JP6506172B2 - 黄色ブドウ球菌(S.aureus)関連性疾患を治療する方法 - Google Patents

黄色ブドウ球菌(S.aureus)関連性疾患を治療する方法 Download PDF

Info

Publication number
JP6506172B2
JP6506172B2 JP2015540852A JP2015540852A JP6506172B2 JP 6506172 B2 JP6506172 B2 JP 6506172B2 JP 2015540852 A JP2015540852 A JP 2015540852A JP 2015540852 A JP2015540852 A JP 2015540852A JP 6506172 B2 JP6506172 B2 JP 6506172B2
Authority
JP
Japan
Prior art keywords
seq
antibody
nos
aureus
amino acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2015540852A
Other languages
English (en)
Japanese (ja)
Other versions
JP2015536951A5 (enExample
JP2015536951A (ja
Inventor
セルマン,ブレット
トカチク,クリスティーン
ハミルトン,メリッサ
ホワ,レイ
Original Assignee
メディミューン,エルエルシー
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by メディミューン,エルエルシー filed Critical メディミューン,エルエルシー
Publication of JP2015536951A publication Critical patent/JP2015536951A/ja
Publication of JP2015536951A5 publication Critical patent/JP2015536951A5/ja
Priority to JP2019063358A priority Critical patent/JP6926138B2/ja
Application granted granted Critical
Publication of JP6506172B2 publication Critical patent/JP6506172B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/02—Peptides of undefined number of amino acids; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1267—Gram-positive bacteria
    • C07K16/1271—Micrococcaceae (F); Staphylococcaceae (F), e.g. Staphylococcus (G)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/085—Staphylococcus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
JP2015540852A 2012-11-06 2013-11-05 黄色ブドウ球菌(S.aureus)関連性疾患を治療する方法 Active JP6506172B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2019063358A JP6926138B2 (ja) 2012-11-06 2019-03-28 黄色ブドウ球菌(S.aureus)関連性疾患を治療する方法

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261723128P 2012-11-06 2012-11-06
US61/723,128 2012-11-06
PCT/US2013/068385 WO2014074470A1 (en) 2012-11-06 2013-11-05 Methods of treating s. aureus-associated diseases

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2019063358A Division JP6926138B2 (ja) 2012-11-06 2019-03-28 黄色ブドウ球菌(S.aureus)関連性疾患を治療する方法

Publications (3)

Publication Number Publication Date
JP2015536951A JP2015536951A (ja) 2015-12-24
JP2015536951A5 JP2015536951A5 (enExample) 2016-12-22
JP6506172B2 true JP6506172B2 (ja) 2019-04-24

Family

ID=50685101

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2015540852A Active JP6506172B2 (ja) 2012-11-06 2013-11-05 黄色ブドウ球菌(S.aureus)関連性疾患を治療する方法
JP2019063358A Active JP6926138B2 (ja) 2012-11-06 2019-03-28 黄色ブドウ球菌(S.aureus)関連性疾患を治療する方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2019063358A Active JP6926138B2 (ja) 2012-11-06 2019-03-28 黄色ブドウ球菌(S.aureus)関連性疾患を治療する方法

Country Status (13)

Country Link
US (3) US9845348B2 (enExample)
EP (1) EP2928490B1 (enExample)
JP (2) JP6506172B2 (enExample)
KR (3) KR20210083389A (enExample)
CN (2) CN112316135A (enExample)
AU (2) AU2013341421A1 (enExample)
BR (1) BR112015010126B1 (enExample)
CA (1) CA2890385C (enExample)
ES (1) ES2912267T3 (enExample)
MX (1) MX367082B (enExample)
RU (1) RU2661406C2 (enExample)
SG (2) SG10201703677VA (enExample)
WO (1) WO2014074470A1 (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2012267732A1 (en) 2011-06-10 2014-01-09 Medimmune Limited Anti-Pseudomonas Psl binding molecules and uses thereof
WO2013070615A1 (en) * 2011-11-07 2013-05-16 Medlmmune, Llc. Combination therapies using anti- pseudomonas psl and pcrv binding molecules
EP2917360B1 (en) * 2012-11-06 2020-01-08 Medlmmune, LLC Antibodies to s. aureus surface determinants
ES2912267T3 (es) * 2012-11-06 2022-05-25 Medimmune Llc Métodos de tratamiento de enfermedades asociadas a S. aureus
TWI719938B (zh) 2014-06-19 2021-03-01 美商麥迪紐有限責任公司 多重細菌感染之治療
TW202311284A (zh) 2017-01-03 2023-03-16 美商再生元醫藥公司 抗金黃色葡萄球菌溶血素a毒素之人類抗體
MX2021000889A (es) 2018-07-24 2021-04-28 Medimmune Llc Anticuerpo dirigido contra el factor de agregación a (clfa) de s. aureus.
WO2020076790A1 (en) 2018-10-09 2020-04-16 Medimmune, Llc Antibodies directed against staphylococcus aureus leukotoxins
MX2021004173A (es) 2018-10-09 2021-09-08 Medimmune Llc Combinaciones de anticuerpos dirigidos contra staphylococcus aureus.
JP7682795B2 (ja) 2019-03-13 2025-05-26 メディミューン,エルエルシー コロニー形成患者における黄色ブドウ球菌(Staphylococcus aureus)感染症の低減
CN112538112B (zh) * 2019-09-20 2023-10-27 迈威(上海)生物科技股份有限公司 抗α-溶血素的抗体及其应用

