MX345285B - Anticuerpos que se unen especificamente a la toxina alfa de staphylococcus aureus y metodos de uso. - Google Patents

Anticuerpos que se unen especificamente a la toxina alfa de staphylococcus aureus y metodos de uso.

Info

Publication number
MX345285B
MX345285B MX2013009127A MX2013009127A MX345285B MX 345285 B MX345285 B MX 345285B MX 2013009127 A MX2013009127 A MX 2013009127A MX 2013009127 A MX2013009127 A MX 2013009127A MX 345285 B MX345285 B MX 345285B
Authority
MX
Mexico
Prior art keywords
antibodies
methods
staphylococcus aureus
alpha toxin
specifically bind
Prior art date
Application number
MX2013009127A
Other languages
English (en)
Other versions
MX2013009127A (es
Inventor
Damschroder Melissa
Sellman Bret
Tkaczyk Christine
Hua Lei
Chowdhury Partha
Varkey Reena
Peng Li
Oganesyan Vaheh
Johnson Hilliard Jamese
Original Assignee
Medimmune Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=46639171&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX345285(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Medimmune Llc filed Critical Medimmune Llc
Publication of MX2013009127A publication Critical patent/MX2013009127A/es
Publication of MX345285B publication Critical patent/MX345285B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1267—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria
    • C07K16/1271—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria from Micrococcaceae (F), e.g. Staphylococcus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/14—Peptides containing saccharide radicals; Derivatives thereof, e.g. bleomycin, phleomycin, muramylpeptides or vancomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/40—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum bacterial
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/14—Drugs for genital or sexual disorders; Contraceptives for lactation disorders, e.g. galactorrhoea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56911—Bacteria
    • G01N33/56938—Staphylococcus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2299/00—Coordinates from 3D structures of peptides, e.g. proteins or enzymes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/195—Assays involving biological materials from specific organisms or of a specific nature from bacteria
    • G01N2333/305—Assays involving biological materials from specific organisms or of a specific nature from bacteria from Micrococcaceae (F)
    • G01N2333/31—Assays involving biological materials from specific organisms or of a specific nature from bacteria from Micrococcaceae (F) from Staphylococcus (G)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/20—Dermatological disorders
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/44—Multiple drug resistance
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/70—Mechanisms involved in disease identification
    • G01N2800/709—Toxin induced
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Mycology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Dermatology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)

Abstract

La presente invención se refiere a composiciones, métodos y fabricación y métodos de uso de anticuerpos y fragmentos que unen la toxina alfa estafilococo aureus. Más específicamente, la descripción proporciona las secuencias de la región VH CDR y VL CDR de anticuerpos o fragmentos que se unen al antígeno. También se describen los métodos de prevenir, tratar o manejar una condición asociada con la infección de estafilococo aureus que utiliza los anticuerpos.
MX2013009127A 2011-02-08 2012-02-07 Anticuerpos que se unen especificamente a la toxina alfa de staphylococcus aureus y metodos de uso. MX345285B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161440581P 2011-02-08 2011-02-08
PCT/US2012/024201 WO2012109285A2 (en) 2011-02-08 2012-02-07 Antibodies that specifically bind staphylococcus aureus alpha toxin and methods of use

Publications (2)

Publication Number Publication Date
MX2013009127A MX2013009127A (es) 2014-01-31
MX345285B true MX345285B (es) 2017-01-24

Family

ID=46639171

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2013009127A MX345285B (es) 2011-02-08 2012-02-07 Anticuerpos que se unen especificamente a la toxina alfa de staphylococcus aureus y metodos de uso.
MX2020009700A MX2020009700A (es) 2011-02-08 2013-08-07 Anticuerpos que se unen especificamente a la toxina alfa de staphylococcus aureus y metodos de uso.

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2020009700A MX2020009700A (es) 2011-02-08 2013-08-07 Anticuerpos que se unen especificamente a la toxina alfa de staphylococcus aureus y metodos de uso.

