JP2019520815A5 - - Google Patents
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- Publication number
- JP2019520815A5 JP2019520815A5 JP2018563880A JP2018563880A JP2019520815A5 JP 2019520815 A5 JP2019520815 A5 JP 2019520815A5 JP 2018563880 A JP2018563880 A JP 2018563880A JP 2018563880 A JP2018563880 A JP 2018563880A JP 2019520815 A5 JP2019520815 A5 JP 2019520815A5
- Authority
- JP
- Japan
- Prior art keywords
- sequence
- aptamer
- seq
- nucleotides
- variant
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108091023037 Aptamer Proteins 0.000 claims 25
- 239000002773 nucleotide Substances 0.000 claims 6
- 125000003729 nucleotide group Chemical group 0.000 claims 6
- 239000000203 mixture Substances 0.000 claims 4
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 3
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 claims 2
- 239000003153 chemical reaction reagent Substances 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 150000007523 nucleic acids Chemical class 0.000 claims 2
- 102000039446 nucleic acids Human genes 0.000 claims 2
- 229910000147 aluminium phosphate Inorganic materials 0.000 claims 1
- 125000003277 amino group Chemical group 0.000 claims 1
- 150000001768 cations Chemical class 0.000 claims 1
- 230000000295 complement effect Effects 0.000 claims 1
- 239000005547 deoxyribonucleotide Substances 0.000 claims 1
- 125000002637 deoxyribonucleotide group Chemical group 0.000 claims 1
- 239000002184 metal Substances 0.000 claims 1
- 239000011541 reaction mixture Substances 0.000 claims 1
- 239000001226 triphosphate Substances 0.000 claims 1
- 235000011178 triphosphate Nutrition 0.000 claims 1
- UNXRWKVEANCORM-UHFFFAOYSA-N triphosphoric acid Chemical compound OP(O)(=O)OP(O)(=O)OP(O)(O)=O UNXRWKVEANCORM-UHFFFAOYSA-N 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022040199A JP7420850B2 (ja) | 2016-06-07 | 2022-03-15 | 熱安定性ポリメラーゼ阻害剤組成物及び方法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662347004P | 2016-06-07 | 2016-06-07 | |
| US62/347,004 | 2016-06-07 | ||
| PCT/US2017/036225 WO2017214202A1 (en) | 2016-06-07 | 2017-06-06 | Thermostable polymerase inhibitor compositions and methods |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022040199A Division JP7420850B2 (ja) | 2016-06-07 | 2022-03-15 | 熱安定性ポリメラーゼ阻害剤組成物及び方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019520815A JP2019520815A (ja) | 2019-07-25 |
| JP2019520815A5 true JP2019520815A5 (enExample) | 2020-07-27 |
| JP7106461B2 JP7106461B2 (ja) | 2022-07-26 |
Family
ID=59258348
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018563880A Active JP7106461B2 (ja) | 2016-06-07 | 2017-06-06 | 熱安定性ポリメラーゼ阻害剤組成物及び方法 |
| JP2022040199A Active JP7420850B2 (ja) | 2016-06-07 | 2022-03-15 | 熱安定性ポリメラーゼ阻害剤組成物及び方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022040199A Active JP7420850B2 (ja) | 2016-06-07 | 2022-03-15 | 熱安定性ポリメラーゼ阻害剤組成物及び方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (3) | US11299739B2 (enExample) |
| EP (1) | EP3464596B1 (enExample) |
| JP (2) | JP7106461B2 (enExample) |
| CN (1) | CN109477111B (enExample) |
| AU (1) | AU2017277304B2 (enExample) |
| CA (1) | CA3026646A1 (enExample) |
| WO (1) | WO2017214202A1 (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109477111B (zh) | 2016-06-07 | 2023-12-15 | 塞弗德公司 | 热稳定聚合酶抑制剂组合物和方法 |
| WO2020010124A2 (en) * | 2018-07-02 | 2020-01-09 | Swift Biosciences, Inc. | Temperature controlled dna polymerase inhibitors |
| SG11202100750XA (en) * | 2018-07-24 | 2021-02-25 | Flagship Pioneering Innovations Vi Llc | Compositions comprising circular polyribonucleotides and uses thereof |
| CN114990126B (zh) * | 2022-08-03 | 2022-11-18 | 珠海宝锐生物科技有限公司 | 特异性结合Bst DNA聚合酶大片段活性位点的核酸适配体及应用 |
| CN116004776A (zh) * | 2022-08-30 | 2023-04-25 | 上海伯杰医疗科技股份有限公司 | 一管式RT-qPCR全预混反应试剂、应用及RT-qPCR方法 |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| US4889818A (en) | 1986-08-22 | 1989-12-26 | Cetus Corporation | Purified thermostable enzyme |
