JP2014508748A5 - - Google Patents
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- Publication number
- JP2014508748A5 JP2014508748A5 JP2013553501A JP2013553501A JP2014508748A5 JP 2014508748 A5 JP2014508748 A5 JP 2014508748A5 JP 2013553501 A JP2013553501 A JP 2013553501A JP 2013553501 A JP2013553501 A JP 2013553501A JP 2014508748 A5 JP2014508748 A5 JP 2014508748A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- antigen
- binding fragment
- antibody
- alpha toxin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161440581P | 2011-02-08 | 2011-02-08 | |
| US61/440,581 | 2011-02-08 | ||
| PCT/US2012/024201 WO2012109285A2 (en) | 2011-02-08 | 2012-02-07 | Antibodies that specifically bind staphylococcus aureus alpha toxin and methods of use |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017023905A Division JP6367393B2 (ja) | 2011-02-08 | 2017-02-13 | 黄色ブドウ球菌（Ｓｔａｐｈｙｌｏｃｏｃｃｕｓ ａｕｒｅｕｓ）α毒素に特異的に結合する抗体及び使用方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2014508748A JP2014508748A (ja) | 2014-04-10 |
| JP2014508748A5 true JP2014508748A5 (enExample) | 2015-03-26 |
Family
ID=46639171
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013553501A Pending JP2014508748A (ja) | 2011-02-08 | 2012-02-07 | 黄色ブドウ球菌（Ｓｔａｐｈｙｌｏｃｏｃｃｕｓａｕｒｅｕｓ）α毒素に特異的に結合する抗体及び使用方法 |
| JP2017023905A Active JP6367393B2 (ja) | 2011-02-08 | 2017-02-13 | 黄色ブドウ球菌（Ｓｔａｐｈｙｌｏｃｏｃｃｕｓ ａｕｒｅｕｓ）α毒素に特異的に結合する抗体及び使用方法 |
| JP2018127340A Active JP6723293B2 (ja) | 2011-02-08 | 2018-07-04 | 黄色ブドウ球菌（Ｓｔａｐｈｙｌｏｃｏｃｃｕｓ ａｕｒｅｕｓ）α毒素に特異的に結合する抗体及び使用方法 |
| JP2020108083A Active JP7047017B2 (ja) | 2011-02-08 | 2020-06-23 | 黄色ブドウ球菌（Ｓｔａｐｈｙｌｏｃｏｃｃｕｓ ａｕｒｅｕｓ）α毒素に特異的に結合する抗体及び使用方法 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017023905A Active JP6367393B2 (ja) | 2011-02-08 | 2017-02-13 | 黄色ブドウ球菌（Ｓｔａｐｈｙｌｏｃｏｃｃｕｓ ａｕｒｅｕｓ）α毒素に特異的に結合する抗体及び使用方法 |
| JP2018127340A Active JP6723293B2 (ja) | 2011-02-08 | 2018-07-04 | 黄色ブドウ球菌（Ｓｔａｐｈｙｌｏｃｏｃｃｕｓ ａｕｒｅｕｓ）α毒素に特異的に結合する抗体及び使用方法 |
| JP2020108083A Active JP7047017B2 (ja) | 2011-02-08 | 2020-06-23 | 黄色ブドウ球菌（Ｓｔａｐｈｙｌｏｃｏｃｃｕｓ ａｕｒｅｕｓ）α毒素に特異的に結合する抗体及び使用方法 |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US9527905B2 (enExample) |
| EP (2) | EP3470526A3 (enExample) |
| JP (4) | JP2014508748A (enExample) |
| KR (1) | KR101993839B1 (enExample) |
| CN (2) | CN103443285B9 (enExample) |
| AU (1) | AU2012214531C1 (enExample) |
| BR (1) | BR112013020086B1 (enExample) |
| CA (1) | CA2826566C (enExample) |
| CY (1) | CY1121389T1 (enExample) |
| DK (1) | DK2673373T6 (enExample) |
| ES (1) | ES2709065T7 (enExample) |
| HR (1) | HRP20182017T4 (enExample) |
| HU (1) | HUE040734T2 (enExample) |
| LT (1) | LT2673373T (enExample) |
| MX (3) | MX345285B (enExample) |
| PL (1) | PL2673373T6 (enExample) |
| PT (1) | PT2673373T (enExample) |
| RS (1) | RS58190B2 (enExample) |
| RU (1) | RU2620065C2 (enExample) |
| SG (3) | SG10201913690SA (enExample) |
| SI (1) | SI2673373T1 (enExample) |
| SM (1) | SMT201800635T1 (enExample) |
| TR (1) | TR201817932T4 (enExample) |