Country Status (24)

Country Link
US (1) US9527905B2 (es)
EP (2) EP3470526A3 (es)
JP (4) JP2014508748A (es)
KR (1) KR101993839B1 (es)
CN (2) CN107474133B (es)
AU (1) AU2012214531C1 (es)
BR (1) BR112013020086B1 (es)
CA (1) CA2826566C (es)
CY (1) CY1121389T1 (es)
DK (1) DK2673373T6 (es)
ES (1) ES2709065T7 (es)
HK (1) HK1248257A1 (es)
HR (1) HRP20182017T4 (es)
HU (1) HUE040734T2 (es)
LT (1) LT2673373T (es)
MX (2) MX345285B (es)
PL (1) PL2673373T6 (es)
PT (1) PT2673373T (es)
RS (1) RS58190B2 (es)
RU (1) RU2620065C2 (es)
SG (3) SG192212A1 (es)
SI (1) SI2673373T1 (es)
TR (1) TR201817932T4 (es)
WO (1) WO2012109285A2 (es)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012170807A2 (en) 2011-06-10 2012-12-13 Medimmune, Llc Anti-pseudomonas psl binding molecules and uses thereof
SI2776065T1 (sl) 2011-11-07 2020-10-30 Medimmune Limited Kombinacijske terapije z uporabo molekul, ki vežejo anti-Pseudomonas Psl in PcrV
US9988439B2 (en) 2011-12-23 2018-06-05 Nicholas B. Lydon Immunoglobulins and variants directed against pathogenic microbes
EP2793944A4 (en) 2011-12-23 2015-09-02 Nicholas B Lydon IMMUNOGLOBULINS AND VARIANTS DIRECTED AGAINST PATHOGENIC MICROBES
JOP20200236A1 (ar) * 2012-09-21 2017-06-16 Regeneron Pharma الأجسام المضادة لمضاد cd3 وجزيئات ربط الأنتيجين ثنائية التحديد التي تربط cd3 وcd20 واستخداماتها
KR20150082367A (ko) * 2012-11-06 2015-07-15 메디뮨 엘엘씨 항슈도모나스 ｐｓｌ 및 ｐｃｒｖ 결합 분자를 이용한 병용 요법
BR112015010126B1 (pt) 2012-11-06 2022-11-01 Medimmune, Llc Uso de um anticorpo anti-alfa toxina (anti-at) de s. aureus isolado
KR102288394B1 (ko) 2012-11-06 2021-08-09 메디뮨 엘엘씨 스타필로코커스 아우레우스 표면 결정인자에 대한 항체
CA2925071A1 (en) * 2013-10-17 2015-04-23 Arsanis Biosciences Gmbh Cross-reactive staphylococcus aureus antibody sequences
US10487140B2 (en) 2014-01-14 2019-11-26 Integrated Biotherapeutics, Inc. Targeting immunological functions to the site of bacterial infections using cell wall targeting domains of bacteriolysins
TWI754319B (zh) 2014-03-19 2022-02-01 美商再生元醫藥公司 用於腫瘤治療之方法及抗體組成物
TWI719938B (zh) * 2014-06-19 2021-03-01 美商麥迪紐有限責任公司 多重細菌感染之治療
