JP2014508748A5 - - Google Patents
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- Publication number
- JP2014508748A5 JP2014508748A5 JP2013553501A JP2013553501A JP2014508748A5 JP 2014508748 A5 JP2014508748 A5 JP 2014508748A5 JP 2013553501 A JP2013553501 A JP 2013553501A JP 2013553501 A JP2013553501 A JP 2013553501A JP 2014508748 A5 JP2014508748 A5 JP 2014508748A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- antigen
- binding fragment
- antibody
- alpha toxin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161440581P | 2011-02-08 | 2011-02-08 | |
| US61/440,581 | 2011-02-08 | ||
| PCT/US2012/024201 WO2012109285A2 (en) | 2011-02-08 | 2012-02-07 | Antibodies that specifically bind staphylococcus aureus alpha toxin and methods of use |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017023905A Division JP6367393B2 (ja) | 2011-02-08 | 2017-02-13 | 黄色ブドウ球菌（Ｓｔａｐｈｙｌｏｃｏｃｃｕｓ ａｕｒｅｕｓ）α毒素に特異的に結合する抗体及び使用方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2014508748A JP2014508748A (ja) | 2014-04-10 |
| JP2014508748A5 true JP2014508748A5 (enExample) | 2015-03-26 |
Family
ID=46639171
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013553501A Pending JP2014508748A (ja) | 2011-02-08 | 2012-02-07 | 黄色ブドウ球菌（Ｓｔａｐｈｙｌｏｃｏｃｃｕｓａｕｒｅｕｓ）α毒素に特異的に結合する抗体及び使用方法 |
| JP2017023905A Active JP6367393B2 (ja) | 2011-02-08 | 2017-02-13 | 黄色ブドウ球菌（Ｓｔａｐｈｙｌｏｃｏｃｃｕｓ ａｕｒｅｕｓ）α毒素に特異的に結合する抗体及び使用方法 |
| JP2018127340A Active JP6723293B2 (ja) | 2011-02-08 | 2018-07-04 | 黄色ブドウ球菌（Ｓｔａｐｈｙｌｏｃｏｃｃｕｓ ａｕｒｅｕｓ）α毒素に特異的に結合する抗体及び使用方法 |
| JP2020108083A Active JP7047017B2 (ja) | 2011-02-08 | 2020-06-23 | 黄色ブドウ球菌（Ｓｔａｐｈｙｌｏｃｏｃｃｕｓ ａｕｒｅｕｓ）α毒素に特異的に結合する抗体及び使用方法 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017023905A Active JP6367393B2 (ja) | 2011-02-08 | 2017-02-13 | 黄色ブドウ球菌（Ｓｔａｐｈｙｌｏｃｏｃｃｕｓ ａｕｒｅｕｓ）α毒素に特異的に結合する抗体及び使用方法 |
| JP2018127340A Active JP6723293B2 (ja) | 2011-02-08 | 2018-07-04 | 黄色ブドウ球菌（Ｓｔａｐｈｙｌｏｃｏｃｃｕｓ ａｕｒｅｕｓ）α毒素に特異的に結合する抗体及び使用方法 |
| JP2020108083A Active JP7047017B2 (ja) | 2011-02-08 | 2020-06-23 | 黄色ブドウ球菌（Ｓｔａｐｈｙｌｏｃｏｃｃｕｓ ａｕｒｅｕｓ）α毒素に特異的に結合する抗体及び使用方法 |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US9527905B2 (enExample) |
| EP (2) | EP2673373B3 (enExample) |
| JP (4) | JP2014508748A (enExample) |
| KR (1) | KR101993839B1 (enExample) |
| CN (2) | CN107474133B (enExample) |
| AU (1) | AU2012214531C1 (enExample) |
| BR (1) | BR112013020086B1 (enExample) |
| CA (1) | CA2826566C (enExample) |
| CY (1) | CY1121389T1 (enExample) |
| DK (1) | DK2673373T6 (enExample) |
| ES (1) | ES2709065T7 (enExample) |
| HR (1) | HRP20182017T4 (enExample) |
| HU (1) | HUE040734T2 (enExample) |
| LT (1) | LT2673373T (enExample) |
| MX (3) | MX345285B (enExample) |
| PL (1) | PL2673373T6 (enExample) |
| PT (1) | PT2673373T (enExample) |
| RS (1) | RS58190B2 (enExample) |
| RU (1) | RU2620065C2 (enExample) |
| SG (3) | SG10201600899PA (enExample) |
| SI (1) | SI2673373T1 (enExample) |
| SM (1) | SMT201800635T1 (enExample) |
| TR (1) | TR201817932T4 (enExample) |
| WO (1) | WO2012109285A2 (enExample) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2012267732A1 (en) | 2011-06-10 | 2014-01-09 | Medimmune Limited | Anti-Pseudomonas Psl binding molecules and uses thereof |