| WO (1) | WO2012109285A2 (enExample) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RS57024B1 (sr) | 2011-06-10 | 2018-05-31 | Medimmune Ltd | Anti-pseudomonas psl vezujući molekuli i njihova upotreba |
| US10597439B2 (en) | 2011-11-07 | 2020-03-24 | Medimmune Limited | Combination therapies using anti-pseudomonas PSL and PCRV binding molecules |
| US9988439B2 (en) | 2011-12-23 | 2018-06-05 | Nicholas B. Lydon | Immunoglobulins and variants directed against pathogenic microbes |
| EP2793944B1 (en) | 2011-12-23 | 2025-10-08 | Nicholas B. Lydon | Immunoglobulins and variants directed against pathogenic microbes |
| JOP20200236A1 (ar) | 2012-09-21 | 2017-06-16 | Regeneron Pharma | الأجسام المضادة لمضاد cd3 وجزيئات ربط الأنتيجين ثنائية التحديد التي تربط cd3 وcd20 واستخداماتها |
| JP6506172B2 (ja) * | 2012-11-06 | 2019-04-24 | メディミューン，エルエルシー | 黄色ブドウ球菌（Ｓ．ａｕｒｅｕｓ）関連性疾患を治療する方法 |
| JP2015535005A (ja) * | 2012-11-06 | 2015-12-07 | メディミューン，エルエルシー | 抗シュードモナス属（Ｐｓｅｕｄｏｍｏｎａｓ）ＰｓｌおよびＰｃｒＶ結合分子を用いた併用治療 |
| CN104968797B (zh) * | 2012-11-06 | 2018-11-30 | 米迪缪尼有限公司 | 金黄色葡萄球菌表面决定簇的抗体 |
| CA2925071A1 (en) * | 2013-10-17 | 2015-04-23 | Arsanis Biosciences Gmbh | Cross-reactive staphylococcus aureus antibody sequences |
| WO2015109012A1 (en) * | 2014-01-14 | 2015-07-23 | Integrated Biotherapeutics, Inc. | Targeting immunological functions to the site of bacterial infections using cell wall targeting domains of bacteriolysins |
| TWI754319B (zh) | 2014-03-19 | 2022-02-01 | 美商再生元醫藥公司 | 用於腫瘤治療之方法及抗體組成物 |
| TWI719938B (zh) * | 2014-06-19 | 2021-03-01 | 美商麥迪紐有限責任公司 | 多重細菌感染之治療 |
| CA2956429A1 (en) * | 2014-08-12 | 2016-02-18 | Arsanis Biosciences Gmbh | Predicting s. aureus disease |
| ES2809455T3 (es) | 2014-11-17 | 2021-03-04 | Regeneron Pharma | Métodos para tratamiento tumoral usando anticuerpo biespecífico CD3xCD20 |
| EP3766987B1 (en) * | 2015-09-24 | 2023-08-02 | F. Hoffmann-La Roche AG | Alpha-hemolysin variants |
| WO2017075188A2 (en) * | 2015-10-30 | 2017-05-04 | Medimmune, Llc | Methods of using anti-alpha toxin antibody |
| TWI781130B (zh) * | 2017-01-03 | 2022-10-21 | 美商再生元醫藥公司 | 抗金黃色葡萄球菌溶血素ａ毒素之人類抗體 |
| MA47468A (fr) * | 2017-02-09 | 2019-12-18 | Bluefin Biomedicine Inc | Anticorps anti-ilt3 et conjugués anticorps-médicament |
| CN108456250B (zh) * | 2017-02-17 | 2025-11-28 | 恺兴生命科技(上海)有限公司 | 靶向il-13ra2的抗体及其应用 |
| CN109384844B (zh) * | 2017-08-04 | 2020-12-18 | 中国人民解放军军事医学科学院基础医学研究所 | 一种抗金黄色葡萄球菌α溶血素单克隆抗体及应用 |
| US11155606B2 (en) | 2018-07-24 | 2021-10-26 | Medimmune, Llc | Antibody directed against S. aureus clumping factor a (ClfA) |
| US11396542B2 (en) | 2018-08-21 | 2022-07-26 | Synkrino Biotherapeutics, Inc. | Astrotactin1-based compositions and pharmaceutical formulations |
| PT3844189T (pt) | 2018-08-31 | 2025-01-29 | Regeneron Pharma | Estratégia de dosagem que mitiga a síndrome de libertação de citocinas para anticorpos bisepecíficos contra cd3/c20 |
| BR112021006622A2 (pt) | 2018-10-09 | 2021-07-20 | Medimmune, Llc | combinações de anticorpos anti-staphylococcus aureus |
| WO2020076790A1 (en) | 2018-10-09 | 2020-04-16 | Medimmune, Llc | Antibodies directed against staphylococcus aureus leukotoxins |
