JP2015536951A5 - - Google Patents
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- JP2015536951A5 JP2015536951A5 JP2015540852A JP2015540852A JP2015536951A5 JP 2015536951 A5 JP2015536951 A5 JP 2015536951A5 JP 2015540852 A JP2015540852 A JP 2015540852A JP 2015540852 A JP2015540852 A JP 2015540852A JP 2015536951 A5 JP2015536951 A5 JP 2015536951A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- nos
- antibody
- amino acid
- acid sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 238000000034 method Methods 0.000 claims 17
- 125000003275 alpha amino acid group Chemical group 0.000 claims 10
- 239000000427 antigen Substances 0.000 claims 8
- 102000036639 antigens Human genes 0.000 claims 8
- 108091007433 antigens Proteins 0.000 claims 8
- 239000012634 fragment Substances 0.000 claims 8
- 230000001580 bacterial effect Effects 0.000 claims 4
- 101710092462 Alpha-hemolysin Proteins 0.000 claims 3
- 101710197219 Alpha-toxin Proteins 0.000 claims 3
- 101710124951 Phospholipase C Proteins 0.000 claims 3
- 239000002776 alpha toxin Substances 0.000 claims 3
- 238000004220 aggregation Methods 0.000 claims 2
- 230000002776 aggregation Effects 0.000 claims 2
- 230000015572 biosynthetic process Effects 0.000 claims 2
- 230000003902 lesion Effects 0.000 claims 2
- 230000009424 thromboembolic effect Effects 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 206010061598 Immunodeficiency Diseases 0.000 claims 1
- 206010035664 Pneumonia Diseases 0.000 claims 1
- 206010040047 Sepsis Diseases 0.000 claims 1
- 229920001184 polypeptide Polymers 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 108010092231 staphylococcal alpha-toxin Proteins 0.000 claims 1
- 239000003053 toxin Substances 0.000 claims 1
- 231100000765 toxin Toxicity 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2019063358A JP6926138B2 (ja) | 2012-11-06 | 2019-03-28 | 黄色ブドウ球菌（Ｓ．ａｕｒｅｕｓ）関連性疾患を治療する方法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261723128P | 2012-11-06 | 2012-11-06 | |
| US61/723,128 | 2012-11-06 | ||
| PCT/US2013/068385 WO2014074470A1 (en) | 2012-11-06 | 2013-11-05 | Methods of treating s. aureus-associated diseases |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019063358A Division JP6926138B2 (ja) | 2012-11-06 | 2019-03-28 | 黄色ブドウ球菌（Ｓ．ａｕｒｅｕｓ）関連性疾患を治療する方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015536951A JP2015536951A (ja) | 2015-12-24 |
| JP2015536951A5 true JP2015536951A5 (enExample) | 2016-12-22 |
| JP6506172B2 JP6506172B2 (ja) | 2019-04-24 |
Family
ID=50685101
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015540852A Active JP6506172B2 (ja) | 2012-11-06 | 2013-11-05 | 黄色ブドウ球菌（Ｓ．ａｕｒｅｕｓ）関連性疾患を治療する方法 |
| JP2019063358A Active JP6926138B2 (ja) | 2012-11-06 | 2019-03-28 | 黄色ブドウ球菌（Ｓ．ａｕｒｅｕｓ）関連性疾患を治療する方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019063358A Active JP6926138B2 (ja) | 2012-11-06 | 2019-03-28 | 黄色ブドウ球菌（Ｓ．ａｕｒｅｕｓ）関連性疾患を治療する方法 |
Country Status (13)
| Country | Link |
|---|---|
| US (3) | US9845348B2 (enExample) |
| EP (1) | EP2928490B1 (enExample) |
| JP (2) | JP6506172B2 (enExample) |
| KR (3) | KR20150092738A (enExample) |
| CN (2) | CN112316135A (enExample) |
| AU (2) | AU2013341421A1 (enExample) |
| BR (1) | BR112015010126B1 (enExample) |
| CA (1) | CA2890385C (enExample) |
| ES (1) | ES2912267T3 (enExample) |
| MX (1) | MX367082B (enExample) |
| RU (1) | RU2661406C2 (enExample) |
| SG (2) | SG10201703677VA (enExample) |
| WO (1) | WO2014074470A1 (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102111171B1 (ko) | 2011-06-10 | 2020-05-14 | 메디뮨 엘엘씨 | 항슈도모나스 ｐｓｌ 결합 분자 및 그의 용도 |
| SMT202000542T1 (it) | 2011-11-07 | 2020-11-10 | Medimmune Ltd | Terapie di combinazione utilizzando molecole di legame anti-psl e pcrv di pseudomonas |
| CA2890427C (en) | 2012-11-06 | 2022-05-31 | Medimmune, Llc | Antibodies to s. aureus surface determinants |