AU2015303147A1 (en) * 2014-08-12 2017-02-23 Arsanis Biosciences Gmbh Predicting S. aureus disease
EP3699198A1 (en) 2014-11-17 2020-08-26 Regeneron Pharmaceuticals, Inc. Methods for tumor treatment using cd3xcd20 bispecific antibody
CA3000561C (en) 2015-09-24 2022-03-22 F. Hoffman-La Roche Ag Alpha-hemolysin variants
US20190077851A1 (en) * 2015-10-30 2019-03-14 Bruno Francois Methods of using anti-alpha toxin antibody
TW202311284A (zh) 2017-01-03 2023-03-16 美商再生元醫藥公司 抗金黃色葡萄球菌溶血素ａ毒素之人類抗體
US11267886B2 (en) 2017-02-09 2022-03-08 Bluefin Biomedicine, Inc. Anti-ILT3 antibodies and antibody drug conjugates
CN109384844B (zh) * 2017-08-04 2020-12-18 中国人民解放军军事医学科学院基础医学研究所 一种抗金黄色葡萄球菌α溶血素单克隆抗体及应用
US11155606B2 (en) 2018-07-24 2021-10-26 Medimmune, Llc Antibody directed against S. aureus clumping factor a (ClfA)
WO2020041532A1 (en) * 2018-08-21 2020-02-27 Sf17 Therapeutics, Inc. Compositions and methods for treating progressive neurodegenerative diseases
JP2021535142A (ja) 2018-08-31 2021-12-16 リジェネロン・ファーマシューティカルズ・インコーポレイテッドRegeneron Pharmaceuticals, Inc. Ｃｄ３／ｃ２０二重特異性抗体のサイトカイン放出症候群を軽減する投与戦略
TW202035443A (zh) 2018-10-09 2020-10-01 美商麥迪紐有限責任公司 抗金黃色葡萄球菌抗體的組合
EP3864040A1 (en) 2018-10-09 2021-08-18 Medimmune, LLC Antibodies directed against staphylococcus aureus leukotoxins
CN113811544A (zh) * 2019-03-13 2021-12-17 免疫医疗有限责任公司 减少定殖患者中的金黄色葡萄球菌感染
WO2020210650A1 (en) 2019-04-12 2020-10-15 Medimmune, Llc Neutralization of tgf-beta or alpha-v-beta-8 integrin for s. aureus infections
CN112538112B (zh) 2019-09-20 2023-10-27 迈威(上海)生物科技股份有限公司 抗α-溶血素的抗体及其应用
CN113444171A (zh) 2020-03-25 2021-09-28 兴盟生物医药(苏州)有限公司 金黄色葡萄球菌α-毒素特异性抗体及其应用
CN112941136B (zh) * 2021-03-24 2023-04-28 成都欧林生物科技股份有限公司 一种重组金黄色葡萄球菌疫苗hi抗原蛋白的纯化方法
CN114455048B (zh) * 2022-03-02 2023-03-14 江苏微导纳米科技股份有限公司 一种桨杆
CN117106077B (zh) * 2022-04-28 2024-07-16 珠海泰诺麦博制药股份有限公司 特异性结合金黄色葡萄球菌Hla毒素的全人源单克隆抗体
CN116589566A (zh) * 2022-11-18 2023-08-15 昆明医科大学第一附属医院 一种HIV-1中和抗体的改造重组单克隆IgM抗体及其应用
CN116023486B (zh) * 2023-01-10 2024-10-08 西北农林科技大学 金黄色葡萄球菌α-溶血素纳米抗体、制备方法及其应用