| US12264194B2 (en) | 2019-03-13 | 2025-04-01 | Medimmune, Llc | Decreasing Staphylococcus aureus infections in colonized patients |
| WO2020210650A1 (en) | 2019-04-12 | 2020-10-15 | Medimmune, Llc | Neutralization of tgf-beta or alpha-v-beta-8 integrin for s. aureus infections |
| CN112538112B (zh) * | 2019-09-20 | 2023-10-27 | 迈威(上海)生物科技股份有限公司 | 抗α-溶血素的抗体及其应用 |
| CN113444172A (zh) | 2020-03-25 | 2021-09-28 | 兴盟生物医药(苏州)有限公司 | 金黄色葡萄球菌α-毒素特异性抗体及其应用 |
| CN117062908A (zh) * | 2021-01-11 | 2023-11-14 | 星济生物(苏州)有限公司 | 靶向金黄色葡萄球菌α-毒素的抗原结合蛋白及其应用 |
| CN112941136B (zh) * | 2021-03-24 | 2023-04-28 | 成都欧林生物科技股份有限公司 | 一种重组金黄色葡萄球菌疫苗hi抗原蛋白的纯化方法 |
| CN114455048B (zh) * | 2022-03-02 | 2023-03-14 | 江苏微导纳米科技股份有限公司 | 一种桨杆 |
| CN117106077B (zh) * | 2022-04-28 | 2024-07-16 | 珠海泰诺麦博制药股份有限公司 | 特异性结合金黄色葡萄球菌Hla毒素的全人源单克隆抗体 |
| CN116589566A (zh) * | 2022-11-18 | 2023-08-15 | 昆明医科大学第一附属医院 | 一种HIV-1中和抗体的改造重组单克隆IgM抗体及其应用 |
| CN116023486B (zh) * | 2023-01-10 | 2024-10-08 | 西北农林科技大学 | 金黄色葡萄球菌α-溶血素纳米抗体、制备方法及其应用 |
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| IL85035A0 (en) | 1987-01-08 | 1988-06-30 | Int Genetic Eng | Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same |
| ATE255131T1 (de) | 1991-06-14 | 2003-12-15 | Genentech Inc | Humanisierter heregulin antikörper |
| IL126544A (en) | 1996-04-25 | 2004-08-31 | Genicon Sciences Inc | Analyte assay using scattered-light detectable particles |
| ATE440959T1 (de) | 2000-06-28 | 2009-09-15 | Glycofi Inc | Verfahren für die herstellung modifizierter glykoproteine |
| US6596541B2 (en) | 2000-10-31 | 2003-07-22 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| JP4336498B2 (ja) | 2000-12-12 | 2009-09-30 | メディミューン，エルエルシー | 延長した半減期を有する分子ならびにその組成物および用途 |
| US20030226155A1 (en) | 2001-08-30 | 2003-12-04 | Biorexis Pharmaceutical Corporation | Modified transferrin-antibody fusion proteins |
| EP1479695B1 (en) | 2003-05-14 | 2010-02-17 | Kenta Biotech AG | Human monoclonal antibody specific for lipopolysaccharides (LPS) of serotype IATS O6 of Pseudomonas aeruginosa |
| CN1324049C (zh) | 2003-08-04 | 2007-07-04 | 中国疾病预防控制中心病毒病预防控制所 | 人源抗sars冠状病毒基因工程抗体 |
| PT1737891E (pt) * | 2004-04-13 | 2013-04-16 | Hoffmann La Roche | Anticorpos anti p-selectina |
| EP2298340B1 (en) * | 2004-09-22 | 2014-04-16 | GlaxoSmithKline Biologicals S.A. | Immunogenic composition for use in vaccination against staphylococcei |
| ES2395842T3 (es) | 2006-01-17 | 2013-02-15 | Synthon Biopharmaceuticals B.V. | Composiciones y métodos para la humanización y optimización de N-glicanos en plantas |
| TW200813091A (en) | 2006-04-10 | 2008-03-16 | Amgen Fremont Inc | Targeted binding agents directed to uPAR and uses thereof |
| US20090053235A1 (en) * | 2006-06-12 | 2009-02-26 | Nabi Biopharmaceuticals | Use of alpha-toxin for treating and preventing staphylococcus infections |
| EP2164869A2 (en) * | 2007-05-31 | 2010-03-24 | Merck Sharp & Dohme Corp. | Antigen-binding proteins targeting s. aureus orf0657n |
| RS56743B1 (sr) | 2007-08-21 | 2018-03-30 | Amgen Inc | Humani c-fms antigen vezujući proteini |
