JP2014508748A5 - - Google Patents

Info

Publication number

JP2014508748A5

JP2014508748A5 JP2013553501A JP2013553501A JP2014508748A5 JP 2014508748 A5 JP2014508748 A5 JP 2014508748A5 JP 2013553501 A JP2013553501 A JP 2013553501A JP 2013553501 A JP2013553501 A JP 2013553501A JP 2014508748 A5 JP2014508748 A5 JP 2014508748A5

Authority

JP

Japan

Prior art keywords

seq

antigen

binding fragment

antibody

alpha toxin

Prior art date

2012-02-07

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
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• 239000012634 fragment Substances 0.000 claims 31
• 239000000427 antigen Substances 0.000 claims 29
• 108091007433 antigens Proteins 0.000 claims 29
• 102000036639 antigens Human genes 0.000 claims 29
• 125000003275 alpha amino acid group Chemical group 0.000 claims 10
• 101710092462 Alpha-hemolysin Proteins 0.000 claims 9
• 101710197219 Alpha-toxin Proteins 0.000 claims 9
• 101710124951 Phospholipase C Proteins 0.000 claims 9
• 239000002776 alpha toxin Substances 0.000 claims 9
• 108010092231 staphylococcal alpha-toxin Proteins 0.000 claims 9
• 239000000203 mixture Substances 0.000 claims 6
• 150000001413 amino acids Chemical class 0.000 claims 5
• 229920001184 polypeptide Polymers 0.000 claims 5
• 108090000765 processed proteins & peptides Proteins 0.000 claims 5
• 102000004196 processed proteins & peptides Human genes 0.000 claims 5
• 230000015572 biosynthetic process Effects 0.000 claims 4
• 238000000034 method Methods 0.000 claims 4
• 206010035664 Pneumonia Diseases 0.000 claims 3
• 230000003115 biocidal effect Effects 0.000 claims 2
• 239000003795 chemical substances by application Substances 0.000 claims 2
• 239000000178 monomer Substances 0.000 claims 2
• 239000008194 pharmaceutical composition Substances 0.000 claims 2
• 230000002265 prevention Effects 0.000 claims 2
• 206010040872 skin infection Diseases 0.000 claims 2
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
• 102000004127 Cytokines Human genes 0.000 claims 1
• 108090000695 Cytokines Proteins 0.000 claims 1
• 206010018910 Haemolysis Diseases 0.000 claims 1
• 239000003242 anti bacterial agent Substances 0.000 claims 1
• 238000003556 assay Methods 0.000 claims 1
• 230000006037 cell lysis Effects 0.000 claims 1
• MYPYJXKWCTUITO-KIIOPKALSA-N chembl3301825 Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=C2C=C3C=C1OC1=CC=C(C=C1Cl)[C@@H](O)[C@H](C(N[C@@H](CC(N)=O)C(=O)N[C@H]3C(=O)N[C@H]1C(=O)N[C@H](C(N[C@H](C3=CC(O)=CC(O)=C3C=3C(O)=CC=C1C=3)C(O)=O)=O)[C@H](O)C1=CC=C(C(=C1)Cl)O2)=O)NC(=O)[C@@H](CC(C)C)NC)[C@H]1C[C@](C)(N)C(O)[C@H](C)O1 MYPYJXKWCTUITO-KIIOPKALSA-N 0.000 claims 1
• 230000001461 cytolytic effect Effects 0.000 claims 1
• 230000008588 hemolysis Effects 0.000 claims 1
• 230000002401 inhibitory effect Effects 0.000 claims 1
• 230000005764 inhibitory process Effects 0.000 claims 1
• 230000009545 invasion Effects 0.000 claims 1
• 230000000770 proinflammatory effect Effects 0.000 claims 1