 | University Research Corporation | Methods for identifying nucleic acid ligands |
| CA2084987C (en) | 1990-06-11 | 2007-02-13 | Gilead Sciences, Inc. | Nucleic acid ligands |
| US5210015A (en) | 1990-08-06 | 1993-05-11 | Hoffman-La Roche Inc. | Homogeneous assay system using the nuclease activity of a nucleic acid polymerase |
| US5200399A (en) | 1990-09-14 | 1993-04-06 | Boyce Thompson Institute For Plant Research, Inc. | Method of protecting biological materials from destructive reactions in the dry state |
| US5538848A (en) | 1994-11-16 | 1996-07-23 | Applied Biosystems Division, Perkin-Elmer Corp. | Method for detecting nucleic acid amplification using self-quenching fluorescence probe |
| US5565318A (en) | 1994-09-02 | 1996-10-15 | Pharmacia Biotech, Inc. | Room temperature stable reagent semi-spheres |
| US5593824A (en) | 1994-09-02 | 1997-01-14 | Pharmacia Biotech, Inc. | Biological reagent spheres |
| US6174670B1 (en) | 1996-06-04 | 2001-01-16 | University Of Utah Research Foundation | Monitoring amplification of DNA during PCR |
| WO1997046707A2 (en) | 1996-06-04 | 1997-12-11 | University Of Utah Research Foundation | System and method for monitoring for dna amplification by fluorescence |
| EP1002875A1 (en) * | 1998-11-17 | 2000-05-24 | Mira Diagnostica GmbH | An oligonucleotide inhibitor of thermostable polymerase |
| JP2003514383A (ja) | 1999-11-17 | 2003-04-15 | ロシュ ダイアグノスティクス ゲゼルシャフト ミット ベシュレンクテル ハフツング | 磁性ガラス粒子、それらの製造方法、及びそれらの使用 |
| EP1466018B2 (en) | 2002-01-08 | 2015-08-12 | Roche Diagnostics GmbH | Use of silica material in an amplification reaction |
| US7407747B2 (en) * | 2002-10-15 | 2008-08-05 | Applera Corporation | Method for drying dye-terminator sequencing reagents |
| AU2004227353B2 (en) * | 2003-04-01 | 2010-02-25 | Luminex Corporation | Polymerase inhibitor and method of using same |
| EP1502958A1 (en) * | 2003-08-01 | 2005-02-02 | Roche Diagnostics GmbH | New detection format for hot start real time polymerase chain reaction |
| WO2005030958A1 (ja) * | 2003-09-30 | 2005-04-07 | Riken | 酵素が固定されている支持体、印刷物、試薬キット、該支持体の製造法、酵素の保存法及び酵素の再生法 |
| US20060099567A1 (en) * | 2004-04-08 | 2006-05-11 | Biomatrica, Inc. | Integration of sample storage and sample management for life science |
| WO2006131391A1 (en) * | 2005-06-10 | 2006-12-14 | Epigenomics Ag | Prognostic assay for prediction of treatment response and/or survival of breast cell proliferative disorder patients |
| ES2393758T3 (es) * | 2006-03-15 | 2012-12-27 | Micronics, Inc. | Ensayos integrados de ácidos nucleicos |
| WO2007137291A1 (en) * | 2006-05-23 | 2007-11-29 | Molecular Detection, Inc. | Ambient temperature stable kits for molecular diagnostics |
| WO2008036544A1 (en) | 2006-09-18 | 2008-03-27 | Ge Healthcare Bio-Sciences Corp. | Preparation of glassified biological reagents |
| DE102006056790B3 (de) * | 2006-12-01 | 2008-01-17 | IfP Privates Institut für Produktqualität GmbH | Laboreinmalartikel für Analyse und Diagnosik |
| WO2008155529A1 (en) * | 2007-06-16 | 2008-12-24 | Enigma Diagnostics Limited | Compositions |
-
2009
- 2009-12-11 CA CA2688174A patent/CA2688174C/en active Active
- 2009-12-17 CN CN200910263837.4A patent/CN101768616B/zh active Active
- 2009-12-17 EP EP09015595A patent/EP2202302B1/en active Active
- 2009-12-17 JP JP2009286615A patent/JP5731113B2/ja active Active
- 2009-12-17 ES ES09015595T patent/ES2394754T3/es active Active
- 2009-12-18 US US12/641,747 patent/US8652811B2/en active Active
-
2014
- 2014-01-31 US US14/169,993 patent/US9163286B2/en active Active
-
2015
- 2015-01-09 JP JP2015003548A patent/JP2015091261A/ja active Pending
- 2015-09-16 US US14/855,915 patent/US9631233B2/en active Active
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