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL85035A0 (en) 1987-01-08 1988-06-30 Int Genetic Eng Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same
LU91067I2 (fr) 1991-06-14 2004-04-02 Genentech Inc Trastuzumab et ses variantes et dérivés immuno chimiques y compris les immotoxines
JP2000510582A (ja) 1996-04-25 2000-08-15 ゼニコン・サイエンシーズ・コーポレーション 微粒子標識を使用した分析物アッセイ
DK1522590T3 (da) 2000-06-28 2009-12-21 Glycofi Inc Fremgangsmåde til fremstilling af modificerede glykoproteiner
US6596541B2 (en) 2000-10-31 2003-07-22 Regeneron Pharmaceuticals, Inc. Methods of modifying eukaryotic cells
DE60143544D1 (de) 2000-12-12 2011-01-05 Medimmune Llc Moleküle mit längeren halbwertszeiten, zusammensetzungen und deren verwendung
US20030226155A1 (en) * 2001-08-30 2003-12-04 Biorexis Pharmaceutical Corporation Modified transferrin-antibody fusion proteins
EP1479695B1 (en) * 2003-05-14 2010-02-17 Kenta Biotech AG Human monoclonal antibody specific for lipopolysaccharides (LPS) of serotype IATS O6 of Pseudomonas aeruginosa
CN1324049C (zh) * 2003-08-04 2007-07-04 中国疾病预防控制中心病毒病预防控制所 人源抗sars冠状病毒基因工程抗体
EP2357201B1 (en) * 2004-04-13 2017-08-30 F. Hoffmann-La Roche AG Anti-P-selectin antibodies
NZ553776A (en) * 2004-09-22 2010-05-28 Glaxosmithkline Biolog Sa Immunogenic composition comprising staphylococcal PNAG and Type 5 and/or 8 Capsular polysaccharide or oligosaccharide.
CA2637252A1 (en) 2006-01-17 2007-07-26 Biolex Therapeutics, Inc. Plants and plant cells having inhibited expression of .alpha.1,3-fucosyltransferase and .beta.1,2-xylosyltransferase
TW200813091A (en) 2006-04-10 2008-03-16 Amgen Fremont Inc Targeted binding agents directed to uPAR and uses thereof
KR20090019007A (ko) * 2006-06-12 2009-02-24 나비 바이오파마슈티컬즈 스타필로코쿠스 감염증을 치료 및 예방하기 위한 알파-독소의 용도
MX2009012891A (es) * 2007-05-31 2009-12-10 Merck & Co Inc Proteinas de union a antigeno dirigidas a staphylococcus aureus orf0657n.
CL2008002444A1 (es) * 2007-08-21 2009-09-04 Amgen Inc Anticuerpo o fragmento del mismo que se une a la proteina c-fms humana; molecula de acido nucleico que la codifica; vector y celula huesped; metodo de elaboracion; composicion farmaceutica que la comprende; y su uso para tratar o prevenir una condicion asociada con c-fms en un paciente.
CN101951948B (zh) * 2007-08-31 2015-12-09 芝加哥大学 与针对葡萄球菌性肺部疾病和病症进行免疫相关的方法和组合物
US8172115B1 (en) 2008-04-10 2012-05-08 Spencer Forrest, Inc. Hair building solids dispenser for one handed operation
US20110152173A1 (en) * 2008-07-02 2011-06-23 Emergent Product Development Seattle ,LLC TNF-a ANTAGONIST MULTI-TARGET BINDING PROTEINS
EP2208787A1 (en) * 2009-01-19 2010-07-21 Université de Liège A recombinant alpha-hemolysin polypeptide of Staphylococcus aureus, having a deletion in the stem domain and heterologous sequences inserted
GB2467939A (en) * 2009-02-20 2010-08-25 Univ Sheffield Removal of bacteria from media
JP5395264B2 (ja) * 2009-06-22 2014-01-22 ワイス・エルエルシー 黄色ブドウ球菌（ｓｔａｐｈｙｌｏｃｏｃｃｕｓａｕｒｅｕｓ）抗原の免疫原性組成物
KR102288394B1 (ko) * 2012-11-06 2021-08-09 메디뮨 엘엘씨 스타필로코커스 아우레우스 표면 결정인자에 대한 항체