| US5874557A (en) | 1990-06-11 | 1999-02-23 | Nexstar Pharmaceuticals, Inc. | Nucleic acid ligand inhibitors to DNA polymerases |
| US6582908B2 (en) * | 1990-12-06 | 2003-06-24 | Affymetrix, Inc. | Oligonucleotides |
| US6183967B1 (en) | 1995-06-07 | 2001-02-06 | Nexstar Pharmaceuticals | Nucleic acid ligand inhibitors to DNA polymerases |
| US5773258A (en) | 1995-08-25 | 1998-06-30 | Roche Molecular Systems, Inc. | Nucleic acid amplification using a reversibly inactivated thermostable enzyme |
| US5998203A (en) | 1996-04-16 | 1999-12-07 | Ribozyme Pharmaceuticals, Inc. | Enzymatic nucleic acids containing 5'-and/or 3'-cap structures |
| US5959090A (en) | 1996-07-02 | 1999-09-28 | Glen Research Corporation | Chemical phosphorylation of oligonucleotides and reactants used therefor |
| US5958349A (en) | 1997-02-28 | 1999-09-28 | Cepheid | Reaction vessel for heat-exchanging chemical processes |
| DK1179585T3 (da) | 1997-12-24 | 2008-11-10 | Cepheid | Indretning og fremgangsmåde til lysis |
| US6183998B1 (en) | 1998-05-29 | 2001-02-06 | Qiagen Gmbh Max-Volmer-Strasse 4 | Method for reversible modification of thermostable enzymes |
| JP4022069B2 (ja) | 1999-05-28 | 2007-12-12 | シーフィード | 細胞破壊装置および方法 |
| US6818185B1 (en) | 1999-05-28 | 2004-11-16 | Cepheid | Cartridge for conducting a chemical reaction |
| US6403037B1 (en) | 2000-02-04 | 2002-06-11 | Cepheid | Reaction vessel and temperature control system |
| US6667165B2 (en) * | 2001-11-13 | 2003-12-23 | Eppendorf Ag | Method and compositions for reversible inhibition of thermostable polymerases |
| AU2004227353B2 (en) | 2003-04-01 | 2010-02-25 | Luminex Corporation | Polymerase inhibitor and method of using same |
| WO2006086669A2 (en) * | 2005-02-09 | 2006-08-17 | California Institute Of Technology | Aptamer regulated nucleic acids and uses thereof |
| WO2007038422A2 (en) | 2005-09-26 | 2007-04-05 | Allelogic Biosciences Corp. | Oligonucleotides as temperature-sensitive inhibitors for dna polymerases |
| EP2458011B1 (en) * | 2005-10-03 | 2013-07-24 | Life Technologies Corporation | Compositions, methods, and kits for amplifying nucleic acids |
| US8071338B2 (en) * | 2007-08-08 | 2011-12-06 | Roche Molecular Systems, Inc. | Suppression of amplification using an oligonucleotide and a polymerase significantly lacking 5′-3′ nuclease activity |
| EP2292781A1 (en) * | 2009-08-17 | 2011-03-09 | Genethon | Baculovirus-based production of biopharmaceuticals free of contaminating baculoviral virions |
| US10036061B2 (en) | 2013-12-20 | 2018-07-31 | Roche Molecular Systems, Inc. | Oligonucleotide inhibitor of DNA polymerases |
| KR101719285B1 (ko) * | 2014-11-04 | 2017-03-23 | 한국과학기술원 | 표적 물질에 의해 조절되는 핵산 중합효소 활성을 이용한 생체물질의 검출 및 정량 방법 |
| CN109477111B (zh) | 2016-06-07 | 2023-12-15 | 塞弗德公司 | 热稳定聚合酶抑制剂组合物和方法 |
| US10724017B1 (en) * | 2017-12-06 | 2020-07-28 | Cepheid | Inhibition of DNA polymerases by uracil-DNA glycosylase-cleavable oligonucleotide ligands |
| US10689629B1 (en) * | 2017-12-06 | 2020-06-23 | Cepheid | Inhibition of nucleic acid polymerases by endonuclease V-cleavable circular oligonucleotide ligands |
| US10724083B1 (en) * | 2017-12-06 | 2020-07-28 | Cepheid | Inhibition of nucleic acid polymerases by endonuclease V-cleavable oligonucleotide ligands |
-
2017
- 2017-06-06 CN CN201780045522.5A patent/CN109477111B/zh active Active
- 2017-06-06 JP JP2018563880A patent/JP7106461B2/ja active Active
- 2017-06-06 AU AU2017277304A patent/AU2017277304B2/en active Active
- 2017-06-06 EP EP17734553.5A patent/EP3464596B1/en active Active
- 2017-06-06 CA CA3026646A patent/CA3026646A1/en active Pending
- 2017-06-06 WO PCT/US2017/036225 patent/WO2017214202A1/en not_active Ceased
- 2017-06-06 US US16/305,858 patent/US11299739B2/en active Active
-
2022
- 2022-03-04 US US17/687,473 patent/US12385045B2/en active Active
- 2022-03-15 JP JP2022040199A patent/JP7420850B2/ja active Active
-
2025
- 2025-08-11 US US19/295,912 patent/US20250369000A1/en active Pending
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