| WO2013070615A1 (en) * | 2011-11-07 | 2013-05-16 | Medlmmune, Llc. | Combination therapies using anti- pseudomonas psl and pcrv binding molecules |
| WO2013096948A1 (en) | 2011-12-23 | 2013-06-27 | Lydon Nicholas B | Immunoglobulins and variants directed against pathogenic microbes |
| US9988439B2 (en) | 2011-12-23 | 2018-06-05 | Nicholas B. Lydon | Immunoglobulins and variants directed against pathogenic microbes |
| JOP20200236A1 (ar) | 2012-09-21 | 2017-06-16 | Regeneron Pharma | الأجسام المضادة لمضاد cd3 وجزيئات ربط الأنتيجين ثنائية التحديد التي تربط cd3 وcd20 واستخداماتها |
| ES2912267T3 (es) | 2012-11-06 | 2022-05-25 | Medimmune Llc | Métodos de tratamiento de enfermedades asociadas a S. aureus |
| US20150284450A1 (en) * | 2012-11-06 | 2015-10-08 | Medimmune, Llc | Combination therapies using anti-pseudomonas psl and pcrv binding molecules |
| EP2917360B1 (en) * | 2012-11-06 | 2020-01-08 | Medlmmune, LLC | Antibodies to s. aureus surface determinants |
| CN105873946A (zh) * | 2013-10-17 | 2016-08-17 | 阿尔萨尼斯生物科学有限责任公司 | 交叉反应性金黄色葡萄球菌抗体序列 |
| EP3094348B1 (en) | 2014-01-14 | 2025-03-05 | AbVacc, Inc. | Targeting immunological functions to the site of bacterial infections using cell wall targeting domains of bacteriolysins |
| TWI754319B (zh) | 2014-03-19 | 2022-02-01 | 美商再生元醫藥公司 | 用於腫瘤治療之方法及抗體組成物 |
| TWI719938B (zh) * | 2014-06-19 | 2021-03-01 | 美商麥迪紐有限責任公司 | 多重細菌感染之治療 |
| WO2016023943A1 (en) * | 2014-08-12 | 2016-02-18 | Arsanis Biosciences Gmbh | Predicting s. aureus disease |
| ES2809455T3 (es) | 2014-11-17 | 2021-03-04 | Regeneron Pharma | Métodos para tratamiento tumoral usando anticuerpo biespecífico CD3xCD20 |
| CN108137656A (zh) * | 2015-09-24 | 2018-06-08 | 豪夫迈·罗氏有限公司 | α-溶血素变体 |
| US20190077851A1 (en) * | 2015-10-30 | 2019-03-14 | Bruno Francois | Methods of using anti-alpha toxin antibody |
| TW202311284A (zh) * | 2017-01-03 | 2023-03-16 | 美商再生元醫藥公司 | 抗金黃色葡萄球菌溶血素ａ毒素之人類抗體 |
| MA47468A (fr) | 2017-02-09 | 2019-12-18 | Bluefin Biomedicine Inc | Anticorps anti-ilt3 et conjugués anticorps-médicament |
| CN108456250B (zh) * | 2017-02-17 | 2025-11-28 | 恺兴生命科技(上海)有限公司 | 靶向il-13ra2的抗体及其应用 |
| CN109384844B (zh) * | 2017-08-04 | 2020-12-18 | 中国人民解放军军事医学科学院基础医学研究所 | 一种抗金黄色葡萄球菌α溶血素单克隆抗体及应用 |
| MX2021000889A (es) | 2018-07-24 | 2021-04-28 | Medimmune Llc | Anticuerpo dirigido contra el factor de agregación a (clfa) de s. aureus. |
| US11396542B2 (en) | 2018-08-21 | 2022-07-26 | Synkrino Biotherapeutics, Inc. | Astrotactin1-based compositions and pharmaceutical formulations |
| ES3009025T3 (en) | 2018-08-31 | 2025-03-25 | Regeneron Pharma | Dosing strategy that mitigates cytokine release syndrome for cd3/cd20 bispecific antibodies |
| MX2021004173A (es) | 2018-10-09 | 2021-09-08 | Medimmune Llc | Combinaciones de anticuerpos dirigidos contra staphylococcus aureus. |
| WO2020076790A1 (en) | 2018-10-09 | 2020-04-16 | Medimmune, Llc | Antibodies directed against staphylococcus aureus leukotoxins |