| JP5658564B2 (ja) * | 2007-08-31 | 2015-01-28 | ザ・ユニバーシティ・オブ・シカゴＴｈｅ Ｕｎｉｖｅｒｓｉｔｙ Ｏｆ Ｃｈｉｃａｇｏ | ブドウ球菌肺疾患および状態に対する免疫に関連した方法および組成物 |
| US8172115B1 (en) | 2008-04-10 | 2012-05-08 | Spencer Forrest, Inc. | Hair building solids dispenser for one handed operation |
| CN102171247A (zh) | 2008-07-02 | 2011-08-31 | 特鲁比昂药品公司 | TNF-α拮抗剂多靶点结合蛋白 |
| EP2208787A1 (en) * | 2009-01-19 | 2010-07-21 | Université de Liège | A recombinant alpha-hemolysin polypeptide of Staphylococcus aureus, having a deletion in the stem domain and heterologous sequences inserted |
| GB2467939A (en) * | 2009-02-20 | 2010-08-25 | Univ Sheffield | Removal of bacteria from media |
| CN102481352A (zh) * | 2009-06-22 | 2012-05-30 | 惠氏有限责任公司 | 金黄色葡萄球菌抗原的免疫原性组合物 |
| CN104968797B (zh) * | 2012-11-06 | 2018-11-30 | 米迪缪尼有限公司 | 金黄色葡萄球菌表面决定簇的抗体 |
-
2012
- 2012-02-07 BR BR112013020086-3A patent/BR112013020086B1/pt active IP Right Grant
- 2012-02-07 LT LTEP12745207.6T patent/LT2673373T/lt unknown
- 2012-02-07 HU HUE12745207A patent/HUE040734T2/hu unknown
- 2012-02-07 PT PT12745207T patent/PT2673373T/pt unknown
- 2012-02-07 PL PL12745207T patent/PL2673373T6/pl unknown
- 2012-02-07 CA CA2826566A patent/CA2826566C/en active Active
- 2012-02-07 TR TR2018/17932T patent/TR201817932T4/en unknown
- 2012-02-07 DK DK12745207.6T patent/DK2673373T6/da active
- 2012-02-07 HR HRP20182017TT patent/HRP20182017T4/hr unknown
- 2012-02-07 EP EP18190790.8A patent/EP3470526A3/en active Pending
- 2012-02-07 KR KR1020137023512A patent/KR101993839B1/ko active Active
- 2012-02-07 WO PCT/US2012/024201 patent/WO2012109285A2/en not_active Ceased
- 2012-02-07 SG SG10201913690SA patent/SG10201913690SA/en unknown
- 2012-02-07 RU RU2013141134A patent/RU2620065C2/ru active
- 2012-02-07 SG SG2013057831A patent/SG192212A1/en unknown
- 2012-02-07 MX MX2013009127A patent/MX345285B/es active IP Right Grant
- 2012-02-07 AU AU2012214531A patent/AU2012214531C1/en active Active
- 2012-02-07 EP EP12745207.6A patent/EP2673373B3/en active Active
- 2012-02-07 CN CN201280007986.4A patent/CN103443285B9/zh active Active
- 2012-02-07 SM SM20180635T patent/SMT201800635T1/it unknown
- 2012-02-07 US US13/983,804 patent/US9527905B2/en active Active
- 2012-02-07 SG SG10201600899PA patent/SG10201600899PA/en unknown
- 2012-02-07 ES ES12745207T patent/ES2709065T7/es active Active
- 2012-02-07 SI SI201231470T patent/SI2673373T1/sl unknown
- 2012-02-07 JP JP2013553501A patent/JP2014508748A/ja active Pending
- 2012-02-07 CN CN201710480750.7A patent/CN107474133B/zh active Active
- 2012-02-07 RS RS20181450A patent/RS58190B2/sr unknown
- 2012-02-07 MX MX2017001101A patent/MX375113B/es unknown
-
2013
- 2013-08-07 MX MX2020009700A patent/MX2020009700A/es unknown
-
2017
- 2017-02-13 JP JP2017023905A patent/JP6367393B2/ja active Active
-
2018
- 2018-07-04 JP JP2018127340A patent/JP6723293B2/ja active Active
- 2018-11-28 CY CY20181101266T patent/CY1121389T1/el unknown
-
2020
- 2020-06-23 JP JP2020108083A patent/JP7047017B2/ja active Active
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