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009539979A (ja) * 2006-06-12 2009-11-19 ナビ バイオファーマシューティカルズ ブドウ球菌感染症を治療および予防するための、α毒素の使用
KR20100072228A (ko) * 2007-08-31 2010-06-30 유니버시티 오브 시카고 스타필로코커스 폐 질환 및 상태에 대한 면역화와 관련된 방법 및 조성물
EP2453881A2 (en) * 2009-07-16 2012-05-23 Georgia Health Sciences University Research Institute, Inc. Porous-wall hollow glass microspheres as carriers for biomolecules
EP2284193A1 (en) * 2009-08-10 2011-02-16 Kenta Biotech AG Human monoclonal antibody against S. aureus derived apha-toxin and its use in treating or preventing abscess formation
RS58190B2 (sr) 2011-02-08 2021-08-31 Medimmune Llc Antitela koja specifično vezuju staphylococcus aureus alfa toksin i postupci njihove primene
AU2012214677B2 (en) * 2011-02-08 2016-11-10 Abvacc, Inc. Immunogenic composition comprising alpha-hemolysin oligopeptides
EP2917360B1 (en) 2012-11-06 2020-01-08 Medlmmune, LLC Antibodies to s. aureus surface determinants
ES2912267T3 (es) * 2012-11-06 2022-05-25 Medimmune Llc Métodos de tratamiento de enfermedades asociadas a S. aureus
TWI719938B (zh) 2014-06-19 2021-03-01 美商麥迪紐有限責任公司 多重細菌感染之治療
US20190077851A1 (en) 2015-10-30 2019-03-14 Bruno Francois Methods of using anti-alpha toxin antibody

Also Published As

Publication number Publication date
EP2928490B1 (en) 2022-03-30
AU2018236849A1 (en) 2018-10-18
KR20210083389A (ko) 2021-07-06
SG11201503231YA (en) 2015-05-28
US10457724B2 (en) 2019-10-29
KR102272744B1 (ko) 2021-07-06
KR20200102533A (ko) 2020-08-31
CN112316135A (zh) 2021-02-05
CN104780934A (zh) 2015-07-15
AU2013341421A1 (en) 2015-06-04
JP6926138B2 (ja) 2021-08-25
CA2890385C (en) 2022-07-12
SG10201703677VA (en) 2017-06-29
JP2019142888A (ja) 2019-08-29
ES2912267T3 (es) 2022-05-25
US10759849B2 (en) 2020-09-01
RU2015121617A (ru) 2016-12-27
RU2661406C2 (ru) 2018-07-16
CA2890385A1 (en) 2014-05-15
US9845348B2 (en) 2017-12-19
US20200109191A1 (en) 2020-04-09
MX2015005481A (es) 2016-01-14
HK1215173A1 (zh) 2016-08-19
MX367082B (es) 2019-08-05
WO2014074470A1 (en) 2014-05-15
AU2018236849B2 (en) 2020-05-21
US20160257733A1 (en) 2016-09-08
US20190002540A1 (en) 2019-01-03
EP2928490A4 (en) 2016-11-02
JP2015536951A (ja) 2015-12-24
BR112015010126A2 (enExample) 2017-08-22
BR112015010126B1 (pt) 2022-11-01
KR20150092738A (ko) 2015-08-13
EP2928490A1 (en) 2015-10-14

Similar Documents

Publication Publication Date Title
US10759849B2 (en) Methods of treating S. aureus-associated diseases
KR102288394B1 (ko) 스타필로코커스 아우레우스 표면 결정인자에 대한 항체
AU2015276938B2 (en) Treatment of polybacterials infections
US20150044168A1 (en) Treatment of Multiple Sclerosis With Anti-CD19 Antibody
JP2022512647A (ja) 抗黄色ブドウ球菌(Staphylococcus aureus)抗体の組み合わせ
CA3121934A1 (en) Clazakizumab in the treatment of chronic antibody-mediated rejection of organ transplant
JP2025515485A (ja) 眼の疾患を治療するための組成物及び方法
HK1215173B (en) Methods of treating s. aureus-associated diseases
RU2804815C2 (ru) Комбинации антител к staphylococcus aureus
TW202511292A (zh) 用於治療NSCLC及cHL之PD-1/TIM-3結合蛋白
HK40025295A (en) Antibodies to s. aureus surface determinants
HK1215452B (en) Antibodies to s. aureus surface determinants
HK1236126A1 (en) Treatment of polybacterials infections
HK1236126B (en) Treatment of polybacterials infections

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20161104

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20161104

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20171024

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20180118

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20180424

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20180529

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20180823

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20181128

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20190108

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20190204

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20190226

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20190328

R150 Certificate of patent or registration of utility model

Ref document number: 6506172

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250