| JP7682795B2 (ja) | 2019-03-13 | 2025-05-26 | メディミューン，エルエルシー | コロニー形成患者における黄色ブドウ球菌（Ｓｔａｐｈｙｌｏｃｏｃｃｕｓ ａｕｒｅｕｓ）感染症の低減 |
| WO2020210650A1 (en) | 2019-04-12 | 2020-10-15 | Medimmune, Llc | Neutralization of tgf-beta or alpha-v-beta-8 integrin for s. aureus infections |
| CN112538112B (zh) * | 2019-09-20 | 2023-10-27 | 迈威(上海)生物科技股份有限公司 | 抗α-溶血素的抗体及其应用 |
| CN113444172A (zh) * | 2020-03-25 | 2021-09-28 | 兴盟生物医药(苏州)有限公司 | 金黄色葡萄球菌α-毒素特异性抗体及其应用 |
| BR112023013790A2 (pt) * | 2021-01-11 | 2023-10-03 | Starmab Biologics Suzhou Co Ltd | Proteína de ligação a antígeno dirigida à alfa-toxina de staphylococcus aureus e aplicação da mesma |
| CN112941136B (zh) * | 2021-03-24 | 2023-04-28 | 成都欧林生物科技股份有限公司 | 一种重组金黄色葡萄球菌疫苗hi抗原蛋白的纯化方法 |
| CN114455048B (zh) * | 2022-03-02 | 2023-03-14 | 江苏微导纳米科技股份有限公司 | 一种桨杆 |
| WO2023208123A1 (zh) * | 2022-04-28 | 2023-11-02 | 珠海泰诺麦博制药股份有限公司 | 特异性结合金黄色葡萄球菌Hla毒素的全人源单克隆抗体 |
| CN116589566A (zh) * | 2022-11-18 | 2023-08-15 | 昆明医科大学第一附属医院 | 一种HIV-1中和抗体的改造重组单克隆IgM抗体及其应用 |
| CN116023486B (zh) * | 2023-01-10 | 2024-10-08 | 西北农林科技大学 | 金黄色葡萄球菌α-溶血素纳米抗体、制备方法及其应用 |
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| IL85035A0 (en) | 1987-01-08 | 1988-06-30 | Int Genetic Eng | Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same |
| EP0590058B1 (en) | 1991-06-14 | 2003-11-26 | Genentech, Inc. | HUMANIZED Heregulin ANTIBODy |
| IL126544A (en) | 1996-04-25 | 2004-08-31 | Genicon Sciences Inc | Analyte assay using scattered-light detectable particles |
| US7029872B2 (en) | 2000-06-28 | 2006-04-18 | Glycofi, Inc | Methods for producing modified glycoproteins |
| US6596541B2 (en) | 2000-10-31 | 2003-07-22 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| EP1355919B1 (en) | 2000-12-12 | 2010-11-24 | MedImmune, LLC | Molecules with extended half-lives, compositions and uses thereof |
| US20030226155A1 (en) * | 2001-08-30 | 2003-12-04 | Biorexis Pharmaceutical Corporation | Modified transferrin-antibody fusion proteins |
| ATE458006T1 (de) * | 2003-05-14 | 2010-03-15 | Kenta Biotech Ag | Humaner monoklonaler antikörper spezifisch für lipopolysacchariden (lps) des serotyps iats o6 von pseudomonas aeruginosa |
| CN1324049C (zh) * | 2003-08-04 | 2007-07-04 | 中国疾病预防控制中心病毒病预防控制所 | 人源抗sars冠状病毒基因工程抗体 |
| WO2005100402A1 (en) * | 2004-04-13 | 2005-10-27 | F.Hoffmann-La Roche Ag | Anti-p-selectin antibodies |
| ES2730275T3 (es) * | 2004-09-22 | 2019-11-11 | Glaxosmithkline Biologicals Sa | Composición inmunógena para uso en vacunación contra estafilococos |
| MX2008009220A (es) | 2006-01-17 | 2008-10-10 | Biolex Therapeutics Inc | Composiciones y metodos para la humanizacion y optimizacion de n-glicanos en plantas. |
| TW200813091A (en) * | 2006-04-10 | 2008-03-16 | Amgen Fremont Inc | Targeted binding agents directed to uPAR and uses thereof |
| JP2009539979A (ja) * | 2006-06-12 | 2009-11-19 | ナビ バイオファーマシューティカルズ | ブドウ球菌感染症を治療および予防するための、α毒素の使用 |
| KR20100021577A (ko) * | 2007-05-31 | 2010-02-25 | 머크 앤드 캄파니 인코포레이티드 | 에스.아우레우스 ＯＲＦ0657ｎ을 표적화하는 항원 결합 단백질 |
| JP5718640B2 (ja) | 2007-08-21 | 2015-05-13 | アムジエン・インコーポレーテツド | ヒトｃ−ｆｍｓ抗原結合性タンパク質 |