Also Published As

Publication number Publication date
TR201817932T4 (tr) 2019-02-21
EP2673373B3 (en) 2021-06-02
BR112013020086B1 (pt) 2020-12-08
SG10201600899PA (en) 2016-03-30
KR101993839B1 (ko) 2019-06-28
HUE040734T2 (hu) 2019-03-28
EP2673373B1 (en) 2018-08-29
KR20140019344A (ko) 2014-02-14
JP2019011329A (ja) 2019-01-24
JP7047017B2 (ja) 2022-04-04
JP6367393B2 (ja) 2018-08-01
WO2012109285A2 (en) 2012-08-16
CN103443285A (zh) 2013-12-11
LT2673373T (lt) 2019-01-25
HRP20182017T1 (hr) 2019-02-08
JP6723293B2 (ja) 2020-07-15
RU2620065C2 (ru) 2017-05-22
SG10201913690SA (en) 2020-03-30
DK2673373T3 (da) 2019-01-02
CN103443285B (zh) 2017-06-23
HRP20182017T4 (hr) 2021-08-20
HK1248257A1 (zh) 2018-10-12
WO2012109285A3 (en) 2012-10-04
EP3470526A3 (en) 2019-07-17
RS58190B1 (sr) 2019-03-29
SI2673373T1 (sl) 2019-03-29
PL2673373T6 (pl) 2021-09-27
CN107474133A (zh) 2017-12-15
CA2826566A1 (en) 2012-08-16
US9527905B2 (en) 2016-12-27
EP3470526A2 (en) 2019-04-17
PL2673373T3 (pl) 2019-04-30
ES2709065T3 (es) 2019-04-15
AU2012214531B2 (en) 2017-03-16
CA2826566C (en) 2022-09-13
CN107474133B (zh) 2021-10-15
BR112013020086A2 (pt) 2016-11-22
DK2673373T6 (da) 2021-08-23
CY1121389T1 (el) 2020-05-29
JP2017128575A (ja) 2017-07-27
RU2013141134A (ru) 2015-03-20
PT2673373T (pt) 2018-12-05
ES2709065T7 (es) 2021-12-09
MX2013009127A (es) 2014-01-31
JP2014508748A (ja) 2014-04-10
JP2020172489A (ja) 2020-10-22
AU2012214531C1 (en) 2021-07-29
MX2020009700A (es) 2020-10-07
EP2673373A4 (en) 2015-06-17
US20140072577A1 (en) 2014-03-13
EP2673373A2 (en) 2013-12-18
CN103443285B9 (zh) 2018-04-24
RS58190B2 (sr) 2021-08-31
SG192212A1 (en) 2013-09-30

Similar Documents

Publication Publication Date Title
MX2020009700A (es) Anticuerpos que se unen especificamente a la toxina alfa de staphylococcus aureus y metodos de uso.
WO2013119716A8 (en) Compositions and methods for using csf1r inhibitors
MX347020B (es) Anticuerpo contra el csf-1r.
WO2016062722A8 (en) Combination
EP4249515A3 (en) Humanized or chimeric cd3 antibodies
MX2022008079A (es) Anticuerpos contra determinantes de la superficie de s. aureus.
NZ626269A (en) Anti-phf-tau antibodies and their uses
MX2013009151A (es) Inmunoterapia mejorada.
PH12016502372A1 (en) Compositions and methods for treating and preventing staphylococcus aureus infections
TN2012000462A1 (en) Anti-cd40 antibodies
WO2012149356A3 (en) Anti-cd40 antibodies and methods of use
NZ707086A (en) Anti-cd40 antibodies and methods of use
MX347164B (es) Anticuerpos anti-il-36r.
NZ602294A (en) Monoclonal antibodies against c-met
PH12014502406B1 (en) Anti-il-23p19 antibodies
AU2013341349A8 (en) Combination therapies using anti-Pseudomonas Psl and PcrV binding molecules
TN2013000378A1 (en) Anti - sclerostin antibody crystals and formulations thereof
MX354988B (es) Formulaciones de anticuerpo y metodos.
MX2016007212A (es) Anticuerpos dirigidos contra la toxina lukgh (lukab) de staphylococcus aureus y secuencias de anticuerpos.
WO2017075188A3 (en) Methods of using anti-alpha toxin antibody
EP4079760A3 (en) Antibodies against clostridium difficile toxins and methods of using the same
WO2012112548A3 (en) Firmocidin, an antimicrobial molecule produced by staphylococcus epidermidis
MX2018009264A (es) Anticuerpo de trombina, fragmento de antigeno y sus usos farmaceuticos.
WO2013138244A3 (en) Treatment of multiple sclerosis with anti-cd19 antibody
NZ702282A (en) Compositions and methods related to antibodies that neutralize coagulase activity during staphylococcus aureus disease

Legal Events

Date Code Title Description
FG Grant or registration