| SG10201703677VA (en) * | 2012-11-06 | 2017-06-29 | Medimmune Llc | Methods of treating s. aureus-associated diseases |
| TWI719938B (zh) | 2014-06-19 | 2021-03-01 | 美商麥迪紐有限責任公司 | 多重細菌感染之治療 |
| TWI781130B (zh) | 2017-01-03 | 2022-10-21 | 美商再生元醫藥公司 | 抗金黃色葡萄球菌溶血素ａ毒素之人類抗體 |
| CN119176871A (zh) | 2018-07-24 | 2024-12-24 | 免疫医疗有限责任公司 | 抗金黄色葡萄球菌凝集因子a(clfa)的抗体 |
| WO2020076789A2 (en) | 2018-10-09 | 2020-04-16 | Medimmune, Llc | Combinations of anti-staphylococcus aureus antibodies |
| MX2021004114A (es) | 2018-10-09 | 2021-07-16 | Medimmune Llc | Anticuerpos dirigidos contra leucotoxinas de staphylococcus aureus. |
| TW202100549A (zh) | 2019-03-13 | 2021-01-01 | 美商麥迪紐有限責任公司 | 降低金黃色葡萄球菌在定殖的患者中之感染 |
| CN112538112B (zh) * | 2019-09-20 | 2023-10-27 | 迈威(上海)生物科技股份有限公司 | 抗α-溶血素的抗体及其应用 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2007259415B2 (en) * | 2006-06-12 | 2013-09-26 | Glaxosmithkline Biologicals Sa | Use of alpha-toxin for treating and preventing Staphylococcus infections |
| CA2697538C (en) * | 2007-08-31 | 2019-02-12 | University Of Chicago | Methods and compositions related to immunizing against staphylococcal lung diseases and conditions |
| WO2011008939A2 (en) * | 2009-07-16 | 2011-01-20 | Medical College Of Georgia Research Institute, Inc. | Porous-wall hollow glass microspheres as carriers for biomolecules |
| EP2284193A1 (en) * | 2009-08-10 | 2011-02-16 | Kenta Biotech AG | Human monoclonal antibody against S. aureus derived apha-toxin and its use in treating or preventing abscess formation |
| AU2012214677B2 (en) * | 2011-02-08 | 2016-11-10 | Abvacc, Inc. | Immunogenic composition comprising alpha-hemolysin oligopeptides |
| PT2673373T (pt) | 2011-02-08 | 2018-12-05 | Medimmune Llc | Anticorpos que ligam especificamente a toxina alfa de staphylococcus aureus e métodos de utilização |
| CA2890427C (en) | 2012-11-06 | 2022-05-31 | Medimmune, Llc | Antibodies to s. aureus surface determinants |
| SG10201703677VA (en) * | 2012-11-06 | 2017-06-29 | Medimmune Llc | Methods of treating s. aureus-associated diseases |
| TWI719938B (zh) | 2014-06-19 | 2021-03-01 | 美商麥迪紐有限責任公司 | 多重細菌感染之治療 |
| US20190077851A1 (en) | 2015-10-30 | 2019-03-14 | Bruno Francois | Methods of using anti-alpha toxin antibody |
-
2013
- 2013-11-05 SG SG10201703677VA patent/SG10201703677VA/en unknown
- 2013-11-05 CA CA2890385A patent/CA2890385C/en active Active
- 2013-11-05 KR KR1020157011460A patent/KR20150092738A/ko not_active Ceased
- 2013-11-05 RU RU2015121617A patent/RU2661406C2/ru active
- 2013-11-05 KR KR1020217020104A patent/KR20210083389A/ko not_active Ceased
- 2013-11-05 SG SG11201503231YA patent/SG11201503231YA/en unknown
- 2013-11-05 KR KR1020207024078A patent/KR102272744B1/ko active Active
- 2013-11-05 MX MX2015005481A patent/MX367082B/es active IP Right Grant
- 2013-11-05 ES ES13853844T patent/ES2912267T3/es active Active
- 2013-11-05 CN CN202011217117.7A patent/CN112316135A/zh active Pending
- 2013-11-05 WO PCT/US2013/068385 patent/WO2014074470A1/en not_active Ceased
- 2013-11-05 CN CN201380057604.3A patent/CN104780934A/zh active Pending
- 2013-11-05 AU AU2013341421A patent/AU2013341421A1/en not_active Abandoned
- 2013-11-05 US US14/440,749 patent/US9845348B2/en active Active
- 2013-11-05 BR BR112015010126-7A patent/BR112015010126B1/pt active IP Right Grant
- 2013-11-05 JP JP2015540852A patent/JP6506172B2/ja active Active
- 2013-11-05 EP EP13853844.2A patent/EP2928490B1/en active Active
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2017
- 2017-12-18 US US15/845,701 patent/US10457724B2/en active Active
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2018
- 2018-09-28 AU AU2018236849A patent/AU2018236849B2/en active Active
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2019
- 2019-03-28 JP JP2019063358A patent/JP6926138B2/ja active Active
- 2019-10-11 US US16/599,595 patent/US10759849B2/en active Active