| KR20100072228A (ko) * | 2007-08-31 | 2010-06-30 | 유니버시티 오브 시카고 | 스타필로코커스 폐 질환 및 상태에 대한 면역화와 관련된 방법 및 조성물 |
| US8172115B1 (en) | 2008-04-10 | 2012-05-08 | Spencer Forrest, Inc. | Hair building solids dispenser for one handed operation |
| KR20110044991A (ko) | 2008-07-02 | 2011-05-03 | 이머전트 프로덕트 디벨롭먼트 시애틀, 엘엘씨 | ＴＮＦ-α 길항제 다-표적 결합 단백질 |
| EP2208787A1 (en) * | 2009-01-19 | 2010-07-21 | Université de Liège | A recombinant alpha-hemolysin polypeptide of Staphylococcus aureus, having a deletion in the stem domain and heterologous sequences inserted |
| GB2467939A (en) * | 2009-02-20 | 2010-08-25 | Univ Sheffield | Removal of bacteria from media |
| AU2010264538B2 (en) * | 2009-06-22 | 2013-10-03 | Wyeth Llc | Immunogenic compositions of Staphylococcus aureus antigens |
| EP2917360B1 (en) * | 2012-11-06 | 2020-01-08 | Medlmmune, LLC | Antibodies to s. aureus surface determinants |
-
2012
- 2012-02-07 RS RS20181450A patent/RS58190B2/sr unknown
- 2012-02-07 PT PT12745207T patent/PT2673373T/pt unknown
- 2012-02-07 SG SG10201600899PA patent/SG10201600899PA/en unknown
- 2012-02-07 MX MX2013009127A patent/MX345285B/es active IP Right Grant
- 2012-02-07 PL PL12745207T patent/PL2673373T6/pl unknown
- 2012-02-07 JP JP2013553501A patent/JP2014508748A/ja active Pending
- 2012-02-07 RU RU2013141134A patent/RU2620065C2/ru active
- 2012-02-07 TR TR2018/17932T patent/TR201817932T4/en unknown
- 2012-02-07 BR BR112013020086-3A patent/BR112013020086B1/pt active IP Right Grant
- 2012-02-07 ES ES12745207T patent/ES2709065T7/es active Active
- 2012-02-07 US US13/983,804 patent/US9527905B2/en active Active
- 2012-02-07 AU AU2012214531A patent/AU2012214531C1/en active Active
- 2012-02-07 HU HUE12745207A patent/HUE040734T2/hu unknown
- 2012-02-07 SG SG10201913690SA patent/SG10201913690SA/en unknown
- 2012-02-07 SI SI201231470T patent/SI2673373T1/sl unknown
- 2012-02-07 DK DK12745207.6T patent/DK2673373T6/da active
- 2012-02-07 CA CA2826566A patent/CA2826566C/en active Active
- 2012-02-07 KR KR1020137023512A patent/KR101993839B1/ko active Active
- 2012-02-07 HR HRP20182017TT patent/HRP20182017T4/hr unknown
- 2012-02-07 CN CN201710480750.7A patent/CN107474133B/zh active Active
- 2012-02-07 LT LTEP12745207.6T patent/LT2673373T/lt unknown
- 2012-02-07 EP EP12745207.6A patent/EP2673373B3/en active Active
- 2012-02-07 WO PCT/US2012/024201 patent/WO2012109285A2/en not_active Ceased
- 2012-02-07 SG SG2013057831A patent/SG192212A1/en unknown
- 2012-02-07 MX MX2017001101A patent/MX375113B/es unknown
- 2012-02-07 SM SM20180635T patent/SMT201800635T1/it unknown
- 2012-02-07 CN CN201280007986.4A patent/CN103443285B9/zh active Active
- 2012-02-07 EP EP18190790.8A patent/EP3470526A3/en active Pending
-
2013
- 2013-08-07 MX MX2020009700A patent/MX2020009700A/es unknown
-
2017
- 2017-02-13 JP JP2017023905A patent/JP6367393B2/ja active Active
-
2018
- 2018-07-04 JP JP2018127340A patent/JP6723293B2/ja active Active
- 2018-11-28 CY CY20181101266T patent/CY1121389T1/el unknown
-
2020
- 2020-06-23 JP JP2020108083A patent/JP7047017B2/ja active Active
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